Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P28798

- GRN_MOUSE

UniProt

P28798 - GRN_MOUSE

Protein

Granulins

Gene

Grn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (01 Oct 1994)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Acts as an autocrine growth factor for PC cells.1 Publication

    GO - Biological processi

    1. blastocyst hatching Source: MGI
    2. embryo implantation Source: MGI
    3. positive regulation of epithelial cell proliferation Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Granulins
    Alternative name(s):
    PC cell-derived growth factor
    Short name:
    PCDGF
    Proepithelin
    Short name:
    PEPI
    Cleaved into the following 8 chains:
    Gene namesi
    Name:Grn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:95832. Grn.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 17171 PublicationAdd
    BLAST
    Chaini18 – 589572AcrograninPRO_0000012702Add
    BLAST
    Peptidei?58 – ?11356Granulin-1PRO_0000012703Add
    BLAST
    Peptidei?122 – ?17857Granulin-2PRO_0000012704Add
    BLAST
    Peptidei205 – 26056Granulin-3PRO_0000012705Add
    BLAST
    Peptidei280 – 33455Granulin-4PRO_0000012706Add
    BLAST
    Peptidei362 – ?41453Granulin-5PRO_0000012707Add
    BLAST
    Peptidei440 – ?49354Granulin-6PRO_0000012708Add
    BLAST
    Peptidei?517 – ?56852Granulin-7PRO_0000012709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi125 ↔ 138By similarity
    Disulfide bondi132 ↔ 148By similarity
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi295 ↔ 312By similarity
    Disulfide bondi305 ↔ 319By similarity
    Disulfide bondi313 ↔ 326By similarity
    Disulfide bondi320 ↔ 333By similarity
    Disulfide bondi364 ↔ 376By similarity
    Disulfide bondi370 ↔ 386By similarity
    Glycosylationi373 – 3731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi395 ↔ 408By similarity
    Disulfide bondi402 ↔ 414By similarity
    Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Granulins are disulfide bridged.
    N-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28798.
    PRIDEiP28798.

    PTM databases

    PhosphoSiteiP28798.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiP28798.
    BgeeiP28798.
    CleanExiMM_GRN.
    GenevestigatoriP28798.

    Interactioni

    Subunit structurei

    Acrogranin/Progranulin is secreted as a homodimer.By similarity

    Protein-protein interaction databases

    IntActiP28798. 7 interactions.
    MINTiMINT-4096910.

    Structurei

    3D structure databases

    ProteinModelPortaliP28798.
    SMRiP28798. Positions 122-153, 209-262, 279-334, 363-416, 439-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the granulin family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG270518.
    HOVERGENiHBG000845.
    InParanoidiP28798.

    Family and domain databases

    InterProiIPR000118. Granulin.
    [Graphical view]
    PfamiPF00396. Granulin. 7 hits.
    [Graphical view]
    SMARTiSM00277. GRAN. 7 hits.
    [Graphical view]
    PROSITEiPS00799. GRANULINS. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28798-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWVLMSWLAF AAGLVAGTQC PDGQFCPVAC CLDQGGANYS CCNPLLDTWP    50
    RITSHHLDGS CQTHGHCPAG YSCLLTVSGT SSCCPFSKGV SCGDGYHCCP 100
    QGFHCSADGK SCFQMSDNPL GAVQCPGSQF ECPDSATCCI MVDGSWGCCP 150
    MPQASCCEDR VHCCPHGASC DLVHTRCVSP TGTHTLLKKF PAQKTNRAVS 200
    LPFSVVCPDA KTQCPDDSTC CELPTGKYGC CPMPNAICCS DHLHCCPQDT 250
    VCDLIQSKCL SKNYTTDLLT KLPGYPVKEV KCDMEVSCPE GYTCCRLNTG 300
    AWGCCPFAKA VCCEDHIHCC PAGFQCHTEK GTCEMGILQV PWMKKVIAPL 350
    RLPDPQILKS DTPCDDFTRC PTNNTCCKLN SGDWGCCPIP EAVCCSDNQH 400
    CCPQGFTCLA QGYCQKGDTM VAGLEKIPAR QTTPLQIGDI GCDQHTSCPV 450
    GQTCCPSLKG SWACCQLPHA VCCEDRQHCC PAGYTCNVKA RTCEKDVDFI 500
    QPPVLLTLGP KVGNVECGEG HFCHDNQTCC KDSAGVWACC PYLKGVCCRD 550
    GRHCCPGGFH CSARGTKCLR KKIPRWDMFL RDPVPRPLL 589
    Length:589
    Mass (Da):63,458
    Last modified:October 1, 1994 - v2
    Checksum:i1DE8229C413CB787
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti251 – 2511V → L in AAA37191. (PubMed:8471244)Curated
    Sequence conflicti254 – 2541L → V in AAA37191. (PubMed:8471244)Curated
    Sequence conflicti261 – 2633SKN → YD AA sequence (PubMed:8496151)Curated
    Sequence conflicti350 – 3501L → R in CAA44197. (PubMed:1618805)Curated
    Sequence conflicti402 – 4032CP → SA in AAA37191. (PubMed:8471244)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16195 Genomic DNA. Translation: BAA03736.1.
    M86736 mRNA. Translation: AAA37191.1.
    X62321 mRNA. Translation: CAA44197.1.
    PIRiC38128.
    UniGeneiMm.1568.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16195 Genomic DNA. Translation: BAA03736.1 .
    M86736 mRNA. Translation: AAA37191.1 .
    X62321 mRNA. Translation: CAA44197.1 .
    PIRi C38128.
    UniGenei Mm.1568.

    3D structure databases

    ProteinModelPortali P28798.
    SMRi P28798. Positions 122-153, 209-262, 279-334, 363-416, 439-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P28798. 7 interactions.
    MINTi MINT-4096910.

    PTM databases

    PhosphoSitei P28798.

    Proteomic databases

    PaxDbi P28798.
    PRIDEi P28798.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95832. Grn.

    Phylogenomic databases

    eggNOGi NOG270518.
    HOVERGENi HBG000845.
    InParanoidi P28798.

    Miscellaneous databases

    ChiTaRSi GRN. mouse.
    PROi P28798.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28798.
    Bgeei P28798.
    CleanExi MM_GRN.
    Genevestigatori P28798.

    Family and domain databases

    InterProi IPR000118. Granulin.
    [Graphical view ]
    Pfami PF00396. Granulin. 7 hits.
    [Graphical view ]
    SMARTi SM00277. GRAN. 7 hits.
    [Graphical view ]
    PROSITEi PS00799. GRANULINS. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin)."
      Baba T., Nemoto H., Watanabe K., Arai Y., Gerton G.L.
      FEBS Lett. 322:89-94(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth."
      Plowman G.D., Green J.M., Neubauer M.G., Buckley S.D., McDonald V.L., Todaro G.J., Shoyab M.
      J. Biol. Chem. 267:13073-13078(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Kidney.
    3. "Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells."
      Baba T., Hoff H.B. III, Nemoto H., Lee H., Orth J., Arai Y., Gerton G.L.
      Mol. Reprod. Dev. 34:233-243(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line."
      Zhou J., Gao G., Crabb J.W., Serrero G.
      J. Biol. Chem. 268:10863-10869(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-32; 116-127; 152-164; 198-226; 228-233; 259-280; 297-304 AND 421-430, FUNCTION, GLYCOSYLATION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGRN_MOUSE
    AccessioniPrimary (citable) accession number: P28798
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: October 1, 1994
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3