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P28852 (KITH_AMEPV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Ordered Locus Names:AMV016
ORF Names:Q2
OrganismAmsacta moorei entomopoxvirus (AmEPV) [Reference proteome]
Taxonomic identifier28321 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
Virus hostAmsacta [TaxID: 340055]

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Thymidine kinase
PRO_0000174942

Regions

Nucleotide binding8 – 158ATP By similarity
Region161 – 1655Substrate binding By similarity

Sites

Active site851Proton acceptor Potential
Metal binding1421Zinc By similarity
Metal binding1451Zinc By similarity
Metal binding1741Zinc By similarity
Metal binding1771Zinc By similarity
Binding site1171Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
P28852 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 982719AFC0DF8D2D

FASTA18221,241
        10         20         30         40         50         60 
MSIELIIGPM FSGKTTELMR KINRYILSNQ KCVIITHNID NRFINKNIIN HDGNILNKEY 

        70         80         90        100        110        120 
LYIKTNNLIN EINIVDNYDI IGIDECQFFE ENDLEQFCDK MANNKKKVIV AGLNCDFNRN 

       130        140        150        160        170        180 
IFNSISKLIP KVEKIKKLQA ICQFCYKDAS FTIKKHNKNQ IIEIGGQDLY VPVCRLCYNN 


SY 

« Hide

References

« Hide 'large scale' references
[1]"Mapping and molecular characterization of a functional thymidine kinase from Amsacta moorei entomopoxvirus."
Gruidl M.E., Hall R.L., Moyer R.W.
Virology 186:507-516(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Comparison of the thymidine kinase genes from three entomopoxviruses."
Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis and comparison with other poxviruses."
Bawden A.L., Glassberg K.J., Diggans J., Shaw R., Farmerie W., Moyer R.W.
Virology 274:120-139(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D10679 Genomic DNA. Translation: BAA01525.1.
M80924 Genomic DNA. Translation: AAA42386.1.
AF250284 Genomic DNA. Translation: AAG02722.1.
PIRKIVZAM. B40818.
RefSeqNP_064798.1. NC_002520.1.

3D structure databases

ProteinModelPortalP28852.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1494606.

Phylogenomic databases

ProtClustDBCLSP2509781.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_AMEPV
AccessionPrimary (citable) accession number: P28852
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families