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Protein

GTP-binding nuclear protein spi1

Gene

spi1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 238GTPBy similarity
Nucleotide bindingi64 – 685GTPBy similarity
Nucleotide bindingi121 – 1244GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: PomBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • poly(A)+ mRNA export from nucleus Source: PomBase
  • protein import into nucleus Source: GO_Central
  • ribosomal subunit export from nucleus Source: GO_Central
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein spi1
Gene namesi
Name:spi1
ORF Names:SPBC1289.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC1289.03c.
PomBaseiSPBC1289.03c. spi1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216GTP-binding nuclear protein spi1PRO_0000208735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP28748.
PRIDEiP28748.

PTM databases

iPTMnetiP28748.

Interactioni

Subunit structurei

Oligomer of dis3, pim1 and spi1. Interacts with fft3.2 Publications

Protein-protein interaction databases

BioGridi276686. 17 interactions.
MINTiMINT-4688107.

Structurei

3D structure databases

ProteinModelPortaliP28748.
SMRiP28748. Positions 2-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

HOGENOMiHOG000216664.
InParanoidiP28748.
KOiK07936.
OMAiNIQYFEI.
OrthoDBiEOG092C4F6L.
PhylomeDBiP28748.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPQNVPTF KLVLVGDGGT GKTTFVKRHL TGEFEKKYIA TLGVEVHPLH
60 70 80 90 100
FHTNFGEICF NVWDTAGQEK LGGLRDGYYI QGQCGIIMFD VTSRITYKNV
110 120 130 140 150
PHWWRDLVRV CENIPIVLCG NKVDVKERKV KAKAITFHRK KNLQYYDISA
160 170 180 190 200
KSNYNFEKPF LWLARKLVGN PNLEFVASPA LAPPEVQVDQ QLLAQYQQEM
210
NEAAAMPLPD EDDADL
Length:216
Mass (Da):24,555
Last modified:December 1, 1992 - v1
Checksum:i9349A9155E315442
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73527 Genomic DNA. No translation available.
CU329671 Genomic DNA. Translation: CAB38683.1.
PIRiA40039.
RefSeqiNP_596827.1. NM_001023848.2.

Genome annotation databases

EnsemblFungiiSPBC1289.03c.1; SPBC1289.03c.1:pep; SPBC1289.03c.
GeneIDi2540149.
KEGGispo:SPBC1289.03c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73527 Genomic DNA. No translation available.
CU329671 Genomic DNA. Translation: CAB38683.1.
PIRiA40039.
RefSeqiNP_596827.1. NM_001023848.2.

3D structure databases

ProteinModelPortaliP28748.
SMRiP28748. Positions 2-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276686. 17 interactions.
MINTiMINT-4688107.

PTM databases

iPTMnetiP28748.

Proteomic databases

MaxQBiP28748.
PRIDEiP28748.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC1289.03c.1; SPBC1289.03c.1:pep; SPBC1289.03c.
GeneIDi2540149.
KEGGispo:SPBC1289.03c.

Organism-specific databases

EuPathDBiFungiDB:SPBC1289.03c.
PomBaseiSPBC1289.03c. spi1.

Phylogenomic databases

HOGENOMiHOG000216664.
InParanoidiP28748.
KOiK07936.
OMAiNIQYFEI.
OrthoDBiEOG092C4F6L.
PhylomeDBiP28748.

Miscellaneous databases

PROiP28748.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPI1_SCHPO
AccessioniPrimary (citable) accession number: P28748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 7, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.