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Protein

Serine/threonine-protein kinase PRR1

Gene

PRR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein kinase that functions as regulator in the pheromone-induced mating pathway downstream of mitogen-activated protein kinase (MAPK) FUS3. Diminishes transcriptional induction of genes in response to pheromone signaling.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei225ATPPROSITE-ProRule annotation1
Active sitei354Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 206ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • receptor signaling protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • negative regulation of conjugation with cellular fusion Source: SGD
  • negative regulation of transcription from RNA polymerase II promoter by pheromones Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Pheromone response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31900-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PRR1 (EC:2.7.11.1)
Alternative name(s):
Pheromone response regulator 1
Gene namesi
Name:PRR1
Ordered Locus Names:YKL116C
ORF Names:YKL516
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL116C.
SGDiS000001599. PRR1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861491 – 518Serine/threonine-protein kinase PRR1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei132PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP28708.
PRIDEiP28708.

PTM databases

iPTMnetiP28708.

Interactioni

Protein-protein interaction databases

BioGridi34019. 76 interactors.
DIPiDIP-1919N.
IntActiP28708. 7 interactors.
MINTiMINT-395513.

Structurei

3D structure databases

ProteinModelPortaliP28708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini192 – 508Protein kinasePROSITE-ProRule annotationAdd BLAST317

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00850000133506.
InParanoidiP28708.
KOiK08286.
OMAiPCDMIMS.
OrthoDBiEOG092C3W56.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016240. Ser/Thr_kin_YKL116c_prd.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 4 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000609. Ser/Thr_PK_YKL116c_prd. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEYSSIYSQ PKTPRLKQEG FPDSIGDQHE KALIDENGEE DKKMASTEGT
60 70 80 90 100
TGDSRSTPLT VSIPTFENVQ ALPTPMTYTP LSPGNLSMSP IDQSSLNIPK
110 120 130 140 150
RRSHARLLDD MLSVTQPNQR VVSELIAPAN LSPQRVVSLP TVTEEALVND
160 170 180 190 200
SVDSDNYTKE PYFPESSSST EKCDDDIFQG FLLDHWDRPL LWKKVRPIGS
210 220 230 240 250
GNFSTVLLYE LMDQSNPKLK QVAVKRLKYP EELSNVEQIN TSLRYKETLS
260 270 280 290 300
RLENSLTREL QVLKSLNHPC IVKLLGINNP IFVTSKKPLC DLIIKTPRAL
310 320 330 340 350
PPCDMIMSYC PAGDLLAAVM ARNGRLEAWL IQRIFTEVVL AVKYLHENSI
360 370 380 390 400
IHRDLKLENI LLKYSFDDIN SFRDSPIYCK QNFIELADFG LCKKIENNEM
410 420 430 440 450
CTARCGSEDY VSPEILMGVP YDGHLSDTWA LGVILYSLFE DRLPFDPPPN
460 470 480 490 500
ASARQRSRAT SHRIARFDWR WYRLSDYKTN VGKQIVENTL TRKNQRWSIN
510
EIYESPFVKT IADTLSFS
Length:518
Mass (Da):58,956
Last modified:December 1, 1992 - v1
Checksum:i4AEB19FAA27671B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S93804 Genomic DNA. Translation: AAB21999.1.
Z28115 Genomic DNA. Translation: CAA81955.1.
BK006944 Genomic DNA. Translation: DAA09043.1.
PIRiS27381.
RefSeqiNP_012806.1. NM_001179682.1.

Genome annotation databases

EnsemblFungiiYKL116C; YKL116C; YKL116C.
GeneIDi853744.
KEGGisce:YKL116C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S93804 Genomic DNA. Translation: AAB21999.1.
Z28115 Genomic DNA. Translation: CAA81955.1.
BK006944 Genomic DNA. Translation: DAA09043.1.
PIRiS27381.
RefSeqiNP_012806.1. NM_001179682.1.

3D structure databases

ProteinModelPortaliP28708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34019. 76 interactors.
DIPiDIP-1919N.
IntActiP28708. 7 interactors.
MINTiMINT-395513.

PTM databases

iPTMnetiP28708.

Proteomic databases

MaxQBiP28708.
PRIDEiP28708.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL116C; YKL116C; YKL116C.
GeneIDi853744.
KEGGisce:YKL116C.

Organism-specific databases

EuPathDBiFungiDB:YKL116C.
SGDiS000001599. PRR1.

Phylogenomic databases

GeneTreeiENSGT00850000133506.
InParanoidiP28708.
KOiK08286.
OMAiPCDMIMS.
OrthoDBiEOG092C3W56.

Enzyme and pathway databases

BioCyciYEAST:G3O-31900-MONOMER.

Miscellaneous databases

PROiP28708.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016240. Ser/Thr_kin_YKL116c_prd.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 4 hits.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000609. Ser/Thr_PK_YKL116c_prd. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRR1_YEAST
AccessioniPrimary (citable) accession number: P28708
Secondary accession number(s): D6VXH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 2, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1510 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.