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Protein

DNA repair protein complementing XP-G cells

Gene

ERCC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30Magnesium 1By similarity1
Metal bindingi77Magnesium 1By similarity1
Metal bindingi789Magnesium 1By similarity1
Metal bindingi791Magnesium 1By similarity1
Metal bindingi810Magnesium 2By similarity1
Metal bindingi812Magnesium 2By similarity1
Metal bindingi861Magnesium 2By similarity1

GO - Molecular functioni

  • bubble DNA binding Source: UniProtKB
  • double-stranded DNA binding Source: UniProtKB
  • endodeoxyribonuclease activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein homodimerization activity Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
  • nucleotide-excision repair, DNA incision Source: Reactome
  • nucleotide-excision repair, DNA incision, 3'-to lesion Source: UniProtKB
  • nucleotide-excision repair, DNA incision, 5'-to lesion Source: Reactome
  • nucleotide-excision repair, preincision complex assembly Source: Reactome
  • nucleotide-excision repair, preincision complex stabilization Source: Reactome
  • response to UV Source: UniProtKB
  • response to UV-C Source: UniProtKB
  • transcription-coupled nucleotide-excision repair Source: UniProtKB
  • UV protection Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

DNA-binding, Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134899-MONOMER.
ReactomeiR-HSA-5696395. Formation of Incision Complex in GG-NER.
R-HSA-5696400. Dual Incision in GG-NER.
R-HSA-6782135. Dual incision in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein complementing XP-G cells (EC:3.1.-.-)
Alternative name(s):
DNA excision repair protein ERCC-5
Xeroderma pigmentosum group G-complementing protein
Gene namesi
Name:ERCC5
Synonyms:ERCM2, XPG, XPGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:3437. ERCC5.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Xeroderma pigmentosum complementation group G (XP-G)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-G patients present features of Cockayne syndrome, cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex.
See also OMIM:278780
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07577328A → D in XP-G; patient cells show a strong DNA repair defect in response to UV light but not in response to oxidative stress; decreased nucleotide-excision repair activity. 1 PublicationCorresponds to variant rs267607281dbSNPEnsembl.1
Natural variantiVAR_01528072P → H in XP-G; combined with features of Cockayne syndrome. 1 PublicationCorresponds to variant rs121434574dbSNPEnsembl.1
Natural variantiVAR_007733792A → V in XP-G; mild form. 2 PublicationsCorresponds to variant rs121434571dbSNPEnsembl.1
Natural variantiVAR_017097858L → P in XP-G; reduced stability and greatly impaired endonuclease activity. 1 PublicationCorresponds to variant rs121434575dbSNPEnsembl.1
Natural variantiVAR_017096874A → T in XP-G; mild form; residual activity. 1 PublicationCorresponds to variant rs28929496dbSNPEnsembl.1
Natural variantiVAR_075774968W → C in XP-G; patient cells show a strong DNA repair defect in response to UV light but not in response to oxidative stress; decreased nucleotide-excision repair activity. 1 PublicationCorresponds to variant rs267607280dbSNPEnsembl.1
Cerebro-oculo-facio-skeletal syndrome 3 (COFS3)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.
See also OMIM:616570

Keywords - Diseasei

Cockayne syndrome, Deafness, Disease mutation, Dwarfism, Xeroderma pigmentosum

Organism-specific databases

DisGeNETi2073.
MalaCardsiERCC5.
MIMi278780. phenotype.
616570. phenotype.
OpenTargetsiENSG00000134899.
Orphaneti1466. COFS syndrome.
276267. Xeroderma pigmentosum complementation group G.
PharmGKBiPA27851.

Chemistry databases

ChEMBLiCHEMBL4736.

Polymorphism and mutation databases

BioMutaiERCC5.
DMDMi205371791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001540311 – 1186DNA repair protein complementing XP-G cellsAdd BLAST1186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8N6-acetyllysineCombined sources1
Modified residuei384PhosphoserineBy similarity1
Modified residuei705PhosphoserineBy similarity1
Modified residuei1069PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP28715.
MaxQBiP28715.
PaxDbiP28715.
PeptideAtlasiP28715.
PRIDEiP28715.

