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P28729

- GP_SEOUR

UniProt

P28729 - GP_SEOUR

Protein

Envelope glycoprotein

Gene

GP

Organism
Seoul virus (strain R22)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    2. signal transduction Source: InterPro
    3. suppression by virus of host innate immune response Source: UniProtKB-KW
    4. suppression by virus of host TRAF activity Source: UniProtKB-KW
    5. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiSeoul virus (strain R22)
    Taxonomic identifieri31620 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    Rattus norvegicus (Rat) [TaxID: 10116]
    Rattus rattus (Black rat) [TaxID: 10117]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 11341118Envelope glycoproteinPRO_0000036835Add
    BLAST
    Chaini17 – 646630Glycoprotein G1By similarityPRO_0000036836Add
    BLAST
    Chaini647 – 1134488Glycoprotein G2By similarityPRO_0000036837Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi927 – 9271N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP28729.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 484468LumenalSequence AnalysisAdd
    BLAST
    Topological domaini505 – 646142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini647 – 1105459LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1126 – 11349CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei485 – 50420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1106 – 112520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28729-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWSLLLLAAL VGQGFALKNV FDMRIQCPHS ANFGETSVSG YTELPPLSLQ     50
    EAEQLVPESS CNMDNHQSLS TINKLTKVVW RKKANQESAN QNSFEVVESE 100
    VSFKGLCMLK HRMVEESYRN RRSVICYDLA CNSTFCKPTV YMIVPKHACN 150
    MMKSCLIGLV PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
    IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
    SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPAEEIATY QISGQIEAKI 300
    PHTVSSKNLK LIAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD 350
    NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
    PMCLVSKQNR FRAAEQQISF ICQRVDMDII VYCNGQKKTI LTKTLVMASA 450
    FILLQVSFHC YQGLPIAIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
    LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS MGCEICKYEC 550
    ETLKELKAHN LSCVQGECPY CFTHCEPTET ATQAHYKVCQ ATHRFREDLK 600
    KTVTPKKYWA RLYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
    LVPLWTDNAH GVGSVPMHRN TYELDFSFPS SSKYTYKRHL TNPVNDQQSV 700
    SLHIEIESQG IGADVHHLGH WYDARLNLKT SFHCYGACTK YQYPWHTAKC 750
    HFEKDYEYEN SWACNPPDCP GVGTGCTACG LYLDQLKPVA TPFRIISVRY 800
    SRKVCVQFGE EYLCKTIDMN DCFVTRHAKI CIIGTVSKFS QGDTLLFLGP 850
    MEGGGIIFKH WCTSTCHFGD PGDVMGPKDK PFICPEFPGQ FRKKCNFATT 900
    PICEYDGNII SGYKKVLATI DSFQSFNTSN IHFTDERIEW RDPDGMLRDH 950
    INIVISKDID FENLAENPCK VGLQAANIEG AWGSGVGFTL TCQVSLTECP 1000
    TFLTSIKACD MAICYGAESV TLSRGQNTVR ITGKGGHSGS SFKCCHGKEC 1050
    SSTGLQASAP HLDKVNGISE LENEKVYDDG APECGVTCWF KKSGEWVMGI 1100
    INGNWVVLIV LCVLLLFSLI LLSILCPVRK HKKS 1134
    Length:1,134
    Mass (Da):126,320
    Last modified:December 1, 1992 - v1
    Checksum:i60F4918FC42EE3ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti285 – 2873EEI → KKF in AAB20470. (PubMed:1962503)Curated
    Sequence conflicti645 – 6451S → T in AAB20470. (PubMed:1962503)Curated
    Sequence conflicti874 – 8741V → D in AAB20470. (PubMed:1962503)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S68035 Genomic RNA. Translation: AAB20470.2.
    PIRiA43960.
    JC1006. GNVU22.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S68035 Genomic RNA. Translation: AAB20470.2 .
    PIRi A43960.
    JC1006. GNVU22.

    3D structure databases

    ProteinModelPortali P28729.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Moleculal cloning and sequencing of the M genome segment of epidemic hemorrhagic fever virus R22 strain."
      Shi L.C., Hang C.S., Li D.X., Yuan J.S., Jin D.Y., Song G.
      Ping Tu Hsueh Pao 7:295-302(1991)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Molecular characterization and expression of glycoprotein gene of Hantavirus R22 strain isolated from Rattus norvegicus in China."
      Xu X.A., Ruo S.L., Tang Y.W., Fisher-Hoch S.P., McCormick J.B.
      Virus Res. 21:35-52(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiGP_SEOUR
    AccessioniPrimary (citable) accession number: P28729
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3