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P28827

- PTPRM_HUMAN

UniProt

P28827 - PTPRM_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase mu

Gene

PTPRM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 159 (01 Oct 2014)
      Sequence version 2 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1063 – 10631SubstrateBy similarity
    Active sitei1095 – 10951Phosphocysteine intermediateBy similarity
    Binding sitei1139 – 11391SubstrateBy similarity
    Active sitei1389 – 13891Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. cadherin binding Source: UniProtKB
    2. identical protein binding Source: IntAct
    3. protein binding Source: UniProtKB
    4. protein tyrosine phosphatase activity Source: UniProtKB
    5. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. homophilic cell adhesion Source: UniProtKB
    2. negative regulation of angiogenesis Source: UniProtKB
    3. negative regulation of endothelial cell migration Source: UniProtKB
    4. negative regulation of endothelial cell proliferation Source: UniProtKB
    5. neuron projection development Source: UniProtKB
    6. peptidyl-tyrosine dephosphorylation Source: GOC
    7. positive regulation of vasodilation Source: Ensembl
    8. protein dephosphorylation Source: UniProtKB
    9. response to drug Source: UniProtKB
    10. retina layer formation Source: UniProtKB
    11. retinal ganglion cell axon guidance Source: UniProtKB
    12. signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase mu (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase mu
    Short name:
    R-PTP-mu
    Gene namesi
    Name:PTPRM
    Synonyms:PTPRL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:9675. PTPRM.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell adherens junction Source: UniProtKB
    2. cell-cell junction Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. integral component of plasma membrane Source: UniProtKB
    5. lamellipodium Source: MGI
    6. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34020.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 14521432Receptor-type tyrosine-protein phosphatase muPRO_0000025448Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 361 PublicationPROSITE-ProRule annotation
    Glycosylationi72 – 721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 1821 PublicationPROSITE-ProRule annotation
    Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
    Disulfide bondi206 ↔ 2601 PublicationPROSITE-ProRule annotation
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi544 – 5441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi598 – 5981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi651 – 6511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi681 – 6811N-linked (GlcNAc...)Sequence Analysis
    Modified residuei821 – 8211Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP28827.
    PaxDbiP28827.
    PRIDEiP28827.

    PTM databases

    PhosphoSiteiP28827.

    Expressioni

    Gene expression databases

    ArrayExpressiP28827.
    BgeeiP28827.
    CleanExiHS_PTPRM.
    GenevestigatoriP28827.

    Organism-specific databases

    HPAiCAB022442.
    CAB022443.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-2257317,EBI-2257317
    Cdh1P098033EBI-2257317,EBI-984420From a different organism.

    Protein-protein interaction databases

    BioGridi111761. 2 interactions.
    DIPiDIP-668N.
    IntActiP28827. 5 interactions.
    MINTiMINT-128128.
    STRINGi9606.ENSP00000331418.

