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P28879

- CAS2_CONST

UniProt

P28879 - CAS2_CONST

Protein

Alpha-conotoxin S2

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Has no effect on the release of catecholamines evoked by nicotine.1 Publication

    GO - Molecular functioni

    1. acetylcholine receptor inhibitor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-conotoxin S2
    Alternative name(s):
    Alpha-conotoxin SII
    OrganismiConus striatus (Striated cone)
    Taxonomic identifieri6493 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri3900. SII precursor.
    9. SII precursor.
    91. SII precursor.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Propeptidei22 – 50291 PublicationPRO_0000034889Add
    BLAST
    Peptidei51 – 6919Alpha-conotoxin S2PRO_0000034890Add
    BLAST
    Propeptidei70 – 723PRO_0000034891

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 681 Publication
    Disulfide bondi53 ↔ 581 Publication
    Disulfide bondi54 ↔ 641 Publication

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Structurei

    3D structure databases

    ProteinModelPortaliP28879.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The cysteine framework is II (CCC-C-C-C).

    Sequence similaritiesi

    Belongs to the conotoxin A superfamily.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR009958. Conotoxin_a-typ.
    IPR018072. Conotoxin_a-typ_CS.
    [Graphical view]
    PfamiPF07365. Toxin_8. 1 hit.
    [Graphical view]
    PROSITEiPS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28879-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMRMMFTVF LLVVLATTVV SFPSDRASDG RDDEAKDERS DMHESDRNGR   50
    GCCCNPACGP NYGCGTSCSR TL 72
    Length:72
    Mass (Da):7,830
    Last modified:September 5, 2006 - v3
    Checksum:i521191749F4A94CF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231P → T no nucleotide entry (PubMed:10573284)Curated
    Sequence conflicti72 – 721L → I in AAN77902. (PubMed:14602116)Curated

    Mass spectrometryi

    Molecular mass is 1790.3 Da from positions 51 - 69. Determined by ESI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157497 mRNA. Translation: AAN77902.1.
    PIRiA44379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY157497 mRNA. Translation: AAN77902.1 .
    PIRi A44379.

    3D structure databases

    ProteinModelPortali P28879.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 3900. SII precursor.
    9. SII precursor.
    91. SII precursor.

    Family and domain databases

    InterProi IPR009958. Conotoxin_a-typ.
    IPR018072. Conotoxin_a-typ_CS.
    [Graphical view ]
    Pfami PF07365. Toxin_8. 1 hit.
    [Graphical view ]
    PROSITEi PS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conopeptides from Conus striatus and Conus textile by cDNA cloning."
      Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.
      Peptides 20:1139-1144(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom duct.
    2. "cDNA cloning of two A-superfamily conotoxins from Conus striatus."
      Wang C.-Z., Jiang H., Ou Z.-L., Chen J.-S., Chi C.-W.
      Toxicon 42:613-619(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom duct.
    3. "The A-superfamily of conotoxins: structural and functional divergence."
      Santos A.D., McIntosh J.M., Hillyard D.R., Cruz L.J., Olivera B.M.
      J. Biol. Chem. 279:17596-17606(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Venom duct.
    4. Cited for: PROTEIN SEQUENCE OF 51-69, SYNTHESIS OF 51-69.
      Tissue: Venom.
    5. "Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study."
      Bingham J.-P., Broxton N.M., Livett B.G., Down J.G., Jones A., Moczydlowski E.G.
      Anal. Biochem. 338:48-61(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS, SYNTHESIS OF 51-69, MASS SPECTROMETRY, FUNCTION.
      Tissue: Venom.

    Entry informationi

    Entry nameiCAS2_CONST
    AccessioniPrimary (citable) accession number: P28879
    Secondary accession number(s): Q8I6R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 76 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3