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Protein

Receptor-type tyrosine-protein phosphatase mu

Gene

PTPRM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1063SubstrateBy similarity1
Active sitei1095Phosphocysteine intermediateBy similarity1
Binding sitei1139SubstrateBy similarity1
Active sitei1389Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • cadherin binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
  • negative regulation of angiogenesis Source: UniProtKB
  • negative regulation of endothelial cell migration Source: UniProtKB
  • negative regulation of endothelial cell proliferation Source: UniProtKB
  • neuron projection development Source: UniProtKB
  • positive regulation of vasodilation Source: Ensembl
  • protein dephosphorylation Source: UniProtKB
  • response to drug Source: UniProtKB
  • retina layer formation Source: UniProtKB
  • retinal ganglion cell axon guidance Source: UniProtKB
  • signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:HS16218-MONOMER.
BRENDAi3.1.3.48. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase mu
Short name:
R-PTP-mu
Gene namesi
Name:PTPRM
Synonyms:PTPRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:9675. PTPRM.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 742ExtracellularSequence analysisAdd BLAST722
Transmembranei743 – 764HelicalSequence analysisAdd BLAST22
Topological domaini765 – 1452CytoplasmicSequence analysisAdd BLAST688

GO - Cellular componenti

  • cell-cell adherens junction Source: UniProtKB
  • cell-cell junction Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • lamellipodium Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5797.
OpenTargetsiENSG00000173482.
PharmGKBiPA34020.

Chemistry databases

ChEMBLiCHEMBL4661.
GuidetoPHARMACOLOGYi1860.

Polymorphism and mutation databases

BioMutaiPTPRM.
DMDMi206729890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002544821 – 1452Receptor-type tyrosine-protein phosphatase muAdd BLAST1432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 36PROSITE-ProRule annotation1 Publication
Glycosylationi72N-linked (GlcNAc...)Sequence analysis1
Glycosylationi92N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 182PROSITE-ProRule annotation1 Publication
Glycosylationi131N-linked (GlcNAc...)1 Publication1
Disulfide bondi206 ↔ 260PROSITE-ProRule annotation1 Publication
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi414N-linked (GlcNAc...)Sequence analysis1
Glycosylationi454N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Glycosylationi544N-linked (GlcNAc...)Sequence analysis1
Glycosylationi598N-linked (GlcNAc...)Sequence analysis1
Glycosylationi651N-linked (GlcNAc...)Sequence analysis1
Glycosylationi681N-linked (GlcNAc...)Sequence analysis1
Modified residuei821PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP28827.
MaxQBiP28827.
PaxDbiP28827.
PeptideAtlasiP28827.
PRIDEiP28827.

PTM databases

DEPODiP28827.
iPTMnetiP28827.
PhosphoSitePlusiP28827.

Expressioni

Gene expression databases

BgeeiENSG00000173482.
CleanExiHS_PTPRM.
ExpressionAtlasiP28827. baseline and differential.
GenevisibleiP28827. HS.

Organism-specific databases

HPAiCAB022442.
CAB022443.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-2257317,EBI-2257317
Cdh1P098033EBI-2257317,EBI-984420From a different organism.

GO - Molecular functioni

  • cadherin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111761. 2 interactors.
DIPiDIP-668N.
IntActiP28827. 5 interactors.
MINTiMINT-128128.
STRINGi9606.ENSP00000331418.

Chemistry databases

BindingDBiP28827.

