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P28845

- DHI1_HUMAN

UniProt

P28845 - DHI1_HUMAN

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Protein
Corticosteroid 11-beta-dehydrogenase isozyme 1
Gene
HSD11B1, HSD11, HSD11L
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol By similarity.

Catalytic activityi

An 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH.4 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei170 – 1701Substrate
Active sitei183 – 1831Proton acceptor

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 6727NADP
Add
BLAST
Nucleotide bindingi92 – 932NADP
Nucleotide bindingi119 – 1213NADP
Nucleotide bindingi183 – 1875NADP
Nucleotide bindingi218 – 2225NADP

GO - Molecular functioni

  1. 11-beta-hydroxysteroid dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity Source: Reactome

GO - Biological processi

  1. glucocorticoid biosynthetic process Source: Reactome
  2. lung development Source: Ensembl
  3. small molecule metabolic process Source: Reactome
  4. steroid metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid metabolism, Steroid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS04154-MONOMER.
BRENDAi1.1.1.146. 2681.
ReactomeiREACT_11036. Glucocorticoid biosynthesis.
SABIO-RKP28845.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC:1.1.1.146)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase 1
Short name:
11-DH
Short name:
11-beta-HSD1
Gene namesi
Name:HSD11B1
Synonyms:HSD11, HSD11L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:5208. HSD11B1.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type II membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 76Cytoplasmic Reviewed prediction
Transmembranei8 – 2417Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini25 – 292268Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Cortisone reductase deficiency (CRD) [MIM:604931]: In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Note: The disease is caused by mutations affecting the gene represented in this entry.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi5 – 62KK → RR: Predominantly inverted topology. No effect on activity. 1 Publication
Mutagenesisi5 – 62KK → SS: Inverted topology. Reduced Vmax. 1 Publication
Mutagenesisi5 – 51K → R: Predominantly inverted topology. No effect on activity. 1 Publication
Mutagenesisi5 – 51K → S: Inverted topology. No effect on activity. 1 Publication
Mutagenesisi6 – 61K → R: No effect on topology. Increased Km for corticosterone. 1 Publication
Mutagenesisi6 – 61K → S: No effect on topology or activity. 1 Publication
Mutagenesisi18 – 214YYYY → AAAA: No effect on topology. Reduced Vmax. 1 Publication
Mutagenesisi18 – 214YYYY → FFFF: No effect on topology or activity. 1 Publication
Mutagenesisi19 – 213YYY → AYA: No effect on topology. Reduced Vmax. 1 Publication
Mutagenesisi25 – 262EE → KK: Inverted topology. Reduced Vmax. 1 Publication
Mutagenesisi25 – 262EE → KQ: No effect on topology. Reduced Vmax. 1 Publication
Mutagenesisi25 – 262EE → QQ: Reduced Vmax. 1 Publication
Mutagenesisi25 – 251E → K or Q: No effect on activity. 1 Publication
Mutagenesisi26 – 261E → K: No effect on activity. 1 Publication
Mutagenesisi35 – 362KK → SS: Complete loss of activity.

Organism-specific databases

MIMi604931. phenotype.
Orphaneti168588. Hyperandrogenism due to cortisone reductase deficiency.
PharmGKBiPA29476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 292291Corticosteroid 11-beta-dehydrogenase isozyme 1
PRO_0000054619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi123 – 1231N-linked (GlcNAc...)1 Publication
Glycosylationi162 – 1621N-linked (GlcNAc...)1 Publication
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP28845.
PaxDbiP28845.
PRIDEiP28845.

PTM databases

PhosphoSiteiP28845.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in liver.

Gene expression databases

BgeeiP28845.
CleanExiHS_HSD11B1.
GenevestigatoriP28845.

Organism-specific databases

HPAiHPA047729.

Interactioni

Subunit structurei

Homodimer.2 Publications

Protein-protein interaction databases

BioGridi109523. 2 interactions.
DIPiDIP-59618N.
IntActiP28845. 1 interaction.
STRINGi9606.ENSP00000261465.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 324
Beta strandi36 – 416
Helixi45 – 5612
Beta strandi60 – 667
Helixi68 – 8114
Beta strandi84 – 907
Helixi96 – 11015
Beta strandi114 – 1185
Helixi133 – 14311
Helixi145 – 16117
Beta strandi164 – 1707
Helixi171 – 1733
Helixi181 – 20424
Beta strandi209 – 2157
Helixi221 – 2266
Helixi229 – 2346
Helixi238 – 25013
Beta strandi254 – 2585
Helixi262 – 2676
Helixi271 – 28010
Helixi281 – 2833
Turni287 – 2893

