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Protein

Protein MSP1

Gene

MSP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intramitochondrial sorting of proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • microtubule-severing ATPase activity Source: GO_Central

GO - Biological processi

  • cytoplasmic microtubule organization Source: GO_Central
  • protein targeting to mitochondrion Source: SGD
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30752-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MSP1
Alternative name(s):
Tat-binding homolog 4
Gene namesi
Name:MSP1
Synonyms:YTA4
Ordered Locus Names:YGR028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR028W.
SGDiS000003260. MSP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei13 – 28HelicalSequence analysisAdd BLAST16
Topological domaini29 – 362CytoplasmicSequence analysisAdd BLAST334

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial outer membrane Source: SGD
  • nucleus Source: GO_Central
  • peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847571 – 362Protein MSP1Add BLAST362

Proteomic databases

MaxQBiP28737.
PRIDEiP28737.

Interactioni

Protein-protein interaction databases

BioGridi33272. 41 interactors.
DIPiDIP-8029N.
IntActiP28737. 20 interactors.
MINTiMINT-4486830.

Structurei

3D structure databases

ProteinModelPortaliP28737.
SMRiP28737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074823.
HOGENOMiHOG000225141.
InParanoidiP28737.
OMAiKWMMNQM.
OrthoDBiEOG092C2QJ3.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKFDLKTI TDLSVLVGTG ISLYYLVSRL LNDVESGPLS GKSRESKAKQ
60 70 80 90 100
SLQWEKLVKR SPALAEVTLD AYERTILSSI VTPDEINITF QDIGGLDPLI
110 120 130 140 150
SDLHESVIYP LMMPEVYSNS PLLQAPSGVL LYGPPGCGKT MLAKALAKES
160 170 180 190 200
GANFISIRMS SIMDKWYGES NKIVDAMFSL ANKLQPCIIF IDEIDSFLRE
210 220 230 240 250
RSSTDHEVTA TLKAEFMTLW DGLLNNGRVM IIGATNRIND IDDAFLRRLP
260 270 280 290 300
KRFLVSLPGS DQRYKILSVL LKDTKLDEDE FDLQLIADNT KGFSGSDLKE
310 320 330 340 350
LCREAALDAA KEYIKQKRQL IDSGTIDVND TSSLKIRPLK TKDFTKKLRM
360
DATSTLSSQP LD
Length:362
Mass (Da):40,343
Last modified:February 1, 1994 - v2
Checksum:i1B3562A32F47F434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68055 Genomic DNA. Translation: CAA48191.1.
X81069 Genomic DNA. Translation: CAA56956.1.
Z72813 Genomic DNA. Translation: CAA97015.1.
X60722 Genomic DNA. No translation available.
AY557772 Genomic DNA. Translation: AAS56098.1.
BK006941 Genomic DNA. Translation: DAA08124.1.
PIRiA49506.
RefSeqiNP_011542.3. NM_001181157.3.

Genome annotation databases

EnsemblFungiiYGR028W; YGR028W; YGR028W.
GeneIDi852915.
KEGGisce:YGR028W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68055 Genomic DNA. Translation: CAA48191.1.
X81069 Genomic DNA. Translation: CAA56956.1.
Z72813 Genomic DNA. Translation: CAA97015.1.
X60722 Genomic DNA. No translation available.
AY557772 Genomic DNA. Translation: AAS56098.1.
BK006941 Genomic DNA. Translation: DAA08124.1.
PIRiA49506.
RefSeqiNP_011542.3. NM_001181157.3.

3D structure databases

ProteinModelPortaliP28737.
SMRiP28737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33272. 41 interactors.
DIPiDIP-8029N.
IntActiP28737. 20 interactors.
MINTiMINT-4486830.

Proteomic databases

MaxQBiP28737.
PRIDEiP28737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGR028W; YGR028W; YGR028W.
GeneIDi852915.
KEGGisce:YGR028W.

Organism-specific databases

EuPathDBiFungiDB:YGR028W.
SGDiS000003260. MSP1.

Phylogenomic databases

GeneTreeiENSGT00550000074823.
HOGENOMiHOG000225141.
InParanoidiP28737.
OMAiKWMMNQM.
OrthoDBiEOG092C2QJ3.

Enzyme and pathway databases

BioCyciYEAST:G3O-30752-MONOMER.

Miscellaneous databases

PROiP28737.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSP1_YEAST
AccessioniPrimary (citable) accession number: P28737
Secondary accession number(s): D6VUG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3530 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.