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P28718 (G6PI_ZYMMO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:ZMO1212
OrganismZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) [Complete proteome] [HAMAP]
Taxonomic identifier264203 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides a gateway for fructose into the Entner-Doudouroff pathway. HAMAP-Rule MF_00473

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180777

Sites

Active site3381Proton donor By similarity
Active site3691 By similarity
Active site4791 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28718 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 5B4E3B1C3CC09399

FASTA50755,399
        10         20         30         40         50         60 
MARIANKAAI DAAWKQVSAC SEKTLKQLFE EDSNRLSGLV VETAKLRFDF SKNHLDSQKL 

        70         80         90        100        110        120 
TAFKKLLEAC DFDARRKALF AGEKINITED RAVEHMAERG QGAPASVARA KEYHARMRTL 

       130        140        150        160        170        180 
IEAIDAGAFG EVKHLLHIGI GGSALGPKLL IDALTRESGR YDVAVVSNVD GQALEEVFKK 

       190        200        210        220        230        240 
FNPHKTLIAV ASKTFTTAET MLNAESAMEW MKKHGVEDPQ GRMIALTANP AKASEMGIDD 

       250        260        270        280        290        300 
TRILPFAESI GGRYSLWSSI GFPAALALGW EGFQQLLEGG AAMDRHFLEA APEKNAPILA 

       310        320        330        340        350        360 
AFADQYYSAV RGAQTHGIFA YDERLQLLPF YLQQLEMESN GKRVDLDGNL IDHPSAFITW 

       370        380        390        400        410        420 
GGVGTDAQHA VFQLLHQGTR LVPIEFIAAI KADDTLNPVH HKTLLTNAFA QGAALMSGRD 

       430        440        450        460        470        480 
NKDPARSYPG DRPSTTILME ELRPAQLGAL IAFYEHRTFT NGVLLGINSF DQFGVELGKE 

       490        500 
MAHAIADHPE NSDFDPSTKA LIAAALK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and nucleotide sequence analysis of a Zymomonas mobilis phosphoglucose isomerase gene that is subject to carbon source-dependent regulation."
Hesman T.L., Barnell W.O., Conway T.
J. Bacteriol. 173:3215-3223(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4."
Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. expand/collapse author list , Kang H.L., Lee S.Y., Lee K.J., Kang H.S.
Nat. Biotechnol. 23:63-68(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M62957 Genomic DNA. Translation: AAA27698.1.
AE008692 Genomic DNA. Translation: AAV89836.1.
PIRA39411.
RefSeqYP_162947.1. NC_006526.2.

3D structure databases

ProteinModelPortalP28718.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING264203.ZMO1212.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAV89836; AAV89836; ZMO1212.
GeneID3187968.
KEGGzmo:ZMO1212.
PATRIC32567718. VBIZymMob102260_1148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261370.
KOK01810.
OMANCHFVAN.
OrthoDBEOG64R61J.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_ZYMMO
AccessionPrimary (citable) accession number: P28718
Secondary accession number(s): Q5NN74
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways