Reviewed,
UniProtKB/Swiss-Prot P28843 (DPP4_MOUSE)
Last modified
November 3, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dipeptidyl peptidase 4 EC=3.4.14.5 Alternative name(s): Dipeptidyl peptidase IV Short name=DPP IV T-cell activation antigen CD26 Thymocyte-activating molecule Short name=THAM CD_antigen=CD26 Cleaved into the following 2 chains: 1- Recommended name: Dipeptidyl peptidase 4 membrane form Alternative name(s): Dipeptidyl peptidase IV membrane form 2- Recommended name: Dipeptidyl peptidase 4 soluble form Alternative name(s): Dipeptidyl peptidase IV soluble form | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 760 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline. |
| Catalytic activity | Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. |
| Subunit structure | Homodimer. |
| Subcellular location | Cell membrane; Single-pass type II membrane protein. Dipeptidyl peptidase 4 soluble form: Secreted. |
| Post-translational modification | The soluble form (SDPP) derives from the membrane form (MDPP) by proteolytic processing. |
| Sequence similarities | Belongs to the peptidase S9B family. DPPIV subfamily. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane Secreted |
| Domain | Signal-anchor Transmembrane |
| Molecular function | Aminopeptidase Hydrolase Protease Serine protease |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell intercellular canaliculusInferred from direct assay. Source: MGI |
| Molecular function | aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 760 | 760 | Dipeptidyl peptidase 4 membrane form | PRO_0000027215 | |||||||
| Chain | 37 – 760 | 724 | Dipeptidyl peptidase 4 soluble form By similarity | PRO_0000027216 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 6 | 6 | Cytoplasmic Potential | ||||||||
| Transmembrane | 7 – 28 | 22 | Signal-anchor for type II membrane protein Potential | ||||||||
| Topological domain | 29 – 760 | 732 | Extracellular Potential | ||||||||
| Compositional bias | 295 – 466 | 172 | Cys-rich | ||||||||
Sites | |||||||||||
| Active site | 624 | 1 | Charge relay system By similarity | ||||||||
| Active site | 702 | 1 | Charge relay system By similarity | ||||||||
| Active site | 734 | 1 | Charge relay system By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 83 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 90 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 145 | 1 | N-linked (GlcNAc...) Ref.7 | ||||||||
| Glycosylation | 213 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 223 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 315 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Glycosylation | 328 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 514 | 1 | N-linked (GlcNAc...) Ref.7 | ||||||||
| Glycosylation | 679 | 1 | N-linked (GlcNAc...) By similarity | ||||||||
| Disulfide bond | 379 ↔ 388 | By similarity | |||||||||
| Disulfide bond | 438 ↔ 441 | By similarity | |||||||||
| Disulfide bond | 448 ↔ 466 | By similarity | |||||||||
| Disulfide bond | 643 ↔ 756 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases." Marguet D.A., Bernard A.-M., Vivier I., Darmoul D., Naquet P., Pierres M. J. Biol. Chem. 267:2200-2208(1992) [PubMed: 1370813] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss. Tissue: Thymus. |
| [2] | Marguet D.A. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. |
| [3] | "Structure of the mouse dipeptidyl peptidase IV (CD26) gene." Bernard A.-M., Mattei M.-G., Pierres M., Marguet D. Biochemistry 33:15204-15214(1994) [PubMed: 7999781] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: B10.A. Tissue: Liver. |
| [4] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J and NOD. Tissue: Kidney and Thymus. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV)." Vivier I., Marguet D.A., Naquet P., Bonicel J., Black D., Li C.X.-Y., Bernard A.-M., Gorvel J.-P., Pierres M. J. Immunol. 147:447-454(1991) [PubMed: 1712807] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-20. |
| [7] | "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-514, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X58384 mRNA. Translation: CAA41274.1. U12620 U12619 Genomic DNA. Translation: AAA82213.1. AK085370 mRNA. Translation: BAC39434.1. AK153939 mRNA. Translation: BAE32266.1. BC022183 mRNA. Translation: AAH22183.1. | |
| IPI | IPI00125813. |
| PIR | S23752. |
| RefSeq | NP_001153015.1. NP_034204.1. |
| UniGene | Mm.1151 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1PFQ based on UniProtKB P27487. |
| SMR | P28843. Positions 37-759. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P28843. |
Protein family/group databases | |
| MEROPS | S09.003. |
PTM databases | |
| PhosphoSite | P28843. |
Proteomic databases | |
| PRIDE | P28843. |
Genome annotation databases | |
| Ensembl | ENSMUST00000047812; ENSMUSP00000044050; ENSMUSG00000035000; Mus musculus. [Genome view] |
| GeneID | 13482. |
| KEGG | mmu:13482. |
| UCSC | uc008jvg.1. mouse. |
Organism-specific databases | |
| CTD | 13482. |
| MGI | MGI:94919. Dpp4. |
Phylogenomic databases | |
| HOGENOM | P28843. |
| HOVERGEN | P28843. |
| OMA | YLASTEN. |
Enzyme and pathway databases | |
| BRENDA | 3.4.14.5. 244. |
Gene expression databases | |
| ArrayExpress | P28843. |
| Bgee | P28843. |
| CleanEx | MM_DPP4. |
| Genevestigator | P28843. |
| GermOnline | ENSMUSG00000035000. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002471. Pept_S9_AS. IPR001375. Peptidase_S9. IPR002469. Peptidase_S9B. [Graphical view] |
| Pfam | PF00930. DPPIV_N. 1 hit. PF00326. Peptidase_S9. 1 hit. [Graphical view] |
| PROSITE | PS00708. PRO_ENDOPEP_SER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 283979. |
| SOURCE | Search... |
Entry information
| Entry name | DPP4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P28843 Secondary accession number(s): Q3U514 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


