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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Provides a gateway for fructose into the Entner-Doudouroff pathway.

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei338 – 3381Proton donorBy similarity
Active sitei369 – 3691By similarity
Active sitei479 – 4791By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:ZMO1212
OrganismiZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Taxonomic identifieri264203 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
ProteomesiUP000001173: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Glucose-6-phosphate isomerasePRO_0000180777Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264203.ZMO1212.

Structurei

3D structure databases

ProteinModelPortaliP28718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28718-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARIANKAAI DAAWKQVSAC SEKTLKQLFE EDSNRLSGLV VETAKLRFDF
60 70 80 90 100
SKNHLDSQKL TAFKKLLEAC DFDARRKALF AGEKINITED RAVEHMAERG
110 120 130 140 150
QGAPASVARA KEYHARMRTL IEAIDAGAFG EVKHLLHIGI GGSALGPKLL
160 170 180 190 200
IDALTRESGR YDVAVVSNVD GQALEEVFKK FNPHKTLIAV ASKTFTTAET
210 220 230 240 250
MLNAESAMEW MKKHGVEDPQ GRMIALTANP AKASEMGIDD TRILPFAESI
260 270 280 290 300
GGRYSLWSSI GFPAALALGW EGFQQLLEGG AAMDRHFLEA APEKNAPILA
310 320 330 340 350
AFADQYYSAV RGAQTHGIFA YDERLQLLPF YLQQLEMESN GKRVDLDGNL
360 370 380 390 400
IDHPSAFITW GGVGTDAQHA VFQLLHQGTR LVPIEFIAAI KADDTLNPVH
410 420 430 440 450
HKTLLTNAFA QGAALMSGRD NKDPARSYPG DRPSTTILME ELRPAQLGAL
460 470 480 490 500
IAFYEHRTFT NGVLLGINSF DQFGVELGKE MAHAIADHPE NSDFDPSTKA

LIAAALK
Length:507
Mass (Da):55,399
Last modified:December 1, 1992 - v1
Checksum:i5B4E3B1C3CC09399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62957 Genomic DNA. Translation: AAA27698.1.
AE008692 Genomic DNA. Translation: AAV89836.1.
PIRiA39411.
RefSeqiWP_011241031.1. NC_006526.2.
YP_162947.1. NC_006526.2.

Genome annotation databases

EnsemblBacteriaiAAV89836; AAV89836; ZMO1212.
GeneIDi3187968.
KEGGizmo:ZMO1212.
PATRICi32567718. VBIZymMob102260_1148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62957 Genomic DNA. Translation: AAA27698.1.
AE008692 Genomic DNA. Translation: AAV89836.1.
PIRiA39411.
RefSeqiWP_011241031.1. NC_006526.2.
YP_162947.1. NC_006526.2.

3D structure databases

ProteinModelPortaliP28718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi264203.ZMO1212.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAV89836; AAV89836; ZMO1212.
GeneIDi3187968.
KEGGizmo:ZMO1212.
PATRICi32567718. VBIZymMob102260_1148.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261370.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and nucleotide sequence analysis of a Zymomonas mobilis phosphoglucose isomerase gene that is subject to carbon source-dependent regulation."
    Hesman T.L., Barnell W.O., Conway T.
    J. Bacteriol. 173:3215-3223(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 31821 / ZM4 / CP4.

Entry informationi

Entry nameiG6PI_ZYMMO
AccessioniPrimary (citable) accession number: P28718
Secondary accession number(s): Q5NN74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.