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Protein

Thymidine kinase

Gene

TK

Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei50 – 501Proton acceptorSequence Analysis
Binding sitei68 – 681SubstrateBy similarity
Binding sitei79 – 791SubstrateBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei157 – 1571ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 308ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Synonyms:5
OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Taxonomic identifieri766178 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
ProteomesiUP000007643 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Thymidine kinasePRO_0000175089Add
BLAST

Proteomic databases

PRIDEiP28855.

Structurei

3D structure databases

ProteinModelPortaliP28855.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCK/DGK family.Curated

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P28855-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALREGPTPA RFLPEGLVFC VEGNIGCGKS TLVKALMERV AGSGVNVVEE
60 70 80 90 100
PVDQWVNHNG KNYLELSYTD PTGYAVPFQN LVFDSYVNVQ RLQNPDIMER
110 120 130 140 150
SPMSATRVFC AVNGSRGVIP ATALPGMAAR GEAVMRTIAT RPVFVYLELP
160 170 180 190 200
PEECLRRMRR RDRTGEAGVG LDYLRLLHER YEAWLSSAED VERVDASRSR
210 220
EEIVDRVIEI LCRRHPRLRA PLTRKSQL
Length:228
Mass (Da):25,642
Last modified:December 1, 1992 - v1
Checksum:i980C26879787280B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75136 Genomic DNA. Translation: AAA88186.1.
M75136 Genomic DNA. Translation: AAA88108.1.
PIRiJQ1336. KIBEIC.
RefSeqiNP_041096.1. NC_001493.2.
NP_041174.1. NC_001493.2.

Genome annotation databases

GeneIDi1488381.
1488423.
KEGGivg:1488381.
vg:1488423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75136 Genomic DNA. Translation: AAA88186.1.
M75136 Genomic DNA. Translation: AAA88108.1.
PIRiJQ1336. KIBEIC.
RefSeqiNP_041096.1. NC_001493.2.
NP_041174.1. NC_001493.2.

3D structure databases

ProteinModelPortaliP28855.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP28855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1488381.
1488423.
KEGGivg:1488381.
vg:1488423.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR002624. DNK.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10513. PTHR10513. 1 hit.
PfamiPF01712. dNK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Channel catfish virus: a new type of herpesvirus."
    Davison A.J.
    Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase."
    Harrison P.T., Thompson R., Davison A.J.
    J. Gen. Virol. 72:2583-2586(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiKITH_ICHVA
AccessioniPrimary (citable) accession number: P28855
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 1, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.