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P28774

- AT1B_ARTSF

UniProt

P28774 - AT1B_ARTSF

Protein

Sodium/potassium-transporting ATPase subunit alpha-B

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei357 – 35714-aspartylphosphate intermediateCurated
    Binding sitei489 – 4891ATPBy similarity
    Metal bindingi698 – 6981MagnesiumBy similarity
    Metal bindingi702 – 7021MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-B (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-B subunit
    Alternative name(s):
    Sodium pump subunit alpha-B
    OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
    Taxonomic identifieri6661 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10041004Sodium/potassium-transporting ATPase subunit alpha-BPRO_0000046307Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP28774.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliP28774.
    SMRiP28774. Positions 7-1004.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei76 – 9621HelicalBy similarityAdd
    BLAST
    Transmembranei110 – 12617HelicalBy similarityAdd
    BLAST
    Transmembranei272 – 29423HelicalBy similarityAdd
    BLAST
    Transmembranei301 – 32929HelicalBy similarityAdd
    BLAST
    Transmembranei768 – 79124HelicalBy similarityAdd
    BLAST
    Transmembranei828 – 85528HelicalBy similarityAdd
    BLAST
    Transmembranei897 – 91822HelicalBy similarityAdd
    BLAST
    Transmembranei934 – 95926HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P28774-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKGKQKKGK DLNELKKELD IDFHKIPIEE CYQRLGSNPE TGLTNAQARS     50
    NIERDGPNCL TPPKTTPEWI KFCKNLFGGF ALLLWTGAIL CFLAYGIEAS 100
    SGNEDMLKDN LYLGIVLATV VIVTGIFSYY QENKSSRIMD SFKNLVPQYA 150
    LALREGQRVT LKAEELTMGD IVEVKFGDRV PADLRVLEAR SFKVDNSSLT 200
    GESEPQARSP EFTNDNPLET KNLAFFSTNA VEGTMRGIVI GIGDNTVMGR 250
    IAGLASGLDT GETPIAKEIA HFIHIITGVA VFLGVTFFII AFVLGYHWLD 300
    AVVFLIGIIV ANVPEGLLAT VTVCLTLTAK RMASKNCLVK NLEAVETLGS 350
    TSTICSDKTG TLTQNRMTVA HMWFDGTITE ADTTEDQSGA QFDKSSAGWK 400
    ALVKIAALCS RAEFKPNQST TPILKREVTG DASEAAILKC VELTTGETEA 450
    IRKRNKKICE IPFNSANKFQ VSIHENEDKS DGRYLLVMKG APERILERCS 500
    TIFMNGKEID MTEELKEAFN NAYMELGGLG ERVLGFCDYL LPLDKYPHGF 550
    AFNADDANFP LTGLRFAGLM SMIDPPRAAV PDAVAKCRSA GIKVIMVTGD 600
    HPITAKAIAK SVGIISEGNE TVEDIAARLN IPVSEVNPRD AKAAVVHGGE 650
    LRDITPDALD EILRHHPEIV FARTSPQQKL IIVEGCQRQG AIVAVTGDGV 700
    NDSPALKKAD IGVAMGIAGS DVSKQAADMI LLDDNFASIV TGVEEGRLIF 750
    DNLKKSIVYT LTSNIPEISP FLLFILFDIP LPLGTVTILC IDLGTDMVPA 800
    ISLAYEEAES DIMKRRPRNP VTDKLVNERL ISLAYGQIGM IQASAGFFVY 850
    FVIMAECGFL PWDLFGLRKH WDSRAVNDLT DSYGQEWTYD ARKQLESSCH 900
    TAYFVSIVIV QWADLIISKT RRNSVFQQGM RNNILNFALV FETCLAAFLS 950
    YTPGMDKGLR MYPLKINWWF PALPFSFLIF VYDEARKFIL RRNPGGWVEQ 1000
    ETYY 1004
    Length:1,004
    Mass (Da):110,699
    Last modified:December 1, 1992 - v1
    Checksum:iCE4E6BECE19A78C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56650 mRNA. Translation: CAA39972.1.
    PIRiJH0470.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56650 mRNA. Translation: CAA39972.1 .
    PIRi JH0470.

    3D structure databases

    ProteinModelPortali P28774.
    SMRi P28774. Positions 7-1004.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P28774.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a cDNA encoding an Artemia franciscana Na/K ATPase alpha-subunit."
      Macias M.T., Martinez J.L., Palmero I., Sastre L.
      Gene 105:197-204(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiAT1B_ARTSF
    AccessioniPrimary (citable) accession number: P28774
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3