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Protein

Kinesin-like protein KIP2

Gene

KIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of the mitotic spindle.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi202 – 2098ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: SGD
  • plus-end directed microfilament motor activity Source: SGD

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • microtubule polymerization Source: SGD
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of microtubule depolymerization Source: SGD
  • nuclear migration along microtubule Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIP2
Gene namesi
Name:KIP2
Ordered Locus Names:YPL155C
ORF Names:P2581
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL155C.
SGDiS000006076. KIP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic microtubule Source: SGD
  • kinesin complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 706706Kinesin-like protein KIP2PRO_0000125453Add
BLAST

Proteomic databases

MaxQBiP28743.

PTM databases

iPTMnetiP28743.

Interactioni

Subunit structurei

Might be dimeric.

Binary interactionsi

WithEntry#Exp.IntActNotes
SPC29P334194EBI-9749,EBI-12041

Protein-protein interaction databases

BioGridi36028. 55 interactions.
DIPiDIP-3012N.
IntActiP28743. 3 interactions.
MINTiMINT-436268.

Structurei

3D structure databases

ProteinModelPortaliP28743.
SMRiP28743. Positions 115-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 493392Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili507 – 54135Sequence analysisAdd
BLAST
Coiled coili569 – 58921Sequence analysisAdd
BLAST
Coiled coili612 – 68978Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00810000125470.
HOGENOMiHOG000000988.
InParanoidiP28743.
OMAiLTERRCE.
OrthoDBiEOG7VHT5Q.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 6 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKMSPSLR RPSTRSSSGS SNIPQSPSVR STSSFSNLTR NSIRSTSNSG
60 70 80 90 100
SQSISASSTR SNSPLRSVSA KSDPFLHPGR IRIRRSDSIN NNSRKNDTYT
110 120 130 140 150
GSITVTIRPK PRSVGTSRDH VGLKSPRYSQ PRSNSHHGSN TFVRDPWFIT
160 170 180 190 200
NDKTIVHEEI GEFKFDHVFA SHCTNLEVYE RTSKPMIDKL LMGFNATIFA
210 220 230 240 250
YGMTGSGKTF TMSGNEQELG LIPLSVSYLF TNIMEQSMNG DKKFDVIISY
260 270 280 290 300
LEIYNERIYD LLESGLEESG SRISTPSRLY MSKSNSNGLG VELKIRDDSQ
310 320 330 340 350
YGVKVIGLTE RRCESSEELL RWIAVGDKSR KIGETDYNAR SSRSHAIVLI
360 370 380 390 400
RLTSTNVKNG TSRSSTLSLC DLAGSERATG QQERRKEGSF INKSLLALGT
410 420 430 440 450
VISKLSADKM NSVGSNIPSP SASGSSSSSG NATNNGTSPS NHIPYRDSKL
460 470 480 490 500
TRLLQPALSG DSIVTTICTV DTRNDAAAET MNTLRFASRA KNVALHVSKK
510 520 530 540 550
SIISNGNNDG DKDRTIELLR RQLEEQRRMI SELKNRSNIG EPLTKSSNES
560 570 580 590 600
TYKDIKATGN DGDPNLALMR AENRVLKYKL ENCEKLLDKD VVDLQDSEIM
610 620 630 640 650
EIVEMLPFEV GTLLETKFQG LESQIRQYRK YTQKLEDKIM ALEKSGHTAM
660 670 680 690 700
SLTGCDGTEV IELQKMLERK DKMIEALQSA KRLRDRALKP LINTQQSPHP

VVDNDK
Length:706
Mass (Da):78,378
Last modified:December 1, 1992 - v1
Checksum:i1E94C004C4E3BF08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11963 Genomic DNA. Translation: CAA78021.1.
X96770 Genomic DNA. Translation: CAA65566.1.
Z73511 Genomic DNA. Translation: CAA97860.1.
BK006949 Genomic DNA. Translation: DAA11279.1.
PIRiC42640.
RefSeqiNP_015170.1. NM_001183969.1.

Genome annotation databases

EnsemblFungiiYPL155C; YPL155C; YPL155C.
GeneIDi855948.
KEGGisce:YPL155C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11963 Genomic DNA. Translation: CAA78021.1.
X96770 Genomic DNA. Translation: CAA65566.1.
Z73511 Genomic DNA. Translation: CAA97860.1.
BK006949 Genomic DNA. Translation: DAA11279.1.
PIRiC42640.
RefSeqiNP_015170.1. NM_001183969.1.

3D structure databases

ProteinModelPortaliP28743.
SMRiP28743. Positions 115-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36028. 55 interactions.
DIPiDIP-3012N.
IntActiP28743. 3 interactions.
MINTiMINT-436268.

PTM databases

iPTMnetiP28743.

Proteomic databases

MaxQBiP28743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL155C; YPL155C; YPL155C.
GeneIDi855948.
KEGGisce:YPL155C.

Organism-specific databases

EuPathDBiFungiDB:YPL155C.
SGDiS000006076. KIP2.

Phylogenomic databases

GeneTreeiENSGT00810000125470.
HOGENOMiHOG000000988.
InParanoidiP28743.
OMAiLTERRCE.
OrthoDBiEOG7VHT5Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-34051-MONOMER.

Miscellaneous databases

PROiP28743.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 6 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Kinesin-related proteins required for assembly of the mitotic spindle."
    Roof D.M., Meluh P.B., Rose M.D.
    J. Cell Biol. 118:95-108(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The sequence of 55 kb on the left arm of yeast chromosome XVI identifies a small nuclear RNA, a new putative protein kinase and two new putative regulators."
    Purnelle B., Coster F., Goffeau A.
    Yeast 12:1483-1492(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKIP2_YEAST
AccessioniPrimary (citable) accession number: P28743
Secondary accession number(s): D6W3L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 6, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.