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P28827

- PTPRM_HUMAN

UniProt

P28827 - PTPRM_HUMAN

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Protein
Receptor-type tyrosine-protein phosphatase mu
Gene
PTPRM, PTPRL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1063 – 10631Substrate By similarity
Active sitei1095 – 10951Phosphocysteine intermediate By similarity
Binding sitei1139 – 11391Substrate By similarity
Active sitei1389 – 13891Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. cadherin binding Source: UniProtKB
  2. identical protein binding Source: IntAct
  3. protein binding Source: UniProtKB
  4. protein tyrosine phosphatase activity Source: UniProtKB
  5. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. homophilic cell adhesion Source: UniProtKB
  2. negative regulation of angiogenesis Source: UniProtKB
  3. negative regulation of endothelial cell migration Source: UniProtKB
  4. negative regulation of endothelial cell proliferation Source: UniProtKB
  5. neuron projection development Source: UniProtKB
  6. peptidyl-tyrosine dephosphorylation Source: GOC
  7. positive regulation of vasodilation Source: Ensembl
  8. protein dephosphorylation Source: UniProtKB
  9. response to drug Source: UniProtKB
  10. retina layer formation Source: UniProtKB
  11. retinal ganglion cell axon guidance Source: UniProtKB
  12. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase mu
Short name:
R-PTP-mu
Gene namesi
Name:PTPRM
Synonyms:PTPRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:9675. PTPRM.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 742722Extracellular Reviewed prediction
Add
BLAST
Transmembranei743 – 76422Helical; Reviewed prediction
Add
BLAST
Topological domaini765 – 1452688Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell-cell adherens junction Source: UniProtKB
  2. cell-cell junction Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. integral component of plasma membrane Source: UniProtKB
  5. lamellipodium Source: MGI
  6. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 14521432Receptor-type tyrosine-protein phosphatase mu
PRO_0000025448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 361 Publication
Glycosylationi72 – 721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi92 – 921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 1821 Publication
Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
Disulfide bondi206 ↔ 2601 Publication
Glycosylationi249 – 2491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi406 – 4061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi454 – 4541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi534 – 5341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi544 – 5441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi598 – 5981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi651 – 6511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi681 – 6811N-linked (GlcNAc...) Reviewed prediction
Modified residuei821 – 8211Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP28827.
PaxDbiP28827.
PRIDEiP28827.

PTM databases

PhosphoSiteiP28827.

Expressioni

Gene expression databases

ArrayExpressiP28827.
BgeeiP28827.
CleanExiHS_PTPRM.
GenevestigatoriP28827.

Organism-specific databases

HPAiCAB022442.
CAB022443.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2257317,EBI-2257317
Cdh1P098033EBI-2257317,EBI-984420From a different organism.

Protein-protein interaction databases

BioGridi111761. 2 interactions.
DIPiDIP-668N.
IntActiP28827. 5 interactions.
MINTiMINT-128128.
STRINGi9606.ENSP00000331418.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 313
Helixi33 – 364
Beta strandi42 – 454
Beta strandi49 – 524
Turni53 – 553
Beta strandi66 – 727
Beta strandi81 – 855
Beta strandi96 – 1049
Beta strandi106 – 1094
Beta strandi111 – 12010
Beta strandi129 – 1324
Beta strandi140 – 1478
Beta strandi155 – 1639
Beta strandi169 – 18012
Beta strandi183 – 1853
Beta strandi194 – 1963
Beta strandi198 – 2003
Beta strandi202 – 2109
Beta strandi217 – 2226
Beta strandi230 – 2378
Beta strandi240 – 2478
Helixi252 – 2543
Beta strandi256 – 2649
Beta strandi267 – 27812
Beta strandi284 – 2863
Beta strandi289 – 2935
Beta strandi298 – 3014
Beta strandi305 – 3095
Beta strandi315 – 32612
Beta strandi328 – 3325
Beta strandi335 – 3406
Beta strandi348 – 3569
Beta strandi370 – 3734
Beta strandi384 – 3918
Beta strandi396 – 4016
Helixi405 – 4084
Beta strandi410 – 4123
Beta strandi414 – 43421
Beta strandi443 – 4464
Beta strandi454 – 4629
Beta strandi467 – 4693
Beta strandi473 – 4764
Turni487 – 4893
Beta strandi491 – 4955
Beta strandi498 – 5025
Beta strandi515 – 52511
Beta strandi536 – 5427
Beta strandi547 – 5504
Beta strandi557 – 56711
Beta strandi570 – 58011
Turni882 – 8843
Helixi885 – 90521
Turni916 – 9194
Helixi921 – 9266
Helixi936 – 9383
Beta strandi939 – 9413
Turni949 – 9524
Beta strandi953 – 9619
Beta strandi964 – 9718
Helixi976 – 9783
Helixi979 – 98810
Beta strandi993 – 9964
Beta strandi1000 – 10023
Beta strandi1014 – 10196
Beta strandi1022 – 103211
Beta strandi1035 – 104410
Beta strandi1051 – 10588
Beta strandi1063 – 10653
Helixi1071 – 108313
Beta strandi1091 – 10999
Helixi1100 – 111819
Beta strandi1119 – 11213
Helixi1123 – 113311
Helixi1141 – 115515

