Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P28704 (RXRB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 147. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Retinoic acid receptor RXR-beta
Alternative name(s):
MHC class I regulatory element-binding protein H-2RIIBP
Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta
Gene names
Name:Rxrb
Synonyms:Nr2b2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length520 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). Binds to both, class I regulatory element of major histocompatibility class I genes (CRE) and the estrogen response element (ERE).

Subcellular location

Nucleus.

Tissue specificity

In all tissues tested including brain, thymus spleen and liver.

Domain

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR2 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionReceptor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcardiac muscle cell proliferation

Inferred from genetic interaction PubMed 9428411. Source: MGI

cellular response to retinoic acid

Inferred from direct assay PubMed 18922886. Source: UniProtKB

in utero embryonic development

Inferred from genetic interaction PubMed 9892670. Source: MGI

maternal placenta development

Inferred from genetic interaction PubMed 9892670. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 7823919. Source: MGI

retinoic acid receptor signaling pathway

Inferred from direct assay Ref.6. Source: MGI

ventricular cardiac muscle cell differentiation

Inferred from mutant phenotype PubMed 9428411. Source: MGI

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function9-cis retinoic acid receptor activity

Inferred from direct assay Ref.6. Source: MGI

sequence-specific DNA binding

Inferred from genetic interaction PubMed 7823919. Source: MGI

steroid hormone receptor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region DNA binding

Inferred from direct assay PubMed 18922886. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P28704-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Short (identifier: P28704-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 520520Retinoic acid receptor RXR-beta
PRO_0000053573

Regions

DNA binding192 – 25766Nuclear receptor
Zinc finger192 – 21221NR C4-type
Zinc finger228 – 25225NR C4-type
Region1 – 191191Modulating By similarity
Region258 – 31760Hinge
Region318 – 520203Ligand-binding By similarity

Natural variations

Alternative sequence1 – 110110Missing in isoform Short.
VSP_003678

Experimental info

Sequence conflict73 – 753SGR → MGP in AAA40081. Ref.4
Sequence conflict75 – 773RDS → EFP in AAA37772. Ref.5
Sequence conflict4331L → M in AAA40081. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform Long [UniParc].

Last modified February 1, 1996. Version 2.
Checksum: 71FAEAEC0D2DB505

FASTA52055,866
        10         20         30         40         50         60 
MSWATRPPFL PPRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA AAGEQQALEP 

        70         80         90        100        110        120 
EPGEAGRDGM GDSGRDSRSP DSSSPNPLSQ GIRPSSPPGP PLTPSAPPPP MPPPPLGSPF 

       130        140        150        160        170        180 
PVISSSMGSP GLPPPAPPGF SGPVSSPQIN STVSLPGGGS GPPEDVKPPV LGVRGLHCPP 

       190        200        210        220        230        240 
PPGGPGAGKR LCAICGDRSS GKHYGVYSCE GCKGFFKRTI RKDLTYSCRD NKDCTVDKRQ 

       250        260        270        280        290        300 
RNRCQYCRYQ KCLATGMKRE AVQEERQRGK DKDGDGDGAG GAPEEMPVDR ILEAELAVEQ 

       310        320        330        340        350        360 
KSDQGVEGPG ATGGGGSSPN DPVTNICQAA DKQLFTLVEW AKRIPHFSSL PLDDQVILLR 

       370        380        390        400        410        420 
AGWNELLIAS FSHRSIDVRD GILLATGLHV HRNSAHSAGV GAIFDRVLTE LVSKMRDMRM 

       430        440        450        460        470        480 
DKTELGCLRA IILFNPDAKG LSNPGEVEIL REKVYASLET YCKQKYPEQQ GRFAKLLLRL 

       490        500        510        520 
PALRSIGLKC LEHLFFFKLI GDTPIDTFLM EMLEAPHQLA 

« Hide

Isoform Short [UniParc].

Checksum: 76353141EEA68AB0
Show »

FASTA41044,396

References

« Hide 'large scale' references
[1]"The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters."
Nagata T., Kanno Y., Ozato K., Taketo M.
Gene 142:183-189(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
Strain: BALB/c.
Tissue: Liver.
[2]"Sequence of the mouse major histocomaptibility locus class II region."
Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
Tissue: Limb.
[4]"Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P.
Cell 68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-520 (ISOFORM LONG).
Tissue: Embryo.
[5]"H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element."
Hamada K., Gleason S.L., Levi B.-Z., Hirschfeld S., Appella E., Ozato K.
Proc. Natl. Acad. Sci. U.S.A. 86:8289-8293(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-520 (ISOFORM LONG).
Tissue: Liver.
[6]"Characterization of three RXR genes that mediate the action of 9-cis retinoic acid."
Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M.
Genes Dev. 6:329-344(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D21831 Genomic DNA. Translation: BAA04858.1.
D21831 Genomic DNA. Translation: BAA04859.1.
AF100956 Genomic DNA. Translation: AAC69904.1.
BC049773 mRNA. Translation: AAH49773.1.
M84818 mRNA. Translation: AAA40081.2.
M26804 mRNA. Translation: AAA37772.1.
X66224 mRNA. Translation: CAA46963.1.
PIRA34418.
D41727.
I84718.
S26669.
RefSeqNP_001192145.1. NM_001205216.1.
NP_035436.1. NM_011306.4.
UniGeneMm.1243.

3D structure databases

ProteinModelPortalP28704.
SMRP28704. Positions 189-519.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid203039. 3 interactions.
IntActP28704. 1 interaction.

Chemistry

BindingDBP28704.
ChEMBLCHEMBL4047.
GuidetoPHARMACOLOGY611.

PTM databases

PhosphoSiteP28704.

Proteomic databases

PaxDbP28704.
PRIDEP28704.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656. [P28704-2]
GeneID20182.
KEGGmmu:20182.
UCSCuc008cax.2. mouse. [P28704-1]

Organism-specific databases

CTD6257.
MGIMGI:98215. Rxrb.

Phylogenomic databases

eggNOGNOG327099.
GeneTreeENSGT00740000115010.
HOGENOMHOG000260821.
HOVERGENHBG005606.
InParanoidP28704.
KOK08525.
PhylomeDBP28704.

Gene expression databases

ArrayExpressP28704.
BgeeP28704.
CleanExMM_RXRB.
GenevestigatorP28704.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio297709.
PROP28704.
SOURCESearch...

Entry information

Entry nameRXRB_MOUSE
AccessionPrimary (citable) accession number: P28704
Secondary accession number(s): P33243
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: April 16, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot