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P28852

- KITH_AMEPV

UniProt

P28852 - KITH_AMEPV

Protein

Thymidine kinase

Gene

TK

Organism
Amsacta moorei entomopoxvirus (AmEPV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Proton acceptorSequence Analysis
    Binding sitei117 – 1171Substrate; via amide nitrogenBy similarity
    Metal bindingi142 – 1421ZincBy similarity
    Metal bindingi145 – 1451ZincBy similarity
    Metal bindingi174 – 1741ZincBy similarity
    Metal bindingi177 – 1771ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 158ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Ordered Locus Names:AMV016
    ORF Names:Q2
    OrganismiAmsacta moorei entomopoxvirus (AmEPV)
    Taxonomic identifieri28321 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeEntomopoxvirinaeBetaentomopoxvirus
    Virus hostiAmsacta [TaxID: 340055]
    ProteomesiUP000000872: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 182182Thymidine kinasePRO_0000174942Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP28852.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1655Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28852-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIELIIGPM FSGKTTELMR KINRYILSNQ KCVIITHNID NRFINKNIIN    50
    HDGNILNKEY LYIKTNNLIN EINIVDNYDI IGIDECQFFE ENDLEQFCDK 100
    MANNKKKVIV AGLNCDFNRN IFNSISKLIP KVEKIKKLQA ICQFCYKDAS 150
    FTIKKHNKNQ IIEIGGQDLY VPVCRLCYNN SY 182
    Length:182
    Mass (Da):21,241
    Last modified:December 1, 1992 - v1
    Checksum:i982719AFC0DF8D2D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10679 Genomic DNA. Translation: BAA01525.1.
    M80924 Genomic DNA. Translation: AAA42386.1.
    AF250284 Genomic DNA. Translation: AAG02722.1.
    PIRiB40818. KIVZAM.
    RefSeqiNP_064798.1. NC_002520.1.

    Genome annotation databases

    GeneIDi1494606.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D10679 Genomic DNA. Translation: BAA01525.1 .
    M80924 Genomic DNA. Translation: AAA42386.1 .
    AF250284 Genomic DNA. Translation: AAG02722.1 .
    PIRi B40818. KIVZAM.
    RefSeqi NP_064798.1. NC_002520.1.

    3D structure databases

    ProteinModelPortali P28852.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1494606.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping and molecular characterization of a functional thymidine kinase from Amsacta moorei entomopoxvirus."
      Gruidl M.E., Hall R.L., Moyer R.W.
      Virology 186:507-516(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Comparison of the thymidine kinase genes from three entomopoxviruses."
      Lytvyn V., Fortin Y., Banville M., Arif B., Richardson C.
      J. Gen. Virol. 73:3235-3240(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis and comparison with other poxviruses."
      Bawden A.L., Glassberg K.J., Diggans J., Shaw R., Farmerie W., Moyer R.W.
      Virology 274:120-139(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_AMEPV
    AccessioniPrimary (citable) accession number: P28852
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3