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Protein

Retinoic acid receptor RXR-gamma

Gene

Rxrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 20466Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. 9-cis retinoic acid receptor activity Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding Source: MGI
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. heart development Source: Ensembl
  2. neuron differentiation Source: Ensembl
  3. peripheral nervous system development Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: MGI
  6. protein homotetramerization Source: MGI
  7. regulation of myelination Source: Ensembl
  8. response to retinoic acid Source: Ensembl
  9. retinoic acid receptor signaling pathway Source: MGI
  10. skeletal muscle tissue development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:Rxrg
Synonyms:Nr2b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98216. Rxrg.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Retinoic acid receptor RXR-gammaPRO_0000053577Add
BLAST

Proteomic databases

PaxDbiP28705.
PRIDEiP28705.

PTM databases

PhosphoSiteiP28705.

Expressioni

Developmental stagei

Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth.1 Publication

Gene expression databases

BgeeiP28705.
CleanExiMM_RXRG.
ExpressionAtlasiP28705. baseline and differential.
GenevestigatoriP28705.

Interactioni

Subunit structurei

Homodimer (By similarity) Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Protein-protein interaction databases

BioGridi203040. 10 interactions.
MINTiMINT-1515860.
STRINGi10090.ENSMUSP00000107017.

Structurei

3D structure databases

ProteinModelPortaliP28705.
SMRiP28705. Positions 132-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 138138ModulatingBy similarityAdd
BLAST
Regioni205 – 26056HingeAdd
BLAST
Regioni261 – 463203Ligand-bindingBy similarityAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri139 – 15921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri175 – 19925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28705.
KOiK08526.
OMAiFIKFPAG.
OrthoDBiEOG72RMZ5.
PhylomeDBiP28705.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28705-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDS
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,893
Last modified:February 1, 1996 - v2
Checksum:i1E29C86FACCE1DD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti341 – 3411A → R in CAA46964. (PubMed:1312497)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84819 mRNA. Translation: AAA40082.1.
X66225 mRNA. Translation: CAA46964.1.
S62948 mRNA. Translation: AAB27244.1.
BC058401 mRNA. Translation: AAH58401.1.
CCDSiCCDS15459.1.
PIRiB41727.
S26670.
RefSeqiNP_001153203.1. NM_001159731.1.
NP_033133.1. NM_009107.3.
UniGeneiMm.3475.

Genome annotation databases

EnsembliENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843.
ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843.
ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843.
GeneIDi20183.
KEGGimmu:20183.
UCSCiuc007dla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84819 mRNA. Translation: AAA40082.1.
X66225 mRNA. Translation: CAA46964.1.
S62948 mRNA. Translation: AAB27244.1.
BC058401 mRNA. Translation: AAH58401.1.
CCDSiCCDS15459.1.
PIRiB41727.
S26670.
RefSeqiNP_001153203.1. NM_001159731.1.
NP_033133.1. NM_009107.3.
UniGeneiMm.3475.

3D structure databases

ProteinModelPortaliP28705.
SMRiP28705. Positions 132-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203040. 10 interactions.
MINTiMINT-1515860.
STRINGi10090.ENSMUSP00000107017.

Chemistry

BindingDBiP28705.
ChEMBLiCHEMBL4402.
GuidetoPHARMACOLOGYi612.

PTM databases

PhosphoSiteiP28705.

Proteomic databases

PaxDbiP28705.
PRIDEiP28705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843.
ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843.
ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843.
GeneIDi20183.
KEGGimmu:20183.
UCSCiuc007dla.2. mouse.

Organism-specific databases

CTDi6258.
MGIiMGI:98216. Rxrg.

Phylogenomic databases

eggNOGiNOG327099.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28705.
KOiK08526.
OMAiFIKFPAG.
OrthoDBiEOG72RMZ5.
PhylomeDBiP28705.
TreeFamiTF352097.

Enzyme and pathway databases

ReactomeiREACT_234105. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi297713.
PROiP28705.
SOURCEiSearch...

Gene expression databases

BgeeiP28705.
CleanExiMM_RXRG.
ExpressionAtlasiP28705. baseline and differential.
GenevestigatoriP28705.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
    Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P.
    Cell 68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid."
    Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M.
    Genes Dev. 6:329-344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms."
    Liu Q., Linney E.
    Mol. Endocrinol. 7:651-658(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10J.
    Tissue: Skeletal muscle.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRXRG_MOUSE
AccessioniPrimary (citable) accession number: P28705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: January 7, 2015
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.