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P28877 (PMA1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Plasma membrane ATPase 1
EC=3.6.3.6
Alternative name(s):
Proton pump 1
Gene names
Name:PMA1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length895 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H+-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 895895Plasma membrane ATPase 1
PRO_0000046266

Regions

Topological domain1 – 9292Cytoplasmic Potential
Transmembrane93 – 11321Helical; Name=1; Potential
Topological domain114 – 1174Extracellular Potential
Transmembrane118 – 13720Helical; Name=2; Potential
Topological domain138 – 268131Cytoplasmic Potential
Transmembrane269 – 29022Helical; Name=3; Potential
Topological domain291 – 30111Extracellular Potential
Transmembrane302 – 32423Helical; Name=4; Potential
Topological domain325 – 696372Cytoplasmic Potential
Transmembrane697 – 71519Helical; Name=5; Potential
Topological domain716 – 73116Extracellular Potential
Transmembrane732 – 75120Helical; Name=6; Potential
Topological domain752 – 80150Cytoplasmic Potential
Transmembrane802 – 82221Helical; Name=7; Potential
Topological domain823 – 83412Extracellular Potential
Transmembrane835 – 85117Helical; Name=8; Potential
Topological domain852 – 89544Cytoplasmic Potential

Sites

Active site35514-aspartylphosphate intermediate By similarity
Metal binding6111Magnesium By similarity
Metal binding6151Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
P28877 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 2CF2451DD3CB25B1

FASTA89597,460
        10         20         30         40         50         60 
MSATEPTNEK VDKIVSDDED EDIDQLVADL QSNPGAGDEE EEEENDSSFK AVPEELLQTD 

        70         80         90        100        110        120 
PRVGLTDDEV TKRRKRYGLN QMAEEQENLV LKFVMFFVGP IQFVMEAAAV LAAGLEDWVD 

       130        140        150        160        170        180 
FGVICALLLL NAFVGFIQEY QAGSIVDELK KTLANSALVV RNGQLVEIPA NEVVPGDILQ 

       190        200        210        220        230        240 
LEDGTVIPTD GRIVSEDCLL QVDQSAITGE SLAVDKRSGD SCYSSSTVKT GEAFMIVTAT 

       250        260        270        280        290        300 
GDSTFVGRAA ALVNKASAGT GHFTEVLNGI GTTLLVFVIV TLLVVWVACF YRTVRIVPIL 

       310        320        330        340        350        360 
RYTLAITIIG VPVGLPAVVT TTMAVGAAYL AKKQAIVQKL SAIESLAGVE ILCSDKTGTL 

       370        380        390        400        410        420 
TKNKLSLHEP YTVEGVEPDD LMLTACLAAS RKKKGLDAID KAFLKSLINY PRAKAALPKY 

       430        440        450        460        470        480 
KVIEFQPFDP VSKKVTAIVE SPEGERIICV KGAPLFVLKT VEDDHPIPED VHENYQNTVA 

       490        500        510        520        530        540 
EFASRGFRSL GVARKRGEGH WEILGIMPCM DPPRDDTAAT VNEARRLGLR VKMLTGDAVG 

       550        560        570        580        590        600 
IAKETCRQLG LGTNIYDADR LGLSGGGDMA GSEIADFVEN ADGFAEGFPT NKYNAVEILQ 

       610        620        630        640        650        660 
SRGYLVAMTG DGVNDAPSLK KADTGIAVEG ATDAARSAAD IVFLAPGLSA IIDALKTSRQ 

       670        680        690        700        710        720 
IFHRMYSYVV YRIALSLHLE LFLGLWIAIL NRSLDINLIV FIAIFADVAT LAIAYDNAPY 

       730        740        750        760        770        780 
DPKPVKWNLP RLWGMSIVLG IILAIGTWIT LTTMLLPKGG IIQNFGGLDG ILFLQISLTE 

       790        800        810        820        830        840 
NWLIFVTRAQ GPFWSSIPSW QLSGAVLIVD IIATCFTLFG WWSQNWTDIV TVVRTWIWSF 

       850        860        870        880        890 
GVFCVMGGAY YLMSTSEAFD NFCNGRKPQQ HTDKRSLEDF LVSMQRVSTQ HEKST

« Hide

References

[1]"Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans."
Monk B.C., Kurtz M.B., Marrinan J.A., Perlin D.S.
J. Bacteriol. 173:6826-6836(1991) [PubMed: 1834633] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M74075 Genomic DNA. Translation: AAA34319.1.
PIRPXCKP. A41336.

3D structure databases

ProteinModelPortalP28877.
SMRP28877. Positions 26-894.
ModBaseSearch...

Protein-protein interaction databases

STRINGP28877.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR000695. ATPase_P-typ_H-transp.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006534. ATPase_P-typ_PM_proton-efflux.
IPR023298. ATPase_P-typ_TM_dom.
IPR005834. Dehalogen-like_hydro.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:1.20.1110.10. ATPase_P-typ_TM_dom. 2 hits.
PANTHERPTHR24093:SF61. PTHR24093:SF61. 1 hit.
PfamPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01647. ATPase-IIIA_H. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePMA1_CANAX
AccessionPrimary (citable) accession number: P28877
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 19, 2011
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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