PTM databases

iPTMnetiP28715.
PhosphoSitePlusiP28715.

Expressioni

Gene expression databases

BgeeiENSG00000134899.
CleanExiHS_ERCC5.
ExpressionAtlasiP28715. baseline and differential.
GenevisibleiP28715. HS.

Organism-specific databases

HPAiHPA045845.
HPA050374.

Interactioni

Subunit structurei

Interacts with PCNA.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • protein N-terminus binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108385. 21 interactors.
DIPiDIP-750N.
IntActiP28715. 10 interactors.
MINTiMINT-192239.
STRINGi9606.ENSP00000347978.

Chemistry databases

BindingDBiP28715.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EKFX-ray2.00B/C1054-1077[»]
5EKGX-ray2.80B/C1168-1186[»]
ProteinModelPortaliP28715.
SMRiP28715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 95N-domainAdd BLAST95
Regioni753 – 881I-domainAdd BLAST129
Regioni981 – 1009Interaction with PCNA1 PublicationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1057 – 1073Nuclear localization signalSequence analysisAdd BLAST17

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2520. Eukaryota.
COG0258. LUCA.
GeneTreeiENSGT00640000091542.
HOVERGENiHBG051501.
InParanoidiP28715.
KOiK10846.
OMAiEAQCCEL.
OrthoDBiEOG091G0OMB.
PhylomeDBiP28715.
TreeFamiTF101235.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
PR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P28715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVQGLWKLL ECSGRQVSPE ALEGKILAVD ISIWLNQALK GVRDRHGNSI
60 70 80 90 100
ENPHLLTLFH RLCKLLFFRI RPIFVFDGDA PLLKKQTLVK RRQRKDLASS
110 120 130 140 150
DSRKTTEKLL KTFLKRQAIK TAFRSKRDEA LPSLTQVRRE NDLYVLPPLQ
160 170 180 190 200
EEEKHSSEEE DEKEWQERMN QKQALQEEFF HNPQAIDIES EDFSSLPPEV
210 220 230 240 250
KHEILTDMKE FTKRRRTLFE AMPEESDDFS QYQLKGLLKK NYLNQHIEHV
260 270 280 290 300
QKEMNQQHSG HIRRQYEDEG GFLKEVESRR VVSEDTSHYI LIKGIQAKTV
310 320 330 340 350
AEVDSESLPS SSKMHGMSFD VKSSPCEKLK TEKEPDATPP SPRTLLAMQA
360 370 380 390 400
ALLGSSSEEE LESENRRQAR GRNAPAAVDE GSISPRTLSA IKRALDDDED
410 420 430 440 450
VKVCAGDDVQ TGGPGAEEMR INSSTENSDE GLKVRDGKGI PFTATLASSS
460 470 480 490 500
VNSAEEHVAS TNEGREPTDS VPKEQMSLVH VGTEAFPISD ESMIKDRKDR
510 520 530 540 550
LPLESAVVRH SDAPGLPNGR ELTPASPTCT NSVSKNETHA EVLEQQNELC
560 570 580 590 600
PYESKFDSSL LSSDDETKCK PNSASEVIGP VSLQETSSIV SVPSEAVDNV
610 620 630 640 650
ENVVSFNAKE HENFLETIQE QQTTESAGQD LISIPKAVEP MEIDSEESES
660 670 680 690 700
DGSFIEVQSV ISDEELQAEF PETSKPPSEQ GEEELVGTRE GEAPAESESL
710 720 730 740 750
LRDNSERDDV DGEPQEAEKD AEDSLHEWQD INLEELETLE SNLLAQQNSL
760 770 780 790 800
KAQKQQQERI AATVTGQMFL ESQELLRLFG IPYIQAPMEA EAQCAILDLT
810 820 830 840 850
DQTSGTITDD SDIWLFGARH VYRNFFNKNK FVEYYQYVDF HNQLGLDRNK
860 870 880 890 900
LINLAYLLGS DYTEGIPTVG CVTAMEILNE FPGHGLEPLL KFSEWWHEAQ
910 920 930 940 950
KNPKIRPNPH DTKVKKKLRT LQLTPGFPNP AVAEAYLKPV VDDSKGSFLW
960 970 980 990 1000
GKPDLDKIRE FCQRYFGWNR TKTDESLFPV LKQLDAQQTQ LRIDSFFRLA
1010 1020 1030 1040 1050
QQEKEDAKRI KSQRLNRAVT CMLRKEKEAA ASEIEAVSVA MEKEFELLDK
1060 1070 1080 1090 1100
AKGKTQKRGI TNTLEESSSL KRKRLSDSKG KNTCGGFLGE TCLSESSDGS
1110 1120 1130 1140 1150
SSEDAESSSL MNVQRRTAAK EPKTSASDSQ NSVKEAPVKN GGATTSSSSD
1160 1170 1180
SDDDGGKEKM VLVTARSVFG KKRRKLRRAR GRKRKT
Length:1,186
Mass (Da):133,108
Last modified:September 2, 2008 - v3
Checksum:iB0A844D617C53F2E
GO
Isoform 2 (identifier: P28715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-767: Missing.

