Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28847

- RIR2_EHV1B

UniProt

P28847 - RIR2_EHV1B

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

20

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Iron 1PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron 1PROSITE-ProRule annotation
    Metal bindingi108 – 1081Iron 2By similarity
    Metal bindingi111 – 1111Iron 1PROSITE-ProRule annotation
    Active sitei115 – 1151PROSITE-ProRule annotation
    Metal bindingi171 – 1711Iron 2By similarity
    Metal bindingi205 – 2051Iron 2By similarity
    Metal bindingi208 – 2081Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:20
    OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
    Taxonomic identifieri31520 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
    Virus hostiEquus caballus (Horse) [TaxID: 9796]
    ProteomesiUP000001189: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 321321Ribonucleoside-diphosphate reductase small chainPRO_0000190508Add
    BLAST

    Expressioni

    Keywords - Developmental stagei

    Early protein

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small chain.

    Structurei

    3D structure databases

    ProteinModelPortaliP28847.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28847-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIENSKEAA LTAELSLAGA FFYTPECPDI EHLRSLSVAN RWLDTDLPIS    50
    DDLKDVAKLT PAEREFYRFL FAFLSAADDL VNLNLGDLSA LFTQKDILHY 100
    YIEQESIEVT HSRVYSAIQL MLFGNDAAAR ARYVASIIGD AAIGRKVAWL 150
    QAKVRECGSV AEKYILMILI EGLFFASSFA SIAYLRTHNL FVVTCQSNDL 200
    ISRDEAIHTR ASCCIYNNYL GGFEKPEPKR IYELFSEAVN IECEFLLSHA 250
    PQYSHLLDIG AIISYVRYSA DRLLGEIGLS PLFNAPKPSP SFPLAFMTVE 300
    KHTNFFERRS TAYSGTLIND L 321
    Length:321
    Mass (Da):36,017
    Last modified:December 1, 1992 - v1
    Checksum:i81E1FF57B12B84A4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67277.1.
    PIRiC36797. WMBEA1.
    RefSeqiYP_053065.1. NC_001491.2.

    Genome annotation databases

    GeneIDi1487524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY665713 Genomic DNA. Translation: AAT67277.1 .
    PIRi C36797. WMBEA1.
    RefSeqi YP_053065.1. NC_001491.2.

    3D structure databases

    ProteinModelPortali P28847.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 1487524.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Tinkering with a viral ribonucleotide reductase."
      Lembo D., Brune W.
      Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiRIR2_EHV1B
    AccessioniPrimary (citable) accession number: P28847
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3