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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Mycobacterium smegmatis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.By similarity

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. Phosphoribosyl isomerase A (priA_2)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC), Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hpsN_3), Histidinol dehydrogenase (hpsN_2), Histidinol dehydrogenase (hpsN_1), Histidinol dehydrogenase (hisD), Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136NADBy similarity1
Binding sitei200NADBy similarity1
Binding sitei228NADBy similarity1
Binding sitei251SubstrateBy similarity1
Metal bindingi273ZincBy similarity1
Binding sitei273SubstrateBy similarity1
Metal bindingi276ZincBy similarity1
Binding sitei276SubstrateBy similarity1
Active sitei342Proton acceptorBy similarity1
Active sitei343Proton acceptorBy similarity1
Binding sitei343SubstrateBy similarity1
Metal bindingi376ZincBy similarity1
Binding sitei376SubstrateBy similarity1
Binding sitei430SubstrateBy similarity1
Metal bindingi435ZincBy similarity1
Binding sitei435SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
OrganismiMycobacterium smegmatis
Taxonomic identifieri1772 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium fortuitum complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001357981 – 445Histidinol dehydrogenaseAdd BLAST445

Structurei

3D structure databases

ProteinModelPortaliP28736
SMRiP28736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105CEK Bacteria
COG0141 LUCA

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P28736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMMAKFQMS RIDLRNRVLS AAQLRSALPR GGVDVDAVVP KVRPIVDAVA
60 70 80 90 100
QRGAQAALEY GESFDGIRPE TVRVPRELLS QALENLDADV RAALQVSIDR
110 120 130 140 150
ARAVHADQRR TDTTTTLAPG ATVTERWVPV ERVGLYVPGG NAVYPSSVVM
160 170 180 190 200
NVVPAQTAGV DSMVIASPPQ GQFGGRPHPT ILAAAALLGV DEVWAVGGAQ
210 220 230 240 250
AVALLAYGGT DTDGAELAPV DMITGPGNIY VTAAKRICRS QVGIDAEAGP
260 270 280 290 300
TEIAILADHT ADPVHVAADL ISQAEHDEMA ASVLVTDSET LAEATDRELA
310 320 330 340 350
NQLATTKHVE RVTAALSGKQ SAIVLVDDID AGVRTVNAYA AEHLEIQTVD
360 370 380 390 400
APGVAGRIRS AGAIFVGAWS PVSLGDYCAG SNHVLPTAGC ARHSSGLSVQ
410 420 430 440
TFLRGIHVVE YDEAALKDVS GHVITLSKAE DLPAHGEAVR RRFER
Length:445
Mass (Da):46,703
Last modified:December 1, 1992 - v1
Checksum:i19996D28D4591170
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65542 Genomic DNA Translation: CAA46509.1
PIRiS26209
RefSeqiWP_011728895.1, NZ_CP009496.1

Similar proteinsi

Entry informationi

Entry nameiHISX_MYCSM
AccessioniPrimary (citable) accession number: P28736
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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