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P28801

- GSTP1_BOVIN

UniProt

P28801 - GSTP1_BOVIN

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Protein
Glutathione S-transferase P
Gene
GSTP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 81Glutathione By similarity
Binding sitei14 – 141Glutathione By similarity
Binding sitei39 – 391Glutathione By similarity
Binding sitei45 – 451Glutathione By similarity

GO - Molecular functioni

  1. S-nitrosoglutathione binding Source: Ensembl
  2. dinitrosyl-iron complex binding Source: Ensembl
  3. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutathione metabolic process Source: Ensembl
  2. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  3. negative regulation of JUN kinase activity Source: Ensembl
  4. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  5. negative regulation of interleukin-1 beta production Source: Ensembl
  6. negative regulation of monocyte chemotactic protein-1 production Source: Ensembl
  7. negative regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  8. negative regulation of tumor necrosis factor production Source: Ensembl
  9. xenobiotic metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiREACT_204534. Detoxification of Reactive Oxygen Species.
REACT_223659. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase P (EC:2.5.1.18)
Alternative name(s):
GST class-pi
Gene namesi
Name:GSTP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 29

Subcellular locationi

Cytoplasm By similarity. Mitochondrion By similarity. Nucleus By similarity
Note: The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization By similarity.

GO - Cellular componenti

  1. TRAF2-GSTP1 complex Source: Ensembl
  2. mitochondrion Source: UniProtKB-SubCell
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 210209Glutathione S-transferase P
PRO_0000185896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Phosphotyrosine; by EGFR By similarity
Modified residuei103 – 1031N6-succinyllysine By similarity
Modified residuei116 – 1161N6-succinyllysine By similarity
Modified residuei128 – 1281N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP28801.
PRIDEiP28801.

Interactioni

Subunit structurei

Homodimer. Interacts with CDK5 By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP28801.
SMRiP28801. Positions 1-210.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 8180GST N-terminal
Add
BLAST
Domaini83 – 204122GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni52 – 532Glutathione binding By similarity
Regioni65 – 662Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Pi family.

Phylogenomic databases

eggNOGiNOG05174.
GeneTreeiENSGT00550000074559.
HOGENOMiHOG000115733.
HOVERGENiHBG108324.
InParanoidiP28801.
KOiK00799.
OMAiMNRPING.
OrthoDBiEOG7KH9M3.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01268. GSTRNSFRASEP.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28801-1 [UniParc]FASTAAdd to Basket

« Hide

MPPYTIVYFP VQGRCEAMRM LLADQGQSWK EEVVAMQSWL QGPLKASCLY    50
GQLPKFQDGD LTLYQSNAIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL 100
RCKYVSLIYT NYEAGKEDYV KALPQHLKPF ETLLSQNKGG QAFIVGDQIS 150
FADYNLLDLL RIHQVLAPSC LDSFPLLSAY VARLNSRPKL KAFLASPEHM 200
NRPINGNGKQ 210
Length:210
Mass (Da):23,613
Last modified:January 23, 2007 - v2
Checksum:i79C45DA2031B1EBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61233 mRNA. Translation: CAA43551.1.
BC102704 mRNA. Translation: AAI02705.1.
PIRiA49180.
RefSeqiNP_803482.1. NM_177516.1.
UniGeneiBt.13949.

Genome annotation databases

EnsembliENSBTAT00000004615; ENSBTAP00000004615; ENSBTAG00000003548.
GeneIDi281806.
KEGGibta:281806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61233 mRNA. Translation: CAA43551.1 .
BC102704 mRNA. Translation: AAI02705.1 .
PIRi A49180.
RefSeqi NP_803482.1. NM_177516.1.
UniGenei Bt.13949.

3D structure databases

ProteinModelPortali P28801.
SMRi P28801. Positions 1-210.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P28801.
PRIDEi P28801.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000004615 ; ENSBTAP00000004615 ; ENSBTAG00000003548 .
GeneIDi 281806.
KEGGi bta:281806.

Organism-specific databases

CTDi 2950.

Phylogenomic databases

eggNOGi NOG05174.
GeneTreei ENSGT00550000074559.
HOGENOMi HOG000115733.
HOVERGENi HBG108324.
InParanoidi P28801.
KOi K00799.
OMAi MNRPING.
OrthoDBi EOG7KH9M3.
TreeFami TF105321.

Enzyme and pathway databases

Reactomei REACT_204534. Detoxification of Reactive Oxygen Species.
REACT_223659. Glutathione conjugation.

Miscellaneous databases

NextBioi 20805719.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR003082. GST_pi.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01268. GSTRNSFRASEP.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA encoding a glutathione S-transferase (GST) class-pi from the bovine ocular ciliary epithelium."
    Hernando N., Martin-Alonso J.M., Ghosh S., Coca-Prados M.
    Exp. Eye Res. 55:711-718(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ocular ciliary epithelium.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  3. "Glutathione transferase from bovine placenta. Preparation, biochemical characterization, crystallization, and preliminary crystallographic analysis of a neutral class PI enzyme."
    Schaeffer J., Gallay O., Ladenstein R.
    J. Biol. Chem. 263:17405-17411(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-16, SUBUNIT.
    Tissue: Placenta.
  4. "Bovine erythrocyte glutathione S-transferase: purification, inhibition, and complex formation."
    Xu F., Hultquist D.E.
    Biochem. Int. 27:265-274(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 3-23.
    Tissue: Erythrocyte.

Entry informationi

Entry nameiGSTP1_BOVIN
AccessioniPrimary (citable) accession number: P28801
Secondary accession number(s): Q3SZU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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