Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P28884

- HN_SV5CP

UniProt

P28884 - HN_SV5CP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Simian virus 5 (isolate Canine/CPI+) (SV5)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

  1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
  2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
  3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

GO - Biological processi

  1. viral entry into host cell Source: UniProtKB-KW
  2. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hemagglutinin, Hydrolase

Keywords - Biological processi

Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83. Glycoside Hydrolase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiSimian virus 5 (isolate Canine/CPI+) (SV5)
Taxonomic identifieri31608 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
Virus hostiCanis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Homo sapiens (Human) [TaxID: 9606]
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) [TaxID: 9541]
Macaca mulatta (Rhesus macaque) [TaxID: 9544]

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 565565Hemagglutinin-neuraminidasePRO_0000142643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi139 – 1391N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi267 – 2671N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi504 – 5041N-linked (GlcNAc...); by hostSequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP28884.
SMRiP28884. Positions 118-565.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020IntravirionSequence AnalysisAdd
BLAST
Topological domaini42 – 565524Virion surfaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view]
PfamiPF00423. HN. 1 hit.
[Graphical view]
PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

P28884 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAEDAPVRG TCRVLFRTTT LIFLCTLLAL SISILYESLI IRKQIMSQAG
60 70 80 90 100
STGSNFRLGS ITDLLNNILS VANQIIYNSA VALPLQLDTL ESTLLTAIKS
110 120 130 140 150
LQTSDKLEQN CSWGAALIND NRYINGINQF YFSIAEGRNL TLGPLLNIPS
160 170 180 190 200
FIPTATTPEG CTRIPSFSLT KTHWCYTHNV ILNGCQDHVS SNQFVSMGII
210 220 230 240 250
EPTSAGFPSF RTLKTLYLSD GVNRKSCSIS TVPGGCMMYC FVSTQPERDD
260 270 280 290 300
YLSTAPPEQR IIIMYYNDTI VERIINPPGV LDVWATLNPG TGSGVYYLGW
310 320 330 340 350
VLFPTYGGVI KDTSLWNNQA NKYFIPQMVA ALCSQNQATQ VQNAKSSYYS
360 370 380 390 400
SWFGNRMIQS GILACPLQQD LTNECLILPF SNDQVLMGAE GRLYMYGDSV
410 420 430 440 450
YYYQRSNSWW PMTMLYKVTI TFTNGQPSAI SAQNVPTQQV PRPGTGDCSA
460 470 480 490 500
TNRCPGFCLK GVYADAWLLT NPSSTSTFGS EATFTGSYLN AATQRINPTM
510 520 530 540 550
YIANNTQIIS SQQFGSSGQE AAYGHTTCFR DTGSVMVYCI YIIELSSSLL
560
GQFQIVPFIR QVTLS
Length:565
Mass (Da):62,307
Last modified:December 1, 1992 - v1
Checksum:i4DA94276AC6F523C
GO

Sequence databases

PIRiJQ1306. HNNZC2.

Cross-referencesi

Sequence databases

PIRi JQ1306. HNNZC2.

3D structure databases

ProteinModelPortali P28884.
SMRi P28884. Positions 118-565.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH83. Glycoside Hydrolase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR000665. Hemagglutn-neuramid.
IPR016285. Hemagglutn-neuramid_paramyxo.
IPR011040. Sialidases.
[Graphical view ]
Pfami PF00423. HN. 1 hit.
[Graphical view ]
PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence comparison between the haemagglutinin-neuraminidase genes of simian, canine and human isolates of simian virus 5."
    Baty D.U., Southern J.A., Randall R.E.
    J. Gen. Virol. 72:3103-3107(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiHN_SV5CP
AccessioniPrimary (citable) accession number: P28884
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3