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Protein

Dihydropteroate synthase

Gene

sul

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.By similarity

Catalytic activityi

6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.By similarity

Cofactori

Mg2+By similarity

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Dihydropteroate synthase (sul)
  2. Dihydrofolate synthase/folylpolyglutamate synthase (folC)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi32MagnesiumBy similarity1
Binding sitei726-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1066-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1256-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei1896-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1
Binding sitei2256-hydroxymethyl-7,8-dihydropterin diphosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFolate biosynthesis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00770-MONOMER
UniPathwayiUPA00077; UER00156

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase (EC:2.5.1.15)
Short name:
DHPS
Alternative name(s):
Dihydropteroate pyrophosphorylase
Gene namesi
Name:sul
Ordered Locus Names:BSU00770
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001682051 – 285Dihydropteroate synthaseAdd BLAST285

Proteomic databases

PaxDbiP28822
PRIDEiP28822

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100000390

Structurei

3D structure databases

ProteinModelPortaliP28822
SMRiP28822
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 271Pterin-bindingPROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni259 – 2616-hydroxymethyl-7,8-dihydropterin diphosphate bindingBy similarity3

Sequence similaritiesi

Belongs to the DHPS family.Curated

Phylogenomic databases

eggNOGiENOG4105EEI Bacteria
COG0294 LUCA
HOGENOMiHOG000217509
InParanoidiP28822
KOiK00796
OMAiWAVRVHD
PhylomeDBiP28822

Family and domain databases

CDDicd00739 DHPS, 1 hit
Gene3Di3.20.20.20, 1 hit
InterProiView protein in InterPro
IPR006390 DHP_synth
IPR011005 Dihydropteroate_synth-like
IPR000489 Pterin-binding_dom
PfamiView protein in Pfam
PF00809 Pterin_bind, 1 hit
SUPFAMiSSF51717 SSF51717, 1 hit
TIGRFAMsiTIGR01496 DHPS, 1 hit
PROSITEiView protein in PROSITE
PS00792 DHPS_1, 1 hit
PS00793 DHPS_2, 1 hit
PS50972 PTERIN_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

P28822-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQHTIDQTQ VIHTKPSALS YKEKTLVMGI LNVTPDSFSD GGKYDSLDKA
60 70 80 90 100
LLHAKEMIDD GAHIIDIGGE STRPGAECVS EDEEMSRVIP VIERITKELG
110 120 130 140 150
VPISVDTYKA SVADEAVKAG ASIINDIWGA KHDPKMASVA AEHNVPIVLM
160 170 180 190 200
HNRPERNYND LLPDMLSDLM ESVKIAVEAG VDEKNIILDP GIGFAKTYHD
210 220 230 240 250
NLAVMNKLEI FSGLGYPVLL ATSRKRFIGR VLDLPPEERA EGTGATVCLG
260 270 280
IQKGCDIVRV HDVKQIARMA KMMDAMLNKG GVHHG
Length:285
Mass (Da):31,002
Last modified:August 4, 2003 - v2
Checksum:iF2878DEC3D9000D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti195A → P in AAA22697 (PubMed:2123867).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34053 Genomic DNA Translation: AAA22697.1
D26185 Genomic DNA Translation: BAA05312.1
AL009126 Genomic DNA Translation: CAB11853.1
PIRiG69719
RefSeqiNP_387958.1, NC_000964.3
WP_003242672.1, NZ_JNCM01000028.1

Genome annotation databases

EnsemblBacteriaiCAB11853; CAB11853; BSU00770
GeneIDi936256
KEGGibsu:BSU00770
PATRICifig|224308.179.peg.77

Similar proteinsi

Entry informationi

Entry nameiDHPS_BACSU
AccessioniPrimary (citable) accession number: P28822
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: August 4, 2003
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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