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XU7X-ray1.80A/B/C/D24-292[»]
1XU9X-ray1.55A/B/C/D24-292[»]
2BELX-ray2.11A/B/C/D26-284[»]
2ILTX-ray2.30A24-285[»]
2IRWX-ray3.10A/B/C/D/E/F/G/H26-289[»]
2RBEX-ray1.90A/B/C/D25-292[»]
3BYZX-ray2.69A/B/C/D25-292[»]
3BZUX-ray2.25A/B/C/D24-292[»]
3CH6X-ray2.35A/B/D/E24-292[»]
3CZRX-ray2.35A/B24-292[»]
3D3EX-ray2.60A/B/C/D24-292[»]
3D4NX-ray2.50A/B/C/D24-292[»]
3D5QX-ray2.55A/B/C/D24-292[»]
3EY4X-ray3.00A/B/C/D25-292[»]
3FCOX-ray2.65A/B24-291[»]
3FRJX-ray2.30A/B24-292[»]
3H6KX-ray2.19A/B/C/D24-292[»]
3HFGX-ray2.30A/B/C/D24-292[»]
3OQ1X-ray2.60A/B/C/D24-292[»]
3PDJX-ray2.30A/B24-292[»]
3QQPX-ray2.72A/B/C/D24-292[»]
3TFQX-ray1.80A/B/D/E24-292[»]
4BB5X-ray2.20A/B/C/D1-292[»]
4BB6X-ray2.55A/B1-292[»]
4C7KX-ray1.91A/B/C/D24-292[»]
4HFRX-ray2.73A/B24-292[»]
4HX5X-ray2.19A/B/C/D24-292[»]
4IJUX-ray2.35A/B/D/E24-292[»]
4IJVX-ray2.35A/B/D/E24-292[»]
4IJWX-ray2.35A/B/D/E24-292[»]
4K1LX-ray1.96A/B/C/D24-292[»]
4P38X-ray2.80A/B26-290[»]
ProteinModelPortaliP28845.
SMRiP28845. Positions 26-277.

Miscellaneous databases

EvolutionaryTraceiP28845.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1028.
HOGENOMiHOG000010276.
HOVERGENiHBG005481.
InParanoidiP28845.
KOiK15680.
OMAiWGGLDML.
OrthoDBiEOG7353X9.
PhylomeDBiP28845.
TreeFamiTF329114.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28845-1 [UniParc]FASTAAdd to Basket

« Hide

MAFMKKYLLP ILGLFMAYYY YSANEEFRPE MLQGKKVIVT GASKGIGREM    50
AYHLAKMGAH VVVTARSKET LQKVVSHCLE LGAASAHYIA GTMEDMTFAE 100
QFVAQAGKLM GGLDMLILNH ITNTSLNLFH DDIHHVRKSM EVNFLSYVVL 150
TVAALPMLKQ SNGSIVVVSS LAGKVAYPMV AAYSASKFAL DGFFSSIRKE 200
YSVSRVNVSI TLCVLGLIDT ETAMKAVSGI VHMQAAPKEE CALEIIKGGA 250
LRQEEVYYDS SLWTTLLIRN PCRKILEFLY STSYNMDRFI NK 292
Length:292
Mass (Da):32,401
Last modified:January 23, 2007 - v3
Checksum:i4632D0F3BBEFC474
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481V → E in a breast cancer sample; somatic mutation. 1 Publication
VAR_035845

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76665
, M76661, M76662, M76663, M76664 Genomic DNA. Translation: AAC31757.1.
AY044084, AY044083 Genomic DNA. Translation: AAK83653.1.
AK313973 mRNA. Translation: BAG36688.1.
AL022398, AL031316 Genomic DNA. Translation: CAA18541.2.
AL031316, AL022398 Genomic DNA. Translation: CAI20063.1.
CH471100 Genomic DNA. Translation: EAW93445.1.
CH471100 Genomic DNA. Translation: EAW93446.1.
BC012593 mRNA. Translation: AAH12593.1.
CCDSiCCDS1489.1.
PIRiA41173. DXHUBH.
RefSeqiNP_001193670.1. NM_001206741.1.
NP_005516.1. NM_005525.3.
NP_861420.1. NM_181755.2.
UniGeneiHs.195040.

Genome annotation databases

EnsembliENST00000261465; ENSP00000261465; ENSG00000117594.
ENST00000367027; ENSP00000355994; ENSG00000117594.
ENST00000367028; ENSP00000355995; ENSG00000117594.
GeneIDi3290.
KEGGihsa:3290.
UCSCiuc001hhj.3. human.