    Structurei

    Secondary structure

    1
    1452
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi29 – 313
    Helixi33 – 364
    Beta strandi42 – 454
    Beta strandi49 – 524
    Turni53 – 553
    Beta strandi66 – 727
    Beta strandi81 – 855
    Beta strandi96 – 1049
    Beta strandi106 – 1094
    Beta strandi111 – 12010
    Beta strandi129 – 1324
    Beta strandi140 – 1478
    Beta strandi155 – 1639
    Beta strandi169 – 18012
    Beta strandi183 – 1853
    Beta strandi194 – 1963
    Beta strandi198 – 2003
    Beta strandi202 – 2109
    Beta strandi217 – 2226
    Beta strandi230 – 2378
    Beta strandi240 – 2478
    Helixi252 – 2543
    Beta strandi256 – 2649
    Beta strandi267 – 27812
    Beta strandi284 – 2863
    Beta strandi289 – 2935
    Beta strandi298 – 3014
    Beta strandi305 – 3095
    Beta strandi315 – 32612
    Beta strandi328 – 3325
    Beta strandi335 – 3406
    Beta strandi348 – 3569
    Beta strandi370 – 3734
    Beta strandi384 – 3918
    Beta strandi396 – 4016
    Helixi405 – 4084
    Beta strandi410 – 4123
    Beta strandi414 – 43421
    Beta strandi443 – 4464
    Beta strandi454 – 4629
    Beta strandi467 – 4693
    Beta strandi473 – 4764
    Turni487 – 4893
    Beta strandi491 – 4955
    Beta strandi498 – 5025
    Beta strandi515 – 52511
    Beta strandi536 – 5427
    Beta strandi547 – 5504
    Beta strandi557 – 56711
    Beta strandi570 – 58011
    Turni882 – 8843
    Helixi885 – 90521
    Turni916 – 9194
    Helixi921 – 9266
    Helixi936 – 9383
    Beta strandi939 – 9413
    Turni949 – 9524
    Beta strandi953 – 9619
    Beta strandi964 – 9718
    Helixi976 – 9783
    Helixi979 – 98810
    Beta strandi993 – 9964
    Beta strandi1000 – 10023
    Beta strandi1014 – 10196
    Beta strandi1022 – 103211
    Beta strandi1035 – 104410
    Beta strandi1051 – 10588
    Beta strandi1063 – 10653
    Helixi1071 – 108313
    Beta strandi1091 – 10999
    Helixi1100 – 111819
    Beta strandi1119 – 11213
    Helixi1123 – 113311
    Helixi1141 – 115515

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RPMX-ray2.30A/B879-1156[»]
    2C9AX-ray2.70A21-279[»]
    2V5YX-ray3.10A21-742[»]
    ProteinModelPortaliP28827.
    SMRiP28827. Positions 21-588, 877-1451.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP28827.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 742722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini765 – 1452688CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei743 – 76422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 184163MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 27792Ig-like C2-typeAdd
    BLAST
    Domaini284 – 37996Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini382 – 48099Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 587106Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini589 – 67183Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 1154255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1186 – 1448263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1095 – 11017Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOVERGENiHBG062785.
    InParanoidiP28827.
    KOiK05693.
    OrthoDBiEOG70KGNP.
    PhylomeDBiP28827.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00047. ig. 1 hit.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P28827-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRGLGTCLAT LAGLLLTAAG ETFSGGCLFD EPYSTCGYSQ SEGDDFNWEQ     50
    VNTLTKPTSD PWMPSGSFML VNASGRPEGQ RAHLLLPQLK ENDTHCIDFH 100
    YFVSSKSNSP PGLLNVYVKV NNGPLGNPIW NISGDPTRTW NRAELAISTF 150
    WPNFYQVIFE VITSGHQGYL AIDEVKVLGH PCTRTPHFLR IQNVEVNAGQ 200
    FATFQCSAIG RTVAGDRLWL QGIDVRDAPL KEIKVTSSRR FIASFNVVNT 250
    TKRDAGKYRC MIRTEGGVGI SNYAELVVKE PPVPIAPPQL ASVGATYLWI 300
    QLNANSINGD GPIVAREVEY CTASGSWNDR QPVDSTSYKI GHLDPDTEYE 350
    ISVLLTRPGE GGTGSPGPAL RTRTKCADPM RGPRKLEVVE VKSRQITIRW 400
    EPFGYNVTRC HSYNLTVHYC YQVGGQEQVR EEVSWDTENS HPQHTITNLS 450
    PYTNVSVKLI LMNPEGRKES QELIVQTDED LPGAVPTESI QGSTFEEKIF 500
    LQWREPTQTY GVITLYEITY KAVSSFDPEI DLSNQSGRVS KLGNETHFLF 550
    FGLYPGTTYS FTIRASTAKG FGPPATNQFT TKISAPSMPA YELETPLNQT 600
    DNTVTVMLKP AHSRGAPVSV YQIVVEEERP RRTKKTTEIL KCYPVPIHFQ 650
    NASLLNSQYY FAAEFPADSL QAAQPFTIGD NKTYNGYWNT PLLPYKSYRI 700
    YFQAASRANG ETKIDCVQVA TKGAATPKPV PEPEKQTDHT VKIAGVIAGI 750
    LLFVIIFLGV VLVMKKRKLA KKRKETMSST RQEMTVMVNS MDKSYAEQGT 800
    NCDEAFSFMD THNLNGRSVS SPSSFTMKTN TLSTSVPNSY YPDETHTMAS 850
    DTSSLVQSHT YKKREPADVP YQTGQLHPAI RVADLLQHIT QMKCAEGYGF 900
    KEEYESFFEG QSAPWDSAKK DENRMKNRYG NIIAYDHSRV RLQTIEGDTN 950
    SDYINGNYID GYHRPNHYIA TQGPMQETIY DFWRMVWHEN TASIIMVTNL 1000
    VEVGRVKCCK YWPDDTEIYK DIKVTLIETE LLAEYVIRTF AVEKRGVHEI 1050
    REIRQFHFTG WPDHGVPYHA TGLLGFVRQV KSKSPPSAGP LVVHCSAGAG 1100
    RTGCFIVIDI MLDMAEREGV VDIYNCVREL RSRRVNMVQT EEQYVFIHDA 1150
    ILEACLCGDT SVPASQVRSL YYDMNKLDPQ TNSSQIKEEF RTLNMVTPTL 1200
    RVEDCSIALL PRNHEKNRCM DILPPDRCLP FLITIDGESS NYINAALMDS 1250
    YKQPSAFIVT QHPLPNTVKD FWRLVLDYHC TSVVMLNDVD PAQLCPQYWP 1300
    ENGVHRHGPI QVEFVSADLE EDIISRIFRI YNAARPQDGY RMVQQFQFLG 1350
    WPMYRDTPVS KRSFLKLIRQ VDKWQEEYNG GEGRTVVHCL NGGGRSGTFC 1400
    AISIVCEMLR HQRTVDVFHA VKTLRNNKPN MVDLLDQYKF CYEVALEYLN 1450
    SG 1452
    Length:1,452
    Mass (Da):163,682
    Last modified:September 23, 2008 - v2
    Checksum:i8319E3D3A583E992
    GO
    Isoform 2 (identifier: P28827-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         842-842: P → PDPFVPTAILVPIN

    Show »
    Length:1,465
    Mass (Da):165,060
    Checksum:iB3D74735CB11E9F6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31G → T in CAA41226. (PubMed:1655529)Curated
    Sequence conflicti68 – 681F → L in CAA41226. (PubMed:1655529)Curated
    Sequence conflicti1300 – 13001P → L in AAI51843. (PubMed:15489334)Curated
    Sequence conflicti1384 – 13841R → P in CAA41226. (PubMed:1655529)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti39 – 391S → R.
    Corresponds to variant rs35224276 [ dbSNP | Ensembl ].
    VAR_046634

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei842 – 8421P → PDPFVPTAILVPIN in isoform 2. 1 PublicationVSP_046677

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58288 mRNA. Translation: CAA41226.1.
    AC006566 Genomic DNA. No translation available.
    AP000897 Genomic DNA. No translation available.
    AP001091 Genomic DNA. No translation available.
    AP001094 Genomic DNA. No translation available.
    AP005118 Genomic DNA. No translation available.
    AP005227 Genomic DNA. No translation available.
    AP005900 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01623.1.
    CH471113 Genomic DNA. Translation: EAX01624.1.
    BC151842 mRNA. Translation: AAI51843.1.
    CCDSiCCDS11840.1. [P28827-1]
    CCDS58613.1. [P28827-2]
    PIRiS17669.
    RefSeqiNP_001098714.1. NM_001105244.1. [P28827-2]
    NP_002836.3. NM_002845.3. [P28827-1]
    UniGeneiHs.49774.

