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P28705 (RXRG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene names
Name:Rxrg
Synonyms:Nr2b3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length463 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid By similarity.

Subunit structure

Homodimer By similarity Heterodimer with a RAR molecule By similarity. Binds DNA preferentially as a RAR/RXR heterodimer By similarity.

Subcellular location

Nucleus.

Developmental stage

Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth. Ref.1

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 463463Retinoic acid receptor RXR-gamma
PRO_0000053577

Regions

DNA binding139 – 20466Nuclear receptor
Zinc finger139 – 15921NR C4-type
Zinc finger175 – 19925NR C4-type
Region1 – 138138Modulating By similarity
Region205 – 26056Hinge
Region261 – 463203Ligand-binding By similarity

Experimental info

Sequence conflict3411A → R in CAA46964. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P28705 [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 1E29C86FACCE1DD9

FASTA46350,893
        10         20         30         40         50         60 
MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV SAPRTLSAVG 

        70         80         90        100        110        120 
TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL NVVNSVSSSE DIKPLPGLPG 

       130        140        150        160        170        180 
IGNMNYPSTS PGSLVKHICA ICGDRSSGKH YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD 

       190        200        210        220        230        240 
CLIDKRQRNR CQYCRYQKCL VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL 

       250        260        270        280        290        300 
EAELAVEPKT ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 

       310        320        330        340        350        360 
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV LTELVSKMKD 

       370        380        390        400        410        420 
MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT LEAYTKQKYP EQPGRFAKLL 

       430        440        450        460 
LRLPALRSIG LKCLEHLFFF KLIGDTPIDS FLMEMLETPL QIT 

« Hide

References

« Hide 'large scale' references
[1]"Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P.
Cell 68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
[2]"Characterization of three RXR genes that mediate the action of 9-cis retinoic acid."
Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M.
Genes Dev. 6:329-344(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms."
Liu Q., Linney E.
Mol. Endocrinol. 7:651-658(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/10J.
Tissue: Skeletal muscle.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M84819 mRNA. Translation: AAA40082.1.
X66225 mRNA. Translation: CAA46964.1.
S62948 mRNA. Translation: AAB27244.1.
BC058401 mRNA. Translation: AAH58401.1.
PIRB41727.
S26670.
RefSeqNP_001153203.1. NM_001159731.1.
NP_033133.1. NM_009107.3.
UniGeneMm.3475.

3D structure databases

ProteinModelPortalP28705.
SMRP28705. Positions 136-456.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203040. 10 interactions.
MINTMINT-1515860.
STRING10090.ENSMUSP00000107017.

Chemistry

BindingDBP28705.
ChEMBLCHEMBL4402.
GuidetoPHARMACOLOGY612.

PTM databases

PhosphoSiteP28705.

Proteomic databases

PaxDbP28705.
PRIDEP28705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843.
ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843.
ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843.
GeneID20183.
KEGGmmu:20183.
UCSCuc007dla.2. mouse.

Organism-specific databases

CTD6258.
MGIMGI:98216. Rxrg.

Phylogenomic databases

eggNOGNOG327099.
GeneTreeENSGT00740000115010.
HOGENOMHOG000260821.
HOVERGENHBG005606.
InParanoidP28705.
KOK08526.
OMACASGGHE.
OrthoDBEOG72RMZ5.
TreeFamTF352097.

Gene expression databases

ArrayExpressP28705.
BgeeP28705.
CleanExMM_RXRG.
GenevestigatorP28705.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297713.
PROP28705.
SOURCESearch...

Entry information

Entry nameRXRG_MOUSE
AccessionPrimary (citable) accession number: P28705
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: February 19, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot