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Protein

Protein transport protein SEC20

Gene

SEC20

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.1 Publication

Miscellaneous

Present with 4910 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: SGD
  • vesicle fusion with endoplasmic reticulum Source: SGD

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30021-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC20
Gene namesi
Name:SEC20
Ordered Locus Names:YDR498C
ORF Names:D9719.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR498C
SGDiS000002906 SEC20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 275CytoplasmicSequence analysisAdd BLAST275
Transmembranei276 – 292Helical; Anchor for type IV membrane proteinAdd BLAST17
Topological domaini293 – 383LumenalSequence analysisAdd BLAST91

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976591 – 383Protein transport protein SEC20Add BLAST383

Post-translational modificationi

O-glycosylated, but not N-glycosylated.Curated

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP28791
PaxDbiP28791
PRIDEiP28791
TopDownProteomicsiP28791

PTM databases

iPTMnetiP28791

Interactioni

Subunit structurei

Component of a SNARE complex consisting of UFE1, USE1, SEC20 and SEC22 or YKT6. Interacts with TIP20 through its cytoplasmic domain.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32549, 420 interactors
DIPiDIP-5844N
IntActiP28791, 16 interactors
MINTiP28791
STRINGi4932.YDR498C

Structurei

3D structure databases

ProteinModelPortaliP28791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili6 – 26Sequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi380 – 383Prevents secretion from ER4

Sequence similaritiesi

Belongs to the SEC20 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000154280
InParanoidiP28791
KOiK08497
OMAiRIVSHDE
OrthoDBiEOG092C4CQT

Family and domain databases

InterProiView protein in InterPro
IPR005606 Sec20
PfamiView protein in Pfam
PF03908 Sec20, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit

Sequencei

Sequence statusi: Complete.

P28791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVTFLQDLE VLQDALLNNL QKLSAISRRK ESGESKHDNK DSFAAIANEH
60 70 80 90 100
NDEEEEIEFE DLVNIIESKV SDFESVLKCS IVEMTYKYPE LKLQWEKSPR
110 120 130 140 150
YDQCDKLHIV KLDKQMNEDI YAQLVEELDF VLQFVDWFYC YRLKVKEILR
160 170 180 190 200
QHHKRDLAWN DEKRDRAIKF HAVDYDKLHQ GTSSSSSLTS TSMEKASTRE
210 220 230 240 250
KLLSKTKQLT NNLVRGNQIL QSGILQSDLN LDELRAQTNS LTQIDDKYTQ
260 270 280 290 300
FETVFKKTAD LVKVLENASH QEKRDVYLSL GFLLCCVSWV LWRRIFKLPV
310 320 330 340 350
KLGLWLLFKF FKGILVTLGL VKSYAGSSSS LQAPSLVLNA PILATTTTSS
360 370 380
ATSVEPFASV SAVSSIQRAV DEAVDRIVSH DEL
Length:383
Mass (Da):43,882
Last modified:December 1, 1992 - v1
Checksum:i9BF8C748B8A8F589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60215 Genomic DNA Translation: CAA42776.1
U33057 Genomic DNA Translation: AAB64940.1
AY693133 Genomic DNA Translation: AAT93152.1
BK006938 Genomic DNA Translation: DAA12330.1
PIRiS19633
RefSeqiNP_010786.3, NM_001180806.3

Genome annotation databases

EnsemblFungiiYDR498C; YDR498C; YDR498C
GeneIDi852109
KEGGisce:YDR498C

Similar proteinsi

Entry informationi

Entry nameiSEC20_YEAST
AccessioniPrimary (citable) accession number: P28791
Secondary accession number(s): D6VTC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health