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Protein

Protein pim1

Gene

pim1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport.

GO - Molecular functioni

  • Ran guanyl-nucleotide exchange factor activity Source: PomBase

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • negative regulation of G2/M transition of mitotic cell cycle Source: PomBase
  • positive regulation of protein export from nucleus Source: PomBase
  • Ran protein signal transduction Source: PomBase
  • regulation of exit from mitosis Source: PomBase
  • regulation of mitotic spindle assembly Source: PomBase
  • regulation of mitotic spindle elongation Source: PomBase

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein pim1
Alternative name(s):
Poly(A)+ RNA transport protein 2
Gene namesi
Name:pim1
Synonyms:dcd1, ptr2
ORF Names:SPBC557.03c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC557.03c
PomBaseiSPBC557.03c pim1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066361 – 539Protein pim1Add BLAST539

Proteomic databases

MaxQBiP28745
PaxDbiP28745
PRIDEiP28745

PTM databases

iPTMnetiP28745

Interactioni

Subunit structurei

Oligomer of dis3, pim1 and spi1. Interacts with ned1.2 Publications

GO - Molecular functioni

  • Ran guanyl-nucleotide exchange factor activity Source: PomBase

Protein-protein interaction databases

BioGridi277574, 12 interactors
STRINGi4896.SPBC557.03c.1

Structurei

3D structure databases

ProteinModelPortaliP28745
SMRiP28745
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati70 – 125RCC1 1Add BLAST56
Repeati127 – 191RCC1 2Add BLAST65
Repeati192 – 243RCC1 3Add BLAST52
Repeati244 – 296RCC1 4Add BLAST53
Repeati298 – 353RCC1 5Add BLAST56
Repeati354 – 417RCC1 6Add BLAST64
Repeati419 – 472RCC1 7Add BLAST54

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000170207
KOiK11493
OMAiLNQFGQC
OrthoDBiEOG092C31D4
PhylomeDBiP28745

Family and domain databases

Gene3Di2.130.10.30, 1 hit
InterProiView protein in InterPro
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
PfamiView protein in Pfam
PF00415 RCC1, 6 hits
PRINTSiPR00633 RCCNDNSATION
SUPFAMiSSF50985 SSF50985, 1 hit
PROSITEiView protein in PROSITE
PS00625 RCC1_1, 1 hit
PS00626 RCC1_2, 3 hits
PS50012 RCC1_3, 7 hits

Sequencei

Sequence statusi: Complete.

P28745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSNRSTRSS TKREEVSKNG VEKRELDESD VMKNGKKPVK RAKVSSLPKP
60 70 80 90 100
VRVPGSAKRI NKIPELPTER LNVYVFGSGS MNELGMGEEE MDVVYRPRLN
110 120 130 140 150
PILSTDKVGV VDLAVGGMHS AALSHDGRVY TWGVNDDYAL GRLTKDQKDE
160 170 180 190 200
NGDKVDNDLL EGTPSKVEGA LSHLRVTKVI CSDNLTAAIT DNGCCFTWGT
210 220 230 240 250
FRCSDGVLGY SDSQKRTAEP TQMRLPEICQ LATGTDHIIA LTTTGKVYTW
260 270 280 290 300
GNGQQFQLGR RMLERRRLQG LTPQPLALKN IISVGAGSYH SFAIDNKGRV
310 320 330 340 350
YAWGLNITRQ CGIEVEDEEE GAVITKPTLV DALEGYNVKS ITGGEHHTLA
360 370 380 390 400
LLEDGRVLAW GRDDRHQLGI PDNALPETVV KDEKGNNYYL STPTIIPGLT
410 420 430 440 450
NVIQVVCGTH HNLAVTSDGK VYSWGSAENY EVGQGDNDED VAVPTLVRSK
460 470 480 490 500
AIKEVAIRVA GAGGQFSIIA GIPNASEEPV ANGIKSEPEN EKKLKTEETS
510 520 530
KTDDSPVTDA KPDVTSNGEP STATSESKDS VLEPSSTTA
Length:539
Mass (Da):58,349
Last modified:January 11, 2001 - v2
Checksum:i35C0AF47CF6581F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124S → L (PubMed:1855255).Curated1
Sequence conflicti526E → D (PubMed:1855255).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73528 Genomic DNA No translation available.
CU329671 Genomic DNA Translation: CAB60670.1
PIRiB40039
T50368
RefSeqiNP_596026.1, NM_001021935.2

Genome annotation databases

EnsemblFungiiSPBC557.03c.1; SPBC557.03c.1:pep; SPBC557.03c
KEGGispo:SPBC557.03c

Similar proteinsi

Entry informationi

Entry nameiRCC1_SCHPO
AccessioniPrimary (citable) accession number: P28745
Secondary accession number(s): Q9USS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: January 11, 2001
Last modified: March 28, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health