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Protein

Ribonucleoside-diphosphate reductase small subunit

Gene

RIR2

Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Iron 1UniRule annotation1
Metal bindingi108Iron 1UniRule annotation1
Metal bindingi108Iron 2UniRule annotation1
Metal bindingi111Iron 1UniRule annotation1
Active sitei115UniRule annotation1
Metal bindingi171Iron 2UniRule annotation1
Metal bindingi205Iron 2UniRule annotation1
Metal bindingi208Iron 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication, Viral latency, Viral reactivation from latency
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small subunitUniRule annotation (EC:1.17.4.1UniRule annotation)
Alternative name(s):
Ribonucleotide reductase small subunitUniRule annotation
Gene namesi
Name:RIR2UniRule annotation
Synonyms:20
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
Proteomesi

Subcellular locationi

  • Host membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei165 – 185HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001905081 – 321Ribonucleoside-diphosphate reductase small subunitAdd BLAST321

Proteomic databases

PRIDEiP28847

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP28847
SMRiP28847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000AL

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.620.20, 1 hit
HAMAPiMF_04028 HSV_RIR2, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR034715 HSV_RIR2
IPR012348 RNR-like
IPR033909 RNR_small
IPR030475 RNR_small_AS
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00368 RIBORED_SMALL, 1 hit

Sequencei

Sequence statusi: Complete.

P28847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIENSKEAA LTAELSLAGA FFYTPECPDI EHLRSLSVAN RWLDTDLPIS
60 70 80 90 100
DDLKDVAKLT PAEREFYRFL FAFLSAADDL VNLNLGDLSA LFTQKDILHY
110 120 130 140 150
YIEQESIEVT HSRVYSAIQL MLFGNDAAAR ARYVASIIGD AAIGRKVAWL
160 170 180 190 200
QAKVRECGSV AEKYILMILI EGLFFASSFA SIAYLRTHNL FVVTCQSNDL
210 220 230 240 250
ISRDEAIHTR ASCCIYNNYL GGFEKPEPKR IYELFSEAVN IECEFLLSHA
260 270 280 290 300
PQYSHLLDIG AIISYVRYSA DRLLGEIGLS PLFNAPKPSP SFPLAFMTVE
310 320
KHTNFFERRS TAYSGTLIND L
Length:321
Mass (Da):36,017
Last modified:December 1, 1992 - v1
Checksum:i81E1FF57B12B84A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY665713 Genomic DNA Translation: AAT67277.1
PIRiC36797 WMBEA1
RefSeqiYP_053065.1, NC_001491.2

Genome annotation databases

GeneIDi1487524
KEGGivg:1487524

Entry informationi

Entry nameiRIR2_EHV1B
AccessioniPrimary (citable) accession number: P28847
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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