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P28738 (KIF5C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin heavy chain isoform 5C
Alternative name(s):
Kinesin heavy chain neuron-specific 2
Gene names
Name:Kif5c
Synonyms:Nkhc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs. Ref.8

Subunit structure

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3. Interacts with TRAK1 By similarity. Ref.7 Ref.9

Subcellular location

Cytoplasmcytoskeleton Probable.

Domain

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similarities

Belongs to the kinesin-like protein family. Kinesin subfamily.

Contains 1 kinesin-motor domain.

Sequence caution

The sequence CAA43677.1 differs from that shown. Reason: Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Mapk8ip3Q9ESN98EBI-2506834,EBI-301496

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Kinesin heavy chain isoform 5C
PRO_0000125356

Regions

Domain2 – 386385Kinesin-motor
Nucleotide binding86 – 938ATP By similarity
Region174 – 315142Microtubule-binding
Region859 – 95698Globular
Coiled coil406 – 923518

Experimental info

Sequence conflict3871Q → H in AAC79804. Ref.2
Sequence conflict7921R → I in AAC79804. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28738 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: A36BC903603D8748

FASTA956109,275
        10         20         30         40         50         60 
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGEETVV IGQGKPYVFD RVLPPNTTQE 

        70         80         90        100        110        120 
QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI 

       130        140        150        160        170        180 
YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV 

       190        200        210        220        230        240 
MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS 

       250        260        270        280        290        300 
KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI 

       310        320        330        340        350        360 
VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKALKSVL 

       370        380        390        400        410        420 
QHLEMELNRW RNGEAVPEDE QISAKDQKSL EPCDNTPIID NITPVVDGIS AEKEKYDEEI 

       430        440        450        460        470        480 
TSLYRQLDDK DDEINQQSQL AEKLKQQMLD QDELLASTRR DYEKIQEELT RLQIENEAAK 

       490        500        510        520        530        540 
DEVKEVLQAL EELAVNYDQK SQEVEDKTRA NEQLTDELAQ KTTTLTTTQR ELSQLQELSN 

       550        560        570        580        590        600 
HQKKRATEIL NLLLKDLGEI GGIIGTNDVK TLADVNGVIE EEFTMARLYI SKMKSEVKSL 

       610        620        630        640        650        660 
VNRSKQLESA QMDSNRKMNA SERELAACQL LISQHEAKIK SLTDYMQNME QKRRQLEESQ 

       670        680        690        700        710        720 
DSLSEELAKL RAQEKMHEVS FQDKEKEHLT RLQDAEEVKK ALEQQMESHR EAHQKQLSRL 

       730        740        750        760        770        780 
RDEIEEKQRI IDEIRDLNQK LQLEQERLSS DYNKLKIEDQ EREVKLEKLL LLNDKREQAR 

       790        800        810        820        830        840 
EDLKGLEETV SRELQTLHNL RKLFVQDLTT RVKKSVELDS DDGGGSAAQK QKISFLENNL 

       850        860        870        880        890        900 
EQLTKVHKQL VRDNADLRCE LPKLEKRLRA TAERVKALES ALKEAKENAM RDRKRYQQEV 

       910        920        930        940        950 
DRIKEAVRAK NMARRAHSAQ IAKPIRPGHY PASSPTAVHA VRGGGGGSSN STHYQK 

« Hide

References

« Hide 'large scale' references
[1]"A collection of cDNA clones with specific expression patterns in mouse brain."
Kato K.
Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Chromosomal localization reveals three kinesin heavy chain genes in mouse."
Xia C., Rahman A., Yang Z., Goldstein L.S.B.
Genomics 52:209-213(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[6]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 133-142; 242-253; 258-274; 287-297; 546-555 AND 815-830, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[7]"Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites."
Setou M., Seog D.-H., Tanaka Y., Kanai Y., Takei Y., Kawagishi M., Hirokawa N.
Nature 417:83-87(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GRIP1.
[8]"Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis."
Kindler S., Dieterich D.C., Schutt J., Sahin J., Karpova A., Mikhaylova M., Schob C., Gundelfinger E.D., Kreienkamp H.J., Kreutz M.R.
J. Biol. Chem. 284:25431-25440(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"KIF1A alternately uses two loops to bind microtubules."
Nitta R., Kikkawa M., Okada Y., Hirokawa N.
Science 305:678-683(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 329-334 IN COMPLEXES WITH KIF1A, SUBUNIT, INTERACTION WITH MICROTUBULES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61435 mRNA. Translation: CAA43677.1. Sequence problems.
AF067180 mRNA. Translation: AAC79804.1.
AL845332, AL929069 Genomic DNA. Translation: CAM20914.1.
AL929069, AL845332 Genomic DNA. Translation: CAM25239.1.
CH466519 Genomic DNA. Translation: EDL26880.1.
BC067051 mRNA. Translation: AAH67051.1.
PIRS37711.
RefSeqNP_032475.2. NM_008449.2.
UniGeneMm.256342.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1VFVX-ray1.85A329-334[»]
1VFWX-ray2.30A329-334[»]
1VFXX-ray2.55A329-334[»]
1VFZX-ray2.24A329-334[»]
ProteinModelPortalP28738.
SMRP28738. Positions 2-372.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200947. 6 interactions.
IntActP28738. 9 interactions.
MINTMINT-236700.
STRING10090.ENSMUSP00000028102.

PTM databases

PhosphoSiteP28738.

Proteomic databases

PaxDbP28738.
PRIDEP28738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028102; ENSMUSP00000028102; ENSMUSG00000026764.
GeneID16574.
KEGGmmu:16574.
UCSCuc008jpy.1. mouse.

Organism-specific databases

CTD3800.
MGIMGI:1098269. Kif5c.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00730000110208.
HOVERGENHBG006210.
InParanoidQ6NXI9.
KOK10396.
OMAIDEIRDM.
OrthoDBEOG7T4MJD.
TreeFamTF105225.

Gene expression databases

ArrayExpressP28738.
BgeeP28738.
CleanExMM_KIF5C.
GenevestigatorP28738.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00411. KINESIN_MOTOR_DOMAIN1. 1 hit.
PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP28738.
NextBio290099.
PROP28738.
SOURCESearch...

Entry information

Entry nameKIF5C_MOUSE
AccessionPrimary (citable) accession number: P28738
Secondary accession number(s): Q6NXI9, Q9Z2F8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot