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P28880

- CO16A_CONST

UniProt

P28880 - CO16A_CONST

Protein

Omega-conotoxin SVIA

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).

    GO - Molecular functioni

    1. ion channel inhibitor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Omega-conotoxin SVIA
    Alternative name(s):
    SNX-157
    OrganismiConus striatus (Striated cone)
    Taxonomic identifieri6493 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri863. SVIA precursor.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism presynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 48261 PublicationPRO_0000034924Add
    BLAST
    Peptidei49 – 7224Omega-conotoxin SVIAPRO_0000034925Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 63
    Modified residuei55 – 5514-hydroxyproline1 Publication
    Disulfide bondi56 ↔ 66
    Disulfide bondi62 ↔ 71
    Modified residuei72 – 721Threonine amide1 Publication

    Keywords - PTMi

    Amidation, Disulfide bond, Hydroxylation

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Family & Domainsi

    Domaini

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
    The cysteine framework is VI/VII (C-C-CC-C-C).

    Sequence similaritiesi

    Belongs to the conotoxin O1 superfamily.Curated

    Keywords - Domaini

    Knottin, Signal

    Family and domain databases

    InterProiIPR004214. Conotoxin.
    IPR012321. Conotoxin_omega-typ_CS.
    [Graphical view]
    PfamiPF02950. Conotoxin. 1 hit.
    [Graphical view]
    PROSITEiPS60004. OMEGA_CONOTOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28880-1 [UniParc]FASTAAdd to Basket

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    MKLTCVMIVA VLLLTACQLI TAEDSRGTQK HRTLRSTARR SKSESTTRCR   50
    SSGSPCGVTS ICCGRCYRGK CT 72
    Length:72
    Mass (Da):7,830
    Last modified:August 29, 2001 - v2
    Checksum:i4A6A412E450469A1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511S → P in SVIA-1, SVIA-2 and SVIA-5. 1 Publication
    Natural varianti54 – 541S → P in SVIA-4. 1 Publication
    Natural varianti55 – 551P → S in SVIA-3. 1 Publication
    Natural varianti59 – 591T → A in SVIA-5. 1 Publication
    Natural varianti67 – 671Y → S in SVIA-2 and SVIA-5. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146347 mRNA. Translation: AAD31907.1.
    PIRiB44379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF146347 mRNA. Translation: AAD31907.1 .
    PIRi B44379.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 863. SVIA precursor.

    Family and domain databases

    InterProi IPR004214. Conotoxin.
    IPR012321. Conotoxin_omega-typ_CS.
    [Graphical view ]
    Pfami PF02950. Conotoxin. 1 hit.
    [Graphical view ]
    PROSITEi PS60004. OMEGA_CONOTOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conopeptides from Conus striatus and Conus textile by cDNA cloning."
      Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.
      Peptides 20:1139-1144(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom duct.
    2. Cited for: PROTEIN SEQUENCE OF 49-72, SYNTHESIS OF 49-72, HYDROXYLATION AT PRO-55, AMIDATION AT THR-72.
      Tissue: Venom.
    3. "Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins."
      Pi C., Liu Y., Peng C., Jiang X., Liu J., Xu B., Yu X., Yu Y., Jiang X., Wang L., Dong M., Chen S., Xu A.-L.
      Biochimie 88:131-140(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 49-72, VARIANTS PRO-51; PRO-54; SER-55; ALA-59 AND SER-67.
      Tissue: Venom duct.

    Entry informationi

    Entry nameiCO16A_CONST
    AccessioniPrimary (citable) accession number: P28880
    Secondary accession number(s): Q9UB26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: August 29, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Caution

    Thr-72 is not followed in the nucleotide sequence by the expected Gly residue required to produce amidation.Curated

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3