P28878 (CA1A_CONST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alpha-conotoxin SIA Alternative name(s): S1A
Organism	Conus striatus (Striated cone)
Taxonomic identifier	6493 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	13 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChR alpha-1/gamma subunits.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom duct.
Domain	The cysteine framework is I (CC-C-C).
Sequence similarities	Belongs to the conotoxin A superfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Acetylcholine receptor inhibiting toxin Neurotoxin Postsynaptic neurotoxin Toxin
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	other organism postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 13	13	Alpha-conotoxin SIA		PRO_0000044463
Amino acid modifications
	Modified residue	13	1	Cysteine amide Ref.1
	Disulfide bond	2 ↔ 7		By similarity Ref.1
	Disulfide bond	3 ↔ 13		By similarity Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P28878 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: DEF1931982457EBD	FASTA	13	1,461
	10 YCCHPACGKN FDC

References

[1]	"Alpha-conotoxins, small peptide probes of nicotinic acetylcholine receptors." Myers R.A., Zafarella G.C., Gray W.R., Abbot J., Cruz L.J., Olivera B.M. Biochemistry 30:9370-9377(1991) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	NTKNAS. A40312.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	25. SIA.
Family and domain databases
PROSITE	PS60014. ALPHA_CONOTOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CA1A_CONST

Accession

Primary (citable) accession number: P28878

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	May 29, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program