Reviewed, UniProtKB/Swiss-Prot P28718 (G6PI_ZYMMO)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase
      Short name=GPI
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase
      Short name=PGI
    Phosphohexose isomerase
      Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	ZMO1212

Organism

Zymomonas mobilis [Complete proteome] [HAMAP]

Taxonomic identifier

542 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Sphingomonadales › Sphingomonadaceae › Zymomonas

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides a gateway for fructose into the Entner-Doudouroff pathway. HAMAP MF_00473
Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm. HAMAP MF_00473
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_0000180777
Sites
	Active site	338	1	Proton donor By similarity
	Active site	369	1	By similarity
	Active site	479	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28718-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 5B4E3B1C3CC09399	FASTA	507	55,399
	10 20 30 40 50 60 MARIANKAAI DAAWKQVSAC SEKTLKQLFE EDSNRLSGLV VETAKLRFDF SKNHLDSQKL 70 80 90 100 110 120 TAFKKLLEAC DFDARRKALF AGEKINITED RAVEHMAERG QGAPASVARA KEYHARMRTL 130 140 150 160 170 180 IEAIDAGAFG EVKHLLHIGI GGSALGPKLL IDALTRESGR YDVAVVSNVD GQALEEVFKK 190 200 210 220 230 240 FNPHKTLIAV ASKTFTTAET MLNAESAMEW MKKHGVEDPQ GRMIALTANP AKASEMGIDD 250 260 270 280 290 300 TRILPFAESI GGRYSLWSSI GFPAALALGW EGFQQLLEGG AAMDRHFLEA APEKNAPILA 310 320 330 340 350 360 AFADQYYSAV RGAQTHGIFA YDERLQLLPF YLQQLEMESN GKRVDLDGNL IDHPSAFITW 370 380 390 400 410 420 GGVGTDAQHA VFQLLHQGTR LVPIEFIAAI KADDTLNPVH HKTLLTNAFA QGAALMSGRD 430 440 450 460 470 480 NKDPARSYPG DRPSTTILME ELRPAQLGAL IAFYEHRTFT NGVLLGINSF DQFGVELGKE 490 500 MAHAIADHPE NSDFDPSTKA LIAAALK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and nucleotide sequence analysis of a Zymomonas mobilis phosphoglucose isomerase gene that is subject to carbon source-dependent regulation." Hesman T.L., Barnell W.O., Conway T. J. Bacteriol. 173:3215-3223(1991) [PubMed: 1708765] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4." Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H., Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J., Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y. , Kang H.L., Lee S.Y., Lee K.J., Kang H.S. Nat. Biotechnol. 23:63-68(2005) [PubMed: 15592456] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 31821 / ZM4 / CP4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M62957 Genomic DNA. Translation: AAA27698.1. AE008692 Genomic DNA. Translation: AAV89836.1.
PIR	A39411.
RefSeq	YP_162947.1.
3D structure databases
HSSP	HSSP built from PDB template 1GZD based on UniProtKB P08059.
ModBase	Search...
Genome annotation databases
GeneID	3187968.
GenomeReviews	Gene locus ZMO1212 in contig AE008692_GR.
KEGG	zmo:ZMO1212.
NMPDR	fig|264203.3.peg.405.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P28718.
OMA	GPKIVSQ.
Enzyme and pathway databases
BioCyc	ZMOB264203:ZMO1212-MON.
BRENDA	5.3.1.9. 1658.
Family and domain databases
HAMAP	MF_00473. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ZYMMO

Accession

Primary (citable) accession number: P28718
Secondary accession number(s): Q5NN74

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)