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Protein

Retinoic acid receptor RXR-gamma

Gene

Rxrg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 204Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • 9-cis retinoic acid receptor activity Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • steroid hormone receptor activity Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: MGI
  • protein homotetramerization Source: MGI
  • retinoic acid receptor signaling pathway Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:Rxrg
Synonyms:Nr2b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98216 Rxrg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4402
GuidetoPHARMACOLOGYi612

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535771 – 463Retinoic acid receptor RXR-gammaAdd BLAST463

Proteomic databases

MaxQBiP28705
PaxDbiP28705
PRIDEiP28705

PTM databases

iPTMnetiP28705
PhosphoSitePlusiP28705

Expressioni

Developmental stagei

Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth.1 Publication

Gene expression databases

BgeeiENSMUSG00000015843
CleanExiMM_RXRG
ExpressionAtlasiP28705 baseline and differential
GenevisibleiP28705 MM

Interactioni

Subunit structurei

Homodimer (By similarity) Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Protein-protein interaction databases

BioGridi203040, 10 interactors
STRINGi10090.ENSMUSP00000015987

Chemistry databases

BindingDBiP28705

Structurei

3D structure databases

ProteinModelPortaliP28705
SMRiP28705
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 459NR LBDPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 138ModulatingBy similarityAdd BLAST138
Regioni205 – 230HingeAdd BLAST26

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri175 – 199NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiP28705
KOiK08526
OMAiFMKFPTG
OrthoDBiEOG091G0YX6
PhylomeDBiP28705
TreeFamiTF352097

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P28705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV
60 70 80 90 100
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL
110 120 130 140 150
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH
160 170 180 190 200
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL
210 220 230 240 250
VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL EAELAVEPKT
260 270 280 290 300
ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI
310 320 330 340 350
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV
360 370 380 390 400
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT
410 420 430 440 450
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDS
460
FLMEMLETPL QIT
Length:463
Mass (Da):50,893
Last modified:February 1, 1996 - v2
Checksum:i1E29C86FACCE1DD9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti341A → R in CAA46964 (PubMed:1312497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M84819 mRNA Translation: AAA40082.1
X66225 mRNA Translation: CAA46964.1
S62948 mRNA Translation: AAB27244.1
BC058401 mRNA Translation: AAH58401.1
CCDSiCCDS15459.1
PIRiB41727
S26670
RefSeqiNP_001153203.1, NM_001159731.1
NP_033133.1, NM_009107.3
UniGeneiMm.3475

Genome annotation databases

EnsembliENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843
ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843
ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843
GeneIDi20183
KEGGimmu:20183
UCSCiuc007dla.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRXRG_MOUSE
AccessioniPrimary (citable) accession number: P28705
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: March 28, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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