Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P28774

- AT1B_ARTSF

UniProt

P28774 - AT1B_ARTSF

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium/potassium-transporting ATPase subunit alpha-B

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei357 – 35714-aspartylphosphate intermediateCurated
Binding sitei489 – 4891ATPBy similarity
Metal bindingi698 – 6981MagnesiumBy similarity
Metal bindingi702 – 7021MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-B (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-B subunit
Alternative name(s):
Sodium pump subunit alpha-B
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Sodium/potassium-transporting ATPase subunit alpha-BPRO_0000046307Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP28774.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP28774.
SMRiP28774. Positions 7-1004.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621HelicalBy similarityAdd
BLAST
Transmembranei110 – 12617HelicalBy similarityAdd
BLAST
Transmembranei272 – 29423HelicalBy similarityAdd
BLAST
Transmembranei301 – 32929HelicalBy similarityAdd
BLAST
Transmembranei768 – 79124HelicalBy similarityAdd
BLAST
Transmembranei828 – 85528HelicalBy similarityAdd
BLAST
Transmembranei897 – 91822HelicalBy similarityAdd
BLAST
Transmembranei934 – 95926HelicalBy similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28774-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKGKQKKGK DLNELKKELD IDFHKIPIEE CYQRLGSNPE TGLTNAQARS
60 70 80 90 100
NIERDGPNCL TPPKTTPEWI KFCKNLFGGF ALLLWTGAIL CFLAYGIEAS
110 120 130 140 150
SGNEDMLKDN LYLGIVLATV VIVTGIFSYY QENKSSRIMD SFKNLVPQYA
160 170 180 190 200
LALREGQRVT LKAEELTMGD IVEVKFGDRV PADLRVLEAR SFKVDNSSLT
210 220 230 240 250
GESEPQARSP EFTNDNPLET KNLAFFSTNA VEGTMRGIVI GIGDNTVMGR
260 270 280 290 300
IAGLASGLDT GETPIAKEIA HFIHIITGVA VFLGVTFFII AFVLGYHWLD
310 320 330 340 350
AVVFLIGIIV ANVPEGLLAT VTVCLTLTAK RMASKNCLVK NLEAVETLGS
360 370 380 390 400
TSTICSDKTG TLTQNRMTVA HMWFDGTITE ADTTEDQSGA QFDKSSAGWK
410 420 430 440 450
ALVKIAALCS RAEFKPNQST TPILKREVTG DASEAAILKC VELTTGETEA
460 470 480 490 500
IRKRNKKICE IPFNSANKFQ VSIHENEDKS DGRYLLVMKG APERILERCS
510 520 530 540 550
TIFMNGKEID MTEELKEAFN NAYMELGGLG ERVLGFCDYL LPLDKYPHGF
560 570 580 590 600
AFNADDANFP LTGLRFAGLM SMIDPPRAAV PDAVAKCRSA GIKVIMVTGD
610 620 630 640 650
HPITAKAIAK SVGIISEGNE TVEDIAARLN IPVSEVNPRD AKAAVVHGGE
660 670 680 690 700
LRDITPDALD EILRHHPEIV FARTSPQQKL IIVEGCQRQG AIVAVTGDGV
710 720 730 740 750
NDSPALKKAD IGVAMGIAGS DVSKQAADMI LLDDNFASIV TGVEEGRLIF
760 770 780 790 800
DNLKKSIVYT LTSNIPEISP FLLFILFDIP LPLGTVTILC IDLGTDMVPA
810 820 830 840 850
ISLAYEEAES DIMKRRPRNP VTDKLVNERL ISLAYGQIGM IQASAGFFVY
860 870 880 890 900
FVIMAECGFL PWDLFGLRKH WDSRAVNDLT DSYGQEWTYD ARKQLESSCH
910 920 930 940 950
TAYFVSIVIV QWADLIISKT RRNSVFQQGM RNNILNFALV FETCLAAFLS
960 970 980 990 1000
YTPGMDKGLR MYPLKINWWF PALPFSFLIF VYDEARKFIL RRNPGGWVEQ

ETYY
Length:1,004
Mass (Da):110,699
Last modified:December 1, 1992 - v1
Checksum:iCE4E6BECE19A78C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56650 mRNA. Translation: CAA39972.1.
PIRiJH0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56650 mRNA. Translation: CAA39972.1 .
PIRi JH0470.

3D structure databases

ProteinModelPortali P28774.
SMRi P28774. Positions 7-1004.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P28774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA encoding an Artemia franciscana Na/K ATPase alpha-subunit."
    Macias M.T., Martinez J.L., Palmero I., Sastre L.
    Gene 105:197-204(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1B_ARTSF
AccessioniPrimary (citable) accession number: P28774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3