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P28774

- AT1B_ARTSF

UniProt

P28774 - AT1B_ARTSF

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Protein

Sodium/potassium-transporting ATPase subunit alpha-B

Gene
N/A
Organism
Artemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei357 – 35714-aspartylphosphate intermediate Inferred
Binding sitei489 – 4891ATP By similarity
Metal bindingi698 – 6981Magnesium By similarity
Metal bindingi702 – 7021Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-B (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-B subunit
Alternative name(s):
Sodium pump subunit alpha-B
OrganismiArtemia franciscana (Brine shrimp) (Artemia sanfranciscana)
Taxonomic identifieri6661 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaBranchiopodaAnostracaArtemiidaeArtemia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9621Helical; By similarityAdd
BLAST
Transmembranei110 – 12617Helical; By similarityAdd
BLAST
Transmembranei272 – 29423Helical; By similarityAdd
BLAST
Transmembranei301 – 32929Helical; By similarityAdd
BLAST
Transmembranei768 – 79124Helical; By similarityAdd
BLAST
Transmembranei828 – 85528Helical; By similarityAdd
BLAST
Transmembranei897 – 91822Helical; By similarityAdd
BLAST
Transmembranei934 – 95926Helical; By similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Sodium/potassium-transporting ATPase subunit alpha-BPRO_0000046307Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP28774.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliP28774.
SMRiP28774. Positions 7-1004.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28774-1 [UniParc]FASTAAdd to Basket

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MAKGKQKKGK DLNELKKELD IDFHKIPIEE CYQRLGSNPE TGLTNAQARS     50
NIERDGPNCL TPPKTTPEWI KFCKNLFGGF ALLLWTGAIL CFLAYGIEAS 100
SGNEDMLKDN LYLGIVLATV VIVTGIFSYY QENKSSRIMD SFKNLVPQYA 150
LALREGQRVT LKAEELTMGD IVEVKFGDRV PADLRVLEAR SFKVDNSSLT 200
GESEPQARSP EFTNDNPLET KNLAFFSTNA VEGTMRGIVI GIGDNTVMGR 250
IAGLASGLDT GETPIAKEIA HFIHIITGVA VFLGVTFFII AFVLGYHWLD 300
AVVFLIGIIV ANVPEGLLAT VTVCLTLTAK RMASKNCLVK NLEAVETLGS 350
TSTICSDKTG TLTQNRMTVA HMWFDGTITE ADTTEDQSGA QFDKSSAGWK 400
ALVKIAALCS RAEFKPNQST TPILKREVTG DASEAAILKC VELTTGETEA 450
IRKRNKKICE IPFNSANKFQ VSIHENEDKS DGRYLLVMKG APERILERCS 500
TIFMNGKEID MTEELKEAFN NAYMELGGLG ERVLGFCDYL LPLDKYPHGF 550
AFNADDANFP LTGLRFAGLM SMIDPPRAAV PDAVAKCRSA GIKVIMVTGD 600
HPITAKAIAK SVGIISEGNE TVEDIAARLN IPVSEVNPRD AKAAVVHGGE 650
LRDITPDALD EILRHHPEIV FARTSPQQKL IIVEGCQRQG AIVAVTGDGV 700
NDSPALKKAD IGVAMGIAGS DVSKQAADMI LLDDNFASIV TGVEEGRLIF 750
DNLKKSIVYT LTSNIPEISP FLLFILFDIP LPLGTVTILC IDLGTDMVPA 800
ISLAYEEAES DIMKRRPRNP VTDKLVNERL ISLAYGQIGM IQASAGFFVY 850
FVIMAECGFL PWDLFGLRKH WDSRAVNDLT DSYGQEWTYD ARKQLESSCH 900
TAYFVSIVIV QWADLIISKT RRNSVFQQGM RNNILNFALV FETCLAAFLS 950
YTPGMDKGLR MYPLKINWWF PALPFSFLIF VYDEARKFIL RRNPGGWVEQ 1000
ETYY 1004
Length:1,004
Mass (Da):110,699
Last modified:December 1, 1992 - v1
Checksum:iCE4E6BECE19A78C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56650 mRNA. Translation: CAA39972.1.
PIRiJH0470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X56650 mRNA. Translation: CAA39972.1 .
PIRi JH0470.

3D structure databases

ProteinModelPortali P28774.
SMRi P28774. Positions 7-1004.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P28774.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a cDNA encoding an Artemia franciscana Na/K ATPase alpha-subunit."
    Macias M.T., Martinez J.L., Palmero I., Sastre L.
    Gene 105:197-204(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAT1B_ARTSF
AccessioniPrimary (citable) accession number: P28774
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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