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P28828

- PTPRM_MOUSE

UniProt

P28828 - PTPRM_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase mu

Gene

Ptprm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1063 – 10631SubstrateBy similarity
Active sitei1095 – 10951Phosphocysteine intermediateBy similarity
Binding sitei1139 – 11391SubstrateBy similarity
Active sitei1389 – 13891Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. homophilic cell adhesion Source: UniProtKB
  2. negative regulation of angiogenesis Source: UniProtKB
  3. negative regulation of endothelial cell migration Source: UniProtKB
  4. negative regulation of endothelial cell proliferation Source: UniProtKB
  5. neuron projection development Source: UniProtKB
  6. peptidyl-tyrosine dephosphorylation Source: GOC
  7. positive regulation of vasodilation Source: MGI
  8. protein dephosphorylation Source: UniProtKB
  9. response to drug Source: UniProtKB
  10. retina layer formation Source: UniProtKB
  11. retinal ganglion cell axon guidance Source: UniProtKB
  12. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase mu
Short name:
R-PTP-mu
Gene namesi
Name:Ptprm
Synonyms:Kiaa4044
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:102694. Ptprm.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell adherens junction Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. lamellipodium Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 14521432Receptor-type tyrosine-protein phosphatase muPRO_0000025449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 36PROSITE-ProRule annotation
Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 182PROSITE-ProRule annotation
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi206 ↔ 260PROSITE-ProRule annotation
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence Analysis
Modified residuei821 – 8211PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP28828.
PaxDbiP28828.
PRIDEiP28828.

PTM databases

PhosphoSiteiP28828.

Expressioni

Tissue specificityi

Most abundant in lung, less in brain and heart.

Gene expression databases

BgeeiP28828.
CleanExiMM_PTPRM.
ExpressionAtlasiP28828. baseline and differential.
GenevestigatoriP28828.

Interactioni

Protein-protein interaction databases

IntActiP28828. 1 interaction.
MINTiMINT-129906.

Structurei

3D structure databases

ProteinModelPortaliP28828.
SMRiP28828. Positions 22-588, 877-1451.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 742722ExtracellularSequence AnalysisAdd
BLAST
Topological domaini765 – 1452688CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei743 – 76422HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 184163MAMPROSITE-ProRule annotationAdd
BLAST
Domaini186 – 27792Ig-like C2-typeAdd
BLAST
Domaini284 – 37996Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 48099Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 587107Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini589 – 67183Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini900 – 1154255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1186 – 1448263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1095 – 11017Substrate bindingBy similarity

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiP28828.
KOiK05693.
OMAiHKSYRIY.
OrthoDBiEOG70KGNP.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTLGTCLVT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ ADEDDFNWEQ
60 70 80 90 100
VNTLTKPTSD PWMPSGSFML VNTSGKPEGQ RAHLLLPQLK ENDTHCIDFH
110 120 130 140 150
YFVSSKSNAA PGLLNVYVKV NNGPLGNPIW NISGDPTRTW HRAELAISTF
160 170 180 190 200
WPNFYQVIFE VVTSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ
210 220 230 240 250
FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT
260 270 280 290 300
TKRDAGKYRC MICTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI
310 320 330 340 350
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE
360 370 380 390 400
ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW
410 420 430 440 450
EPFGYNVTRC HSYNLTVHYG YQVGGQEQVR EEVSWDTDNS HPQHTITNLS
460 470 480 490 500
PYTNVSVKLI LMNPEGRKES QELTVQTDED LPGAVPTESI QGSAFEEKIF
510 520 530 540 550
LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF
560 570 580 590 600
FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YEFETPLNQT
610 620 630 640 650
DNTVTVMLKP AQSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ
660 670 680 690 700
NASILNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPHKSYRI
710 720 730 740 750
YYQAASRANG ETKIDCVRVA TKGAVTPKPV PEPEKQTDHT VKIAGVIAGI
760 770 780 790 800
LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT
810 820 830 840 850
NCDEAFSFMG THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS
860 870 880 890 900
DTSSLAQPHT YKKREAADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF
910 920 930 940 950
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQMLEGDNN
960 970 980 990 1000
SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL
1010 1020 1030 1040 1050
VEVGRVKCCK YWPDDTEIYK DIKVTLIDTE LLAEYVIRTF AVEKRGIHEI
1060 1070 1080 1090 1100
REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPNAGP LVVHCSAGAG
1110 1120 1130 1140 1150
RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA
1160 1170 1180 1190 1200
ILEACLCGDT SIPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL
1210 1220 1230 1240 1250
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS
1260 1270 1280 1290 1300
YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP
1310 1320 1330 1340 1350
ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNASRPQDGH RMVQQFQFLG
1360 1370 1380 1390 1400
WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC
1410 1420 1430 1440 1450
AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN

SG
Length:1,452
Mass (Da):163,653
Last modified:July 27, 2011 - v2
Checksum:iA1170FC67A41AF1D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1384 – 13841R → P in CAA41225. (PubMed:1655529)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58287 mRNA. Translation: CAA41225.1.
AC109261 Genomic DNA. No translation available.
AC139750 Genomic DNA. No translation available.
AC154596 Genomic DNA. No translation available.
AC163731 Genomic DNA. No translation available.
CT030654 Genomic DNA. No translation available.
AK220171 mRNA. Translation: BAD90356.1.
CCDSiCCDS28948.1.
PIRiS17670.
RefSeqiNP_033010.2. NM_008984.2.
UniGeneiMm.311809.

Genome annotation databases

EnsembliENSMUST00000037974; ENSMUSP00000045603; ENSMUSG00000033278.
GeneIDi19274.
KEGGimmu:19274.
UCSCiuc008dka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58287 mRNA. Translation: CAA41225.1 .
AC109261 Genomic DNA. No translation available.
AC139750 Genomic DNA. No translation available.
AC154596 Genomic DNA. No translation available.
AC163731 Genomic DNA. No translation available.
CT030654 Genomic DNA. No translation available.
AK220171 mRNA. Translation: BAD90356.1 .
CCDSi CCDS28948.1.
PIRi S17670.
RefSeqi NP_033010.2. NM_008984.2.
UniGenei Mm.311809.

3D structure databases

ProteinModelPortali P28828.
SMRi P28828. Positions 22-588, 877-1451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P28828. 1 interaction.
MINTi MINT-129906.

PTM databases

PhosphoSitei P28828.

Proteomic databases

MaxQBi P28828.
PaxDbi P28828.
PRIDEi P28828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037974 ; ENSMUSP00000045603 ; ENSMUSG00000033278 .
GeneIDi 19274.
KEGGi mmu:19274.
UCSCi uc008dka.2. mouse.

Organism-specific databases

CTDi 5797.
MGIi MGI:102694. Ptprm.
Rougei Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000049029.
HOVERGENi HBG062785.
InParanoidi P28828.
KOi K05693.
OMAi HKSYRIY.
OrthoDBi EOG70KGNP.
TreeFami TF312900.

Miscellaneous databases

NextBioi 296172.
PROi P28828.
SOURCEi Search...

Gene expression databases

Bgeei P28828.
CleanExi MM_PTPRM.
ExpressionAtlasi P28828. baseline and differential.
Genevestigatori P28828.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase."
    Gebbink M.F.B.G., van Etten I., Hateboer G., Suijkerbuijk R., Beijersbergen R., Geurts van Kessel A., Moolenaar W.H.
    FEBS Lett. 290:123-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-1452.

Entry informationi

Entry nameiPTPRM_MOUSE
AccessioniPrimary (citable) accession number: P28828
Secondary accession number(s): E9QKU4, Q571L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3