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Reviewed, UniProtKB/Swiss-Prot P28741 (KIF3A_MOUSE)

Last modified February 9, 2010. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Kinesin-like protein KIF3A
Alternative name(s):
    Microtubule plus end-directed kinesin motor 3A
Gene names
Name: Kif3a
Synonyms: Kif3
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length701 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro.

Subunit structure

Heterodimer of KIF3A and KIF3B.

Tissue specificity

Expressed almost exclusively in adult brain tissue (mainly in the cerebellar granular layer) within a single type of neuronal cell.

Sequence similarities

Belongs to the kinesin-like protein family. Kinesin II subfamily.

Contains 1 kinesin-motor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 701701Kinesin-like protein KIF3A
PRO_0000125394

Regions

Domain1 – 350350Kinesin-motor
Nucleotide binding100 – 1078ATP By similarity
Region599 – 701103Globular
Coiled coil355 – 592238 Potential
Compositional bias442 – 4454Poly-Glu
Compositional bias509 – 5124Poly-Arg

Amino acid modifications

Modified residue6351Phosphothreonine Ref.3
Modified residue6891Phosphoserine Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28741-1 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 2405872DF2D85A29

FASTA70180,168
        10         20         30         40         50         60 
MPINKSEKPE SCDNVKVVVR CRPLNEREKS MCYRQAVSVD EMRGTITVHK TDSSNEPPKT 

        70         80         90        100        110        120 
FTFDTVFGPE SKQLDVYNLT ARPIIDSVLE GYNGTIFAYG QTGTGKTFTM EGVRAVPGLR 

       130        140        150        160        170        180 
GVIPNSFAHI FGHIAKAEGD TRFLVRVSYL EIYNEEVRDL LGKDQTQRLE VKERPDVGVY 

       190        200        210        220        230        240 
IKDLSAYVVN NADDMDRIMT LGHKNRSVGA TNMNEHSSRS HAIFTITIEC SEKGVDGNMH 

       250        260        270        280        290        300 
VRMGKLHLVD LAGSERQAKT GATGQRLKEA TKINLSLSTL GNVISALVDG KSTHVPYRNS 

       310        320        330        340        350        360 
KLTRLLQDSL GGNSKTMMCA NIGPADYNYD ETISTLRYAN RAKNIKNKAR INEDPKDALL 

       370        380        390        400        410        420 
RQFQKEIEEL KKKLEEGEEV SGSDISGSEE DDEEGELGED GEKRKKRRDQ AGKKKVSPDK 

       430        440        450        460        470        480 
MVEMQAKIDE ERKALETKLD MEEEERNKAR AELERREKDL LKAQQEHQSL LEKLSALEKK 

       490        500        510        520        530        540 
VIVGGVDLLA KAEEQEKLLE ESNMELEERR RRAEQLRKEL EEKEQERLDI EEKYTSLQEE 

       550        560        570        580        590        600 
AQGKTKKLKK VWTMLMAAKS EMADLQQEHQ REIEGLLENI RQLSRELRLQ MLIIDNFIPQ 

       610        620        630        640        650        660 
DYQEMIENYV HWNEDIGEWQ LKCVAYTGNN MRKQTPVPDK KERDPFEVDL SHVYLAYTEE 

       670        680        690        700 
SLRQSLMKLE RPRTSKGKAR PKTGRRKRSA KPETVIDSLL Q 

« Hide

References

« Hide 'large scale' references
[1]"Kinesin family in murine central nervous system."
Aizawa H., Sekine Y., Takemura R., Zhang Z., Nangaku M., Hirokawa N.
J. Cell Biol. 119:1287-1296(1992) [PubMed: 1447303] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed: 15345747] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-689, MASS SPECTROMETRY.
Tissue: Brain.
[3]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed: 18973353] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-635, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12645 mRNA. Translation: BAA02166.1.
IPIIPI00312076.
PIRB44259.
UniGeneMm.88694

3D structure databases

SMRP28741. Positions 13-363.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-46318N.
STRINGP28741.

PTM databases

PhosphoSiteP28741.

Proteomic databases

PRIDEP28741.

Genome annotation databases

EnsemblENSMUST00000108958; ENSMUSP00000104586; ENSMUSG00000018395; Mus musculus. [Genome view]
ENSMUST00000120613; ENSMUSP00000112782; ENSMUSG00000018395; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:107689. Kif3a.

Phylogenomic databases

eggNOGroNOG04329.
HOVERGENP28741.

Gene expression databases

ArrayExpressP28741.
BgeeP28741.
CleanExMM_KIF3A.
GenevestigatorP28741.
GermOnlineENSMUSG00000018395. Mus musculus.

Family and domain databases

InterProIPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
[Graphical view]
Gene3DG3DSA:3.40.850.10. kinesin_motor. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

Entry information

Entry nameKIF3A_MOUSE
AccessionPrimary (citable) accession number: P28741
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 9, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents