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P28855

- KITH_ICHVA

UniProt

P28855 - KITH_ICHVA

Protein

Thymidine kinase

Gene

TK

Organism
Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei50 – 501Proton acceptorSequence Analysis
    Binding sitei68 – 681SubstrateBy similarity
    Binding sitei79 – 791SubstrateBy similarity
    Binding sitei109 – 1091SubstrateBy similarity
    Binding sitei157 – 1571ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 308ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphotransferase activity, alcohol group as acceptor Source: InterPro
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Synonyms:5
    OrganismiIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus)
    Taxonomic identifieri766178 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
    Virus hostiIctaluridae (bullhead catfishes) [TaxID: 7996]
    ProteomesiUP000007643: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228228Thymidine kinasePRO_0000175089Add
    BLAST

    Proteomic databases

    PRIDEiP28855.

    Structurei

    3D structure databases

    ProteinModelPortaliP28855.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCK/DGK family.Curated

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10513. PTHR10513. 1 hit.
    PfamiPF01712. dNK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000705. DNK. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P28855-1 [UniParc]FASTAAdd to Basket

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    MALREGPTPA RFLPEGLVFC VEGNIGCGKS TLVKALMERV AGSGVNVVEE    50
    PVDQWVNHNG KNYLELSYTD PTGYAVPFQN LVFDSYVNVQ RLQNPDIMER 100
    SPMSATRVFC AVNGSRGVIP ATALPGMAAR GEAVMRTIAT RPVFVYLELP 150
    PEECLRRMRR RDRTGEAGVG LDYLRLLHER YEAWLSSAED VERVDASRSR 200
    EEIVDRVIEI LCRRHPRLRA PLTRKSQL 228
    Length:228
    Mass (Da):25,642
    Last modified:December 1, 1992 - v1
    Checksum:i980C26879787280B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75136 Genomic DNA. Translation: AAA88186.1.
    M75136 Genomic DNA. Translation: AAA88108.1.
    PIRiJQ1336. KIBEIC.
    RefSeqiNP_041096.1. NC_001493.2.
    NP_041174.1. NC_001493.2.

    Genome annotation databases

    GeneIDi1488381.
    1488423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M75136 Genomic DNA. Translation: AAA88186.1 .
    M75136 Genomic DNA. Translation: AAA88108.1 .
    PIRi JQ1336. KIBEIC.
    RefSeqi NP_041096.1. NC_001493.2.
    NP_041174.1. NC_001493.2.

    3D structure databases

    ProteinModelPortali P28855.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P28855.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1488381.
    1488423.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR002624. DNK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10513. PTHR10513. 1 hit.
    Pfami PF01712. dNK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000705. DNK. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Channel catfish virus: a new type of herpesvirus."
      Davison A.J.
      Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase."
      Harrison P.T., Thompson R., Davison A.J.
      J. Gen. Virol. 72:2583-2586(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiKITH_ICHVA
    AccessioniPrimary (citable) accession number: P28855
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3