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Protein

Alpha-conotoxin S2

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Has no effect on the release of catecholamines evoked by nicotine.1 Publication

GO - Molecular functioni

  1. acetylcholine receptor inhibitor activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin S2
Alternative name(s):
Alpha-conotoxin SII
OrganismiConus striatus (Striated cone)
Taxonomic identifieri6493 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri3900. SII precursor.
9. SII precursor.
91. SII precursor.

Subcellular locationi

GO - Cellular componenti

  1. other organism postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Propeptidei22 – 50291 PublicationPRO_0000034889Add
BLAST
Peptidei51 – 6919Alpha-conotoxin S2PRO_0000034890Add
BLAST
Propeptidei70 – 723PRO_0000034891

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 681 Publication
Disulfide bondi53 ↔ 581 Publication
Disulfide bondi54 ↔ 641 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

ProteinModelPortaliP28879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is II (CCC-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
[Graphical view]
PfamiPF07365. Toxin_8. 1 hit.
[Graphical view]
PROSITEiPS60014. ALPHA_CONOTOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28879-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SFPSDRASDG RDDEAKDERS DMHESDRNGR
60 70
GCCCNPACGP NYGCGTSCSR TL
Length:72
Mass (Da):7,830
Last modified:September 4, 2006 - v3
Checksum:i521191749F4A94CF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231P → T no nucleotide entry (PubMed:10573284).Curated
Sequence conflicti72 – 721L → I in AAN77902 (PubMed:14602116).Curated

Mass spectrometryi

Molecular mass is 1790.3 Da from positions 51 - 69. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157497 mRNA. Translation: AAN77902.1.
PIRiA44379.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY157497 mRNA. Translation: AAN77902.1.
PIRiA44379.

3D structure databases

ProteinModelPortaliP28879.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri3900. SII precursor.
9. SII precursor.
91. SII precursor.

Family and domain databases

InterProiIPR009958. Conotoxin_a-typ.
IPR018072. Conotoxin_a-typ_CS.
[Graphical view]
PfamiPF07365. Toxin_8. 1 hit.
[Graphical view]
PROSITEiPS60014. ALPHA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conopeptides from Conus striatus and Conus textile by cDNA cloning."
    Lu B.-S., Yu F., Zhao D., Huang P.-T., Huang C.-F.
    Peptides 20:1139-1144(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom duct.
  2. "cDNA cloning of two A-superfamily conotoxins from Conus striatus."
    Wang C.-Z., Jiang H., Ou Z.-L., Chen J.-S., Chi C.-W.
    Toxicon 42:613-619(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom duct.
  3. "The A-superfamily of conotoxins: structural and functional divergence."
    Santos A.D., McIntosh J.M., Hillyard D.R., Cruz L.J., Olivera B.M.
    J. Biol. Chem. 279:17596-17606(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Venom duct.
  4. Cited for: PROTEIN SEQUENCE OF 51-69, SYNTHESIS OF 51-69.
    Tissue: Venom.
  5. "Optimizing the connectivity in disulfide-rich peptides: alpha-conotoxin SII as a case study."
    Bingham J.-P., Broxton N.M., Livett B.G., Down J.G., Jones A., Moczydlowski E.G.
    Anal. Biochem. 338:48-61(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS, SYNTHESIS OF 51-69, MASS SPECTROMETRY, FUNCTION.
    Tissue: Venom.

Entry informationi

Entry nameiCAS2_CONST
AccessioniPrimary (citable) accession number: P28879
Secondary accession number(s): Q8I6R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 1992
Last sequence update: September 4, 2006
Last modified: September 30, 2014
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.