ID   GRN_MOUSE               Reviewed;         589 AA.
AC   P28798;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 2.
DT   03-NOV-2009, entry version 76.
DE   RecName: Full=Granulins;
DE   AltName: Full=Proepithelin;
DE            Short=PEPI;
DE   AltName: Full=PC cell-derived growth factor;
DE            Short=PCDGF;
DE   Contains:
DE     RecName: Full=Acrogranin;
DE   Contains:
DE     RecName: Full=Granulin-1;
DE   Contains:
DE     RecName: Full=Granulin-2;
DE   Contains:
DE     RecName: Full=Granulin-3;
DE   Contains:
DE     RecName: Full=Granulin-4;
DE   Contains:
DE     RecName: Full=Granulin-5;
DE   Contains:
DE     RecName: Full=Granulin-6;
DE   Contains:
DE     RecName: Full=Granulin-7;
DE   Flags: Precursor;
GN   Name=Grn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=93245991; PubMed=8482392; DOI=10.1016/0014-5793(93)81544-A;
RA   Baba T., Nemoto H., Watanabe K., Arai Y., Gerton G.L.;
RT   "Exon/intron organization of the gene encoding the mouse
RT   epithelin/granulin precursor (acrogranin).";
RL   FEBS Lett. 322:89-94(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Kidney;
RX   MEDLINE=92317004; PubMed=1618805;
RA   Plowman G.D., Green J.M., Neubauer M.G., Buckley S.D., McDonald V.L.,
RA   Todaro G.J., Shoyab M.;
RT   "The epithelin precursor encodes two proteins with opposing activities
RT   on epithelial cell growth.";
RL   J. Biol. Chem. 267:13073-13078(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=93228994; PubMed=8471244; DOI=10.1002/mrd.1080340302;
RA   Baba T., Hoff H.B. III, Nemoto H., Lee H., Orth J., Arai Y.,
RA   Gerton G.L.;
RT   "Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor
RT   of the growth-modulating peptides, granulins, and epithelins, and is
RT   expressed in somatic as well as male germ cells.";
RL   Mol. Reprod. Dev. 34:233-243(1993).
RN   [4]
RP   PROTEIN SEQUENCE OF 18-32; 116-127; 152-164; 198-226; 228-233;
RP   259-280; 297-304 AND 421-430, FUNCTION, GLYCOSYLATION, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=8496151;
RA   Zhou J., Gao G., Crabb J.W., Serrero G.;
RT   "Purification of an autocrine growth factor homologous with mouse
RT   epithelin precursor from a highly tumorigenic cell line.";
RL   J. Biol. Chem. 268:10863-10869(1993).
CC   -!- FUNCTION: Granulins have possible cytokine-like activity. They may
CC       play a role in inflammation, wound repair, and tissue remodeling.
CC       Acts as an autocrine growth factor for PC cells.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- PTM: Granulins are disulfide bridged.
CC   -!- PTM: N-glycosylated.
CC   -!- SIMILARITY: Belongs to the granulin family.
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DR   EMBL; D16195; BAA03736.1; -; Genomic_DNA.
DR   EMBL; M86736; AAA37191.1; -; mRNA.
DR   EMBL; X62321; CAA44197.1; -; mRNA.
DR   IPI; IPI00124640; -.
DR   PIR; C38128; C38128.
DR   UniGene; Mm.1568; -.
DR   HSSP; P28799; 1G26.
DR   IntAct; P28798; 1.
DR   STRING; P28798; -.
DR   PRIDE; P28798; -.
DR   Ensembl; ENSMUST00000049460; ENSMUSP00000046340; ENSMUSG00000034708; Mus musculus.
DR   UCSC; uc007lrv.1; mouse.
DR   MGI; MGI:95832; Grn.
DR   HOVERGEN; P28798; -.
DR   NextBio; 287027; -.
DR   ArrayExpress; P28798; -.
DR   Bgee; P28798; -.
DR   CleanEx; MM_GRN; -.
DR   Genevestigator; P28798; -.
DR   GermOnline; ENSMUSG00000034708; Mus musculus.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005739; C:mitochondrion; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0001835; P:blastocyst hatching; IDA:MGI.
DR   GO; GO:0007566; P:embryo implantation; IDA:MGI.
DR   GO; GO:0050679; P:positive regulation of epithelial cell prol...; IDA:MGI.
DR   InterPro; IPR000118; Granulin.
DR   Pfam; PF00396; Granulin; 7.
DR   SMART; SM00277; GRAN; 7.
DR   PROSITE; PS00799; GRANULINS; 7.
PE   1: Evidence at protein level;
KW   Cytokine; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Repeat; Secreted; Signal.
FT   SIGNAL        1     17
FT   CHAIN        18    589       Acrogranin.
FT                                /FTId=PRO_0000012702.
FT   PEPTIDE     ?58   ?113       Granulin-1.
FT                                /FTId=PRO_0000012703.
FT   PEPTIDE    ?122   ?178       Granulin-2.
FT                                /FTId=PRO_0000012704.
FT   PEPTIDE     205    260       Granulin-3.
FT                                /FTId=PRO_0000012705.
FT   PEPTIDE     280    334       Granulin-4.
FT                                /FTId=PRO_0000012706.
FT   PEPTIDE     362   ?414       Granulin-5.
FT                                /FTId=PRO_0000012707.
FT   PEPTIDE     440   ?493       Granulin-6.
FT                                /FTId=PRO_0000012708.
FT   PEPTIDE    ?517   ?568       Granulin-7.
FT                                /FTId=PRO_0000012709.
FT   CARBOHYD     38     38       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    263    263       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    373    373       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    526    526       N-linked (GlcNAc...) (Potential).
FT   CONFLICT    251    251       V -> L (in Ref. 3; AAA37191).
FT   CONFLICT    254    254       L -> V (in Ref. 3; AAA37191).
FT   CONFLICT    261    263       SKN -> YD (in Ref. 4; AA sequence).
FT   CONFLICT    350    350       L -> R (in Ref. 2; CAA44197).
FT   CONFLICT    402    403       CP -> SA (in Ref. 3; AAA37191).
SQ   SEQUENCE   589 AA;  63458 MW;  1DE8229C413CB787 CRC64;
     MWVLMSWLAF AAGLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP RITSHHLDGS
     CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP QGFHCSADGK SCFQMSDNPL
     GAVQCPGSQF ECPDSATCCI MVDGSWGCCP MPQASCCEDR VHCCPHGASC DLVHTRCVSP
     TGTHTLLKKF PAQKTNRAVS LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS
     DHLHCCPQDT VCDLIQSKCL SKNYTTDLLT KLPGYPVKEV KCDMEVSCPE GYTCCRLNTG
     AWGCCPFAKA VCCEDHIHCC PAGFQCHTEK GTCEMGILQV PWMKKVIAPL RLPDPQILKS
     DTPCDDFTRC PTNNTCCKLN SGDWGCCPIP EAVCCSDNQH CCPQGFTCLA QGYCQKGDTM
     VAGLEKIPAR QTTPLQIGDI GCDQHTSCPV GQTCCPSLKG SWACCQLPHA VCCEDRQHCC
     PAGYTCNVKA RTCEKDVDFI QPPVLLTLGP KVGNVECGEG HFCHDNQTCC KDSAGVWACC
     PYLKGVCCRD GRHCCPGGFH CSARGTKCLR KKIPRWDMFL RDPVPRPLL
//