P28851 (KITH_MYXVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	TK
ORF Names:	MVF8

Organism

Myxoma virus (strain Uriarra) (MYXV)

Taxonomic identifier

265876 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Leporipoxvirus › Myxoma virus

Virus host

Oryctolagus cuniculus (Rabbit) [TaxID: 9986]

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Thymidine kinase		PRO_0000174933
Regions
	Nucleotide binding	13 – 20	8	ATP By similarity
	Region	159 – 163	5	Substrate binding By similarity
Sites
	Active site	85	1	Proton acceptor Potential
	Metal binding	140	1	Zinc By similarity
	Metal binding	143	1	Zinc By similarity
	Metal binding	172	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28851 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 09F747A584D88AD9	FASTA	178	19,931
	10 20 30 40 50 60 MAMYGGQIHL IIGPMFAGKS TELIRLVKRY QIARYKCLVV NYEKDARYGN GVRTHDNTCI 70 80 90 100 110 120 SAVPTASLDD VESISEHVEV IGIDEGQFFP NIVSFCERMA NAGKVLIVAA LDGTFQRKPF 130 140 150 160 170 TNICELIPLA ENVTKLNAVC MYCYKDASFS KRLGNETEIE IIGGSDKYKS VCRKCYFF

References

[1]	"The myxoma virus thymidine kinase gene: sequence and transcriptional mapping." Jackson R.J., Bults H.G. J. Gen. Virol. 73:323-328(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X52655 Genomic DNA. Translation: CAA36880.1.
PIR	KIVZM1. JQ1421.
3D structure databases
ProteinModelPortal	P28851.
SMR	P28851. Positions 6-177.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_MYXVU

Accession

Primary (citable) accession number: P28851

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program