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Protein

Retinoic acid receptor RXR-beta

Gene

Rxrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 257Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri192 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri228 – 252NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle cell proliferation Source: MGI
  • cellular response to retinoic acid Source: UniProtKB
  • in utero embryonic development Source: MGI
  • maternal placenta development Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • retinoic acid receptor signaling pathway Source: MGI
  • ventricular cardiac muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.
R-MMU-5362517. Signaling by Retinoic Acid.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-beta
Alternative name(s):
MHC class I regulatory element-binding protein H-2RIIBP
Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta
Gene namesi
Name:Rxrb
Synonyms:Nr2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98215. Rxrb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4047.
GuidetoPHARMACOLOGYi611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535731 – 520Retinoic acid receptor RXR-betaAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP28704.
PaxDbiP28704.
PeptideAtlasiP28704.
PRIDEiP28704.

PTM databases

iPTMnetiP28704.
PhosphoSitePlusiP28704.

Expressioni

Tissue specificityi

In all tissues tested, including brain, thymus, spleen and liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000039656.
CleanExiMM_RXRB.
ExpressionAtlasiP28704. baseline and differential.
GenevisibleiP28704. MM.

Interactioni

Subunit structurei

Homodimer (in vitro). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer. Interacts with NR1H3 (By similarity). Interacts with AKAP13 (PubMed:20139090).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi203039. 3 interactors.
IntActiP28704. 1 interactor.
STRINGi10090.ENSMUSP00000036585.

Chemistry databases

BindingDBiP28704.

Structurei

3D structure databases

ProteinModelPortaliP28704.
SMRiP28704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 191ModulatingBy similarityAdd BLAST191
Regioni258 – 317HingeAdd BLAST60
Regioni318 – 520Ligand-bindingBy similarityAdd BLAST203

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.1 Publication

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri228 – 252NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28704.
KOiK08525.
PhylomeDBiP28704.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P28704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWATRPPFL PPRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA
60 70 80 90 100
AAGEQQALEP EPGEAGRDGM GDSGRDSRSP DSSSPNPLSQ GIRPSSPPGP
110 120 130 140 150
PLTPSAPPPP MPPPPLGSPF PVISSSMGSP GLPPPAPPGF SGPVSSPQIN
160 170 180 190 200
STVSLPGGGS GPPEDVKPPV LGVRGLHCPP PPGGPGAGKR LCAICGDRSS
210 220 230 240 250
GKHYGVYSCE GCKGFFKRTI RKDLTYSCRD NKDCTVDKRQ RNRCQYCRYQ
260 270 280 290 300
KCLATGMKRE AVQEERQRGK DKDGDGDGAG GAPEEMPVDR ILEAELAVEQ
310 320 330 340 350
KSDQGVEGPG ATGGGGSSPN DPVTNICQAA DKQLFTLVEW AKRIPHFSSL
360 370 380 390 400
PLDDQVILLR AGWNELLIAS FSHRSIDVRD GILLATGLHV HRNSAHSAGV
410 420 430 440 450
GAIFDRVLTE LVSKMRDMRM DKTELGCLRA IILFNPDAKG LSNPGEVEIL
460 470 480 490 500
REKVYASLET YCKQKYPEQQ GRFAKLLLRL PALRSIGLKC LEHLFFFKLI
510 520
GDTPIDTFLM EMLEAPHQLA
Length:520
Mass (Da):55,866
Last modified:February 1, 1996 - v2
Checksum:i71FAEAEC0D2DB505
GO
Isoform Short (identifier: P28704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:410
Mass (Da):44,396
Checksum:i76353141EEA68AB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73 – 75SGR → MGP in AAA40081 (PubMed:1310259).Curated3
Sequence conflicti75 – 77RDS → EFP in AAA37772 (PubMed:2554307).Curated3
Sequence conflicti433L → M in AAA40081 (PubMed:1310259).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0036781 – 110Missing in isoform Short. CuratedAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21831 Genomic DNA. Translation: BAA04858.1.
D21831 Genomic DNA. Translation: BAA04859.1.
AF100956 Genomic DNA. Translation: AAC69904.1.
BC049773 mRNA. Translation: AAH49773.1.
M84818 mRNA. Translation: AAA40081.2.
M26804 mRNA. Translation: AAA37772.1.
X66224 mRNA. Translation: CAA46963.1.
CCDSiCCDS57068.1. [P28704-2]
PIRiA34418.
D41727.
I84718.
S26669.
RefSeqiNP_001192145.1. NM_001205216.1. [P28704-2]
NP_035436.1. NM_011306.4. [P28704-1]
UniGeneiMm.1243.

Genome annotation databases

EnsembliENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656. [P28704-2]
GeneIDi20182.
KEGGimmu:20182.
UCSCiuc008cax.2. mouse. [P28704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21831 Genomic DNA. Translation: BAA04858.1.
D21831 Genomic DNA. Translation: BAA04859.1.
AF100956 Genomic DNA. Translation: AAC69904.1.
BC049773 mRNA. Translation: AAH49773.1.
M84818 mRNA. Translation: AAA40081.2.
M26804 mRNA. Translation: AAA37772.1.
X66224 mRNA. Translation: CAA46963.1.
CCDSiCCDS57068.1. [P28704-2]
PIRiA34418.
D41727.
I84718.
S26669.
RefSeqiNP_001192145.1. NM_001205216.1. [P28704-2]
NP_035436.1. NM_011306.4. [P28704-1]
UniGeneiMm.1243.

3D structure databases

ProteinModelPortaliP28704.
SMRiP28704.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203039. 3 interactors.
IntActiP28704. 1 interactor.
STRINGi10090.ENSMUSP00000036585.

Chemistry databases

BindingDBiP28704.
ChEMBLiCHEMBL4047.
GuidetoPHARMACOLOGYi611.

PTM databases

iPTMnetiP28704.
PhosphoSitePlusiP28704.

Proteomic databases

MaxQBiP28704.
PaxDbiP28704.
PeptideAtlasiP28704.
PRIDEiP28704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656. [P28704-2]
GeneIDi20182.
KEGGimmu:20182.
UCSCiuc008cax.2. mouse. [P28704-1]

Organism-specific databases

CTDi6257.
MGIiMGI:98215. Rxrb.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00760000118948.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28704.
KOiK08525.
PhylomeDBiP28704.

Enzyme and pathway databases

ReactomeiR-MMU-383280. Nuclear Receptor transcription pathway.
R-MMU-5362517. Signaling by Retinoic Acid.

Miscellaneous databases

PROiP28704.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039656.
CleanExiMM_RXRB.
ExpressionAtlasiP28704. baseline and differential.
GenevisibleiP28704. MM.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXRB_MOUSE
AccessioniPrimary (citable) accession number: P28704
Secondary accession number(s): P33243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: November 2, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.