Polymorphism databases

DMDMi118569.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M76665
, M76661 , M76662 , M76663 , M76664 Genomic DNA. Translation: AAC31757.1 .
AY044084 , AY044083 Genomic DNA. Translation: AAK83653.1 .
AK313973 mRNA. Translation: BAG36688.1 .
AL022398 , AL031316 Genomic DNA. Translation: CAA18541.2 .
AL031316 , AL022398 Genomic DNA. Translation: CAI20063.1 .
CH471100 Genomic DNA. Translation: EAW93445.1 .
CH471100 Genomic DNA. Translation: EAW93446.1 .
BC012593 mRNA. Translation: AAH12593.1 .
CCDSi CCDS1489.1.
PIRi A41173. DXHUBH.
RefSeqi NP_001193670.1. NM_001206741.1.
NP_005516.1. NM_005525.3.
NP_861420.1. NM_181755.2.
UniGenei Hs.195040.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XU7 X-ray 1.80 A/B/C/D 24-292 [» ]
1XU9 X-ray 1.55 A/B/C/D 24-292 [» ]
2BEL X-ray 2.11 A/B/C/D 26-284 [» ]
2ILT X-ray 2.30 A 24-285 [» ]
2IRW X-ray 3.10 A/B/C/D/E/F/G/H 26-289 [» ]
2RBE X-ray 1.90 A/B/C/D 25-292 [» ]
3BYZ X-ray 2.69 A/B/C/D 25-292 [» ]
3BZU X-ray 2.25 A/B/C/D 24-292 [» ]
3CH6 X-ray 2.35 A/B/D/E 24-292 [» ]
3CZR X-ray 2.35 A/B 24-292 [» ]
3D3E X-ray 2.60 A/B/C/D 24-292 [» ]
3D4N X-ray 2.50 A/B/C/D 24-292 [» ]
3D5Q X-ray 2.55 A/B/C/D 24-292 [» ]
3EY4 X-ray 3.00 A/B/C/D 25-292 [» ]
3FCO X-ray 2.65 A/B 24-291 [» ]
3FRJ X-ray 2.30 A/B 24-292 [» ]
3H6K X-ray 2.19 A/B/C/D 24-292 [» ]
3HFG X-ray 2.30 A/B/C/D 24-292 [» ]
3OQ1 X-ray 2.60 A/B/C/D 24-292 [» ]
3PDJ X-ray 2.30 A/B 24-292 [» ]
3QQP X-ray 2.72 A/B/C/D 24-292 [» ]
3TFQ X-ray 1.80 A/B/D/E 24-292 [» ]
4BB5 X-ray 2.20 A/B/C/D 1-292 [» ]
4BB6 X-ray 2.55 A/B 1-292 [» ]
4C7K X-ray 1.91 A/B/C/D 24-292 [» ]
4HFR X-ray 2.73 A/B 24-292 [» ]
4HX5 X-ray 2.19 A/B/C/D 24-292 [» ]
4IJU X-ray 2.35 A/B/D/E 24-292 [» ]
4IJV X-ray 2.35 A/B/D/E 24-292 [» ]
4IJW X-ray 2.35 A/B/D/E 24-292 [» ]
4K1L X-ray 1.96 A/B/C/D 24-292 [» ]
4P38 X-ray 2.80 A/B 26-290 [» ]
ProteinModelPortali P28845.
SMRi P28845. Positions 26-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109523. 2 interactions.
DIPi DIP-59618N.
IntActi P28845. 1 interaction.
STRINGi 9606.ENSP00000261465.

Chemistry

BindingDBi P28845.
ChEMBLi CHEMBL4235.
DrugBanki DB00157. NADH.
GuidetoPHARMACOLOGYi 2763.

PTM databases

PhosphoSitei P28845.

Polymorphism databases

DMDMi 118569.

Proteomic databases

MaxQBi P28845.
PaxDbi P28845.
PRIDEi P28845.

Protocols and materials databases

DNASUi 3290.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261465 ; ENSP00000261465 ; ENSG00000117594 .
ENST00000367027 ; ENSP00000355994 ; ENSG00000117594 .
ENST00000367028 ; ENSP00000355995 ; ENSG00000117594 .
GeneIDi 3290.
KEGGi hsa:3290.
UCSCi uc001hhj.3. human.

Organism-specific databases

CTDi 3290.
GeneCardsi GC01P209859.
HGNCi HGNC:5208. HSD11B1.
HPAi HPA047729.
MIMi 600713. gene.
604931. phenotype.
neXtProti NX_P28845.
Orphaneti 168588. Hyperandrogenism due to cortisone reductase deficiency.
PharmGKBi PA29476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1028.
HOGENOMi HOG000010276.
HOVERGENi HBG005481.
InParanoidi P28845.
KOi K15680.
OMAi WGGLDML.
OrthoDBi EOG7353X9.
PhylomeDBi P28845.
TreeFami TF329114.

Enzyme and pathway databases

BioCyci MetaCyc:HS04154-MONOMER.
BRENDAi 1.1.1.146. 2681.
Reactomei REACT_11036. Glucocorticoid biosynthesis.
SABIO-RK P28845.

