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P28880 (CO16A_CONST) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Omega-conotoxin SVIA
Alternative name(s):
SNX-157
OrganismConus striatus (Striated cone)
Taxonomic identifier6493 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length72 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Domain

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

The cysteine framework is VI/VII (C-C-CC-C-C).

Sequence similarities

Belongs to the conotoxin O1 superfamily.

Caution

Thr-72 is not followed in the nucleotide sequence by the expected Gly residue required to produce amidation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 4826
PRO_0000034924
Peptide49 – 7224Omega-conotoxin SVIA Ref.2
PRO_0000034925

Amino acid modifications

Modified residue5514-hydroxyproline
Modified residue721Threonine amide Ref.2
Disulfide bond49 ↔ 63
Disulfide bond56 ↔ 66
Disulfide bond62 ↔ 71

Natural variations

Natural variant511S → P in SVIA-1, SVIA-2 and SVIA-5. Ref.3
Natural variant541S → P in SVIA-4. Ref.3
Natural variant551P → S in SVIA-3. Ref.3
Natural variant591T → A in SVIA-5. Ref.3
Natural variant671Y → S in SVIA-2 and SVIA-5. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P28880 [UniParc].

Last modified August 29, 2001. Version 2.
Checksum: 4A6A412E450469A1

FASTA727,830
        10         20         30         40         50         60 
MKLTCVMIVA VLLLTACQLI TAEDSRGTQK HRTLRSTARR SKSESTTRCR SSGSPCGVTS 

        70 
ICCGRCYRGK CT 

« Hide

References

[1]"Conopeptides from Conus striatus and Conus textile by cDNA cloning."
Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.
Peptides 20:1139-1144(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Venom duct.
[2]"Novel alpha- and omega-conotoxins from Conus striatus venom."
Ramilo C., Zafaralla G.C., Nadasdi L., Hammerland L.G., Yoshikami D., Gray W.R., Kristipati R., Ramachandran J., Miljanich G.P., Olivera B.M., Cruz L.J.
Biochemistry 31:9919-9926(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 49-72, SYNTHESIS OF 49-72, AMIDATION AT THR-72.
Tissue: Venom.
[3]"Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins."
Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X., Wang L., Dong M., Chen S., Xu A.-L.
Biochimie 88:131-140(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-72, VARIANTS PRO-51; PRO-54; SER-55; ALA-59 AND SER-67.
Tissue: Venom duct.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF146347 mRNA. Translation: AAD31907.1.
PIRB44379.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer863. SVIA precursor.

Family and domain databases

InterProIPR004214. Conotoxin.
IPR012321. Conotoxin_omega-typ_CS.
[Graphical view]
PfamPF02950. Conotoxin. 1 hit.
[Graphical view]
PROSITEPS60004. OMEGA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCO16A_CONST
AccessionPrimary (citable) accession number: P28880
Secondary accession number(s): Q9UB26
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 29, 2001
Last modified: October 16, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families