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P28728

- GP_HANTB

UniProt

P28728 - GP_HANTB

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Protein

Envelope glycoprotein

Gene
GP
Organism
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidase By similarity

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. signal transduction Source: InterPro
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. suppression by virus of host TRAF activity Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain B-1) (Korean hemorrhagic fever virus)
Taxonomic identifieri31617 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane; Single-pass type I membrane protein Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 485469Lumenal Reviewed predictionAdd
BLAST
Transmembranei486 – 50621Helical; Reviewed predictionAdd
BLAST
Topological domaini507 – 646140Cytoplasmic Reviewed predictionAdd
BLAST
Topological domaini647 – 1103457Lumenal Reviewed predictionAdd
BLAST
Transmembranei1104 – 112421Helical; Reviewed predictionAdd
BLAST
Topological domaini1125 – 11339Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. host cell Golgi membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 11331117Envelope glycoproteinPRO_0000036806Add
BLAST
Chaini17 – 646630Glycoprotein G1 By similarityPRO_0000036807Add
BLAST
Chaini647 – 1133487Glycoprotein G2 By similarityPRO_0000036808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi345 – 3451N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi397 – 3971N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi926 – 9261N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAMAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28728-1 [UniParc]FASTAAdd to Basket

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MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VNFGETSVSG YTELPPLSLQ     50
EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFEVVESE 100
VSFKGLCMLK HRMVEESYRN RRSVIYYDLA GNSTFCKPTV YMIVPIHACN 150
MMKSCLIGLG PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA 200
IASIETICFF IHQKWNKYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN 250
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY HISGQIEAKI 300
PHTVSSKNLR LAAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD 350
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS 400
PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC 450
IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT 500
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKRKGS MVCEICKYEC 550
ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK 600
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP 650
LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SKYTYKRHLT NPVNDQQSVS 700
LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH 750
FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS 800
RKVCVQFGEE HLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM 850
EGGGIIFKHW CTSTCHFGDP RDVMGPKDKP FICPEFPGQF RKKCNFATTP 900
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI 950
NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT 1000
FLTSIKACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS 1050
STGLQASAPH LDKVNGISEL ENEKVYDDGA PECGVTCWFK KSGEWVMGII 1100
NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS 1133
Length:1,133
Mass (Da):125,909
Last modified:December 1, 1992 - v1
Checksum:i0A25160A32862FD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53861 mRNA. Translation: CAA37854.1.
PIRiS12597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X53861 mRNA. Translation: CAA37854.1 .
PIRi S12597.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1."
    Isegawa Y., Fujiwara Y., Ohshima A., Fukunaga R., Murakami H., Yamanishi K., Sokawa Y.
    Nucleic Acids Res. 18:4936-4936(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGP_HANTB
AccessioniPrimary (citable) accession number: P28728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 19, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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