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Protein

Kinesin-like protein KIP1

Gene

KIP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of the mitotic spindle. Interact with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3.

Miscellaneous

Present with 56 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi141 – 148ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
  • microtubule binding Source: InterPro
  • microtubule motor activity Source: SGD
  • structural constituent of cytoskeleton Source: SGD

GO - Biological processi

  • 2-micrometer plasmid partitioning Source: SGD
  • cell division Source: UniProtKB-KW
  • microtubule-based movement Source: GO_Central
  • microtubule depolymerization Source: SGD
  • mitotic sister chromatid segregation Source: SGD
  • mitotic spindle assembly Source: SGD
  • mitotic spindle elongation Source: SGD
  • spindle pole body separation Source: SGD

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28960-MONOMER.
ReactomeiR-SCE-5610787. Hedgehog 'off' state.
R-SCE-5620924. Intraflagellar transport.
R-SCE-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-SCE-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIP1
Alternative name(s):
Chromosome instability protein 9
Gene namesi
Name:KIP1
Synonyms:CIN9
Ordered Locus Names:YBL063W
ORF Names:YBL0504, YBL0521
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL063W.
SGDiS000000159. KIP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • kinesin complex Source: SGD
  • spindle microtubule Source: SGD
  • spindle pole body Source: SGD

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253691 – 1111Kinesin-like protein KIP1Add BLAST1111

Proteomic databases

MaxQBiP28742.
PRIDEiP28742.

PTM databases

iPTMnetiP28742.

Interactioni

Subunit structurei

Might be dimeric.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32636. 64 interactors.
DIPiDIP-174N.
IntActiP28742. 1 interactor.
MINTiMINT-670364.
STRINGi4932.YBL063W.

Structurei

3D structure databases

ProteinModelPortaliP28742.
SMRiP28742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 410Kinesin motorPROSITE-ProRule annotationAdd BLAST359

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 510Sequence analysisAdd BLAST87
Coiled coili648 – 670Sequence analysisAdd BLAST23
Coiled coili710 – 780Sequence analysisAdd BLAST71
Coiled coili808 – 828Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

GeneTreeiENSGT00880000137847.
HOGENOMiHOG000113228.
InParanoidiP28742.
KOiK10398.
OrthoDBiEOG092C2D4G.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiView protein in InterPro
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00225. Kinesin. 1 hit.
PRINTSiPR00380. KINESINHEAVY.
SMARTiView protein in SMART
SM00129. KISc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P28742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSSLPNRR TAQFEANKRR TIAHAPSPSL SNGMHTLTPP TCNNGAATSD
60 70 80 90 100
SNIHVYVRCR SRNKREIEEK SSVVISTLGP QGKEIILSNG SHQSYSSSKK
110 120 130 140 150
TYQFDQVFGA ESDQETVFNA TAKNYIKEML HGYNCTIFAY GQTGTGKTYT
160 170 180 190 200
MSGDINILGD VQSTDNLLLG EHAGIIPRVL VDLFKELSSL NKEYSVKISF
210 220 230 240 250
LELYNENLKD LLSDSEDDDP AVNDPKRQIR IFDNNNNNSS IMVKGMQEIF
260 270 280 290 300
INSAHEGLNL LMQGSLKRKV AATKCNDLSS RSHTVFTITT NIVEQDSKDH
310 320 330 340 350
GQNKNFVKIG KLNLVDLAGS ENINRSGAEN KRAQEAGLIN KSLLTLGRVI
360 370 380 390 400
NALVDHSNHI PYRESKLTRL LQDSLGGMTK TCIIATISPA KISMEETAST
410 420 430 440 450
LEYATRAKSI KNTPQVNQSL SKDTCLKDYI QEIEKLRNDL KNSRNKQGIF
460 470 480 490 500
ITQDQLDLYE SNSILIDEQN LKIHNLREQI KKFKENYLNQ LDINNLLQSE
510 520 530 540 550
KEKLIAIIQN FNVDFSNFYS EIQKIHHTNL ELMNEVIQQR DFSLENSQKQ
560 570 580 590 600
YNTNQNMQLK ISQQVLQTLN TLQGSLNNYN SKCSEVIKGV TEELTRNVNT
610 620 630 640 650
HKAKHDSTLK SLLNITTNLL MNQMNELVRS ISTSLEIFQS DSTSHYRKDL
660 670 680 690 700
NEIYQSHQQF LKNLQNDIKS CLDSIGSSIL TSINEISQNC TTNLNSMNVL
710 720 730 740 750
IENQQSGSSK LIKEQDLEIK KLKNDLINER RISNQFNQQL AEMKRYFQDH
760 770 780 790 800
VSRTRSEFHD ELNKCIDNLK DKQSKLDQDI WQKTASIFNE TDIVVNKIHS
810 820 830 840 850
DSIASLAHNA ENTLKTVSQN NESFTNDLIS LSRGMNMDIS SKLRSLPINE
860 870 880 890 900
FLNKISQTIC ETCGDDNTIA SNPVLTSIKK FQNIICSDIA LTNEKIMSLI
910 920 930 940 950
DEIQSQIETI SNENNINLIA INENFNSLCN FILTDYDENI MQISKTQDEV
960 970 980 990 1000
LSEHCEKLQS LKILGMDIFT AHSIEKPLHE HTRPEASVIK ALPLLDYPKQ
1010 1020 1030 1040 1050
FQIYRDAENK SKDDTSNSRT CIPNLSTNEN FPLSQFSPKT PVPVPDQPLP
1060 1070 1080 1090 1100
KVLIPKSINS AKSNRSKTLP NTEGTGRESQ NNLKRRFTTE PILKGEETEN
1110
NDILQNKKLH Q
Length:1,111
Mass (Da):125,795
Last modified:December 1, 1992 - v1
Checksum:i212F8279766137FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11962 Genomic DNA. Translation: CAA78019.1.
Z23261 Genomic DNA. Translation: CAA80785.1.
Z35824 Genomic DNA. Translation: CAA84883.1.
BK006936 Genomic DNA. Translation: DAA07057.1.
PIRiA42640.
RefSeqiNP_009490.1. NM_001178303.1.

Genome annotation databases

EnsemblFungiiYBL063W; YBL063W; YBL063W.
GeneIDi852216.
KEGGisce:YBL063W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiKIP1_YEAST
AccessioniPrimary (citable) accession number: P28742
Secondary accession number(s): D6VPT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: July 5, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names