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P28795

- PEX3_YEAST

UniProt

P28795 - PEX3_YEAST

Protein

Peroxisomal biogenesis factor 3

Gene

PEX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Involved in peroxisome biosynthesis. May function as a receptor protein. Lack of this protein causes the peroxisomal-deficient phenotype and mislocalization in the cytosol of peroxisomal matrix proteins.

    GO - Molecular functioni

    1. protein binding Source: SGD
    2. protein binding, bridging Source: SGD

    GO - Biological processi

    1. ER-dependent peroxisome organization Source: SGD
    2. peroxisome inheritance Source: SGD
    3. protein import into peroxisome membrane Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29885-MONOMER.

    Protein family/group databases

    TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.
    9.A.17.1.1. the integral membrane peroxisomal protein importer-2 (ppi2) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peroxisomal biogenesis factor 3
    Alternative name(s):
    Peroxin-3
    Peroxisomal membrane protein PAS3
    Gene namesi
    Name:PEX3
    Synonyms:PAS3
    Ordered Locus Names:YDR329C
    ORF Names:D9798.15
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR329c.
    SGDiS000002737. PEX3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. integral component of peroxisomal membrane Source: InterPro
    3. peroxisomal membrane Source: SGD
    4. peroxisome Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Peroxisomal biogenesis factor 3PRO_0000208747Add
    BLAST

    Proteomic databases

    MaxQBiP28795.
    PaxDbiP28795.

    Expressioni

    Inductioni

    By oleic acid.

    Gene expression databases

    GenevestigatoriP28795.

    Interactioni

    Protein-protein interaction databases

    BioGridi32386. 59 interactions.
    DIPiDIP-2477N.
    IntActiP28795. 4 interactions.
    MINTiMINT-474353.
    STRINGi4932.YDR329C.

    Structurei

    3D structure databases

    ProteinModelPortaliP28795.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717PeroxisomalSequence AnalysisAdd
    BLAST
    Topological domaini40 – 441402CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peroxin-3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302392.
    HOGENOMiHOG000001061.
    KOiK13336.
    OMAiINEQAFL.
    OrthoDBiEOG7RJQ17.

    Family and domain databases

    InterProiIPR006966. Peroxin-3.
    [Graphical view]
    PfamiPF04882. Peroxin-3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28795-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPNQRSRSL LQRHRGKVLI SLTGIAALFT TGSVVVFFVK RWLYKQQLRI    50
    TEQHFIKEQI KRRFEQTQED SLYTIYELLP VWRMVLNEND LNLDSIVTQL 100
    KDQKNQLTRA KSSESRESSP LKSKAELWNE LELKSLIKLV TVTYTVSSLI 150
    LLTRLQLNIL TRNEYLDSAI KLTMQQENCN KLQNRFYNWV TSWWSDPEDK 200
    ADDAMVMAAK KSKKEGQEVY INEQAFLSLS WWILNKGWLS YNEIITNQIE 250
    IEFDGIHPRD TLTLEEFSSR LTNIFRNTNS QIFQQNNNNL TSILLPKDSS 300
    GQEFLLSQTL DADALTSFHS NTLVFNQLVN ELTQCIESTA TSIVLESLIN 350
    ESFHFIMNKV GIKTIAKKKP GQEDQQQYQM AVFAMSMKDC CQEMLQTTAG 400
    SSHSGSVNEY LATLDSVQPL DDLSASVYSN FGVSSSFSFK P 441
    Length:441
    Mass (Da):50,676
    Last modified:December 1, 1992 - v1
    Checksum:i3CDC1D036DF0D0F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58407 Genomic DNA. Translation: CAA41309.1.
    U32517 Genomic DNA. Translation: AAB64764.1.
    BK006938 Genomic DNA. Translation: DAA12171.1.
    PIRiA40550.
    RefSeqiNP_010616.3. NM_001180637.3.

    Genome annotation databases

    EnsemblFungiiYDR329C; YDR329C; YDR329C.
    GeneIDi851929.
    KEGGisce:YDR329C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58407 Genomic DNA. Translation: CAA41309.1 .
    U32517 Genomic DNA. Translation: AAB64764.1 .
    BK006938 Genomic DNA. Translation: DAA12171.1 .
    PIRi A40550.
    RefSeqi NP_010616.3. NM_001180637.3.

    3D structure databases

    ProteinModelPortali P28795.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32386. 59 interactions.
    DIPi DIP-2477N.
    IntActi P28795. 4 interactions.
    MINTi MINT-474353.
    STRINGi 4932.YDR329C.

    Protein family/group databases

    TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.
    9.A.17.1.1. the integral membrane peroxisomal protein importer-2 (ppi2) family.

    Proteomic databases

    MaxQBi P28795.
    PaxDbi P28795.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR329C ; YDR329C ; YDR329C .
    GeneIDi 851929.
    KEGGi sce:YDR329C.

    Organism-specific databases

    CYGDi YDR329c.
    SGDi S000002737. PEX3.

    Phylogenomic databases

    eggNOGi NOG302392.
    HOGENOMi HOG000001061.
    KOi K13336.
    OMAi INEQAFL.
    OrthoDBi EOG7RJQ17.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29885-MONOMER.

    Miscellaneous databases

    NextBioi 969986.

    Gene expression databases

    Genevestigatori P28795.

    Family and domain databases

    InterProi IPR006966. Peroxin-3.
    [Graphical view ]
    Pfami PF04882. Peroxin-3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis."
      Hoehfeld J., Veenhuis M., Kunau W.-H.
      J. Cell Biol. 114:1167-1178(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPEX3_YEAST
    AccessioniPrimary (citable) accession number: P28795
    Secondary accession number(s): D6VSW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1400 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3