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P28705

- RXRG_MOUSE

UniProt

P28705 - RXRG_MOUSE

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Protein
Retinoic acid receptor RXR-gamma
Gene
Rxrg, Nr2b3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi139 – 20466Nuclear receptor
Add
BLAST
Zinc fingeri139 – 15921NR C4-type
Add
BLAST
Zinc fingeri175 – 19925NR C4-type
Add
BLAST

GO - Molecular functioni

  1. 9-cis retinoic acid receptor activity Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. steroid hormone receptor activity Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. heart development Source: Ensembl
  2. neuron differentiation Source: Ensembl
  3. peripheral nervous system development Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. regulation of myelination Source: Ensembl
  6. response to retinoic acid Source: Ensembl
  7. retinoic acid receptor signaling pathway Source: MGI
  8. skeletal muscle tissue development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:Rxrg
Synonyms:Nr2b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:98216. Rxrg.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463Retinoic acid receptor RXR-gamma
PRO_0000053577Add
BLAST

Proteomic databases

PaxDbiP28705.
PRIDEiP28705.

PTM databases

PhosphoSiteiP28705.

Expressioni

Developmental stagei

Expressed from embryo day 10.5 to birth. At day 10-13, expression in somites and the ventral horns of the spinal chord. At day 13.5, strongly expressed in the corpus striatum. At day 16.5, expression also in the pituitary with weaker expression in the neck, skeletal muscle and tongue. Expression in the corpus striatum continues until at least 7 days after birth.1 Publication

Gene expression databases

ArrayExpressiP28705.
BgeeiP28705.
CleanExiMM_RXRG.
GenevestigatoriP28705.

Interactioni

Subunit structurei

Homodimer By similarity Heterodimer with a RAR molecule By similarity. Binds DNA preferentially as a RAR/RXR heterodimer By similarity.

Protein-protein interaction databases

BioGridi203040. 10 interactions.
MINTiMINT-1515860.
STRINGi10090.ENSMUSP00000107017.

Structurei

3D structure databases

ProteinModelPortaliP28705.
SMRiP28705. Positions 132-459.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 138138Modulating By similarity
Add
BLAST
Regioni205 – 26056Hinge
Add
BLAST
Regioni261 – 463203Ligand-binding By similarity
Add
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
GeneTreeiENSGT00740000115010.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28705.
KOiK08526.
OMAiFIKFPAG.
OrthoDBiEOG72RMZ5.
PhylomeDBiP28705.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P28705-1 [UniParc]FASTAAdd to Basket

« Hide

MYGNYSHFMK FPTGFGGSPG HTGSTSMSPS VALPTGKPMD SHPSYTDTPV    50
SAPRTLSAVG TPLNALGSPY RVITSAMGPP SGALAAPPGI NLVAPPSSQL 100
NVVNSVSSSE DIKPLPGLPG IGNMNYPSTS PGSLVKHICA ICGDRSSGKH 150
YGVYSCEGCK GFFKRTIRKD LIYTCRDNKD CLIDKRQRNR CQYCRYQKCL 200
VMGMKREAVQ EERQRSRERA ESEAECASSS HEDMPVERIL EAELAVEPKT 250
ESYGDMNVEN STNDPVTNIC HAADKQLFTL VEWAKRIPHF SDLTLEDQVI 300
LLRAGWNELL IASFSHRSVS VQDGILLATG LHVHRSSAHS AGVGSIFDRV 350
LTELVSKMKD MQMDKSELGC LRAIVLFNPD AKGLSNPSEV ETLREKVYAT 400
LEAYTKQKYP EQPGRFAKLL LRLPALRSIG LKCLEHLFFF KLIGDTPIDS 450
FLMEMLETPL QIT 463
Length:463
Mass (Da):50,893
Last modified:February 1, 1996 - v2
Checksum:i1E29C86FACCE1DD9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti341 – 3411A → R in CAA46964. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84819 mRNA. Translation: AAA40082.1.
X66225 mRNA. Translation: CAA46964.1.
S62948 mRNA. Translation: AAB27244.1.
BC058401 mRNA. Translation: AAH58401.1.
CCDSiCCDS15459.1.
PIRiB41727.
S26670.
RefSeqiNP_001153203.1. NM_001159731.1.
NP_033133.1. NM_009107.3.
UniGeneiMm.3475.

Genome annotation databases

EnsembliENSMUST00000015987; ENSMUSP00000015987; ENSMUSG00000015843.
ENSMUST00000111384; ENSMUSP00000107015; ENSMUSG00000015843.
ENSMUST00000111386; ENSMUSP00000107017; ENSMUSG00000015843.
GeneIDi20183.
KEGGimmu:20183.
UCSCiuc007dla.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M84819 mRNA. Translation: AAA40082.1 .
X66225 mRNA. Translation: CAA46964.1 .
S62948 mRNA. Translation: AAB27244.1 .
BC058401 mRNA. Translation: AAH58401.1 .
CCDSi CCDS15459.1.
PIRi B41727.
S26670.
RefSeqi NP_001153203.1. NM_001159731.1.
NP_033133.1. NM_009107.3.
UniGenei Mm.3475.

3D structure databases

ProteinModelPortali P28705.
SMRi P28705. Positions 132-459.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203040. 10 interactions.
MINTi MINT-1515860.
STRINGi 10090.ENSMUSP00000107017.

Chemistry

BindingDBi P28705.
ChEMBLi CHEMBL4402.
GuidetoPHARMACOLOGYi 612.

PTM databases

PhosphoSitei P28705.

Proteomic databases

PaxDbi P28705.
PRIDEi P28705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000015987 ; ENSMUSP00000015987 ; ENSMUSG00000015843 .
ENSMUST00000111384 ; ENSMUSP00000107015 ; ENSMUSG00000015843 .
ENSMUST00000111386 ; ENSMUSP00000107017 ; ENSMUSG00000015843 .
GeneIDi 20183.
KEGGi mmu:20183.
UCSCi uc007dla.2. mouse.

Organism-specific databases

CTDi 6258.
MGIi MGI:98216. Rxrg.

Phylogenomic databases

eggNOGi NOG327099.
GeneTreei ENSGT00740000115010.
HOGENOMi HOG000260821.
HOVERGENi HBG005606.
InParanoidi P28705.
KOi K08526.
OMAi FIKFPAG.
OrthoDBi EOG72RMZ5.
PhylomeDBi P28705.
TreeFami TF352097.

Miscellaneous databases

NextBioi 297713.
PROi P28705.
SOURCEi Search...

Gene expression databases

ArrayExpressi P28705.
Bgeei P28705.
CleanExi MM_RXRG.
Genevestigatori P28705.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR021780. Nuc_recep-AF1.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
    Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P.
    Cell 68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  2. "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid."
    Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M.
    Genes Dev. 6:329-344(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The mouse retinoid-X receptor-gamma gene: genomic organization and evidence for functional isoforms."
    Liu Q., Linney E.
    Mol. Endocrinol. 7:651-658(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/10J.
    Tissue: Skeletal muscle.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiRXRG_MOUSE
AccessioniPrimary (citable) accession number: P28705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: September 3, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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