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Protein

Alpha-2-antiplasmin

Gene

SERPINF2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei404 – 405Reactive bond for plasmin2
Sitei405 – 406Reactive bond for chymotrypsin2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Acute phase

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-75205. Dissolution of Fibrin Clot.

Protein family/group databases

MEROPSiI04.023.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-antiplasmin
Short name:
Alpha-2-AP
Alternative name(s):
Alpha-2-plasmin inhibitor
Short name:
Alpha-2-PI
Serpin F2
Gene namesi
Name:SERPINF2
Synonyms:PLI
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PropeptideiPRO_000043066723 – 401 PublicationAdd BLAST18
ChainiPRO_000003251041 – 492Alpha-2-antiplasminAdd BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 1441 Publication
Glycosylationi127N-linked (GlcNAc...)1 Publication1
Glycosylationi249N-linked (GlcNAc...)1 Publication1
Glycosylationi296N-linked (GlcNAc...)1 Publication1
Glycosylationi310N-linked (GlcNAc...)1 Publication1
Glycosylationi317N-linked (GlcNAc...)1 Publication1
Modified residuei485SulfotyrosineBy similarity1

Post-translational modificationi

Proteolytically cleaved at Pro-31 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei40 – 41Cleavage; by prolyl endopeptidase FAP, antiplasmin-cleaving enzyme FAP soluble formBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiP28800.
PeptideAtlasiP28800.
PRIDEiP28800.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSBTAG00000020859.

Interactioni

Subunit structurei

Forms protease inhibiting heterodimer with TMPRSS7.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027793.

Structurei

3D structure databases

ProteinModelPortaliP28800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00850000132312.
HOGENOMiHOG000231761.
HOVERGENiHBG000043.
InParanoidiP28800.
KOiK03983.
OMAiWRSKFDP.
OrthoDBiEOG091G066U.
TreeFamiTF317350.

Family and domain databases

CDDicd02053. alpha2AP. 1 hit.
InterProiIPR033833. Alpha2AP.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLWGLLAL ILSCLSSLCS AQFSPVSTME PLDLQLMDGQ AQQKLPPLSL
60 70 80 90 100
LKLDNQEPGG QIAPKKAPED CKLSPTPEQT RRLARAMMTF TTDLFSLVAQ
110 120 130 140 150
SSTRPNLILS PLSVALALSH LALGAQNQTL QRLKEVLHAD SGPCLPHLLS
160 170 180 190 200
RLCQDLGPGA FRLAARMYLQ KGFPIKEDFL EQSEQLFGAK PMSLTGMKGE
210 220 230 240 250
DLANINRWVK EATEGKIEDF LSDLPDDTVL LLLNAIHFQG FWRSKFDPNL
260 270 280 290 300
TQRGAFHLDE QFTVPVDMMQ ALTYPLHWFL LEQPEIQVAH FPFKNNMSFV
310 320 330 340 350
VLMPTRFEWN ASQVLANLTW DILHQPSLSE RPTKVQLPKL HLKYQLDLVA
360 370 380 390 400
TLSQLGLQEL FQAPDLRGIS DERLVVSSVQ HQSALELSEA GVQAAAATST
410 420 430 440 450
AMSRMSLSSF IVNRPFLFFI LEDSTSLPLF VGSVRNPNPG AQPERKEQQD
460 470 480 490
SPDGKDSFQD HKGLPRGDKP FDPDLKLGPP SEEDYAQPSS PK
Length:492
Mass (Da):54,711
Last modified:November 1, 1995 - v2
Checksum:i0755D6FC89B2DF5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28T → Q AA sequence (PubMed:1385210).Curated1
Sequence conflicti40Q → P AA sequence (PubMed:1385210).Curated1
Sequence conflicti43Q → E AA sequence (PubMed:1385210).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78436 mRNA. Translation: CAA55200.1.
PIRiS43977.
RefSeqiNP_777095.1. NM_174670.2.
UniGeneiBt.9352.

Genome annotation databases

EnsembliENSBTAT00000027793; ENSBTAP00000027793; ENSBTAG00000020859.
GeneIDi282522.
KEGGibta:282522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78436 mRNA. Translation: CAA55200.1.
PIRiS43977.
RefSeqiNP_777095.1. NM_174670.2.
UniGeneiBt.9352.

3D structure databases

ProteinModelPortaliP28800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027793.

Protein family/group databases

MEROPSiI04.023.

Proteomic databases

PaxDbiP28800.
PeptideAtlasiP28800.
PRIDEiP28800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000027793; ENSBTAP00000027793; ENSBTAG00000020859.
GeneIDi282522.
KEGGibta:282522.

Organism-specific databases

CTDi5345.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00850000132312.
HOGENOMiHOG000231761.
HOVERGENiHBG000043.
InParanoidiP28800.
KOiK03983.
OMAiWRSKFDP.
OrthoDBiEOG091G066U.
TreeFamiTF317350.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-75205. Dissolution of Fibrin Clot.

Gene expression databases

BgeeiENSBTAG00000020859.

Family and domain databases

CDDicd02053. alpha2AP. 1 hit.
InterProiIPR033833. Alpha2AP.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2AP_BOVIN
AccessioniPrimary (citable) accession number: P28800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.