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P28878 (CA1A_CONST) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alpha-conotoxin SIA
Alternative name(s):
S1A
OrganismConus striatus (Striated cone)
Taxonomic identifier6493 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length13 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChR alpha-1/gamma subunits.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Domain

The cysteine framework is I (CC-C-C).

Sequence similarities

Belongs to the conotoxin A superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 1313Alpha-conotoxin SIA
PRO_0000044463

Amino acid modifications

Modified residue131Cysteine amide Ref.1
Disulfide bond2 ↔ 7 By similarity Ref.1
Disulfide bond3 ↔ 13 By similarity Ref.1

Sequences

Sequence LengthMass (Da)Tools
P28878 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: DEF1931982457EBD

FASTA131,461
        10 
YCCHPACGKN FDC 

« Hide

References

[1]"Alpha-conotoxins, small peptide probes of nicotinic acetylcholine receptors."
Myers R.A., Zafarella G.C., Gray W.R., Abbot J., Cruz L.J., Olivera B.M.
Biochemistry 30:9370-9377(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRNTKNAS. A40312.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer25. SIA.

Family and domain databases

PROSITEPS60014. ALPHA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCA1A_CONST
AccessionPrimary (citable) accession number: P28878
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 24, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families