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Protein

Protein kinase byr2

Gene

byr2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei423ATPPROSITE-ProRule annotation1
Active sitei522Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi400 – 408ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: UniProtKB-EC
  • MAP kinase kinase kinase kinase activity Source: PomBase

GO - Biological processi

  • induction of conjugation upon nitrogen starvation Source: PomBase
  • induction of conjugation with cellular fusion Source: PomBase
  • MAPK cascade involved in ascospore formation Source: PomBase
  • MAPK cascade involved in conjugation with cellular fusion Source: PomBase
  • mitotic cell cycle arrest in response to pheromone Source: PomBase
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion Source: PomBase
  • signal transduction involved in conjugation with cellular fusion Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Conjugation, Sporulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.25. 5613.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase byr2 (EC:2.7.11.25)
Alternative name(s):
MAPK kinase kinase
Short name:
MAPKKK
Protein kinase ste8
Gene namesi
Name:byr2
Synonyms:ste8
ORF Names:SPBC1D7.05, SPBC2F12.01
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.05.
PomBaseiSPBC1D7.05. byr2.

Subcellular locationi

GO - Cellular componenti

  • barrier septum Source: PomBase
  • cell division site Source: PomBase
  • cell tip Source: PomBase
  • cytoplasm Source: PomBase
  • plasma membrane Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856891 – 659Protein kinase byr2Add BLAST659

Proteomic databases

PRIDEiP28829.

Interactioni

Protein-protein interaction databases

BioGridi277138. 42 interactors.
DIPiDIP-136N.
IntActiP28829. 1 interactor.
MINTiMINT-221819.

Structurei

Secondary structure

1659
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi72 – 76Combined sources5
Turni78 – 80Combined sources3
Beta strandi82 – 86Combined sources5
Helixi91 – 102Combined sources12
Beta strandi109 – 115Combined sources7
Beta strandi117 – 122Combined sources6
Helixi127 – 133Combined sources7
Beta strandi138 – 140Combined sources3
Beta strandi143 – 150Combined sources8
Helixi155 – 160Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I35NMR-A71-165[»]
1K8RX-ray3.00B71-180[»]
ProteinModelPortaliP28829.
SMRiP28829.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 67SAMPROSITE-ProRule annotationAdd BLAST64
Domaini394 – 658Protein kinasePROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiP28829.
KOiK11228.
OMAiARESSMN.
OrthoDBiEOG092C030N.
PhylomeDBiP28829.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR029458. Ras-bd_By2.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR008271. Ser/Thr_kinase_AS.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14847. Ras_bdg_2. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM01304. Ras_bdg_2. 1 hit.
SM00220. S_TKc. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYYTSKEVA EWLKSIGLEK YIEQFSQNNI EGRHLNHLTL PLLKDLGIEN
60 70 80 90 100
TAKGKQFLKQ RDYLREFPRP CILRFIACNG QTRAVQSRGD YQKTLAIALK
110 120 130 140 150
KFSLEDASKF IVCVSQSSRI KLITEEEFKQ ICFNSSSPER DRLIIVPKEK
160 170 180 190 200
PCPSFEDLRR SWEIELAQPA ALSSQSSLSP KLSSVLPTST QKRSVRSNNA
210 220 230 240 250
KPFESYQRPP SELINSRISD FFPDHQPKLL EKTISNSLRR NLSIRTSQGH
260 270 280 290 300
NLGNFGQEIL PRSSRRARPS ELVCPLSSLR ISVAEDVNRL PRIDRGFDPP
310 320 330 340 350
LTVSSTQRIS RPPSLQKSIT MVGVEPLYQS NGNEKSSKYN VFSESAHGNH
360 370 380 390 400
QVLSFSPGSS PSFIEQPSPI SPTSTTSEDT NTLEEDTDDQ SIKWIRGALI
410 420 430 440 450
GSGSFGQVYL GMNASSGELM AVKQVILDSV SESKDRHAKL LDALAGEIAL
460 470 480 490 500
LQELSHEHIV QYLGSNLNSD HLNIFLEYVP GGSVAGLLTM YGSFEETLVK
510 520 530 540 550
NFIKQTLKGL EYLHSRGIVH RDIKGANILV DNKGKIKISD FGISKKLELN
560 570 580 590 600
STSTKTGGAR PSFQGSSFWM APEVVKQTMH TEKTDIWSLG CLVIEMLTSK
610 620 630 640 650
HPYPNCDQMQ AIFRIGENIL PEFPSNISSS AIDFLEKTFA IDCNLRPTAS

ELLSHPFVS
Length:659
Mass (Da):73,633
Last modified:December 1, 1992 - v1
Checksum:i18CD78F1D1FABBCD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74293 Genomic DNA. Translation: AAA35289.1.
X68851 Genomic DNA. Translation: CAA48731.1.
CU329671 Genomic DNA. Translation: CAB10150.1.
PIRiA39723.
RefSeqiNP_595714.2. NM_001021611.3.

Genome annotation databases

EnsemblFungiiSPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05.
GeneIDi2540612.
KEGGispo:SPBC1D7.05.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74293 Genomic DNA. Translation: AAA35289.1.
X68851 Genomic DNA. Translation: CAA48731.1.
CU329671 Genomic DNA. Translation: CAB10150.1.
PIRiA39723.
RefSeqiNP_595714.2. NM_001021611.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I35NMR-A71-165[»]
1K8RX-ray3.00B71-180[»]
ProteinModelPortaliP28829.
SMRiP28829.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi277138. 42 interactors.
DIPiDIP-136N.
IntActiP28829. 1 interactor.
MINTiMINT-221819.

Proteomic databases

PRIDEiP28829.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1D7.05.1; SPBC1D7.05.1:pep; SPBC1D7.05.
GeneIDi2540612.
KEGGispo:SPBC1D7.05.

Organism-specific databases

EuPathDBiFungiDB:SPBC1D7.05.
PomBaseiSPBC1D7.05. byr2.

Phylogenomic databases

InParanoidiP28829.
KOiK11228.
OMAiARESSMN.
OrthoDBiEOG092C030N.
PhylomeDBiP28829.

Enzyme and pathway databases

BRENDAi2.7.11.25. 5613.

Miscellaneous databases

EvolutionaryTraceiP28829.
PROiP28829.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR029458. Ras-bd_By2.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR008271. Ser/Thr_kinase_AS.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF14847. Ras_bdg_2. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
SMARTiSM01304. Ras_bdg_2. 1 hit.
SM00220. S_TKc. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
SSF54236. SSF54236. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBYR2_SCHPO
AccessioniPrimary (citable) accession number: P28829
Secondary accession number(s): Q7LGJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.