P28855 (KITH_ICHVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	TK
Synonyms:	5

Organism

Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish herpesvirus) [Reference proteome]

Taxonomic identifier

766178 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Alloherpesviridae › Ictalurivirus › Ictalurid herpesvirus 1

Virus host

Ictaluridae (bullhead catfishes) [TaxID: 7996]

Protein attributes

Sequence length	228 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the DCK/DGK family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 228	228	Thymidine kinase		PRO_0000175089
Regions
	Nucleotide binding	23 – 30	8	ATP By similarity
Sites
	Active site	50	1	Proton acceptor Potential
	Binding site	68	1	Substrate By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	109	1	Substrate By similarity
	Binding site	157	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28855 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 980C26879787280B	FASTA	228	25,642
	10 20 30 40 50 60 MALREGPTPA RFLPEGLVFC VEGNIGCGKS TLVKALMERV AGSGVNVVEE PVDQWVNHNG 70 80 90 100 110 120 KNYLELSYTD PTGYAVPFQN LVFDSYVNVQ RLQNPDIMER SPMSATRVFC AVNGSRGVIP 130 140 150 160 170 180 ATALPGMAAR GEAVMRTIAT RPVFVYLELP PEECLRRMRR RDRTGEAGVG LDYLRLLHER 190 200 210 220 YEAWLSSAED VERVDASRSR EEIVDRVIEI LCRRHPRLRA PLTRKSQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Channel catfish virus: a new type of herpesvirus." Davison A.J. Virology 186:9-14(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Evolution of herpesvirus thymidine kinases from cellular deoxycytidine kinase." Harrison P.T., Thompson R., Davison A.J. J. Gen. Virol. 72:2583-2586(1991) [PubMed] [Europe PMC] [Abstract] Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M75136 Genomic DNA. Translation: AAA88186.1. M75136 Genomic DNA. Translation: AAA88108.1.
PIR	KIBEIC. JQ1336.
RefSeq	NP_041096.1. NC_001493.1. NP_041174.1. NC_001493.1.
3D structure databases
ProteinModelPortal	P28855.
ModBase	Search...
Proteomic databases
PRIDE	P28855.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1488381. 1488423.
Phylogenomic databases
ProtClustDB	CLSP2509737.
Family and domain databases
InterPro	IPR002624. Deoxynucleoside_kinase. [Graphical view]
PANTHER	PTHR10513. PTHR10513. 1 hit.
Pfam	PF01712. dNK. 1 hit. [Graphical view]
PIRSF	PIRSF000705. DNK. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KITH_ICHVA

Accession

Primary (citable) accession number: P28855

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program