    Genome annotation databases

    EnsembliENST00000332175; ENSP00000331418; ENSG00000173482. [P28827-1]
    ENST00000580170; ENSP00000463325; ENSG00000173482. [P28827-2]
    GeneIDi5797.
    KEGGihsa:5797.
    UCSCiuc002knn.4. human. [P28827-1]

    Polymorphism databases

    DMDMi206729890.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58288 mRNA. Translation: CAA41226.1 .
    AC006566 Genomic DNA. No translation available.
    AP000897 Genomic DNA. No translation available.
    AP001091 Genomic DNA. No translation available.
    AP001094 Genomic DNA. No translation available.
    AP005118 Genomic DNA. No translation available.
    AP005227 Genomic DNA. No translation available.
    AP005900 Genomic DNA. No translation available.
    CH471113 Genomic DNA. Translation: EAX01623.1 .
    CH471113 Genomic DNA. Translation: EAX01624.1 .
    BC151842 mRNA. Translation: AAI51843.1 .
    CCDSi CCDS11840.1. [P28827-1 ]
    CCDS58613.1. [P28827-2 ]
    PIRi S17669.
    RefSeqi NP_001098714.1. NM_001105244.1. [P28827-2 ]
    NP_002836.3. NM_002845.3. [P28827-1 ]
    UniGenei Hs.49774.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RPM X-ray 2.30 A/B 879-1156 [» ]
    2C9A X-ray 2.70 A 21-279 [» ]
    2V5Y X-ray 3.10 A 21-742 [» ]
    ProteinModelPortali P28827.
    SMRi P28827. Positions 21-588, 877-1451.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111761. 2 interactions.
    DIPi DIP-668N.
    IntActi P28827. 5 interactions.
    MINTi MINT-128128.
    STRINGi 9606.ENSP00000331418.

    Chemistry

    BindingDBi P28827.
    ChEMBLi CHEMBL4661.

    PTM databases

    PhosphoSitei P28827.

    Polymorphism databases

    DMDMi 206729890.

    Proteomic databases

    MaxQBi P28827.
    PaxDbi P28827.
    PRIDEi P28827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000332175 ; ENSP00000331418 ; ENSG00000173482 . [P28827-1 ]
    ENST00000580170 ; ENSP00000463325 ; ENSG00000173482 . [P28827-2 ]
    GeneIDi 5797.
    KEGGi hsa:5797.
    UCSCi uc002knn.4. human. [P28827-1 ]

    Organism-specific databases

    CTDi 5797.
    GeneCardsi GC18P007557.
    H-InvDB HIX0027374.
    HGNCi HGNC:9675. PTPRM.
    HPAi CAB022442.
    CAB022443.
    MIMi 176888. gene.
    neXtProti NX_P28827.
    PharmGKBi PA34020.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOVERGENi HBG062785.
    InParanoidi P28827.
    KOi K05693.
    OrthoDBi EOG70KGNP.
    PhylomeDBi P28827.
    TreeFami TF312900.

    Miscellaneous databases

    ChiTaRSi PTPRM. human.
    EvolutionaryTracei P28827.
    GeneWikii PTPRM.
    GenomeRNAii 5797.
    NextBioi 22574.
    PROi P28827.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28827.
    Bgeei P28827.
    CleanExi HS_PTPRM.
    Genevestigatori P28827.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00047. ig. 1 hit.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 4 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase."
      Gebbink M.F.B.G., van Etten I., Hateboer G., Suijkerbuijk R., Beijersbergen R., Geurts van Kessel A., Moolenaar W.H.
      FEBS Lett. 290:123-130(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131.
      Tissue: Plasma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "The crystal structure of domain 1 of receptor protein-tyrosine phosphatase mu."
      Hoffmann K.M., Tonks N.K., Barford D.
      J. Biol. Chem. 272:27505-27508(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 879-1156.
    8. "Molecular analysis of receptor protein tyrosine phosphatase mu-mediated cell adhesion."
      Aricescu A.R., Hon W.-C., Siebold C., Lu W., van der Merwe P.A., Jones E.Y.
      EMBO J. 25:701-712(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-279, FUNCTION, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPTPRM_HUMAN
    AccessioniPrimary (citable) accession number: P28827
    Secondary accession number(s): A7MBN1, D3DUH8, J3QL11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 159 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3