Structurei

Secondary structure

11452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3
Helixi33 – 36Combined sources4
Beta strandi42 – 45Combined sources4
Beta strandi49 – 52Combined sources4
Turni53 – 55Combined sources3
Beta strandi66 – 72Combined sources7
Beta strandi81 – 85Combined sources5
Beta strandi96 – 104Combined sources9
Beta strandi106 – 109Combined sources4
Beta strandi111 – 120Combined sources10
Beta strandi129 – 132Combined sources4
Beta strandi140 – 147Combined sources8
Beta strandi155 – 163Combined sources9
Beta strandi169 – 180Combined sources12
Beta strandi183 – 185Combined sources3
Beta strandi194 – 196Combined sources3
Beta strandi198 – 200Combined sources3
Beta strandi202 – 210Combined sources9
Beta strandi217 – 222Combined sources6
Beta strandi230 – 237Combined sources8
Beta strandi240 – 247Combined sources8
Helixi252 – 254Combined sources3
Beta strandi256 – 264Combined sources9
Beta strandi267 – 278Combined sources12
Beta strandi284 – 286Combined sources3
Beta strandi289 – 293Combined sources5
Beta strandi298 – 301Combined sources4
Beta strandi305 – 309Combined sources5
Beta strandi315 – 326Combined sources12
Beta strandi328 – 332Combined sources5
Beta strandi335 – 340Combined sources6
Beta strandi348 – 356Combined sources9
Beta strandi370 – 373Combined sources4
Beta strandi384 – 391Combined sources8
Beta strandi396 – 401Combined sources6
Helixi405 – 408Combined sources4
Beta strandi410 – 412Combined sources3
Beta strandi414 – 434Combined sources21
Beta strandi443 – 446Combined sources4
Beta strandi454 – 462Combined sources9
Beta strandi467 – 469Combined sources3
Beta strandi473 – 476Combined sources4
Turni487 – 489Combined sources3
Beta strandi491 – 495Combined sources5
Beta strandi498 – 502Combined sources5
Beta strandi515 – 525Combined sources11
Beta strandi536 – 542Combined sources7
Beta strandi547 – 550Combined sources4
Beta strandi557 – 567Combined sources11
Beta strandi570 – 580Combined sources11
Turni882 – 884Combined sources3
Helixi885 – 905Combined sources21
Turni916 – 919Combined sources4
Helixi921 – 926Combined sources6
Helixi936 – 938Combined sources3
Beta strandi939 – 941Combined sources3
Turni949 – 952Combined sources4
Beta strandi953 – 961Combined sources9
Beta strandi964 – 971Combined sources8
Helixi976 – 978Combined sources3
Helixi979 – 988Combined sources10
Beta strandi993 – 996Combined sources4
Beta strandi1000 – 1002Combined sources3
Beta strandi1014 – 1019Combined sources6
Beta strandi1022 – 1032Combined sources11
Beta strandi1035 – 1044Combined sources10
Beta strandi1051 – 1058Combined sources8
Beta strandi1063 – 1065Combined sources3
Helixi1071 – 1083Combined sources13
Beta strandi1091 – 1099Combined sources9
Helixi1100 – 1118Combined sources19
Beta strandi1119 – 1121Combined sources3
Helixi1123 – 1133Combined sources11
Helixi1141 – 1155Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RPMX-ray2.30A/B879-1156[»]
2C9AX-ray2.70A21-279[»]
2V5YX-ray3.10A21-742[»]
ProteinModelPortaliP28827.
SMRiP28827.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28827.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 184MAMPROSITE-ProRule annotationAdd BLAST163
Domaini186 – 277Ig-like C2-typeAdd BLAST92
Domaini284 – 379Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini382 – 480Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST99
Domaini482 – 587Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST106
Domaini589 – 671Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST83
Domaini900 – 1154Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1186 – 1448Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1095 – 1101Substrate bindingBy similarity7

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiP28827.
KOiK05693.
OMAiNWEQVNT.
OrthoDBiEOG091G00CK.
PhylomeDBiP28827.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P28827-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ
60 70 80 90 100
VNTLTKPTSD PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH
110 120 130 140 150
YFVSSKSNSP PGLLNVYVKV NNGPLGNPIW NISGDPTRTW NRAELAISTF
160 170 180 190 200
WPNFYQVIFE VITSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ
210 220 230 240 250
FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT
260 270 280 290 300
TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI
310 320 330 340 350
QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE
360 370 380 390 400
ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW
410 420 430 440 450
EPFGYNVTRC HSYNLTVHYC YQVGGQEQVR EEVSWDTENS HPQHTITNLS
460 470 480 490 500
PYTNVSVKLI LMNPEGRKES QELIVQTDED LPGAVPTESI QGSTFEEKIF
510 520 530 540 550
LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF
560 570 580 590 600
FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT
610 620 630 640 650
DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ
660 670 680 690 700
NASLLNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI
710 720 730 740 750
YFQAASRANG ETKIDCVQVA TKGAATPKPV PEPEKQTDHT VKIAGVIAGI
760 770 780 790 800
LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT
810 820 830 840 850
NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS
860 870 880 890 900
DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF
910 920 930 940 950
KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN
960 970 980 990 1000
SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL
1010 1020 1030 1040 1050
VEVGRVKCCK YWPDDTEIYK DIKVTLIETE LLAEYVIRTF AVEKRGVHEI
1060 1070 1080 1090 1100
REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPSAGP LVVHCSAGAG
1110 1120 1130 1140 1150
RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA
1160 1170 1180 1190 1200
ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL
1210 1220 1230 1240 1250
RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS
1260 1270 1280 1290 1300
YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP
1310 1320 1330 1340 1350
ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNAARPQDGY RMVQQFQFLG
1360 1370 1380 1390 1400
WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC
1410 1420 1430 1440 1450
AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN

SG
Length:1,452
Mass (Da):163,682
Last modified:September 23, 2008 - v2
Checksum:i8319E3D3A583E992
GO
Isoform 2 (identifier: P28827-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     842-842: P → PDPFVPTAILVPIN

