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Protein

Kinesin-like protein KIP2

Gene

KIP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of the mitotic spindle.

Miscellaneous

Present with 656 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi202 – 209ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: SGD
  • microtubule binding Source: InterPro

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • microtubule polymerization Source: SGD
  • negative regulation of microtubule depolymerization Source: SGD
  • nuclear migration along microtubule Source: SGD

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-34051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIP2
Gene namesi
Name:KIP2
Ordered Locus Names:YPL155C
ORF Names:P2581
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL155C.
SGDiS000006076. KIP2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254531 – 706Kinesin-like protein KIP2Add BLAST706

Proteomic databases

MaxQBiP28743.
PRIDEiP28743.

PTM databases

iPTMnetiP28743.

Interactioni

Subunit structurei

Might be dimeric.

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi36028. 103 interactors.
DIPiDIP-3012N.
IntActiP28743. 11 interactors.
MINTiMINT-436268.
STRINGi4932.YPL155C.

Structurei

3D structure databases

ProteinModelPortaliP28743.
SMRiP28743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 493Kinesin motorPROSITE-ProRule annotationAdd BLAST392

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili507 – 541Sequence analysisAdd BLAST35
Coiled coili569 – 589Sequence analysisAdd BLAST21
Coiled coili612 – 689Sequence analysisAdd BLAST78

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00870000136450.
HOGENOMiHOG000000988.
InParanoidiP28743.
OMAiILCTIHL.
OrthoDBiEOG092C2D4G.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P28743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQKMSPSLR RPSTRSSSGS SNIPQSPSVR STSSFSNLTR NSIRSTSNSG
60 70 80 90 100
SQSISASSTR SNSPLRSVSA KSDPFLHPGR IRIRRSDSIN NNSRKNDTYT
110 120 130 140 150
GSITVTIRPK PRSVGTSRDH VGLKSPRYSQ PRSNSHHGSN TFVRDPWFIT
160 170 180 190 200
NDKTIVHEEI GEFKFDHVFA SHCTNLEVYE RTSKPMIDKL LMGFNATIFA
210 220 230 240 250
YGMTGSGKTF TMSGNEQELG LIPLSVSYLF TNIMEQSMNG DKKFDVIISY
260 270 280 290 300
LEIYNERIYD LLESGLEESG SRISTPSRLY MSKSNSNGLG VELKIRDDSQ
310 320 330 340 350
YGVKVIGLTE RRCESSEELL RWIAVGDKSR KIGETDYNAR SSRSHAIVLI
360 370 380 390 400
RLTSTNVKNG TSRSSTLSLC DLAGSERATG QQERRKEGSF INKSLLALGT
410 420 430 440 450
VISKLSADKM NSVGSNIPSP SASGSSSSSG NATNNGTSPS NHIPYRDSKL
460 470 480 490 500
TRLLQPALSG DSIVTTICTV DTRNDAAAET MNTLRFASRA KNVALHVSKK
510 520 530 540 550
SIISNGNNDG DKDRTIELLR RQLEEQRRMI SELKNRSNIG EPLTKSSNES
560 570 580 590 600
TYKDIKATGN DGDPNLALMR AENRVLKYKL ENCEKLLDKD VVDLQDSEIM
610 620 630 640 650
EIVEMLPFEV GTLLETKFQG LESQIRQYRK YTQKLEDKIM ALEKSGHTAM
660 670 680 690 700
SLTGCDGTEV IELQKMLERK DKMIEALQSA KRLRDRALKP LINTQQSPHP

VVDNDK
Length:706
Mass (Da):78,378
Last modified:December 1, 1992 - v1
Checksum:i1E94C004C4E3BF08
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11963 Genomic DNA. Translation: CAA78021.1.
X96770 Genomic DNA. Translation: CAA65566.1.
Z73511 Genomic DNA. Translation: CAA97860.1.
BK006949 Genomic DNA. Translation: DAA11279.1.
PIRiC42640.
RefSeqiNP_015170.1. NM_001183969.1.

Genome annotation databases

EnsemblFungiiYPL155C; YPL155C; YPL155C.
GeneIDi855948.
KEGGisce:YPL155C.

Similar proteinsi

Entry informationi

Entry nameiKIP2_YEAST
AccessioniPrimary (citable) accession number: P28743
Secondary accession number(s): D6W3L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: September 27, 2017
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names