Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P28847 (RIR2_EHV1B) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:20
OrganismEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus) [Complete proteome]
Taxonomic identifier31520 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostEquus caballus (Horse) [TaxID: 9796]

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Keywords
   Biological processDNA replication
   Developmental stageEarly protein
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-UniPathway

deoxyribonucleoside diphosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Ribonucleoside-diphosphate reductase small chain
PRO_0000190508

Sites

Active site1151 By similarity
Metal binding781Iron 1 By similarity
Metal binding1081Iron 1 By similarity
Metal binding1081Iron 2 By similarity
Metal binding1111Iron 1 By similarity
Metal binding1711Iron 2 By similarity
Metal binding2051Iron 2 By similarity
Metal binding2081Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28847 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 81E1FF57B12B84A4

FASTA32136,017
        10         20         30         40         50         60 
MSIENSKEAA LTAELSLAGA FFYTPECPDI EHLRSLSVAN RWLDTDLPIS DDLKDVAKLT 

        70         80         90        100        110        120 
PAEREFYRFL FAFLSAADDL VNLNLGDLSA LFTQKDILHY YIEQESIEVT HSRVYSAIQL 

       130        140        150        160        170        180 
MLFGNDAAAR ARYVASIIGD AAIGRKVAWL QAKVRECGSV AEKYILMILI EGLFFASSFA 

       190        200        210        220        230        240 
SIAYLRTHNL FVVTCQSNDL ISRDEAIHTR ASCCIYNNYL GGFEKPEPKR IYELFSEAVN 

       250        260        270        280        290        300 
IECEFLLSHA PQYSHLLDIG AIISYVRYSA DRLLGEIGLS PLFNAPKPSP SFPLAFMTVE 

       310        320 
KHTNFFERRS TAYSGTLIND L 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of equine herpesvirus-1."
Telford E.A.R., Watson M.S., McBride K., Davison A.J.
Virology 189:304-316(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Tinkering with a viral ribonucleotide reductase."
Lembo D., Brune W.
Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY665713 Genomic DNA. Translation: AAT67277.1.
PIRWMBEA1. C36797.
RefSeqYP_053065.1. NC_001491.2.

3D structure databases

ProteinModelPortalP28847.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1487524.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_EHV1B
AccessionPrimary (citable) accession number: P28847
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways