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P28729 (GP_SEOUR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismSeoul virus (strain R22)
Taxonomic identifier31620 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]
Rattus norvegicus (Rat) [TaxID: 10116]
Rattus rattus (Black rat) [TaxID: 10117]

Protein attributes

Sequence length1134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to a cell receptor and to promote fusion of membranes after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane; Single-pass type I membrane protein Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Sequence similarities

Belongs to the hantavirus envelope glycoprotein family.

Contains 1 ITAM domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 11341118Envelope glycoprotein
PRO_0000036835
Chain17 – 646630Glycoprotein G1 By similarity
PRO_0000036836
Chain647 – 1134488Glycoprotein G2 By similarity
PRO_0000036837

Regions

Topological domain17 – 484468Lumenal Potential
Transmembrane485 – 50420Helical; Potential
Topological domain505 – 646142Cytoplasmic Potential
Topological domain647 – 1105459Lumenal Potential
Transmembrane1106 – 112520Helical; Potential
Topological domain1126 – 11349Cytoplasmic Potential
Domain609 – 63224ITAM

Sites

Site646 – 6472Cleavage; by host signal peptidase By similarity

Amino acid modifications

Glycosylation1321N-linked (GlcNAc...); by host Potential
Glycosylation2331N-linked (GlcNAc...); by host Potential
Glycosylation3451N-linked (GlcNAc...); by host Potential
Glycosylation3971N-linked (GlcNAc...); by host Potential
Glycosylation9271N-linked (GlcNAc...); by host Potential

Experimental info

Sequence conflict285 – 2873EEI → KKF in AAB20470. Ref.2
Sequence conflict6451S → T in AAB20470. Ref.2
Sequence conflict8741V → D in AAB20470. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28729 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 60F4918FC42EE3ED

FASTA1,134126,320
        10         20         30         40         50         60 
MWSLLLLAAL VGQGFALKNV FDMRIQCPHS ANFGETSVSG YTELPPLSLQ EAEQLVPESS 

        70         80         90        100        110        120 
CNMDNHQSLS TINKLTKVVW RKKANQESAN QNSFEVVESE VSFKGLCMLK HRMVEESYRN 

       130        140        150        160        170        180 
RRSVICYDLA CNSTFCKPTV YMIVPKHACN MMKSCLIGLV PYRIQVVYER TYCTTGILTE 

       190        200        210        220        230        240 
GKCFVPDKAV VSALKRGMYA IASIETICFF IHQKGNTYKI VTAITSAMGS KCNNTDTKVQ 

       250        260        270        280        290        300 
GYYICIIGGN SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPAEEIATY QISGQIEAKI 

       310        320        330        340        350        360 
PHTVSSKNLK LIAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD NNALPLIWRG 

       370        380        390        400        410        420 
LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS PMCLVSKQNR FRAAEQQISF 

       430        440        450        460        470        480 
ICQRVDMDII VYCNGQKKTI LTKTLVMASA FILLQVSFHC YQGLPIAIAI ELCVPGFHGW 

       490        500        510        520        530        540 
ATAALLITFC FGWVLIPACT LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKTKGS 

       550        560        570        580        590        600 
MGCEICKYEC ETLKELKAHN LSCVQGECPY CFTHCEPTET ATQAHYKVCQ ATHRFREDLK 

       610        620        630        640        650        660 
KTVTPKKYWA RLYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP LVPLWTDNAH 

       670        680        690        700        710        720 
GVGSVPMHRN TYELDFSFPS SSKYTYKRHL TNPVNDQQSV SLHIEIESQG IGADVHHLGH 

       730        740        750        760        770        780 
WYDARLNLKT SFHCYGACTK YQYPWHTAKC HFEKDYEYEN SWACNPPDCP GVGTGCTACG 

       790        800        810        820        830        840 
LYLDQLKPVA TPFRIISVRY SRKVCVQFGE EYLCKTIDMN DCFVTRHAKI CIIGTVSKFS 

       850        860        870        880        890        900 
QGDTLLFLGP MEGGGIIFKH WCTSTCHFGD PGDVMGPKDK PFICPEFPGQ FRKKCNFATT 

       910        920        930        940        950        960 
PICEYDGNII SGYKKVLATI DSFQSFNTSN IHFTDERIEW RDPDGMLRDH INIVISKDID 

       970        980        990       1000       1010       1020 
FENLAENPCK VGLQAANIEG AWGSGVGFTL TCQVSLTECP TFLTSIKACD MAICYGAESV 

      1030       1040       1050       1060       1070       1080 
TLSRGQNTVR ITGKGGHSGS SFKCCHGKEC SSTGLQASAP HLDKVNGISE LENEKVYDDG 

      1090       1100       1110       1120       1130 
APECGVTCWF KKSGEWVMGI INGNWVVLIV LCVLLLFSLI LLSILCPVRK HKKS 

« Hide

References

[1]"Moleculal cloning and sequencing of the M genome segment of epidemic hemorrhagic fever virus R22 strain."
Shi L.C., Hang C.S., Li D.X., Yuan J.S., Jin D.Y., Song G.
Ping Tu Hsueh Pao 7:295-302(1991)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Molecular characterization and expression of glycoprotein gene of Hantavirus R22 strain isolated from Rattus norvegicus in China."
Xu X.A., Ruo S.L., Tang Y.W., Fisher-Hoch S.P., McCormick J.B.
Virus Res. 21:35-52(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S68035 Genomic RNA. Translation: AAB20470.2.
PIRA43960.
GNVU22. JC1006.

3D structure databases

ProteinModelPortalP28729.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFPIRSF003945. M_poly_HantaV. 1 hit.
ProDomPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_SEOUR
AccessionPrimary (citable) accession number: P28729
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families