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P28851

- KITH_MYXVU

UniProt

P28851 - KITH_MYXVU

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Protein
Thymidine kinase
Gene
TK, MVF8
Organism
Myxoma virus (strain Uriarra) (MYXV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Proton acceptor Reviewed prediction
Binding sitei115 – 1151Substrate; via amide nitrogen By similarity
Metal bindingi140 – 1401Zinc By similarity
Metal bindingi143 – 1431Zinc By similarity
Metal bindingi172 – 1721Zinc By similarity
Metal bindingi175 – 1751Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
ORF Names:MVF8
OrganismiMyxoma virus (strain Uriarra) (MYXV)
Taxonomic identifieri265876 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeLeporipoxvirus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 178178Thymidine kinase
PRO_0000174933Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28851.
SMRiP28851. Positions 6-177.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 1635Substrate binding By similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28851-1 [UniParc]FASTAAdd to Basket

« Hide

MAMYGGQIHL IIGPMFAGKS TELIRLVKRY QIARYKCLVV NYEKDARYGN    50
GVRTHDNTCI SAVPTASLDD VESISEHVEV IGIDEGQFFP NIVSFCERMA 100
NAGKVLIVAA LDGTFQRKPF TNICELIPLA ENVTKLNAVC MYCYKDASFS 150
KRLGNETEIE IIGGSDKYKS VCRKCYFF 178
Length:178
Mass (Da):19,931
Last modified:December 1, 1992 - v1
Checksum:i09F747A584D88AD9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52655 Genomic DNA. Translation: CAA36880.1.
PIRiJQ1421. KIVZM1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X52655 Genomic DNA. Translation: CAA36880.1 .
PIRi JQ1421. KIVZM1.

3D structure databases

ProteinModelPortali P28851.
SMRi P28851. Positions 6-177.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The myxoma virus thymidine kinase gene: sequence and transcriptional mapping."
    Jackson R.J., Bults H.G.
    J. Gen. Virol. 73:323-328(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_MYXVU
AccessioniPrimary (citable) accession number: P28851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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