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P28728

- GP_HANTB

UniProt

P28728 - GP_HANTB

Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

    GO - Biological processi

    1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. signal transduction Source: InterPro
    4. suppression by virus of host innate immune response Source: UniProtKB-KW
    5. suppression by virus of host TRAF activity Source: UniProtKB-KW
    6. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiHantaan virus (strain B-1) (Korean hemorrhagic fever virus)
    Taxonomic identifieri31617 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
    Homo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 11331117Envelope glycoproteinPRO_0000036806Add
    BLAST
    Chaini17 – 646630Glycoprotein G1By similarityPRO_0000036807Add
    BLAST
    Chaini647 – 1133487Glycoprotein G2By similarityPRO_0000036808Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi926 – 9261N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 485469LumenalSequence AnalysisAdd
    BLAST
    Topological domaini507 – 646140CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini647 – 1103457LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1125 – 11339CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1104 – 112421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28728-1 [UniParc]FASTAAdd to Basket

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    MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VNFGETSVSG YTELPPLSLQ     50
    EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFEVVESE 100
    VSFKGLCMLK HRMVEESYRN RRSVIYYDLA GNSTFCKPTV YMIVPIHACN 150
    MMKSCLIGLG PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
    IASIETICFF IHQKWNKYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
    SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY HISGQIEAKI 300
    PHTVSSKNLR LAAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD 350
    NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
    PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC 450
    IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
    LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKRKGS MVCEICKYEC 550
    ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK 600
    KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
    LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SKYTYKRHLT NPVNDQQSVS 700
    LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH 750
    FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS 800
    RKVCVQFGEE HLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM 850
    EGGGIIFKHW CTSTCHFGDP RDVMGPKDKP FICPEFPGQF RKKCNFATTP 900
    VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI 950
    NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT 1000
    FLTSIKACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS 1050
    STGLQASAPH LDKVNGISEL ENEKVYDDGA PECGVTCWFK KSGEWVMGII 1100
    NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS 1133
    Length:1,133
    Mass (Da):125,909
    Last modified:December 1, 1992 - v1
    Checksum:i0A25160A32862FD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53861 mRNA. Translation: CAA37854.1.
    PIRiS12597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X53861 mRNA. Translation: CAA37854.1 .
    PIRi S12597.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1."
      Isegawa Y., Fujiwara Y., Ohshima A., Fukunaga R., Murakami H., Yamanishi K., Sokawa Y.
      Nucleic Acids Res. 18:4936-4936(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGP_HANTB
    AccessioniPrimary (citable) accession number: P28728
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3