Show »
Length:419
Mass (Da):47,319
Checksum:iA26C01C3C1DFAC28
GO
Isoform 3 (identifier: P28715-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-232: ESDDFSQY → VYLPLLQP
     233-1186: Missing.

Note: No experimental confirmation available. Includes a cryptic exon found in intron 6.
Show »
Length:232
Mass (Da):27,259
Checksum:iE2808BE7528D94F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → P in BAA03812 (PubMed:7510366).Curated1
Sequence conflicti120 – 122KTA → QTS in BAA03812 (PubMed:7510366).Curated3
Sequence conflicti126K → Q in BAA03812 (PubMed:7510366).Curated1
Sequence conflicti264 – 266RQY → SSH in BAA03812 (PubMed:7510366).Curated3
Sequence conflicti760I → F in BAA03812 (PubMed:7510366).Curated1
Sequence conflicti796I → V in BAA03812 (PubMed:7510366).Curated1
Sequence conflicti864 – 872EGIPTVGCV → GNTNCGLC in BAA03812 (PubMed:7510366).Curated9
Sequence conflicti959R → S in BAA03812 (PubMed:7510366).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07577328A → D in XP-G; patient cells show a strong DNA repair defect in response to UV light but not in response to oxidative stress; decreased nucleotide-excision repair activity. 1 PublicationCorresponds to variant rs267607281dbSNPEnsembl.1
Natural variantiVAR_01528072P → H in XP-G; combined with features of Cockayne syndrome. 1 PublicationCorresponds to variant rs121434574dbSNPEnsembl.1
Natural variantiVAR_020431145V → I.Corresponds to variant rs4987063dbSNPEnsembl.1
Natural variantiVAR_023120181H → R.1 PublicationCorresponds to variant rs4150295dbSNPEnsembl.1
Natural variantiVAR_007732254M → V.4 PublicationsCorresponds to variant rs1047769dbSNPEnsembl.1
Natural variantiVAR_020432256Q → R.1 PublicationCorresponds to variant rs4150313dbSNPEnsembl.1
Natural variantiVAR_014829311S → C.1 PublicationCorresponds to variant rs2307491dbSNPEnsembl.1
Natural variantiVAR_023121399E → K.1 PublicationCorresponds to variant rs4150315dbSNPEnsembl.1
Natural variantiVAR_020433529C → S.1 PublicationCorresponds to variant rs2227869dbSNPEnsembl.1
Natural variantiVAR_023122590V → I.1 PublicationCorresponds to variant rs4150318dbSNPEnsembl.1
Natural variantiVAR_023123597V → L.1 PublicationCorresponds to variant rs4150319dbSNPEnsembl.1
Natural variantiVAR_046373670F → L.Corresponds to variant rs1803542dbSNPEnsembl.1
Natural variantiVAR_020434680Q → R.Corresponds to variant rs4987168dbSNPEnsembl.1
Natural variantiVAR_007733792A → V in XP-G; mild form. 2 PublicationsCorresponds to variant rs121434571dbSNPEnsembl.1
Natural variantiVAR_017097858L → P in XP-G; reduced stability and greatly impaired endonuclease activity. 1 PublicationCorresponds to variant rs121434575dbSNPEnsembl.1
Natural variantiVAR_017096874A → T in XP-G; mild form; residual activity. 1 PublicationCorresponds to variant rs28929496dbSNPEnsembl.1
Natural variantiVAR_020435879N → S.1 PublicationCorresponds to variant rs4150342dbSNPEnsembl.1
Natural variantiVAR_075774968W → C in XP-G; patient cells show a strong DNA repair defect in response to UV light but not in response to oxidative stress; decreased nucleotide-excision repair activity. 1 PublicationCorresponds to variant rs267607280dbSNPEnsembl.1
Natural variantiVAR_0231241009R → H.1 PublicationCorresponds to variant rs4150387dbSNPEnsembl.1
Natural variantiVAR_0463741053G → R.6 PublicationsCorresponds to variant rs9514066dbSNPEnsembl.1
Natural variantiVAR_0231251080G → Q Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant rs587778291dbSNPEnsembl.1
Natural variantiVAR_0463751080G → R.6 PublicationsCorresponds to variant rs9514067dbSNPEnsembl.1
Natural variantiVAR_0077341104D → H.1 PublicationCorresponds to variant rs17655dbSNPEnsembl.1
Natural variantiVAR_0204361119A → V.Corresponds to variant rs2227871dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0353801 – 767Missing in isoform 2. CuratedAdd BLAST767
Alternative sequenceiVSP_053828225 – 232ESDDFSQY → VYLPLLQP in isoform 3. Curated8
Alternative sequenceiVSP_053829233 – 1186Missing in isoform 3. CuratedAdd BLAST954

