Reviewed, UniProtKB/Swiss-Prot P28776 (I23O_MOUSE)

Names and origin

Protein names

Recommended name:
    Indoleamine 2,3-dioxygenase
      Short name=IDO
    EC=1.13.11.52
Alternative name(s):
    Indoleamine-pyrrole 2,3-dioxygenase

Gene names

Name:	Indo
Synonyms:	Ido

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
Catalytic activity	D-tryptophan + O2 = N-formyl-D-kynurenine. L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 1 heme group per subunit.
Induction	By interferon gamma.
Sequence similarities	Belongs to the indoleamine 2,3-dioxygenase family.

Ontologies

Keywords
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	defense response Traceable author statement. Source: MGI oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of T cell tolerance induction Inferred from mutant phenotype. Source: MGI positive regulation of T-helper 2 type immune response Inferred from mutant phenotype. Source: MGI positive regulation of chronic inflammatory response Inferred from mutant phenotype. Source: MGI tryptophan catabolic process to kynurenine Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Inferred from direct assay. Source: MGI
Molecular function	heme binding Inferred from electronic annotation. Source: InterPro indoleamine 2,3-dioxygenase activity Inferred from electronic annotation. Source: EC tryptophan 2,3-dioxygenase activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 407	407	Indoleamine 2,3-dioxygenase		PRO_0000215205
Sites
	Metal binding	350	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28776-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 317681EABF96A727	FASTA	407	45,641
	10 20 30 40 50 60 MALSKISPTE GSRRILEDHH IDEDVGFALP HPLVELPDAY SPWVLVARNL PVLIENGQLR 70 80 90 100 110 120 EEVEKLPTLS TDGLRGHRLQ RLAHLALGYI TMAYVWNRGD DDVRKVLPRN IAVPYCELSE 130 140 150 160 170 180 KLGLPPILSY ADCVLANWKK KDPNGPMTYE NMDILFSFPG GDCDKGFFLV SLLVEIAASP 190 200 210 220 230 240 AIKAIPTVSS AVERQDLKAL EKALHDIATS LEKAKEIFKR MRDFVDPDTF FHVLRIYLSG 250 260 270 280 290 300 WKCSSKLPEG LLYEGVWDTP KMFSGGSAGQ SSIFQSLDVL LGIKHEAGKE SPAEFLQEMR 310 320 330 340 350 360 EYMPPAHRNF LFFLESAPPV REFVISRHNE DLTKAYNECV NGLVSVRKFH LAIVDTYIMK 370 380 390 400 PSKKKPTDGD KSEEPSNVES RGTGGTNPMT FLRSVKDTTE KALLSWP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of a cDNA encoding mouse indoleamine 2,3-dioxygenase." Habara-Ohkubo A., Takikawa O., Yoshida R. Gene 105:221-227(1991) [PubMed: 1937018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: NMRI. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M69109 mRNA. Translation: AAA37872.1. BC049931 mRNA. Translation: AAH49931.1.
IPI	IPI00124558.
PIR	JH0492.
RefSeq	NP_032350.1.
UniGene	Mm.392
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000031551. Mus musculus. [Contig view]
GeneID	15930.
KEGG	mmu:15930.
Organism-specific databases
MGI	MGI:96416. Indo.
Phylogenomic databases
HOGENOM	P28776.
HOVERGEN	P28776.
OMA	P28776. SLRSYHL.
Enzyme and pathway databases
BRENDA	1.13.11.11. 244. 1.13.11.52. 244.
Gene expression databases
ArrayExpress	P28776.
Bgee	P28776.
CleanEx	MM_INDO.
GermOnline	ENSMUSG00000031551. Mus musculus.
Family and domain databases
InterPro	IPR000898. Indolamine_dOase. [Graphical view]
Pfam	PF01231. IDO. 1 hit. [Graphical view]
PROSITE	PS00876. IDO_1. 1 hit. PS00877. IDO_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	288648.
SOURCE	Search...

Entry information

Entry name

I23O_MOUSE

Accession

Primary (citable) accession number: P28776

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)