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P28736

- HISX_MYCSM

UniProt

P28736 - HISX_MYCSM

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium smegmatis
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361NADBy similarity
Binding sitei200 – 2001NADBy similarity
Binding sitei228 – 2281NADBy similarity
Binding sitei251 – 2511SubstrateBy similarity
Metal bindingi273 – 2731ZincBy similarity
Binding sitei273 – 2731SubstrateBy similarity
Metal bindingi276 – 2761ZincBy similarity
Binding sitei276 – 2761SubstrateBy similarity
Active sitei342 – 3421Proton acceptorBy similarity
Active sitei343 – 3431Proton acceptorBy similarity
Binding sitei343 – 3431SubstrateBy similarity
Metal bindingi376 – 3761ZincBy similarity
Binding sitei376 – 3761SubstrateBy similarity
Binding sitei430 – 4301SubstrateBy similarity
Metal bindingi435 – 4351ZincBy similarity
Binding sitei435 – 4351SubstrateBy similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
OrganismiMycobacterium smegmatis
Taxonomic identifieri1772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenasePRO_0000135798Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP28736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28736-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMMAKFQMS RIDLRNRVLS AAQLRSALPR GGVDVDAVVP KVRPIVDAVA
60 70 80 90 100
QRGAQAALEY GESFDGIRPE TVRVPRELLS QALENLDADV RAALQVSIDR
110 120 130 140 150
ARAVHADQRR TDTTTTLAPG ATVTERWVPV ERVGLYVPGG NAVYPSSVVM
160 170 180 190 200
NVVPAQTAGV DSMVIASPPQ GQFGGRPHPT ILAAAALLGV DEVWAVGGAQ
210 220 230 240 250
AVALLAYGGT DTDGAELAPV DMITGPGNIY VTAAKRICRS QVGIDAEAGP
260 270 280 290 300
TEIAILADHT ADPVHVAADL ISQAEHDEMA ASVLVTDSET LAEATDRELA
310 320 330 340 350
NQLATTKHVE RVTAALSGKQ SAIVLVDDID AGVRTVNAYA AEHLEIQTVD
360 370 380 390 400
APGVAGRIRS AGAIFVGAWS PVSLGDYCAG SNHVLPTAGC ARHSSGLSVQ
410 420 430 440
TFLRGIHVVE YDEAALKDVS GHVITLSKAE DLPAHGEAVR RRFER
Length:445
Mass (Da):46,703
Last modified:December 1, 1992 - v1
Checksum:i19996D28D4591170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65542 Genomic DNA. Translation: CAA46509.1.
PIRiS26209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65542 Genomic DNA. Translation: CAA46509.1 .
PIRi S26209.

3D structure databases

ProteinModelPortali P28736.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of mycobacterial histidine synthesis genes by complementation of a Mycobacterium smegmatis auxotroph."
    Hinshelwood S., Stoker N.G.
    Mol. Microbiol. 6:2887-2895(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 607 / DSM 43465 / JCM 20379 / NBRC 3207 / NRRL B-692.

Entry informationi

Entry nameiHISX_MYCSM
AccessioniPrimary (citable) accession number: P28736
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3