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69978 mRNA. Translation: CAA49598.1.
D16305 mRNA. Translation: BAA03812.1.
L20046 mRNA. Translation: AAC37533.1.
AF255436
, AF255431, AF255433, AF255434, AF255435 Genomic DNA. Translation: AAF89178.1.
AF255442
, AF255431, AF255433, AF255434, AF255435, AF255436, AF255437, AF255438, AF255439, AF255440, AF255441 Genomic DNA. Translation: AAF89179.1.
AF462447 mRNA. Translation: AAP97715.1.
AF550128 Genomic DNA. Translation: AAN46091.1.
AL157769 Genomic DNA. Translation: CAI14530.1.
AL157769 Genomic DNA. Translation: CAI14531.1.
BC031522 mRNA. Translation: AAH31522.1.
X71341, X71342 Genomic DNA. Translation: CAA50481.1.
CCDSiCCDS32004.1. [P28715-1]
PIRiI58009.
S35993.
RefSeqiNP_000114.2. NM_000123.3.
UniGeneiHs.258429.

Genome annotation databases

EnsembliENST00000355739; ENSP00000347978; ENSG00000134899. [P28715-1]
ENST00000375954; ENSP00000365121; ENSG00000134899. [P28715-2]
ENST00000535557; ENSP00000442117; ENSG00000134899. [P28715-3]
GeneIDi2073.
KEGGihsa:2073.
UCSCiuc001vpw.4. human. [P28715-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Allelic variations of the XP genes
Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69978 mRNA. Translation: CAA49598.1.
D16305 mRNA. Translation: BAA03812.1.
L20046 mRNA. Translation: AAC37533.1.
AF255436
, AF255431, AF255433, AF255434, AF255435 Genomic DNA. Translation: AAF89178.1.
AF255442
, AF255431, AF255433, AF255434, AF255435, AF255436, AF255437, AF255438, AF255439, AF255440, AF255441 Genomic DNA. Translation: AAF89179.1.
AF462447 mRNA. Translation: AAP97715.1.
AF550128 Genomic DNA. Translation: AAN46091.1.
AL157769 Genomic DNA. Translation: CAI14530.1.
AL157769 Genomic DNA. Translation: CAI14531.1.
BC031522 mRNA. Translation: AAH31522.1.
X71341, X71342 Genomic DNA. Translation: CAA50481.1.
CCDSiCCDS32004.1. [P28715-1]
PIRiI58009.
S35993.
RefSeqiNP_000114.2. NM_000123.3.
UniGeneiHs.258429.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EKFX-ray2.00B/C1054-1077[»]
5EKGX-ray2.80B/C1168-1186[»]
ProteinModelPortaliP28715.
SMRiP28715.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108385. 21 interactors.
DIPiDIP-750N.
IntActiP28715. 10 interactors.
MINTiMINT-192239.
STRINGi9606.ENSP00000347978.

