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P28704

- RXRB_MOUSE

UniProt

P28704 - RXRB_MOUSE

Protein

Retinoic acid receptor RXR-beta

Gene

Rxrb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (01 Feb 1996)
      Previous versions | rss
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    Functioni

    Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). Binds to both, class I regulatory element of major histocompatibility class I genes (CRE) and the estrogen response element (ERE).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi192 – 25766Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri192 – 21221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25225NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 9-cis retinoic acid receptor activity Source: MGI
    2. protein binding Source: UniProtKB
    3. protein homodimerization activity Source: MGI
    4. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
    5. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    6. sequence-specific DNA binding Source: MGI
    7. steroid hormone receptor activity Source: InterPro
    8. transcription regulatory region DNA binding Source: UniProtKB
    9. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cardiac muscle cell proliferation Source: MGI
    2. cellular response to retinoic acid Source: UniProtKB
    3. in utero embryonic development Source: MGI
    4. maternal placenta development Source: MGI
    5. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    6. retinoic acid receptor signaling pathway Source: MGI
    7. ventricular cardiac muscle cell differentiation Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinoic acid receptor RXR-beta
    Alternative name(s):
    MHC class I regulatory element-binding protein H-2RIIBP
    Nuclear receptor subfamily 2 group B member 2
    Retinoid X receptor beta
    Gene namesi
    Name:Rxrb
    Synonyms:Nr2b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:98215. Rxrb.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Retinoic acid receptor RXR-betaPRO_0000053573Add
    BLAST

    Proteomic databases

    PaxDbiP28704.
    PRIDEiP28704.

    PTM databases

    PhosphoSiteiP28704.

    Expressioni

    Tissue specificityi

    In all tissues tested including brain, thymus spleen and liver.

    Gene expression databases

    ArrayExpressiP28704.
    BgeeiP28704.
    CleanExiMM_RXRB.
    GenevestigatoriP28704.

    Interactioni

    Protein-protein interaction databases

    BioGridi203039. 3 interactions.
    IntActiP28704. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP28704.
    SMRiP28704. Positions 189-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 191191ModulatingBy similarityAdd
    BLAST
    Regioni258 – 31760HingeAdd
    BLAST
    Regioni318 – 520203Ligand-bindingBy similarityAdd
    BLAST

    Domaini

    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri192 – 21221NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25225NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    GeneTreeiENSGT00740000115010.
    HOGENOMiHOG000260821.
    HOVERGENiHBG005606.
    InParanoidiP28704.
    KOiK08525.
    PhylomeDBiP28704.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR000003. Retinoid-X_rcpt/HNF4.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR00545. RETINOIDXR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform Long (identifier: P28704-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWATRPPFL PPRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA    50
    AAGEQQALEP EPGEAGRDGM GDSGRDSRSP DSSSPNPLSQ GIRPSSPPGP 100
    PLTPSAPPPP MPPPPLGSPF PVISSSMGSP GLPPPAPPGF SGPVSSPQIN 150
    STVSLPGGGS GPPEDVKPPV LGVRGLHCPP PPGGPGAGKR LCAICGDRSS 200
    GKHYGVYSCE GCKGFFKRTI RKDLTYSCRD NKDCTVDKRQ RNRCQYCRYQ 250
    KCLATGMKRE AVQEERQRGK DKDGDGDGAG GAPEEMPVDR ILEAELAVEQ 300
    KSDQGVEGPG ATGGGGSSPN DPVTNICQAA DKQLFTLVEW AKRIPHFSSL 350
    PLDDQVILLR AGWNELLIAS FSHRSIDVRD GILLATGLHV HRNSAHSAGV 400
    GAIFDRVLTE LVSKMRDMRM DKTELGCLRA IILFNPDAKG LSNPGEVEIL 450
    REKVYASLET YCKQKYPEQQ GRFAKLLLRL PALRSIGLKC LEHLFFFKLI 500
    GDTPIDTFLM EMLEAPHQLA 520
    Length:520
    Mass (Da):55,866
    Last modified:February 1, 1996 - v2
    Checksum:i71FAEAEC0D2DB505
    GO
    Isoform Short (identifier: P28704-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-110: Missing.

