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Protein

Omega-conotoxin SVIB

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-, P- and Q-type calcium channels.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Omega-conotoxin SVIB1 Publication
Alternative name(s):
SNX-1831 Publication
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri862. SVIB precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

On fish, this toxin causes paralysis and death on intramuscular injection at doses of approximately 20 pmol/g. On intracranial injection into mice, it causes respiratory distress at around 70 pmol/g mouse and is lethal at around 300 pmol/g mouse.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000003492623 – 45CuratedAdd BLAST23
PeptideiPRO_000003492746 – 71Omega-conotoxin SVIB1 PublicationAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 611 PublicationImported
Disulfide bondi53 ↔ 651 PublicationImported
Disulfide bondi60 ↔ 711 PublicationImported
Modified residuei71Cysteine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Structurei

Secondary structure

172
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni55 – 57Combined sources3
Beta strandi60 – 62Combined sources3
Beta strandi67 – 69Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVJNMR-A46-71[»]
SMRiP28881.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28881.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.1 Publication
The cysteine framework is VI/VII (C-C-CC-C-C).Curated

Sequence similaritiesi

Belongs to the conotoxin O1 superfamily.Curated

Keywords - Domaini

Knottin, Signal

Family and domain databases

InterProiView protein in InterPro
IPR004214. Conotoxin.
IPR012321. Conotoxin_omega-typ_CS.
PfamiView protein in Pfam
PF02950. Conotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS60004. OMEGA_CONOTOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTCVVIVA VLLLTACQLI TADDSRGTQK HRALRSDTKL PMSTRCKLKG
60 70
QSCRKTSYDC CSGSCGRSGK CG
Length:72
Mass (Da):7,741
Last modified:August 29, 2001 - v2
Checksum:i1F753546AAD39908
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF146346 mRNA. Translation: AAD31906.1.
PIRiC44379.

Similar proteinsi

Entry informationi

Entry nameiCO16B_CONST
AccessioniPrimary (citable) accession number: P28881
Secondary accession number(s): Q9UB25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 29, 2001
Last modified: July 5, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families