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P28855 (KITH_ICHVA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Synonyms:5
OrganismIctalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) [Reference proteome]
Taxonomic identifier766178 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesAlloherpesviridaeIctalurivirus
Virus hostIctaluridae (bullhead catfishes) [TaxID: 7996]

Protein attributes

Sequence length228 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the DCK/DGK family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 228228Thymidine kinase
PRO_0000175089

Regions

Nucleotide binding23 – 308ATP By similarity

Sites

Active site501Proton acceptor Potential
Binding site681Substrate By similarity
Binding site791Substrate By similarity
Binding site1091Substrate By similarity
Binding site1571ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P28855 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 980C26879787280B

FASTA22825,642
        10         20         30         40         50         60 
MALREGPTPA RFLPEGLVFC VEGNIGCGKS TLVKALMERV AGSGVNVVEE PVDQWVNHNG 

        70         80         90        100        110        120 
KNYLELSYTD PTGYAVPFQN LVFDSYVNVQ RLQNPDIMER SPMSATRVFC AVNGSRGVIP 

       130        140        150        160        170        180 
ATALPGMAAR GEAVMRTIAT RPVFVYLELP PEECLRRMRR RDRTGEAGVG LDYLRLLHER 

       190        200        210        220 
YEAWLSSAED VERVDASRSR EEIVDRVIEI LCRRHPRLRA PLTRKSQL 

« Hide

References

« Hide 'large scale' references
[1]"Channel catfish virus: a new type of herpesvirus."
Davison A.J.
Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase."
Harrison P.T., Thompson R., Davison A.J.
J. Gen. Virol. 72:2583-2586(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M75136 Genomic DNA. Translation: AAA88186.1.
M75136 Genomic DNA. Translation: AAA88108.1.
PIRKIBEIC. JQ1336.
RefSeqNP_041096.1. NC_001493.2.
NP_041174.1. NC_001493.2.

3D structure databases

ProteinModelPortalP28855.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP28855.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488381.
1488423.

Phylogenomic databases

ProtClustDBCLSP2509737.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR002624. Deoxynucleoside_kinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10513. PTHR10513. 1 hit.
PfamPF01712. dNK. 1 hit.
[Graphical view]
PIRSFPIRSF000705. DNK. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_ICHVA
AccessionPrimary (citable) accession number: P28855
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families