Chemistry databases

BindingDBiP28715.
ChEMBLiCHEMBL4736.

PTM databases

iPTMnetiP28715.
PhosphoSitePlusiP28715.

Polymorphism and mutation databases

BioMutaiERCC5.
DMDMi205371791.

Proteomic databases

EPDiP28715.
MaxQBiP28715.
PaxDbiP28715.
PeptideAtlasiP28715.
PRIDEiP28715.

Protocols and materials databases

DNASUi2073.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355739; ENSP00000347978; ENSG00000134899. [P28715-1]
ENST00000375954; ENSP00000365121; ENSG00000134899. [P28715-2]
ENST00000535557; ENSP00000442117; ENSG00000134899. [P28715-3]
GeneIDi2073.
KEGGihsa:2073.
UCSCiuc001vpw.4. human. [P28715-1]

Organism-specific databases

CTDi2073.
DisGeNETi2073.
GeneCardsiERCC5.
GeneReviewsiERCC5.
HGNCiHGNC:3437. ERCC5.
HPAiHPA045845.
HPA050374.
MalaCardsiERCC5.
MIMi133530. gene.
278780. phenotype.
616570. phenotype.
neXtProtiNX_P28715.
OpenTargetsiENSG00000134899.
Orphaneti1466. COFS syndrome.
276267. Xeroderma pigmentosum complementation group G.
PharmGKBiPA27851.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2520. Eukaryota.
COG0258. LUCA.
GeneTreeiENSGT00640000091542.
HOVERGENiHBG051501.
InParanoidiP28715.
KOiK10846.
OMAiEAQCCEL.
OrthoDBiEOG091G0OMB.
PhylomeDBiP28715.
TreeFamiTF101235.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134899-MONOMER.
ReactomeiR-HSA-5696395. Formation of Incision Complex in GG-NER.
R-HSA-5696400. Dual Incision in GG-NER.
R-HSA-6782135. Dual incision in TC-NER.

Miscellaneous databases

GeneWikiiERCC5.
GenomeRNAii2073.
PROiP28715.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134899.
CleanExiHS_ERCC5.
ExpressionAtlasiP28715. baseline and differential.
GenevisibleiP28715. HS.

Family and domain databases

Gene3Di3.40.50.1010. 2 hits.
InterProiIPR020045. 5-3_exonuclease_C.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR006086. XPG-I_dom.
IPR006084. XPG/Rad2.
IPR001044. XPG/Rad2_eukaryotes.
IPR019974. XPG_CS.
IPR006085. XPG_DNA_repair_N.
[Graphical view]
PfamiPF00867. XPG_I. 1 hit.
PF00752. XPG_N. 1 hit.
[Graphical view]
PRINTSiPR00853. XPGRADSUPER.
PR00066. XRODRMPGMNTG.
SMARTiSM00279. HhH2. 1 hit.
SM00484. XPGI. 1 hit.
SM00485. XPGN. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 2 hits.
SSF88723. SSF88723. 2 hits.
TIGRFAMsiTIGR00600. rad2. 1 hit.
PROSITEiPS00841. XPG_1. 1 hit.
PS00842. XPG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiERCC5_HUMAN
AccessioniPrimary (citable) accession number: P28715
Secondary accession number(s): A6NGT4
, Q5JUS4, Q5JUS5, Q7Z2V3, Q8IZL6, Q8N1B7, Q9HD59, Q9HD60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1993
Last sequence update: September 2, 2008
Last modified: November 2, 2016
This is version 195 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.