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P28795

- PEX3_YEAST

UniProt

P28795 - PEX3_YEAST

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Protein

Peroxisomal biogenesis factor 3

Gene

PEX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in peroxisome biosynthesis. May function as a receptor protein. Lack of this protein causes the peroxisomal-deficient phenotype and mislocalization in the cytosol of peroxisomal matrix proteins.

GO - Molecular functioni

  1. protein binding, bridging Source: SGD

GO - Biological processi

  1. ER-dependent peroxisome organization Source: SGD
  2. peroxisome inheritance Source: SGD
  3. protein import into peroxisome membrane Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29885-MONOMER.

Protein family/group databases

TCDBi3.A.20.1.5. the peroxisomal protein importer (ppi) family.
9.A.17.1.1. the integral membrane peroxisomal protein importer-2 (ppi2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal biogenesis factor 3
Alternative name(s):
Peroxin-3
Peroxisomal membrane protein PAS3
Gene namesi
Name:PEX3
Synonyms:PAS3
Ordered Locus Names:YDR329C
ORF Names:D9798.15
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR329c.
SGDiS000002737. PEX3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: SGD
  2. integral component of peroxisomal membrane Source: InterPro
  3. peroxisomal membrane Source: SGD
  4. peroxisome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Peroxisomal biogenesis factor 3PRO_0000208747Add
BLAST

Proteomic databases

MaxQBiP28795.
PaxDbiP28795.

Expressioni

Inductioni

By oleic acid.

Gene expression databases

GenevestigatoriP28795.

Interactioni

Protein-protein interaction databases

BioGridi32386. 59 interactions.
DIPiDIP-2477N.
IntActiP28795. 4 interactions.
MINTiMINT-474353.
STRINGi4932.YDR329C.

Structurei

3D structure databases

ProteinModelPortaliP28795.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717PeroxisomalSequence AnalysisAdd
BLAST
Topological domaini40 – 441402CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3922HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxin-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302392.
HOGENOMiHOG000001061.
InParanoidiP28795.
KOiK13336.
OMAiINEQAFL.
OrthoDBiEOG7RJQ17.

Family and domain databases

InterProiIPR006966. Peroxin-3.
[Graphical view]
PfamiPF04882. Peroxin-3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28795-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPNQRSRSL LQRHRGKVLI SLTGIAALFT TGSVVVFFVK RWLYKQQLRI
60 70 80 90 100
TEQHFIKEQI KRRFEQTQED SLYTIYELLP VWRMVLNEND LNLDSIVTQL
110 120 130 140 150
KDQKNQLTRA KSSESRESSP LKSKAELWNE LELKSLIKLV TVTYTVSSLI
160 170 180 190 200
LLTRLQLNIL TRNEYLDSAI KLTMQQENCN KLQNRFYNWV TSWWSDPEDK
210 220 230 240 250
ADDAMVMAAK KSKKEGQEVY INEQAFLSLS WWILNKGWLS YNEIITNQIE
260 270 280 290 300
IEFDGIHPRD TLTLEEFSSR LTNIFRNTNS QIFQQNNNNL TSILLPKDSS
310 320 330 340 350
GQEFLLSQTL DADALTSFHS NTLVFNQLVN ELTQCIESTA TSIVLESLIN
360 370 380 390 400
ESFHFIMNKV GIKTIAKKKP GQEDQQQYQM AVFAMSMKDC CQEMLQTTAG
410 420 430 440
SSHSGSVNEY LATLDSVQPL DDLSASVYSN FGVSSSFSFK P
Length:441
Mass (Da):50,676
Last modified:December 1, 1992 - v1
Checksum:i3CDC1D036DF0D0F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58407 Genomic DNA. Translation: CAA41309.1.
U32517 Genomic DNA. Translation: AAB64764.1.
BK006938 Genomic DNA. Translation: DAA12171.1.
PIRiA40550.
RefSeqiNP_010616.3. NM_001180637.3.

Genome annotation databases

EnsemblFungiiYDR329C; YDR329C; YDR329C.
GeneIDi851929.
KEGGisce:YDR329C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X58407 Genomic DNA. Translation: CAA41309.1 .
U32517 Genomic DNA. Translation: AAB64764.1 .
BK006938 Genomic DNA. Translation: DAA12171.1 .
PIRi A40550.
RefSeqi NP_010616.3. NM_001180637.3.

3D structure databases

ProteinModelPortali P28795.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32386. 59 interactions.
DIPi DIP-2477N.
IntActi P28795. 4 interactions.
MINTi MINT-474353.
STRINGi 4932.YDR329C.

Protein family/group databases

TCDBi 3.A.20.1.5. the peroxisomal protein importer (ppi) family.
9.A.17.1.1. the integral membrane peroxisomal protein importer-2 (ppi2) family.

Proteomic databases

MaxQBi P28795.
PaxDbi P28795.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR329C ; YDR329C ; YDR329C .
GeneIDi 851929.
KEGGi sce:YDR329C.

Organism-specific databases

CYGDi YDR329c.
SGDi S000002737. PEX3.

Phylogenomic databases

eggNOGi NOG302392.
HOGENOMi HOG000001061.
InParanoidi P28795.
KOi K13336.
OMAi INEQAFL.
OrthoDBi EOG7RJQ17.

Enzyme and pathway databases

BioCyci YEAST:G3O-29885-MONOMER.

Miscellaneous databases

NextBioi 969986.

Gene expression databases

Genevestigatori P28795.

Family and domain databases

InterProi IPR006966. Peroxin-3.
[Graphical view ]
Pfami PF04882. Peroxin-3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAS3, a Saccharomyces cerevisiae gene encoding a peroxisomal integral membrane protein essential for peroxisome biogenesis."
    Hoehfeld J., Veenhuis M., Kunau W.-H.
    J. Cell Biol. 114:1167-1178(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPEX3_YEAST
AccessioniPrimary (citable) accession number: P28795
Secondary accession number(s): D6VSW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3