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Protein

Protein MSP1

Gene

MSP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in intramitochondrial sorting of proteins.

Miscellaneous

Present with 3530 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • protein targeting to mitochondrion Source: SGD

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30752-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MSP1
Alternative name(s):
Tat-binding homolog 4
Gene namesi
Name:MSP1
Synonyms:YTA4
Ordered Locus Names:YGR028W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR028W
SGDiS000003260 MSP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12Mitochondrial intermembraneSequence analysisAdd BLAST12
Transmembranei13 – 28HelicalSequence analysisAdd BLAST16
Topological domaini29 – 362CytoplasmicSequence analysisAdd BLAST334

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847571 – 362Protein MSP1Add BLAST362

Proteomic databases

MaxQBiP28737
PaxDbiP28737
PRIDEiP28737

Interactioni

Protein-protein interaction databases

BioGridi33272, 93 interactors
DIPiDIP-8029N
IntActiP28737, 20 interactors
MINTiP28737
STRINGi4932.YGR028W

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 60Combined sources10
Helixi62 – 66Combined sources5
Helixi71 – 77Combined sources7
Turni83 – 85Combined sources3
Turni97 – 99Combined sources3
Helixi100 – 106Combined sources7
Helixi108 – 112Combined sources5
Helixi114 – 119Combined sources6
Beta strandi127 – 132Combined sources6
Helixi139 – 149Combined sources11
Beta strandi153 – 156Combined sources4
Helixi159 – 166Combined sources8
Helixi167 – 169Combined sources3
Helixi170 – 183Combined sources14
Beta strandi186 – 191Combined sources6
Helixi194 – 196Combined sources3
Helixi207 – 222Combined sources16
Beta strandi229 – 236Combined sources8
Helixi238 – 240Combined sources3
Helixi243 – 246Combined sources4
Beta strandi251 – 254Combined sources4
Helixi260 – 270Combined sources11
Turni271 – 273Combined sources3
Beta strandi278 – 280Combined sources3
Helixi283 – 288Combined sources6
Helixi295 – 322Combined sources28
Helixi341 – 345Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W0TX-ray2.63A51-345[»]
ProteinModelPortaliP28737
SMRiP28737
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074823
HOGENOMiHOG000225141
InParanoidiP28737
OMAiMPHLYSH
OrthoDBiEOG092C2QJ3

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

P28737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKFDLKTI TDLSVLVGTG ISLYYLVSRL LNDVESGPLS GKSRESKAKQ
60 70 80 90 100
SLQWEKLVKR SPALAEVTLD AYERTILSSI VTPDEINITF QDIGGLDPLI
110 120 130 140 150
SDLHESVIYP LMMPEVYSNS PLLQAPSGVL LYGPPGCGKT MLAKALAKES
160 170 180 190 200
GANFISIRMS SIMDKWYGES NKIVDAMFSL ANKLQPCIIF IDEIDSFLRE
210 220 230 240 250
RSSTDHEVTA TLKAEFMTLW DGLLNNGRVM IIGATNRIND IDDAFLRRLP
260 270 280 290 300
KRFLVSLPGS DQRYKILSVL LKDTKLDEDE FDLQLIADNT KGFSGSDLKE
310 320 330 340 350
LCREAALDAA KEYIKQKRQL IDSGTIDVND TSSLKIRPLK TKDFTKKLRM
360
DATSTLSSQP LD
Length:362
Mass (Da):40,343
Last modified:February 1, 1994 - v2
Checksum:i1B3562A32F47F434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68055 Genomic DNA Translation: CAA48191.1
X81069 Genomic DNA Translation: CAA56956.1
Z72813 Genomic DNA Translation: CAA97015.1
X60722 Genomic DNA No translation available.
AY557772 Genomic DNA Translation: AAS56098.1
BK006941 Genomic DNA Translation: DAA08124.1
PIRiA49506
RefSeqiNP_011542.3, NM_001181157.3

Genome annotation databases

EnsemblFungiiYGR028W; YGR028W; YGR028W
GeneIDi852915
KEGGisce:YGR028W

Similar proteinsi

Entry informationi

Entry nameiMSP1_YEAST
AccessioniPrimary (citable) accession number: P28737
Secondary accession number(s): D6VUG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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