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P28795 (PEX3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal membrane protein PAS3
Gene names
Name:PEX3
Synonyms:PAS3
Ordered Locus Names:YDR329C
ORF Names:D9798.15
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in peroxisome biosynthesis. May function as a receptor protein. Lack of this protein causes the peroxisomal-deficient phenotype and mislocalization in the cytosol of peroxisomal matrix proteins.

Subcellular location

Peroxisome membrane; Single-pass membrane protein.

Induction

By oleic acid.

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the peroxin-3 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Peroxisomal biogenesis factor 3
PRO_0000208747

Regions

Topological domain1 – 1717Peroxisomal Potential
Transmembrane18 – 3922Helical; Potential
Topological domain40 – 441402Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
P28795 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 3CDC1D036DF0D0F9

FASTA44150,676
        10         20         30         40         50         60 
MAPNQRSRSL LQRHRGKVLI SLTGIAALFT TGSVVVFFVK RWLYKQQLRI TEQHFIKEQI 

        70         80         90        100        110        120 
KRRFEQTQED SLYTIYELLP VWRMVLNEND LNLDSIVTQL KDQKNQLTRA KSSESRESSP 

       130        140        150        160        170        180 
LKSKAELWNE LELKSLIKLV TVTYTVSSLI LLTRLQLNIL TRNEYLDSAI KLTMQQENCN 

       190        200        210        220        230        240 
KLQNRFYNWV TSWWSDPEDK ADDAMVMAAK KSKKEGQEVY INEQAFLSLS WWILNKGWLS 

       250        260        270        280        290        300 
YNEIITNQIE IEFDGIHPRD TLTLEEFSSR LTNIFRNTNS QIFQQNNNNL TSILLPKDSS 

       310        320        330        340        350        360 
GQEFLLSQTL DADALTSFHS NTLVFNQLVN ELTQCIESTA TSIVLESLIN ESFHFIMNKV 

       370        380        390        400        410        420 
GIKTIAKKKP GQEDQQQYQM AVFAMSMKDC CQEMLQTTAG SSHSGSVNEY LATLDSVQPL 

       430        440 
DDLSASVYSN FGVSSSFSFK P 

« Hide

References

« Hide 'large scale' references
[1]"PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis."
Hoehfeld J., Veenhuis M., Kunau W.-H.
J. Cell Biol. 114:1167-1178(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X58407 Genomic DNA. Translation: CAA41309.1.
U32517 Genomic DNA. Translation: AAB64764.1.
BK006938 Genomic DNA. Translation: DAA12171.1.
PIRA40550.
RefSeqNP_010616.3. NM_001180637.3.

3D structure databases

ProteinModelPortalP28795.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid32386. 59 interactions.
DIPDIP-2477N.
IntActP28795. 4 interactions.
MINTMINT-474353.
STRING4932.YDR329C.

Protein family/group databases

TCDB3.A.20.1.5. the peroxisomal protein importer (ppi) family.
9.A.17.1.1. the integral membrane peroxisomal protein importer-2 (ppi2) family.

Proteomic databases

PaxDbP28795.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR329C; YDR329C; YDR329C.
GeneID851929.
KEGGsce:YDR329C.

Organism-specific databases

CYGDYDR329c.
SGDS000002737. PEX3.

Phylogenomic databases

eggNOGNOG302392.
HOGENOMHOG000001061.
KOK13336.
OMAINEQAFL.
OrthoDBEOG7RJQ17.

Enzyme and pathway databases

BioCycYEAST:G3O-29885-MONOMER.

Gene expression databases

GenevestigatorP28795.

Family and domain databases

InterProIPR006966. Peroxin-3.
[Graphical view]
PfamPF04882. Peroxin-3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969986.

Entry information

Entry namePEX3_YEAST
AccessionPrimary (citable) accession number: P28795
Secondary accession number(s): D6VSW1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families