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P28729

- GP_SEOUR

UniProt

P28729 - GP_SEOUR

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Protein
Envelope glycoprotein
Gene
GP
Organism
Seoul virus (strain R22)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  2. signal transduction Source: InterPro
  3. suppression by virus of host TRAF activity Source: UniProtKB-KW
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiSeoul virus (strain R22)
Taxonomic identifieri31620 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 484468Lumenal Reviewed prediction
Add
BLAST
Transmembranei485 – 50420Helical; Reviewed prediction
Add
BLAST
Topological domaini505 – 646142Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini647 – 1105459Lumenal Reviewed prediction
Add
BLAST
Transmembranei1106 – 112520Helical; Reviewed prediction
Add
BLAST
Topological domaini1126 – 11349Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 11341118Envelope glycoprotein
PRO_0000036835Add
BLAST
Chaini17 – 646630Glycoprotein G1 By similarity
PRO_0000036836Add
BLAST
Chaini647 – 1134488Glycoprotein G2 By similarity
PRO_0000036837Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi345 – 3451N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi927 – 9271N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Structurei

3D structure databases

ProteinModelPortaliP28729.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28729-1 [UniParc]FASTAAdd to Basket

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MWSLLLLAAL VGQGFALKNV FDMRIQCPHS ANFGETSVSG YTELPPLSLQ     50
EAEQLVPESS CNMDNHQSLS TINKLTKVVW RKKANQESAN QNSFEVVESE 100
VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPKHACN 150
MMKSCLIGLV PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPAEEIATY QISGQIEAKI 300
PHTVSSKNLK LIAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD 350
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
PMCLVSKQNR FRAAEQQISF ICQRVDMDII VYCNGQKKTI LTKTLVMASA 450
FILLQVSFHC YQGLPIAIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MGCEICKYEC 550
ETLKELKAHN LSCVQGECPY CFTHCEPTET ATQAHYKVCQ ATHRFREDLK 600
KTVTPKKYWA RLYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
LVPLWTDNAH GVGSVPMHRN TYELDFSFPS SSKYTYKRHL TNPVNDQQSV 700
SLHIEIESQG IGADVHHLGH WYDARLNLKT SFHCYGACTK YQYPWHTAKC 750
HFEKDYEYEN SWACNPPDCP GVGTGCTACG LYLDQLKPVA TPFRIISVRY 800
SRKVCVQFGE EYLCKTIDMN DCFVTRHAKI CIIGTVSKFS QGDTLLFLGP 850
MEGGGIIFKH WCTSTCHFGD PGDVMGPKDK PFICPEFPGQ FRKKCNFATT 900
PICEYDGNII SGYKKVLATI DSFQSFNTSN IHFTDERIEW RDPDGMLRDH 950
INIVISKDID FENLAENPCK VGLQAANIEG AWGSGVGFTL TCQVSLTECP 1000
TFLTSIKACD MAICYGAESV TLSRGQNTVR ITGKGGHSGS SFKCCHGKEC 1050
SSTGLQASAP HLDKVNGISE LENEKVYDDG APECGVTCWF KKSGEWVMGI 1100
INGNWVVLIV LCVLLLFSLI LLSILCPVRK HKKS 1134
Length:1,134
Mass (Da):126,320
Last modified:December 1, 1992 - v1
Checksum:i60F4918FC42EE3ED
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2873EEI → KKF in AAB20470. 1 Publication
Sequence conflicti645 – 6451S → T in AAB20470. 1 Publication
Sequence conflicti874 – 8741V → D in AAB20470. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S68035 Genomic RNA. Translation: AAB20470.2.
PIRiA43960.
JC1006. GNVU22.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S68035 Genomic RNA. Translation: AAB20470.2 .
PIRi A43960.
JC1006. GNVU22.

3D structure databases

ProteinModelPortali P28729.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Moleculal cloning and sequencing of the M genome segment of epidemic hemorrhagic fever virus R22 strain."
    Shi L.C., Hang C.S., Li D.X., Yuan J.S., Jin D.Y., Song G.
    Ping Tu Hsueh Pao 7:295-302(1991)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Molecular characterization and expression of glycoprotein gene of Hantavirus R22 strain isolated from Rattus norvegicus in China."
    Xu X.A., Ruo S.L., Tang Y.W., Fisher-Hoch S.P., McCormick J.B.
    Virus Res. 21:35-52(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Entry informationi

Entry nameiGP_SEOUR
AccessioniPrimary (citable) accession number: P28729
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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