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P28847

- RIR2_EHV1B

UniProt

P28847 - RIR2_EHV1B

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
20
Organism
Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Iron 1 By similarity
Metal bindingi108 – 1081Iron 1 By similarity
Metal bindingi108 – 1081Iron 2 By similarity
Metal bindingi111 – 1111Iron 1 By similarity
Active sitei115 – 1151 By similarity
Metal bindingi171 – 1711Iron 2 By similarity
Metal bindingi205 – 2051Iron 2 By similarity
Metal bindingi208 – 2081Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:20
OrganismiEquine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus)
Taxonomic identifieri31520 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiEquus caballus (Horse) [TaxID: 9796]
ProteomesiUP000001189: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Ribonucleoside-diphosphate reductase small chain
PRO_0000190508Add
BLAST

Expressioni

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliP28847.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28847-1 [UniParc]FASTAAdd to Basket

« Hide

MSIENSKEAA LTAELSLAGA FFYTPECPDI EHLRSLSVAN RWLDTDLPIS    50
DDLKDVAKLT PAEREFYRFL FAFLSAADDL VNLNLGDLSA LFTQKDILHY 100
YIEQESIEVT HSRVYSAIQL MLFGNDAAAR ARYVASIIGD AAIGRKVAWL 150
QAKVRECGSV AEKYILMILI EGLFFASSFA SIAYLRTHNL FVVTCQSNDL 200
ISRDEAIHTR ASCCIYNNYL GGFEKPEPKR IYELFSEAVN IECEFLLSHA 250
PQYSHLLDIG AIISYVRYSA DRLLGEIGLS PLFNAPKPSP SFPLAFMTVE 300
KHTNFFERRS TAYSGTLIND L 321
Length:321
Mass (Da):36,017
Last modified:December 1, 1992 - v1
Checksum:i81E1FF57B12B84A4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67277.1.
PIRiC36797. WMBEA1.
RefSeqiYP_053065.1. NC_001491.2.

Genome annotation databases

GeneIDi1487524.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY665713 Genomic DNA. Translation: AAT67277.1 .
PIRi C36797. WMBEA1.
RefSeqi YP_053065.1. NC_001491.2.

3D structure databases

ProteinModelPortali P28847.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1487524.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR2_EHV1B
AccessioniPrimary (citable) accession number: P28847
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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