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Protein

Uncharacterized fimbrial chaperone YhcA

Gene

yhcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could be required for the biogenesis of a putative fimbria.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Enzyme and pathway databases

BioCyciEcoCyc:EG11515-MONOMER.
ECOL316407:JW3182-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized fimbrial chaperone YhcA
Gene namesi
Name:yhcA
Ordered Locus Names:b3215, JW3182
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11515. yhcA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 224205Uncharacterized fimbrial chaperone YhcAPRO_0000009295Add
BLAST

Proteomic databases

PaxDbiP28722.
PRIDEiP28722.

Interactioni

Protein-protein interaction databases

BioGridi4259287. 6 interactions.
IntActiP28722. 14 interactions.
STRINGi511145.b3215.

Structurei

3D structure databases

ProteinModelPortaliP28722.
SMRiP28722. Positions 39-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG4108S1B. Bacteria.
ENOG4111FTJ. LUCA.
HOGENOMiHOG000260652.
OMAiLPHAWIL.
PhylomeDBiP28722.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR016148. Pili_assmbl_chaperone_C.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF00345. PapD_N. 1 hit.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRHITFTVF ITTSMNTLAT GMVPETSVLL VDEKRGEASI NIKNTDDHPS
60 70 80 90 100
LLYTTIVDLP ESNKSIRLIP TQPVIRVEAG QVQQVRFLLQ ATVPLQSEEL
110 120 130 140 150
KRVTFEGIPP KDDKSSRVTV SIRQDLPVLI HPASLPEERE TWKFLEWRKN
160 170 180 190 200
GDQIEISNPS NYVVRMTLQF KTLPSGKTGA INKTYFLPHT STTTALTNAT
210 220
DTKVEFYPAS RYGYRGNKYV TDLK
Length:224
Mass (Da):25,339
Last modified:November 1, 1995 - v2
Checksum:iCFD7E170E7C99684
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 5835PETSV…TTIVD → LKHQYCWLMKSVVKLVLILR IQMIILHCFTPPLLI (PubMed:1447980).CuratedAdd
BLAST
Sequence conflicti204 – 22421VEFYP…VTDLK → GRVLPSQPIWLSR in AAA23910 (PubMed:1447980).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74162 Genomic DNA. Translation: AAA23910.1.
U18997 Genomic DNA. Translation: AAA58017.1.
U00096 Genomic DNA. Translation: AAC76247.1.
AP009048 Genomic DNA. Translation: BAE77259.1.
PIRiA65113.
RefSeqiNP_417682.1. NC_000913.3.
WP_001311157.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76247; AAC76247; b3215.
BAE77259; BAE77259; BAE77259.
GeneIDi947741.
KEGGiecj:JW3182.
eco:b3215.
PATRICi32121852. VBIEscCol129921_3310.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74162 Genomic DNA. Translation: AAA23910.1.
U18997 Genomic DNA. Translation: AAA58017.1.
U00096 Genomic DNA. Translation: AAC76247.1.
AP009048 Genomic DNA. Translation: BAE77259.1.
PIRiA65113.
RefSeqiNP_417682.1. NC_000913.3.
WP_001311157.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP28722.
SMRiP28722. Positions 39-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259287. 6 interactions.
IntActiP28722. 14 interactions.
STRINGi511145.b3215.

Proteomic databases

PaxDbiP28722.
PRIDEiP28722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76247; AAC76247; b3215.
BAE77259; BAE77259; BAE77259.
GeneIDi947741.
KEGGiecj:JW3182.
eco:b3215.
PATRICi32121852. VBIEscCol129921_3310.

Organism-specific databases

EchoBASEiEB1477.
EcoGeneiEG11515. yhcA.

Phylogenomic databases

eggNOGiENOG4108S1B. Bacteria.
ENOG4111FTJ. LUCA.
HOGENOMiHOG000260652.
OMAiLPHAWIL.
PhylomeDBiP28722.

Enzyme and pathway databases

BioCyciEcoCyc:EG11515-MONOMER.
ECOL316407:JW3182-MONOMER.

Miscellaneous databases

PROiP28722.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR016148. Pili_assmbl_chaperone_C.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF00345. PapD_N. 1 hit.
[Graphical view]
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYHCA_ECOLI
AccessioniPrimary (citable) accession number: P28722
Secondary accession number(s): Q2M8Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.