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P28738

- KIF5C_MOUSE

UniProt

P28738 - KIF5C_MOUSE

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Protein

Kinesin heavy chain isoform 5C

Gene

Kif5c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 938ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
  2. mRNA transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain isoform 5C
Alternative name(s):
Kinesin heavy chain neuron-specific 2
Gene namesi
Name:Kif5c
Synonyms:Nkhc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1098269. Kif5c.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Kinesin heavy chain isoform 5CPRO_0000125356Add
BLAST

Proteomic databases

MaxQBiP28738.
PaxDbiP28738.
PRIDEiP28738.

PTM databases

PhosphoSiteiP28738.

Expressioni

Gene expression databases

BgeeiP28738.
CleanExiMM_KIF5C.
ExpressionAtlasiP28738. baseline and differential.
GenevestigatoriP28738.

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3. Interacts with TRAK1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8ip3Q9ESN98EBI-2506834,EBI-301496

Protein-protein interaction databases

BioGridi200947. 6 interactions.
IntActiP28738. 10 interactions.
MINTiMINT-236700.
STRINGi10090.ENSMUSP00000028102.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VFVX-ray1.85A329-334[»]
1VFWX-ray2.30A329-334[»]
1VFXX-ray2.55A329-334[»]
1VFZX-ray2.24A329-334[»]
ProteinModelPortaliP28738.
SMRiP28738. Positions 2-372, 724-763.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28738.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 327320Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni174 – 315142Microtubule-bindingAdd
BLAST
Regioni859 – 95698GlobularAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili406 – 923518Add
BLAST

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00760000118872.
HOVERGENiHBG006210.
InParanoidiP28738.
KOiK10396.
OMAiIRDMNQK.
OrthoDBiEOG7T4MJD.
TreeFamiTF105225.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGEETVV IGQGKPYVFD
60 70 80 90 100
RVLPPNTTQE QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL
110 120 130 140 150
HDPQLMGIIP RIAHDIFDHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVS
160 170 180 190 200
KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV MDVIDEGKAN RHVAVTNMNE
210 220 230 240 250
HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS KTGAEGAVLD
260 270 280 290 300
EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI
310 320 330 340 350
VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK
360 370 380 390 400
EKNKALKSVL QHLEMELNRW RNGEAVPEDE QISAKDQKSL EPCDNTPIID
410 420 430 440 450
NITPVVDGIS AEKEKYDEEI TSLYRQLDDK DDEINQQSQL AEKLKQQMLD
460 470 480 490 500
QDELLASTRR DYEKIQEELT RLQIENEAAK DEVKEVLQAL EELAVNYDQK
510 520 530 540 550
SQEVEDKTRA NEQLTDELAQ KTTTLTTTQR ELSQLQELSN HQKKRATEIL
560 570 580 590 600
NLLLKDLGEI GGIIGTNDVK TLADVNGVIE EEFTMARLYI SKMKSEVKSL
610 620 630 640 650
VNRSKQLESA QMDSNRKMNA SERELAACQL LISQHEAKIK SLTDYMQNME
660 670 680 690 700
QKRRQLEESQ DSLSEELAKL RAQEKMHEVS FQDKEKEHLT RLQDAEEVKK
710 720 730 740 750
ALEQQMESHR EAHQKQLSRL RDEIEEKQRI IDEIRDLNQK LQLEQERLSS
760 770 780 790 800
DYNKLKIEDQ EREVKLEKLL LLNDKREQAR EDLKGLEETV SRELQTLHNL
810 820 830 840 850
RKLFVQDLTT RVKKSVELDS DDGGGSAAQK QKISFLENNL EQLTKVHKQL
860 870 880 890 900
VRDNADLRCE LPKLEKRLRA TAERVKALES ALKEAKENAM RDRKRYQQEV
910 920 930 940 950
DRIKEAVRAK NMARRAHSAQ IAKPIRPGHY PASSPTAVHA VRGGGGGSSN

STHYQK
Length:956
Mass (Da):109,275
Last modified:July 27, 2011 - v3
Checksum:iA36BC903603D8748
GO

