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Protein

Kinesin heavy chain isoform 5C

Gene

Kif5c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in synaptic transmission (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • cytoskeleton-dependent intracellular transport Source: GO_Central
  • microtubule-based movement Source: GO_Central
  • motor neuron axon guidance Source: MGI
  • mRNA transport Source: UniProtKB
  • protein localization Source: GO_Central

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin heavy chain isoform 5C
Alternative name(s):
Kinesin heavy chain neuron-specific 2
Gene namesi
Name:Kif5c
Synonyms:Nkhc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1098269 Kif5c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001253561 – 956Kinesin heavy chain isoform 5CAdd BLAST956

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei403PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP28738
MaxQBiP28738
PaxDbiP28738
PeptideAtlasiP28738
PRIDEiP28738

PTM databases

iPTMnetiP28738
PhosphoSitePlusiP28738

Expressioni

Gene expression databases

BgeeiENSMUSG00000026764
CleanExiMM_KIF5C
ExpressionAtlasiP28738 baseline and differential
GenevisibleiP28738 MM

Interactioni

Subunit structurei

Oligomer composed of two heavy chains and two light chains (PubMed:15286375). Interacts with GRIP1 (PubMed:11986669). Interacts with KLC3 and TRAK1 (By similarity). Interacts with ZFYVE27 (PubMed:21976701).By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8ip3Q9ESN98EBI-2506834,EBI-301496

GO - Molecular functioni

Protein-protein interaction databases

BioGridi20094715 interactors.
CORUMiP28738
IntActiP28738 18 interactors.
MINTiP28738
STRINGi10090.ENSMUSP00000028102

Structurei

Secondary structure

1956
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 15Combined sources6
Helixi20 – 24Combined sources5
Beta strandi31 – 34Combined sources4
Turni35 – 37Combined sources3
Beta strandi38 – 41Combined sources4
Beta strandi46 – 48Combined sources3
Beta strandi50 – 53Combined sources4
Helixi59 – 66Combined sources8
Helixi68 – 74Combined sources7
Turni75 – 77Combined sources3
Beta strandi80 – 86Combined sources7
Helixi92 – 96Combined sources5
Turni103 – 105Combined sources3
Helixi108 – 122Combined sources15
Beta strandi125 – 139Combined sources15
Beta strandi142 – 147Combined sources6
Beta strandi156 – 158Combined sources3
Beta strandi164 – 168Combined sources5
Beta strandi172 – 176Combined sources5
Helixi177 – 191Combined sources15
Helixi199 – 202Combined sources4
Beta strandi206 – 216Combined sources11
Turni218 – 220Combined sources3
Beta strandi223 – 232Combined sources10
Helixi258 – 267Combined sources10
Helixi279 – 281Combined sources3
Helixi283 – 287Combined sources5
Turni288 – 293Combined sources6
Beta strandi294 – 304Combined sources11
Beta strandi306 – 308Combined sources3
Helixi311 – 324Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VFVX-ray1.85A329-334[»]
1VFWX-ray2.30A329-334[»]
1VFXX-ray2.55A329-334[»]
1VFZX-ray2.24A329-334[»]
3J6Helectron microscopy8.10K1-345[»]
3WRDX-ray2.86A/B1-334[»]
3X2TX-ray2.70A/B1-334[»]
ProteinModelPortaliP28738
SMRiP28738
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28738

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 327Kinesin motorPROSITE-ProRule annotationAdd BLAST320

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni174 – 315Microtubule-bindingAdd BLAST142
Regioni859 – 956GlobularAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili406 – 923Add BLAST518

Domaini

Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0240 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000144010
HOVERGENiHBG006210
InParanoidiP28738
KOiK10396
OMAiSAQIDSN
OrthoDBiEOG091G02A2
TreeFamiTF105225

Family and domain databases

Gene3Di3.40.850.101 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28738-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGEETVV IGQGKPYVFD
60 70 80 90 100
RVLPPNTTQE QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL
110 120 130 140 150
HDPQLMGIIP RIAHDIFDHI YSMDENLEFH IKVSYFEIYL DKIRDLLDVS
160 170 180 190 200
KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV MDVIDEGKAN RHVAVTNMNE
210 220 230 240 250
HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS KTGAEGAVLD
260 270 280 290 300
EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI
310 320 330 340 350
VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK
360 370 380 390 400
EKNKALKSVL QHLEMELNRW RNGEAVPEDE QISAKDQKSL EPCDNTPIID
410 420 430 440 450
NITPVVDGIS AEKEKYDEEI TSLYRQLDDK DDEINQQSQL AEKLKQQMLD
460 470 480 490 500
QDELLASTRR DYEKIQEELT RLQIENEAAK DEVKEVLQAL EELAVNYDQK
510 520 530 540 550
SQEVEDKTRA NEQLTDELAQ KTTTLTTTQR ELSQLQELSN HQKKRATEIL
560 570 580 590 600
NLLLKDLGEI GGIIGTNDVK TLADVNGVIE EEFTMARLYI SKMKSEVKSL
610 620 630 640 650
VNRSKQLESA QMDSNRKMNA SERELAACQL LISQHEAKIK SLTDYMQNME
660 670 680 690 700
QKRRQLEESQ DSLSEELAKL RAQEKMHEVS FQDKEKEHLT RLQDAEEVKK
710 720 730 740 750
ALEQQMESHR EAHQKQLSRL RDEIEEKQRI IDEIRDLNQK LQLEQERLSS
760 770 780 790 800
DYNKLKIEDQ EREVKLEKLL LLNDKREQAR EDLKGLEETV SRELQTLHNL
810 820 830 840 850
RKLFVQDLTT RVKKSVELDS DDGGGSAAQK QKISFLENNL EQLTKVHKQL
860 870 880 890 900
VRDNADLRCE LPKLEKRLRA TAERVKALES ALKEAKENAM RDRKRYQQEV
910 920 930 940 950
DRIKEAVRAK NMARRAHSAQ IAKPIRPGHY PASSPTAVHA VRGGGGGSSN

STHYQK
Length:956
Mass (Da):109,275
Last modified:July 27, 2011 - v3
Checksum:iA36BC903603D8748
GO

Sequence cautioni

The sequence CAA43677 differs from that shown. Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti387Q → H in AAC79804 (PubMed:9782088).Curated1
Sequence conflicti792R → I in AAC79804 (PubMed:9782088).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61435 mRNA Translation: CAA43677.1 Sequence problems.
AF067180 mRNA Translation: AAC79804.1
AL845332, AL929069 Genomic DNA Translation: CAM20914.1
AL929069, AL845332 Genomic DNA Translation: CAM25239.1
CH466519 Genomic DNA Translation: EDL26880.1
BC067051 mRNA Translation: AAH67051.1
CCDSiCCDS16024.1
PIRiS37711
RefSeqiNP_032475.2, NM_008449.2
UniGeneiMm.256342

Genome annotation databases

EnsembliENSMUST00000028102; ENSMUSP00000028102; ENSMUSG00000026764
GeneIDi16574
KEGGimmu:16574
UCSCiuc008jpy.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKIF5C_MOUSE
AccessioniPrimary (citable) accession number: P28738
Secondary accession number(s): Q6NXI9, Q9Z2F8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome