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P28828

- PTPRM_MOUSE

UniProt

P28828 - PTPRM_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase mu
Gene
Ptprm, Kiaa4044
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1063 – 10631Substrate By similarity
Active sitei1095 – 10951Phosphocysteine intermediate By similarity
Binding sitei1139 – 11391Substrate By similarity
Active sitei1389 – 13891Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. homophilic cell adhesion Source: UniProtKB
  2. negative regulation of angiogenesis Source: UniProtKB
  3. negative regulation of endothelial cell migration Source: UniProtKB
  4. negative regulation of endothelial cell proliferation Source: UniProtKB
  5. neuron projection development Source: UniProtKB
  6. positive regulation of vasodilation Source: MGI
  7. protein dephosphorylation Source: UniProtKB
  8. response to drug Source: UniProtKB
  9. retina layer formation Source: UniProtKB
  10. retinal ganglion cell axon guidance Source: UniProtKB
  11. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase mu
Short name:
R-PTP-mu
Gene namesi
Name:Ptprm
Synonyms:Kiaa4044
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:102694. Ptprm.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 742722Extracellular Reviewed prediction
Add
BLAST
Transmembranei743 – 76422Helical; Reviewed prediction
Add
BLAST
Topological domaini765 – 1452688Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell adherens junction Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. lamellipodium Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 14521432Receptor-type tyrosine-protein phosphatase mu
PRO_0000025449Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 36 By similarity
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 182 By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi206 ↔ 260 By similarity
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi598 – 5981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction
Modified residuei821 – 8211Phosphoserine By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP28828.
PaxDbiP28828.
PRIDEiP28828.

PTM databases

PhosphoSiteiP28828.

Expressioni

Tissue specificityi

Most abundant in lung, less in brain and heart.

Gene expression databases

ArrayExpressiP28828.
BgeeiP28828.
CleanExiMM_PTPRM.
GenevestigatoriP28828.

Interactioni

Protein-protein interaction databases

IntActiP28828. 1 interaction.
MINTiMINT-129906.

Structurei

3D structure databases

ProteinModelPortaliP28828.
SMRiP28828. Positions 22-588, 877-1451.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 184163MAM
Add
BLAST
Domaini186 – 27792Ig-like C2-type
Add
BLAST
Domaini284 – 37996Fibronectin type-III 1
Add
BLAST
Domaini382 – 48099Fibronectin type-III 2
Add
BLAST
Domaini481 – 587107Fibronectin type-III 3
Add
BLAST
Domaini589 – 67183Fibronectin type-III 4
Add
BLAST
Domaini900 – 1154255Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1186 – 1448263Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1095 – 11017Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00640000091300.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
KOiK05693.
OMAiHKSYRIY.
OrthoDBiEOG70KGNP.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28828-1 [UniParc]FASTAAdd to Basket

« Hide

MRTLGTCLVT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ ADEDDFNWEQ     50
VNTLTKPTSD PWMPSGSFML VNTSGKPEGQ RAHLLLPQLK ENDTHCIDFH 100
YFVSSKSNAA PGLLNVYVKV NNGPLGNPIW NISGDPTRTW HRAELAISTF 150
WPNFYQVIFE VVTSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ 200
FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT 250
TKRDAGKYRC MICTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE 350
ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW 400
EPFGYNVTRC HSYNLTVHYG YQVGGQEQVR EEVSWDTDNS HPQHTITNLS 450
PYTNVSVKLI LMNPEGRKES QELTVQTDED LPGAVPTESI QGSAFEEKIF 500
LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF 550
FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YEFETPLNQT 600
DNTVTVMLKP AQSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ 650
NASILNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPHKSYRI 700
YYQAASRANG ETKIDCVRVA TKGAVTPKPV PEPEKQTDHT VKIAGVIAGI 750
LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT 800
NCDEAFSFMG THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS 850
DTSSLAQPHT YKKREAADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQMLEGDNN 950
SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL 1000
VEVGRVKCCK YWPDDTEIYK DIKVTLIDTE LLAEYVIRTF AVEKRGIHEI 1050
REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPNAGP LVVHCSAGAG 1100
RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA 1150
ILEACLCGDT SIPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS 1250
YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP 1300
ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNASRPQDGH RMVQQFQFLG 1350
WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC 1400
AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN 1450
SG 1452
Length:1,452
Mass (Da):163,653
Last modified:July 27, 2011 - v2
Checksum:iA1170FC67A41AF1D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1384 – 13841R → P in CAA41225. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58287 mRNA. Translation: CAA41225.1.
AC109261 Genomic DNA. No translation available.
AC139750 Genomic DNA. No translation available.
AC154596 Genomic DNA. No translation available.
AC163731 Genomic DNA. No translation available.
CT030654 Genomic DNA. No translation available.
AK220171 mRNA. Translation: BAD90356.1.
CCDSiCCDS28948.1.
PIRiS17670.
RefSeqiNP_033010.2. NM_008984.2.
UniGeneiMm.311809.

Genome annotation databases

EnsembliENSMUST00000037974; ENSMUSP00000045603; ENSMUSG00000033278.
GeneIDi19274.
KEGGimmu:19274.
UCSCiuc008dka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58287 mRNA. Translation: CAA41225.1 .
AC109261 Genomic DNA. No translation available.
AC139750 Genomic DNA. No translation available.
AC154596 Genomic DNA. No translation available.
AC163731 Genomic DNA. No translation available.
CT030654 Genomic DNA. No translation available.
AK220171 mRNA. Translation: BAD90356.1 .
CCDSi CCDS28948.1.
PIRi S17670.
RefSeqi NP_033010.2. NM_008984.2.
UniGenei Mm.311809.

3D structure databases

ProteinModelPortali P28828.
SMRi P28828. Positions 22-588, 877-1451.
ModBasei Search...

Protein-protein interaction databases

IntActi P28828. 1 interaction.
MINTi MINT-129906.

PTM databases

PhosphoSitei P28828.

Proteomic databases

MaxQBi P28828.
PaxDbi P28828.
PRIDEi P28828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037974 ; ENSMUSP00000045603 ; ENSMUSG00000033278 .
GeneIDi 19274.
KEGGi mmu:19274.
UCSCi uc008dka.2. mouse.

Organism-specific databases

CTDi 5797.
MGIi MGI:102694. Ptprm.
Rougei Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00640000091300.
HOGENOMi HOG000049029.
HOVERGENi HBG062785.
KOi K05693.
OMAi HKSYRIY.
OrthoDBi EOG70KGNP.
TreeFami TF312900.

Miscellaneous databases

NextBioi 296172.
PROi P28828.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28828.
Bgeei P28828.
CleanExi MM_PTPRM.
Genevestigatori P28828.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase."
    Gebbink M.F.B.G., van Etten I., Hateboer G., Suijkerbuijk R., Beijersbergen R., Geurts van Kessel A., Moolenaar W.H.
    FEBS Lett. 290:123-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 101-1452.

Entry informationi

Entry nameiPTPRM_MOUSE
AccessioniPrimary (citable) accession number: P28828
Secondary accession number(s): E9QKU4, Q571L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi