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P28878

- CA1A_CONST

UniProt

P28878 - CA1A_CONST

Protein

Alpha-conotoxin SIA

Gene
N/A
Organism
Conus striatus (Striated cone)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks muscular nAChR alpha-1/gamma subunits.

    Keywords - Molecular functioni

    Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-conotoxin SIA
    Alternative name(s):
    S1A
    OrganismiConus striatus (Striated cone)
    Taxonomic identifieri6493 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri25. SIA.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1313Alpha-conotoxin SIAPRO_0000044463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 7By similarity
    Disulfide bondi3 ↔ 13By similarity
    Modified residuei13 – 131Cysteine amide1 Publication

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Family & Domainsi

    Domaini

    The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

    Sequence similaritiesi

    Belongs to the conotoxin A superfamily.Curated

    Family and domain databases

    PROSITEiPS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28878-1 [UniParc]FASTAAdd to Basket

    « Hide

    YCCHPACGKN FDC                                           13
    Length:13
    Mass (Da):1,461
    Last modified:December 1, 1992 - v1
    Checksum:iDEF1931982457EBD
    GO

    Sequence databases

    PIRiA40312. NTKNAS.

    Cross-referencesi

    Sequence databases

    PIRi A40312. NTKNAS.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 25. SIA.

    Family and domain databases

    PROSITEi PS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alpha-conotoxins, small peptide probes of nicotinic acetylcholine receptors."
      Myers R.A., Zafarella G.C., Gray W.R., Abbot J., Cruz L.J., Olivera B.M.
      Biochemistry 30:9370-9377(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiCA1A_CONST
    AccessioniPrimary (citable) accession number: P28878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3