Sequence cautioni

The sequence CAA43677.1 differs from that shown. Reason: Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti387 – 3871Q → H in AAC79804. (PubMed:9782088)Curated
Sequence conflicti792 – 7921R → I in AAC79804. (PubMed:9782088)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61435 mRNA. Translation: CAA43677.1. Sequence problems.
AF067180 mRNA. Translation: AAC79804.1.
AL845332, AL929069 Genomic DNA. Translation: CAM20914.1.
AL929069, AL845332 Genomic DNA. Translation: CAM25239.1.
CH466519 Genomic DNA. Translation: EDL26880.1.
BC067051 mRNA. Translation: AAH67051.1.
CCDSiCCDS16024.1.
PIRiS37711.
RefSeqiNP_032475.2. NM_008449.2.
UniGeneiMm.256342.

Genome annotation databases

EnsembliENSMUST00000028102; ENSMUSP00000028102; ENSMUSG00000026764.
GeneIDi16574.
KEGGimmu:16574.
UCSCiuc008jpy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61435 mRNA. Translation: CAA43677.1 . Sequence problems.
AF067180 mRNA. Translation: AAC79804.1 .
AL845332 , AL929069 Genomic DNA. Translation: CAM20914.1 .
AL929069 , AL845332 Genomic DNA. Translation: CAM25239.1 .
CH466519 Genomic DNA. Translation: EDL26880.1 .
BC067051 mRNA. Translation: AAH67051.1 .
CCDSi CCDS16024.1.
PIRi S37711.
RefSeqi NP_032475.2. NM_008449.2.
UniGenei Mm.256342.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VFV X-ray 1.85 A 329-334 [» ]
1VFW X-ray 2.30 A 329-334 [» ]
1VFX X-ray 2.55 A 329-334 [» ]
1VFZ X-ray 2.24 A 329-334 [» ]
ProteinModelPortali P28738.
SMRi P28738. Positions 2-372, 724-763.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200947. 6 interactions.
IntActi P28738. 10 interactions.
MINTi MINT-236700.
STRINGi 10090.ENSMUSP00000028102.

PTM databases

PhosphoSitei P28738.

Proteomic databases

MaxQBi P28738.
PaxDbi P28738.
PRIDEi P28738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028102 ; ENSMUSP00000028102 ; ENSMUSG00000026764 .
GeneIDi 16574.
KEGGi mmu:16574.
UCSCi uc008jpy.1. mouse.

Organism-specific databases

CTDi 3800.
MGIi MGI:1098269. Kif5c.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00760000118872.
HOVERGENi HBG006210.
InParanoidi P28738.
KOi K10396.
OMAi IRDMNQK.
OrthoDBi EOG7T4MJD.
TreeFami TF105225.

Miscellaneous databases

EvolutionaryTracei P28738.
NextBioi 290099.
PROi P28738.
SOURCEi Search...

Gene expression databases

Bgeei P28738.
CleanExi MM_KIF5C.
ExpressionAtlasi P28738. baseline and differential.
Genevestigatori P28738.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A collection of cDNA clones with specific expression patterns in mouse brain."
    Kato K.
    Eur. J. Neurosci. 2:704-711(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "Chromosomal localization reveals three kinesin heavy chain genes in mouse."
    Xia C., Rahman A., Yang Z., Goldstein L.S.B.
    Genomics 52:209-213(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 133-142; 242-253; 258-274; 287-297; 546-555 AND 815-830, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  7. "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites."
    Setou M., Seog D.-H., Tanaka Y., Kanai Y., Takei Y., Kawagishi M., Hirokawa N.
    Nature 417:83-87(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GRIP1.
  8. "Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis."
    Kindler S., Dieterich D.C., Schutt J., Sahin J., Karpova A., Mikhaylova M., Schob C., Gundelfinger E.D., Kreienkamp H.J., Kreutz M.R.
    J. Biol. Chem. 284:25431-25440(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "KIF1A alternately uses two loops to bind microtubules."
    Nitta R., Kikkawa M., Okada Y., Hirokawa N.
    Science 305:678-683(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 329-334 IN COMPLEXES WITH KIF1A, SUBUNIT, INTERACTION WITH MICROTUBULES.

Entry informationi

Entry nameiKIF5C_MOUSE
AccessioniPrimary (citable) accession number: P28738
Secondary accession number(s): Q6NXI9, Q9Z2F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3