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P28820 (PABB_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Para-aminobenzoate synthase component 1
EC=2.6.1.85
Alternative name(s):
ADC synthase
Para-aminobenzoate synthase component I
Gene names
Name:pabB
Synonyms:pab
Ordered Locus Names:BSU00740
OrganismBacillus subtilis
Taxonomic identifier1423 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine.

Catalytic activity

Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.

Subunit structure

Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity.

Sequence similarities

Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
   Biological processFolate biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processfolic acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular function4-amino-4-deoxychorismate synthase activity

Inferred from electronic annotation. Source: EC

oxo-acid-lyase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 470470Para-aminobenzoate synthase component 1
PRO_0000154135

Sequences

Sequence LengthMass (Da)Tools
P28820 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: CA7544C30689383E

FASTA47053,251
        10         20         30         40         50         60 
MAQRRPAGKK IPFQKDSFLQ QFEKLAQSRK HHVLLESARG GRYSIAGLDP IATVKGKDGI 

        70         80         90        100        110        120 
TTIKHGDEML FKEGDPLRAF HSWFKTLETE TNHEFPDFQG GAIGFLSYDY ARYIENFKML 

       130        140        150        160        170        180 
SLDDLETPDI YFLVFDDIAV YDHQEESLWL ITHVNGSDQE TADVKLSELE QMWLTELPAV 

       190        200        210        220        230        240 
TSREMKPETA GSFAAPFTED GFSQAVEKIK QYIASGDVFQ VNLSIRQSQS LSVHPYQIYK 

       250        260        270        280        290        300 
TLREVNPSPY MAYLETPDFQ IICGSPELLV SKKGKLLETR PIAGTRSRGK TNEEDEALAN 

       310        320        330        340        350        360 
ELIHNEKERA EHVMLVDLER NDLGRVSRYG SVRVNEFMAI EKYSHVMHIV SNVQGELQDG 

       370        380        390        400        410        420 
YDAVDIIHAV FPGGTITGAP KVRTMEIIEE LEPTRRGLYT GSIGWFGYNH DLQFNIVIRT 

       430        440        450        460        470 
IYATGGQAFM QSGAGVVIDS VPKHEYKESF KKAFAMQRAL ELSEEETKIR

« Hide

References

« Hide 'large scale' references
[1]"An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene."
Slock J., Stahly D.P., Han C.-Y., Six E.W., Crawford I.P.
J. Bacteriol. 172:7211-7226(1990) [PubMed: 2123867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ASB342.
[2]"Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin."
Ogasawara N., Nakai S., Yoshikawa H.
DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed: 9384377] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M34053 Genomic DNA. Translation: AAA22694.1.
D26185 Genomic DNA. Translation: BAA05309.1.
AL009126 Genomic DNA. Translation: CAB11850.1.
PIRA37854.
RefSeqNP_387955.1. NC_000964.3.

3D structure databases

ProteinModelPortalP28820.
SMRP28820. Positions 10-462.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000001781; EBBACP00000001781; EBBACG00000001778.
GeneID936926.
GenomeReviewsGene locus BSU00740 in contig AL009126_GR.
KEGGbsu:BSU00740.
NMPDRfig|224308.1.peg.74.
PATRIC18971623. VBIBacSub10457_0075.

Organism-specific databases

GenoListBSU00740. [Micado]

Phylogenomic databases

GeneTreeEBGT00050000001425.
HOGENOMHBG507440.
OMAHEYKESF.
PhylomeDBP28820.
ProtClustDBCLSK2752294.

Enzyme and pathway databases

BioCycBSUB:BSU00740-MONOMER.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR019999. Anth_synth_I.
IPR006805. Anth_synth_I_N.
IPR015890. Chorismate-bd_C.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KOK01665.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
SUPFAMSSF56322. TRPE_1_chor_bd. 1 hit.
ProtoNetSearch...

Entry information

Entry namePABB_BACSU
AccessionPrimary (citable) accession number: P28820
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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