P28820 (PABB_BACSU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 90.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Para-aminobenzoate synthase component 1 EC=2.6.1.85 Alternative name(s): ADC synthase Para-aminobenzoate synthase component I | ||||||
| Gene names |
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| Organism | Bacillus subtilis | ||||||
| Taxonomic identifier | 1423 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 470 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. |
| Catalytic activity | Chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate. |
| Pathway | Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2. |
| Subunit structure | Consists of two non-identical chains: component I catalyzes the formation of ADC by binding chorismate and ammonia; component II provides the glutamine amidotransferase activity. |
| Sequence similarities | Belongs to the anthranilate synthase component I family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Folate biosynthesis |
| Molecular function | Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | folic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 4-amino-4-deoxychorismate synthase activity Inferred from electronic annotation. Source: EC oxo-acid-lyase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 470 | 470 | Para-aminobenzoate synthase component 1 | PRO_0000154135 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene." Slock J., Stahly D.P., Han C.-Y., Six E.W., Crawford I.P. J. Bacteriol. 172:7211-7226(1990) [PubMed: 2123867] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ASB342. |
| [2] | "Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin." Ogasawara N., Nakai S., Yoshikawa H. DNA Res. 1:1-14(1994) [PubMed: 7584024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168. |
| [3] | "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A.Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M34053 Genomic DNA. Translation: AAA22694.1. D26185 Genomic DNA. Translation: BAA05309.1. AL009126 Genomic DNA. Translation: CAB11850.1. |
| PIR | A37854. |
| RefSeq | NP_387955.1. NC_000964.3. |
3D structure databases | |
| ProteinModelPortal | P28820. |
| SMR | P28820. Positions 10-462. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000001781; EBBACP00000001781; EBBACG00000001778. |
| GeneID | 936926. |
| GenomeReviews | Gene locus BSU00740 in contig AL009126_GR. |
| KEGG | bsu:BSU00740. |
| NMPDR | fig|224308.1.peg.74. |
| PATRIC | 18971623. VBIBacSub10457_0075. |
Organism-specific databases | |
| GenoList | BSU00740. [Micado] |
Phylogenomic databases | |
| GeneTree | EBGT00050000001425. |
| HOGENOM | HBG507440. |
| OMA | HEYKESF. |
| PhylomeDB | P28820. |
| ProtClustDB | CLSK2752294. |
Enzyme and pathway databases | |
| BioCyc | BSUB:BSU00740-MONOMER. |
Family and domain databases | |
| InterPro | IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR015890. Chorismate-bd_C. [Graphical view] |
| Gene3D | G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit. |
| KO | K01665. |
| Pfam | PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view] |
| PRINTS | PR00095. ANTSNTHASEI. |
| SUPFAM | SSF56322. TRPE_1_chor_bd. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PABB_BACSU | ||||||||
| Accession | Primary (citable) accession number: P28820 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Bacillus subtilis Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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