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P28724

- DHE4_GIAIN

UniProt

P28724 - DHE4_GIAIN

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Protein
NADP-specific glutamate dehydrogenase
Gene
N/A
Organism
Giardia intestinalis (Giardia lamblia)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei125 – 1251 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
OrganismiGiardia intestinalis (Giardia lamblia)
Taxonomic identifieri5741 [NCBI]
Taxonomic lineageiEukaryotaDiplomonadidaHexamitidaeGiardiinaeGiardia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449NADP-specific glutamate dehydrogenase
PRO_0000182786Add
BLAST

Proteomic databases

PRIDEiP28724.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP28724.
SMRiP28724. Positions 4-449.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28724-1 [UniParc]FASTAAdd to Basket

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MPAQTIEELI AVIKQRDGHM TEFRQAVEEV VDSLKVIFER EPKYIPIFER    50
MLEPERVIIF RVPWMDDAGR INVNRGFRVQ YNSALGPYKG GLRFHPSVNL 100
SILKFLGFEQ ILKNSLTTLP MGGGKGGSDF DPKGKSDNEV MRFCQSFMTE 150
LQRHVGADTD VPAGDIGVGA REIGYLYGQY KRLRNEFTGV LTGKNVKWGG 200
SFIRPEATGY GAVYFLEEMC KDNNTVIRGK NVLLSGSGNV AQFACEKLIQ 250
LGAKVLTFSD SNGTIVDKDG FNEEKLAHLM YLKNEKRGRV SEFKDKYPSV 300
AYYEGKKPWE CFEGQMDCIM PCATQNEVSG DDATRLVGLG LKFVAEGANM 350
PSTAEAVHVY HAKGVMYGPA KASNAGGVSV SGLEMSQNSV RLQWTAEEVD 400
QKLRGIMRGI FVACRDTAKK YGHPKNYQMG ANIAGFLKVA DSMIEQGCV 449
Length:449
Mass (Da):49,766
Last modified:December 1, 1992 - v1
Checksum:i5497B35209B549F6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491I → L in AAB05400. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84604 mRNA. Translation: AAA29155.1.
U47632 Genomic DNA. Translation: AAB05400.1.
PIRiA42489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84604 mRNA. Translation: AAA29155.1 .
U47632 Genomic DNA. Translation: AAB05400.1 .
PIRi A42489.

3D structure databases

ProteinModelPortali P28724.
SMRi P28724. Positions 4-449.
ModBasei Search...

Proteomic databases

PRIDEi P28724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a NADP-dependent glutamate dehydrogenase gene from the primitive eucaryote Giardia lamblia."
    Yee J., Dennis P.P.
    J. Biol. Chem. 267:7539-7544(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Molecular genetic analysis of Giardia intestinalis isolates at the glutamate dehydrogenase locus."
    Monis P.T., Mayrhofer G., Andrews R.H., Homan W.L., Limper L., Ey P.L.
    Parasitology 112:1-12(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 59-261.

Entry informationi

Entry nameiDHE4_GIAIN
AccessioniPrimary (citable) accession number: P28724
Secondary accession number(s): Q24961
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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