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Protein

MmsAB operon regulatory protein

Gene

mmsR

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulatory protein for the mmsAB operon. Activates the transcription of the mmsAB genes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi217 – 23620H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MmsAB operon regulatory proteinCurated
Gene namesi
Name:mmsR1 Publication
Ordered Locus Names:PA3571
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3571.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307MmsAB operon regulatory proteinPRO_0000194539Add
BLAST

Proteomic databases

PaxDbiP28809.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA3571.

Structurei

3D structure databases

ProteinModelPortaliP28809.
SMRiP28809. Positions 205-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HTH araC/xylS-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41063TF. Bacteria.
ENOG4111G16. LUCA.
HOGENOMiHOG000225868.
InParanoidiP28809.
OMAiPYEYLIR.
OrthoDBiEOG61VZ4B.
PhylomeDBiP28809.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYIAEPATD MSHTSDWPLP ADSLRLPIPA ALLEKLAVHP LSRDLYPTSL
60 70 80 90 100
GHYRRARDHR MSRERHDEHL LIYCSEGQGL LRVREGEAWR EYRVGSGDLL
110 120 130 140 150
WLPPGMAHDY AADDRQPWTI FWTHLRGDSA TWLQHSAGYR DTPLRHWGLQ
160 170 180 190 200
HALLGGFEQL LEVRHSGYRF QHFLLAASRL RSLLCQLPLL RPLREGSLDL
210 220 230 240 250
DGLHAYMREH LHARLELERL AAFCNLSKFH FVSRYKAITG RTPIQHFLHL
260 270 280 290 300
KIEYACQLLD SSDQSVARVG QAVGYDDSYY FSRLFSKVMG LSPSAYRQRV

RQGEGGA
Length:307
Mass (Da):35,379
Last modified:December 8, 2000 - v2
Checksum:i9BF7AEE348FAFD45
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti129 – 1291S → T in AAA25890 (PubMed:1339433).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84911 Genomic DNA. Translation: AAA25890.1.
AE004091 Genomic DNA. Translation: AAG06959.1.
PIRiA42902.
F83198.
RefSeqiNP_252261.1. NC_002516.2.
WP_003122160.1. NZ_ASJY01000583.1.

Genome annotation databases

EnsemblBacteriaiAAG06959; AAG06959; PA3571.
GeneIDi878815.
KEGGipae:PA3571.
PATRICi19841759. VBIPseAer58763_3737.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84911 Genomic DNA. Translation: AAA25890.1.
AE004091 Genomic DNA. Translation: AAG06959.1.
PIRiA42902.
F83198.
RefSeqiNP_252261.1. NC_002516.2.
WP_003122160.1. NZ_ASJY01000583.1.

3D structure databases

ProteinModelPortaliP28809.
SMRiP28809. Positions 205-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3571.

Proteomic databases

PaxDbiP28809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06959; AAG06959; PA3571.
GeneIDi878815.
KEGGipae:PA3571.
PATRICi19841759. VBIPseAer58763_3737.

Organism-specific databases

PseudoCAPiPA3571.

Phylogenomic databases

eggNOGiENOG41063TF. Bacteria.
ENOG4111G16. LUCA.
HOGENOMiHOG000225868.
InParanoidiP28809.
OMAiPYEYLIR.
OrthoDBiEOG61VZ4B.
PhylomeDBiP28809.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
2.60.120.280. 1 hit.
InterProiIPR003313. AraC-bd.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
IPR018062. HTH_AraC-typ_CS.
IPR020449. Tscrpt_reg_HTH_AraC-type.
[Graphical view]
PfamiPF02311. AraC_binding. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
PRINTSiPR00032. HTHARAC.
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF51215. SSF51215. 1 hit.
PROSITEiPS00041. HTH_ARAC_FAMILY_1. 1 hit.
PS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyisobutyrate dehydrogenase."
    Steele M.I., Lorenz D., Hatter K., Park A., Sokatch J.R.
    J. Biol. Chem. 267:13585-13592(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiMMSR_PSEAE
AccessioniPrimary (citable) accession number: P28809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 8, 2000
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.