Show »
Length:1,465
Mass (Da):165,060
Checksum:iB3D74735CB11E9F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3G → T in CAA41226 (PubMed:1655529).Curated1
Sequence conflicti68F → L in CAA41226 (PubMed:1655529).Curated1
Sequence conflicti1300P → L in AAI51843 (PubMed:15489334).Curated1
Sequence conflicti1384R → P in CAA41226 (PubMed:1655529).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04663439S → R.Corresponds to variant rs35224276dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046677842P → PDPFVPTAILVPIN in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58288 mRNA. Translation: CAA41226.1.
AC006566 Genomic DNA. No translation available.
AP000897 Genomic DNA. No translation available.
AP001091 Genomic DNA. No translation available.
AP001094 Genomic DNA. No translation available.
AP005118 Genomic DNA. No translation available.
AP005227 Genomic DNA. No translation available.
AP005900 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01623.1.
CH471113 Genomic DNA. Translation: EAX01624.1.
BC151842 mRNA. Translation: AAI51843.1.
CCDSiCCDS11840.1. [P28827-1]
CCDS58613.1. [P28827-2]
PIRiS17669.
RefSeqiNP_001098714.1. NM_001105244.1. [P28827-2]
NP_002836.3. NM_002845.3. [P28827-1]
UniGeneiHs.49774.

Genome annotation databases

EnsembliENST00000332175; ENSP00000331418; ENSG00000173482. [P28827-1]
ENST00000580170; ENSP00000463325; ENSG00000173482. [P28827-2]
GeneIDi5797.
KEGGihsa:5797.
UCSCiuc002knn.5. human. [P28827-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58288 mRNA. Translation: CAA41226.1.
AC006566 Genomic DNA. No translation available.
AP000897 Genomic DNA. No translation available.
AP001091 Genomic DNA. No translation available.
AP001094 Genomic DNA. No translation available.
AP005118 Genomic DNA. No translation available.
AP005227 Genomic DNA. No translation available.
AP005900 Genomic DNA. No translation available.
CH471113 Genomic DNA. Translation: EAX01623.1.
CH471113 Genomic DNA. Translation: EAX01624.1.
BC151842 mRNA. Translation: AAI51843.1.
CCDSiCCDS11840.1. [P28827-1]
CCDS58613.1. [P28827-2]
PIRiS17669.
RefSeqiNP_001098714.1. NM_001105244.1. [P28827-2]
NP_002836.3. NM_002845.3. [P28827-1]
UniGeneiHs.49774.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RPMX-ray2.30A/B879-1156[»]
2C9AX-ray2.70A21-279[»]
2V5YX-ray3.10A21-742[»]
ProteinModelPortaliP28827.
SMRiP28827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111761. 2 interactors.
DIPiDIP-668N.
IntActiP28827. 5 interactors.
MINTiMINT-128128.
STRINGi9606.ENSP00000331418.

Chemistry databases

BindingDBiP28827.
ChEMBLiCHEMBL4661.
GuidetoPHARMACOLOGYi1860.

PTM databases

DEPODiP28827.
iPTMnetiP28827.
PhosphoSitePlusiP28827.

Polymorphism and mutation databases

BioMutaiPTPRM.
DMDMi206729890.

Proteomic databases

EPDiP28827.
MaxQBiP28827.
PaxDbiP28827.
PeptideAtlasiP28827.
PRIDEiP28827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332175; ENSP00000331418; ENSG00000173482. [P28827-1]
ENST00000580170; ENSP00000463325; ENSG00000173482. [P28827-2]
GeneIDi5797.
KEGGihsa:5797.
UCSCiuc002knn.5. human. [P28827-1]

Organism-specific databases

CTDi5797.
DisGeNETi5797.
GeneCardsiPTPRM.
H-InvDBHIX0027374.
HGNCiHGNC:9675. PTPRM.
HPAiCAB022442.
CAB022443.
MIMi176888. gene.
neXtProtiNX_P28827.
OpenTargetsiENSG00000173482.
PharmGKBiPA34020.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiP28827.
KOiK05693.
OMAiNWEQVNT.
OrthoDBiEOG091G00CK.
PhylomeDBiP28827.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS16218-MONOMER.
BRENDAi3.1.3.48. 2681.

Miscellaneous databases

ChiTaRSiPTPRM. human.
EvolutionaryTraceiP28827.
GeneWikiiPTPRM.
GenomeRNAii5797.
PROiP28827.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173482.
CleanExiHS_PTPRM.
ExpressionAtlasiP28827. baseline and differential.
GenevisibleiP28827. HS.

Family and domain databases

CDDicd00063. FN3. 3 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00047. ig. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRM_HUMAN
AccessioniPrimary (citable) accession number: P28827
Secondary accession number(s): A7MBN1, D3DUH8, J3QL11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 181 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.