Miscellaneous databases

EvolutionaryTracei P28845.
GeneWikii 11%CE%B2-hydroxysteroid_dehydrogenase_type_1.
GenomeRNAii 3290.
NextBioi 13049.
PROi P28845.
SOURCEi Search...

Gene expression databases

Bgeei P28845.
CleanExi HS_HSD11B1.
Genevestigatori P28845.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization."
    Tannin G.M., Agarwal A.K., Monder C., New M.I., White P.C.
    J. Biol. Chem. 266:16653-16658(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Testis.
  2. "Association studies between microsatellite markers within the gene encoding human 11beta-hydroxysteroid dehydrogenase type 1 and body mass index, waist to hip ratio, and glucocorticoid metabolism."
    Draper N., Echwald S.M., Lavery G.G., Walker E.A., Fraser R., Davies E., Soerensen T.I.A., Astrup A., Adamski J., Hewison M., Connell J.M., Pedersen O., Stewart P.M.
    J. Clin. Endocrinol. Metab. 87:4984-4990(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane."
    Odermatt A., Arnold P., Stauffer A., Frey B.M., Frey F.J.
    J. Biol. Chem. 274:28762-28770(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION, MUTAGENESIS OF LYS-5; 5-LYS-LYS-6; LYS-6; 18-TYR--TYR-21 AND 19-TYR--TYR-21.
  8. "Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency."
    Draper N., Walker E.A., Bujalska I.J., Tomlinson J.W., Chalder S.M., Arlt W., Lavery G.G., Bedendo O., Ray D.W., Laing I., Malunowicz E., White P.C., Hewison M., Mason P.J., Connell J.M., Shackleton C.H.L., Stewart P.M.
    Nat. Genet. 34:434-439(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CDR.
  9. "Appropriate function of 11beta-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum lumen is dependent on its N-terminal region sharing similar topological determinants with 50-kDa esterase."
    Frick C., Atanasov A.G., Arnold P., Ozols J., Odermatt A.
    J. Biol. Chem. 279:31131-31138(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, TOPOLOGY, MUTAGENESIS OF 5-LYS-LYS-6; GLU-25; 25-GLU-GLU-26; GLU-26 AND 35-LYS-LYS-36.
  10. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-123 AND ASN-162.
    Tissue: Liver.
  11. "Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation."
    Hosfield D.J., Wu Y., Skene R.J., Hilgers M., Jennings A., Snell G.P., Aertgeerts K.
    J. Biol. Chem. 280:4639-4648(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 24-292 IN COMPLEX WITH NADP AND SUBSTRATE ANALOG, SUBUNIT.
  12. Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 24-284 IN COMPLEXES WITH ADAMANTANE SULFONE AND SULFONAMIDE INHIBITORS, CATALYTIC ACTIVITY.
  13. Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-292 IN COMPLEX WITH NADP AND INHIBITOR, SUBUNIT, CATALYTIC ACTIVITY.
  14. Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 24-292 IN COMPLEX WITH NADP AND INHIBITOR.
  15. "Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor."
    Hale C., Veniant M., Wang Z., Chen M., McCormick J., Cupples R., Hickman D., Min X., Sudom A., Xu H., Matsumoto G., Fotsch C., St Jean D.J. Jr., Wang M.
    Chem. Biol. Drug Des. 71:36-44(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 24-292 IN COMPLEX WITH NADP AND INHIBITOR.
  16. "Discovery of novel, potent benzamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) exhibiting oral activity in an enzyme inhibition ex vivo model."
    Julian L.D., Wang Z., Bostick T., Caille S., Choi R., DeGraffenreid M., Di Y., He X., Hungate R.W., Jaen J.C., Liu J., Monshouwer M., McMinn D., Rew Y., Sudom A., Sun D., Tu H., Ursu S.
    , Walker N., Yan X., Ye Q., Powers J.P.
    J. Med. Chem. 51:3953-3960(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 24-292 IN COMPLEX WITH NADP AND INHIBITOR.
  17. "Discovery and optimization of piperidyl benzamide derivatives as a novel class of 11beta-HSD1 inhibitors."
    Rew Y., McMinn D.L., Wang Z., He X., Hungate R.W., Jaen J.C., Sudom A., Sun D., Tu H., Ursu S., Villemure E., Walker N.P.C., Yan X., Ye Q., Powers J.P.
    Bioorg. Med. Chem. Lett. 19:1797-1801(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 24-292 IN COMPLEX WITH NADP AND INHIBITOR.
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-148.

Entry informationi

Entry nameiDHI1_HUMAN
AccessioniPrimary (citable) accession number: P28845
Secondary accession number(s): B2R9Z1, D3DT89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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