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P28828

- PTPRM_MOUSE

UniProt

P28828 - PTPRM_MOUSE

Protein

Receptor-type tyrosine-protein phosphatase mu

Gene

Ptprm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1063 – 10631SubstrateBy similarity
    Active sitei1095 – 10951Phosphocysteine intermediateBy similarity
    Binding sitei1139 – 11391SubstrateBy similarity
    Active sitei1389 – 13891Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. cadherin binding Source: UniProtKB
    2. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. homophilic cell adhesion Source: UniProtKB
    2. negative regulation of angiogenesis Source: UniProtKB
    3. negative regulation of endothelial cell migration Source: UniProtKB
    4. negative regulation of endothelial cell proliferation Source: UniProtKB
    5. neuron projection development Source: UniProtKB
    6. positive regulation of vasodilation Source: MGI
    7. protein dephosphorylation Source: UniProtKB
    8. response to drug Source: UniProtKB
    9. retina layer formation Source: UniProtKB
    10. retinal ganglion cell axon guidance Source: UniProtKB
    11. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase mu
    Short name:
    R-PTP-mu
    Gene namesi
    Name:Ptprm
    Synonyms:Kiaa4044
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:102694. Ptprm.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell adherens junction Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. lamellipodium Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 14521432Receptor-type tyrosine-protein phosphatase muPRO_0000025449Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 36PROSITE-ProRule annotation
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 182PROSITE-ProRule annotation
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 260PROSITE-ProRule annotation
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei821 – 8211PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP28828.
    PaxDbiP28828.
    PRIDEiP28828.

    PTM databases

    PhosphoSiteiP28828.

    Expressioni

    Tissue specificityi

    Most abundant in lung, less in brain and heart.

    Gene expression databases

    ArrayExpressiP28828.
    BgeeiP28828.
    CleanExiMM_PTPRM.
    GenevestigatoriP28828.

    Interactioni

    Protein-protein interaction databases

    IntActiP28828. 1 interaction.
    MINTiMINT-129906.

    Structurei

    3D structure databases

    ProteinModelPortaliP28828.
    SMRiP28828. Positions 22-588, 877-1451.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 742722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini765 – 1452688CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei743 – 76422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 184163MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 27792Ig-like C2-typeAdd
    BLAST
    Domaini284 – 37996Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini382 – 48099Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini481 – 587107Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini589 – 67183Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 1154255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1186 – 1448263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1095 – 11017Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00640000091300.
    HOGENOMiHOG000049029.
    HOVERGENiHBG062785.
    KOiK05693.
    OMAiHKSYRIY.
    OrthoDBiEOG70KGNP.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00047. ig. 1 hit.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28828-1 [UniParc]FASTAAdd to Basket

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    MRTLGTCLVT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ ADEDDFNWEQ     50
    VNTLTKPTSD PWMPSGSFML VNTSGKPEGQ RAHLLLPQLK ENDTHCIDFH 100
    YFVSSKSNAA PGLLNVYVKV NNGPLGNPIW NISGDPTRTW HRAELAISTF 150
    WPNFYQVIFE VVTSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ 200
    FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT 250
    TKRDAGKYRC MICTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300
    QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE 350
    ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW 400
    EPFGYNVTRC HSYNLTVHYG YQVGGQEQVR EEVSWDTDNS HPQHTITNLS 450
    PYTNVSVKLI LMNPEGRKES QELTVQTDED LPGAVPTESI QGSAFEEKIF 500
    LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF 550
    FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YEFETPLNQT 600
    DNTVTVMLKP AQSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ 650
    NASILNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPHKSYRI 700
    YYQAASRANG ETKIDCVRVA TKGAVTPKPV PEPEKQTDHT VKIAGVIAGI 750
    LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT 800
    NCDEAFSFMG THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS 850
    DTSSLAQPHT YKKREAADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900
    KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQMLEGDNN 950
    SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL 1000
    VEVGRVKCCK YWPDDTEIYK DIKVTLIDTE LLAEYVIRTF AVEKRGIHEI 1050
    REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPNAGP LVVHCSAGAG 1100
    RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA 1150
    ILEACLCGDT SIPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200
    RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS 1250
    YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP 1300
    ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNASRPQDGH RMVQQFQFLG 1350
    WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC 1400
    AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN 1450
    SG 1452
    Length:1,452
    Mass (Da):163,653
    Last modified:July 27, 2011 - v2
    Checksum:iA1170FC67A41AF1D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1384 – 13841R → P in CAA41225. (PubMed:1655529)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58287 mRNA. Translation: CAA41225.1.
    AC109261 Genomic DNA. No translation available.
    AC139750 Genomic DNA. No translation available.
    AC154596 Genomic DNA. No translation available.
    AC163731 Genomic DNA. No translation available.
    CT030654 Genomic DNA. No translation available.
    AK220171 mRNA. Translation: BAD90356.1.
    CCDSiCCDS28948.1.
    PIRiS17670.
    RefSeqiNP_033010.2. NM_008984.2.
    UniGeneiMm.311809.

    Genome annotation databases

    EnsembliENSMUST00000037974; ENSMUSP00000045603; ENSMUSG00000033278.
    GeneIDi19274.
    KEGGimmu:19274.
    UCSCiuc008dka.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58287 mRNA. Translation: CAA41225.1 .
    AC109261 Genomic DNA. No translation available.
    AC139750 Genomic DNA. No translation available.
    AC154596 Genomic DNA. No translation available.
    AC163731 Genomic DNA. No translation available.
    CT030654 Genomic DNA. No translation available.
    AK220171 mRNA. Translation: BAD90356.1 .
    CCDSi CCDS28948.1.
    PIRi S17670.
    RefSeqi NP_033010.2. NM_008984.2.
    UniGenei Mm.311809.

    3D structure databases

    ProteinModelPortali P28828.
    SMRi P28828. Positions 22-588, 877-1451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P28828. 1 interaction.
    MINTi MINT-129906.

    PTM databases

    PhosphoSitei P28828.

    Proteomic databases

    MaxQBi P28828.
    PaxDbi P28828.
    PRIDEi P28828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037974 ; ENSMUSP00000045603 ; ENSMUSG00000033278 .
    GeneIDi 19274.
    KEGGi mmu:19274.
    UCSCi uc008dka.2. mouse.

    Organism-specific databases

    CTDi 5797.
    MGIi MGI:102694. Ptprm.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00640000091300.
    HOGENOMi HOG000049029.
    HOVERGENi HBG062785.
    KOi K05693.
    OMAi HKSYRIY.
    OrthoDBi EOG70KGNP.
    TreeFami TF312900.

    Miscellaneous databases

    NextBioi 296172.
    PROi P28828.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28828.
    Bgeei P28828.
    CleanExi MM_PTPRM.
    Genevestigatori P28828.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00047. ig. 1 hit.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase."
      Gebbink M.F.B.G., van Etten I., Hateboer G., Suijkerbuijk R., Beijersbergen R., Geurts van Kessel A., Moolenaar W.H.
      FEBS Lett. 290:123-130(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-1452.

    Entry informationi

    Entry nameiPTPRM_MOUSE
    AccessioniPrimary (citable) accession number: P28828
    Secondary accession number(s): E9QKU4, Q571L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 137 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3