Reviewed, UniProtKB/Swiss-Prot P28714 (GPX5_MACFA)

Names and origin

Protein names

Recommended name:
    Epididymal secretory glutathione peroxidase
    EC=1.11.1.9
Alternative name(s):
    Epididymis-specific glutathione peroxidase-like protein
      Short name=EGLP

Gene names

Name:

GPX5

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Subcellular location	Secreted.
Tissue specificity	Epididymis.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 221	200	Epididymal secretory glutathione peroxidase		PRO_0000013077
Sites
	Active site	73	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P28714-1 [UniParc]. Last modified December 1, 1992. Version 1. Checksum: 32AE912ED6C73D93	FASTA	221	25,212
	10 20 30 40 50 60 MTTQLRVVHL LPLLLACFVQ TSPKQETMKM DCHKDEKGTI YDYEAIALNK NEYVPFKQYV 70 80 90 100 110 120 GKHILFVNVA TYCGLTAQYP ELNALQEELK PYGLVVLGFP CNQFGKQEPG DNKEILPGLK 130 140 150 160 170 180 YVRPGGGFVP NFQLFEKGDV NGEKEQKVFS FLKHSCPHPS EILGTFKSIS WDPVKVHDIR 190 200 210 220 WNFEKFLVGP DGIPVMRWSH RATVSSVKTD ILAYLKQFKT K

References

[1]

"Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon." Perry A.C.F., Jones R., Niang L.S.P., Jackson R.M., Hall L. Biochem. J. 285:863-870(1992) [PubMed: 1386734] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Epididymis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X62403 mRNA. Translation: CAA44273.1.
PIR	S24327.
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	3738. MfaGPx05.
Phylogenomic databases
HOVERGEN	P28714.
Enzyme and pathway databases
BRENDA	1.11.1.9. 3438.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX5_MACFA

Accession

Primary (citable) accession number: P28714

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 1992
Last sequence update:	December 1, 1992
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)