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RPMX-ray2.30A/B879-1156[»]
2C9AX-ray2.70A21-279[»]
2V5YX-ray3.10A21-742[»]
ProteinModelPortaliP28827.
SMRiP28827. Positions 21-588, 877-1451.

Miscellaneous databases

EvolutionaryTraceiP28827.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 184163MAM
Add
BLAST
Domaini186 – 27792Ig-like C2-type
Add
BLAST
Domaini284 – 37996Fibronectin type-III 1
Add
BLAST
Domaini382 – 48099Fibronectin type-III 2
Add
BLAST
Domaini482 – 587106Fibronectin type-III 3
Add
BLAST
Domaini589 – 67183Fibronectin type-III 4
Add
BLAST
Domaini900 – 1154255Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1186 – 1448263Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1095 – 11017Substrate binding By similarity

Sequence similaritiesi

Contains 1 MAM domain.

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
HOVERGENiHBG062785.
InParanoidiP28827.
KOiK05693.
OrthoDBiEOG70KGNP.
PhylomeDBiP28827.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P28827-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ     50
VNTLTKPTSD PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH 100
YFVSSKSNSP PGLLNVYVKV NNGPLGNPIW NISGDPTRTW NRAELAISTF 150
WPNFYQVIFE VITSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ 200
FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT 250
TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE 350
ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW 400
EPFGYNVTRC HSYNLTVHYC YQVGGQEQVR EEVSWDTENS HPQHTITNLS 450
PYTNVSVKLI LMNPEGRKES QELIVQTDED LPGAVPTESI QGSTFEEKIF 500
LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF 550
FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 600
DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ 650
NASLLNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI 700
YFQAASRANG ETKIDCVQVA TKGAATPKPV PEPEKQTDHT VKIAGVIAGI 750
LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT 800
NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS 850
DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN 950
SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL 1000
VEVGRVKCCK YWPDDTEIYK DIKVTLIETE LLAEYVIRTF AVEKRGVHEI 1050
REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPSAGP LVVHCSAGAG 1100
RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA 1150
ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS 1250
YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP 1300
ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNAARPQDGY RMVQQFQFLG 1350
WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC 1400
AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN 1450
SG 1452
Length:1,452
Mass (Da):163,682
Last modified:September 23, 2008 - v2
Checksum:i8319E3D3A583E992
GO
Isoform 2 (identifier: P28827-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     842-842: P → PDPFVPTAILVPIN

Show »
Length:1,465
Mass (Da):165,060
Checksum:iB3D74735CB11E9F6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391S → R.
Corresponds to variant rs35224276 [ dbSNP | Ensembl ].
VAR_046634

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei842 – 8421P → PDPFVPTAILVPIN in isoform 2.
VSP_046677

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31G → T in CAA41226. 1 Publication
Sequence conflicti68 – 681F → L in CAA41226. 1 Publication
Sequence conflicti1300 – 13001P → L in AAI51843. 1 Publication
Sequence conflicti1384 – 13841R → P in CAA41226. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58288 mRNA. Translation: CAA41226.1.
AC006566 Genomic DNA. No translation available.
AP000897 Genomic DNA. No translation available.
AP001091 Genomic DNA. No translation available.
AP001094 Genomic DNA. No translation available.
AP005118 Genomic DNA. No translation available.
AP005227 Genomic DNA. No translation available.
AP005900 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01623.1.
CH471113 Genomic DNA. Translation: EAX01624.1.
BC151842 mRNA. Translation: AAI51843.1.
CCDSiCCDS11840.1. [P28827-1]
CCDS58613.1. [P28827-2]
PIRiS17669.
RefSeqiNP_001098714.1. NM_001105244.1. [P28827-2]
NP_002836.3. NM_002845.3. [P28827-1]
UniGeneiHs.49774.

