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Protein

Tryptophanase

Gene

tnaA

Organism
Proteus vulgaris
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-tryptophan + H2O = indole + pyruvate + NH3.

Cofactori

Pathwayi: L-tryptophan degradation via pyruvate pathway

This protein is involved in step 1 of the subpathway that synthesizes indole and pyruvate from L-tryptophan.
Proteins known to be involved in this subpathway in this organism are:
  1. Tryptophanase (tnaA), Tryptophanase (tnaA), Tryptophanase (tnaA), Tryptophanase (tnaA)
This subpathway is part of the pathway L-tryptophan degradation via pyruvate pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes indole and pyruvate from L-tryptophan, the pathway L-tryptophan degradation via pyruvate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Tryptophan catabolism

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

SABIO-RKP28796.
UniPathwayiUPA00332; UER00452.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophanase (EC:4.1.99.1)
Alternative name(s):
L-tryptophan indole-lyase
Short name:
TNase
Gene namesi
Name:tnaA
OrganismiProteus vulgaris
Taxonomic identifieri585 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001956191 – 467TryptophanaseAdd BLAST467

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei266N6-(pyridoxal phosphate)lysine1

Proteomic databases

PRIDEiP28796.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1467
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 16Combined sources9
Helixi22 – 31Combined sources10
Helixi36 – 38Combined sources3
Helixi41 – 43Combined sources3
Beta strandi45 – 47Combined sources3
Beta strandi51 – 53Combined sources3
Helixi59 – 66Combined sources8
Beta strandi72 – 74Combined sources3
Helixi76 – 89Combined sources14
Beta strandi93 – 99Combined sources7
Helixi100 – 117Combined sources18
Beta strandi125 – 130Combined sources6
Helixi133 – 141Combined sources9
Beta strandi145 – 148Combined sources4
Helixi152 – 155Combined sources4
Turni162 – 165Combined sources4
Helixi169 – 179Combined sources11
Helixi181 – 183Combined sources3
Beta strandi184 – 193Combined sources10
Turni194 – 197Combined sources4
Helixi203 – 216Combined sources14
Beta strandi220 – 223Combined sources4
Helixi227 – 237Combined sources11
Helixi239 – 241Combined sources3
Helixi246 – 253Combined sources8
Helixi254 – 256Combined sources3
Beta strandi258 – 263Combined sources6
Beta strandi274 – 280Combined sources7
Helixi282 – 295Combined sources14
Turni299 – 303Combined sources5
Helixi306 – 318Combined sources13
Helixi322 – 341Combined sources20
Beta strandi352 – 359Combined sources8
Turni360 – 362Combined sources3
Helixi368 – 370Combined sources3
Helixi372 – 384Combined sources13
Beta strandi389 – 392Combined sources4
Helixi393 – 396Combined sources4
Turni400 – 402Combined sources3
Beta strandi412 – 416Combined sources5
Helixi424 – 435Combined sources12
Helixi438 – 441Combined sources4
Beta strandi447 – 451Combined sources5
Helixi457 – 460Combined sources4
Beta strandi462 – 465Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AX4X-ray2.10A/B/C/D1-467[»]
ProteinModelPortaliP28796.
SMRiP28796.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28796.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-eliminating lyase family.Curated

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00544. Tryptophanase. 1 hit.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR011166. Beta-eliminating_lyase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR013440. TNase.
IPR018176. Tryptophanase_CS.
[Graphical view]
PfamiPF01212. Beta_elim_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF001386. Trpase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00853. BETA_ELIM_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28796-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRIVEPFR IKMVEKIRVP SREEREAALK EAGYNPFLLP SSAVYIDLLT
60 70 80 90 100
DSGTNAMSDH QWAAMITGDE AYAGSRNYYD LKDKAKELFN YDYIIPAHQG
110 120 130 140 150
RGAENILFPV LLKYKQKEGK AKNPVFISNF HFDTTAAHVE LNGCKAINIV
160 170 180 190 200
TEKAFDSETY DDWKGDFDIK KLKENIAQHG ADNIVAIVST VTCNSAGGQP
210 220 230 240 250
VSMSNLKEVY EIAKQHGIFV VMDSARFCEN AYFIKARDPK YKNATIKEVI
260 270 280 290 300
FDMYKYADAL TMSAKKDPLL NIGGLVAIRD NEEIFTLARQ RCVPMEGFVT
310 320 330 340 350
YGGLAGRDMA AMVQGLEEGT EEEYLHYRIG QVKYLGDRLR EAGIPIQYPT
360 370 380 390 400
GGHAVFVDCK KLVPQIPGDQ FPAQAVINAL YLESGVRAVE IGSFLLGRDP
410 420 430 440 450
ATGEQKHADM EFMRLTIARR VYTNDHMDYI ADALIGLKEK FATLKGLEFE
460
YEPPVLRHFT ARLKPIE
Length:467
Mass (Da):52,490
Last modified:December 1, 1992 - v1
Checksum:iBFDE8E18ED20EF37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93277 Genomic DNA. Translation: AAA25664.1.
PIRiB44038.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93277 Genomic DNA. Translation: AAA25664.1.
PIRiB44038.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AX4X-ray2.10A/B/C/D1-467[»]
ProteinModelPortaliP28796.
SMRiP28796.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP28796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00332; UER00452.
SABIO-RKP28796.

Miscellaneous databases

EvolutionaryTraceiP28796.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00544. Tryptophanase. 1 hit.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR011166. Beta-eliminating_lyase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR013440. TNase.
IPR018176. Tryptophanase_CS.
[Graphical view]
PfamiPF01212. Beta_elim_lyase. 1 hit.
[Graphical view]
PIRSFiPIRSF001386. Trpase. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00853. BETA_ELIM_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNAA_PROVU
AccessioniPrimary (citable) accession number: P28796
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.