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P28728

- GP_HANTB

UniProt

P28728 - GP_HANTB

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Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei646 – 6472Cleavage; by host signal peptidaseBy similarity

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. signal transduction Source: InterPro
  4. suppression by virus of host innate immune response Source: UniProtKB-KW
  5. suppression by virus of host TRAF activity Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain B-1) (Korean hemorrhagic fever virus)
Taxonomic identifieri31617 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Curated; Single-pass type I membrane protein Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 485469LumenalSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Topological domaini507 – 646140CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini647 – 1103457LumenalSequence AnalysisAdd
BLAST
Transmembranei1104 – 112421HelicalSequence AnalysisAdd
BLAST
Topological domaini1125 – 11339CytoplasmicSequence Analysis

GO - Cellular componenti

  1. host cell endoplasmic reticulum Source: UniProtKB-KW
  2. host cell Golgi apparatus Source: UniProtKB-KW
  3. host cell membrane Source: UniProtKB-KW
  4. integral component of membrane Source: UniProtKB-KW
  5. viral envelope Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 11331117Envelope glycoproteinPRO_0000036806Add
BLAST
Chaini17 – 646630Glycoprotein G1By similarityPRO_0000036807Add
BLAST
Chaini647 – 1133487Glycoprotein G2By similarityPRO_0000036808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi397 – 3971N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi926 – 9261N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini609 – 63224ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28728-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MWSLLLLAAL VGQGFALKNV FDMRIQCPHS VNFGETSVSG YTELPPLSLQ
60 70 80 90 100
EAEQLVPESS CNMDNHQSLS TINKLTKVIW RKKANQESAN QNSFEVVESE
110 120 130 140 150
VSFKGLCMLK HRMVEESYRN RRSVIYYDLA GNSTFCKPTV YMIVPIHACN
160 170 180 190 200
MMKSCLIGLG PYRIQVVYER TYCTTGILTE GKCFVPDKAV VSALKRGMYA
210 220 230 240 250
IASIETICFF IHQKWNKYKI VTAITSAMGS KCNNTDTKVQ GYYICIIGGN
260 270 280 290 300
SAPVYAPAGE DFRAMEVFSG IITSPHGEDH DLPGEEIATY HISGQIEAKI
310 320 330 340 350
PHTVSSKNLR LAAFAGIPSY SSTSILAASE DGRFIFSPGL FPNLNQSVCD
360 370 380 390 400
NNALPLIWRG LIDLTGYYEA VHPCNVFCVL SGPGASCEAF SEGGIFNITS
410 420 430 440 450
PMCLVSKQNR FRAAEQQISF VCQRVDMDII VYCNGQKKTI LTKTLVIGQC
460 470 480 490 500
IYTITSLFSL LPGVAHSIAI ELCVPGFHGW ATAALLITFC FGWVLIPACT
510 520 530 540 550
LAILLVLKFF ANILHTSNQE NRFKAILRKI KEEFEKRKGS MVCEICKYEC
560 570 580 590 600
ETLKELKAHN LSCVQGECPY CFTHCEPTET AIQAHYKVCQ ATHRFREDLK
610 620 630 640 650
KTVTPQNIGP GCYRTLNLFR YKSRCYILTM WTLLLIIESI LWAASAAEIP
660 670 680 690 700
LVPLWTDNAH GVGSVPMHTD LELDFSLPSS SKYTYKRHLT NPVNDQQSVS
710 720 730 740 750
LHIEIESQGI GADVHHLGHW YDARLNLKTS FHCYGACTKY QYPWHTAKCH
760 770 780 790 800
FEKDYEYENS WACNPPDCPG VGTGCTACGL YLDQLKPVGT AFKIISVRYS
810 820 830 840 850
RKVCVQFGEE HLCKTIDMND CFVTRHAKIC IIGTVSKFSQ GDTLLFLGPM
860 870 880 890 900
EGGGIIFKHW CTSTCHFGDP RDVMGPKDKP FICPEFPGQF RKKCNFATTP
910 920 930 940 950
VCEYDGNIIS GYKKVLATID SFQSFNTSNI HFTDERIEWR DPDGMLRDHI
960 970 980 990 1000
NIVISKDIDF ENLAENPCKV GLQAANIEGA WGSGVGFTLT CQVSLTECPT
1010 1020 1030 1040 1050
FLTSIKACDM AICYGAESVT LSRGQNTVKI TGKGGHSGSS FKCCHGKECS
1060 1070 1080 1090 1100
STGLQASAPH LDKVNGISEL ENEKVYDDGA PECGVTCWFK KSGEWVMGII
1110 1120 1130
NGNWVVLIVL CVLLLFSLIL LSILCPVRKH KKS
Length:1,133
Mass (Da):125,909
Last modified:December 1, 1992 - v1
Checksum:i0A25160A32862FD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53861 mRNA. Translation: CAA37854.1.
PIRiS12597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53861 mRNA. Translation: CAA37854.1 .
PIRi S12597.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the M genome segment of hemorrhagic fever with renal syndrome virus strain B-1."
    Isegawa Y., Fujiwara Y., Ohshima A., Fukunaga R., Murakami H., Yamanishi K., Sokawa Y.
    Nucleic Acids Res. 18:4936-4936(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGP_HANTB
AccessioniPrimary (citable) accession number: P28728
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3