Genome annotation databases

EnsembliENST00000332175; ENSP00000331418; ENSG00000173482. [P28827-1]
ENST00000580170; ENSP00000463325; ENSG00000173482. [P28827-2]
GeneIDi5797.
KEGGihsa:5797.
UCSCiuc002knn.4. human. [P28827-1]

Polymorphism databases

DMDMi206729890.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58288 mRNA. Translation: CAA41226.1 .
AC006566 Genomic DNA. No translation available.
AP000897 Genomic DNA. No translation available.
AP001091 Genomic DNA. No translation available.
AP001094 Genomic DNA. No translation available.
AP005118 Genomic DNA. No translation available.
AP005227 Genomic DNA. No translation available.
AP005900 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01623.1 .
CH471113 Genomic DNA. Translation: EAX01624.1 .
BC151842 mRNA. Translation: AAI51843.1 .
CCDSi CCDS11840.1. [P28827-1 ]
CCDS58613.1. [P28827-2 ]
PIRi S17669.
RefSeqi NP_001098714.1. NM_001105244.1. [P28827-2 ]
NP_002836.3. NM_002845.3. [P28827-1 ]
UniGenei Hs.49774.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RPM X-ray 2.30 A/B 879-1156 [» ]
2C9A X-ray 2.70 A 21-279 [» ]
2V5Y X-ray 3.10 A 21-742 [» ]
ProteinModelPortali P28827.
SMRi P28827. Positions 21-588, 877-1451.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111761. 2 interactions.
DIPi DIP-668N.
IntActi P28827. 5 interactions.
MINTi MINT-128128.
STRINGi 9606.ENSP00000331418.

Chemistry

BindingDBi P28827.
ChEMBLi CHEMBL4661.

PTM databases

PhosphoSitei P28827.

Polymorphism databases

DMDMi 206729890.

Proteomic databases

MaxQBi P28827.
PaxDbi P28827.
PRIDEi P28827.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000332175 ; ENSP00000331418 ; ENSG00000173482 . [P28827-1 ]
ENST00000580170 ; ENSP00000463325 ; ENSG00000173482 . [P28827-2 ]
GeneIDi 5797.
KEGGi hsa:5797.
UCSCi uc002knn.4. human. [P28827-1 ]

Organism-specific databases

CTDi 5797.
GeneCardsi GC18P007557.
H-InvDB HIX0027374.
HGNCi HGNC:9675. PTPRM.
HPAi CAB022442.
CAB022443.
MIMi 176888. gene.
neXtProti NX_P28827.
PharmGKBi PA34020.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
HOVERGENi HBG062785.
InParanoidi P28827.
KOi K05693.
OrthoDBi EOG70KGNP.
PhylomeDBi P28827.
TreeFami TF312900.

Miscellaneous databases

ChiTaRSi PTPRM. human.
EvolutionaryTracei P28827.
GeneWikii PTPRM.
GenomeRNAii 5797.
NextBioi 22574.
PROi P28827.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28827.
Bgeei P28827.
CleanExi HS_PTPRM.
Genevestigatori P28827.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase."
    Gebbink M.F.B.G., van Etten I., Hateboer G., Suijkerbuijk R., Beijersbergen R., Geurts van Kessel A., Moolenaar W.H.
    FEBS Lett. 290:123-130(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131.
    Tissue: Plasma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu."
    Hoffmann K.M., Tonks N.K., Barford D.
    J. Biol. Chem. 272:27505-27508(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 879-1156.
  8. "Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion."
    Aricescu A.R., Hon W.-C., Siebold C., Lu W., van der Merwe P.A., Jones E.Y.
    EMBO J. 25:701-712(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-279, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiPTPRM_HUMAN
AccessioniPrimary (citable) accession number: P28827
Secondary accession number(s): A7MBN1, D3DUH8, J3QL11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 158 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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