    Show »
    Length:410
    Mass (Da):44,396
    Checksum:i76353141EEA68AB0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 753SGR → MGP in AAA40081. (PubMed:1310259)Curated
    Sequence conflicti75 – 773RDS → EFP in AAA37772. (PubMed:2554307)Curated
    Sequence conflicti433 – 4331L → M in AAA40081. (PubMed:1310259)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 110110Missing in isoform Short. CuratedVSP_003678Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21831 Genomic DNA. Translation: BAA04858.1.
    D21831 Genomic DNA. Translation: BAA04859.1.
    AF100956 Genomic DNA. Translation: AAC69904.1.
    BC049773 mRNA. Translation: AAH49773.1.
    M84818 mRNA. Translation: AAA40081.2.
    M26804 mRNA. Translation: AAA37772.1.
    X66224 mRNA. Translation: CAA46963.1.
    CCDSiCCDS57068.1. [P28704-2]
    PIRiA34418.
    D41727.
    I84718.
    S26669.
    RefSeqiNP_001192145.1. NM_001205216.1. [P28704-2]
    NP_035436.1. NM_011306.4. [P28704-1]
    UniGeneiMm.1243.

    Genome annotation databases

    EnsembliENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656. [P28704-2]
    GeneIDi20182.
    KEGGimmu:20182.
    UCSCiuc008cax.2. mouse. [P28704-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D21831 Genomic DNA. Translation: BAA04858.1 .
    D21831 Genomic DNA. Translation: BAA04859.1 .
    AF100956 Genomic DNA. Translation: AAC69904.1 .
    BC049773 mRNA. Translation: AAH49773.1 .
    M84818 mRNA. Translation: AAA40081.2 .
    M26804 mRNA. Translation: AAA37772.1 .
    X66224 mRNA. Translation: CAA46963.1 .
    CCDSi CCDS57068.1. [P28704-2 ]
    PIRi A34418.
    D41727.
    I84718.
    S26669.
    RefSeqi NP_001192145.1. NM_001205216.1. [P28704-2 ]
    NP_035436.1. NM_011306.4. [P28704-1 ]
    UniGenei Mm.1243.

    3D structure databases

    ProteinModelPortali P28704.
    SMRi P28704. Positions 189-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203039. 3 interactions.
    IntActi P28704. 1 interaction.

    Chemistry

    BindingDBi P28704.
    ChEMBLi CHEMBL4047.
    GuidetoPHARMACOLOGYi 611.

    PTM databases

    PhosphoSitei P28704.

    Proteomic databases

    PaxDbi P28704.
    PRIDEi P28704.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000116612 ; ENSMUSP00000112311 ; ENSMUSG00000039656 . [P28704-2 ]
    GeneIDi 20182.
    KEGGi mmu:20182.
    UCSCi uc008cax.2. mouse. [P28704-1 ]

    Organism-specific databases

    CTDi 6257.
    MGIi MGI:98215. Rxrb.

    Phylogenomic databases

    eggNOGi NOG327099.
    GeneTreei ENSGT00740000115010.
    HOGENOMi HOG000260821.
    HOVERGENi HBG005606.
    InParanoidi P28704.
    KOi K08525.
    PhylomeDBi P28704.

    Miscellaneous databases

    NextBioi 297709.
    PROi P28704.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P28704.
    Bgeei P28704.
    CleanExi MM_RXRB.
    Genevestigatori P28704.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR000003. Retinoid-X_rcpt/HNF4.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR00545. RETINOIDXR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse Rxrb gene encoding RXR beta: genomic organization and two mRNA isoforms generated by alternative splicing of transcripts initiated from CpG island promoters."
      Nagata T., Kanno Y., Ozato K., Taketo M.
      Gene 142:183-189(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING.
      Strain: BALB/c.
      Tissue: Liver.
    2. "Sequence of the mouse major histocomaptibility locus class II region."
      Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Limb.
    4. "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently."
      Leid M., Kastner P., Lyons R., Nakshatri H., Saunders M., Zacharewsi T., Chen J.Y., Staub A., Garnier J.-M., Mader S., Chambon P.
      Cell 68:377-395(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-520 (ISOFORM LONG).
      Tissue: Embryo.
    5. "H-2RIIBP, a member of the nuclear hormone receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element."
      Hamada K., Gleason S.L., Levi B.-Z., Hirschfeld S., Appella E., Ozato K.
      Proc. Natl. Acad. Sci. U.S.A. 86:8289-8293(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-520 (ISOFORM LONG).
      Tissue: Liver.
    6. "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid."
      Mangelsdorf D.J., Borgmeyer U., Heyman R.A., Zhou J.Y., Ong E.S., Oro A.E., Kakizuka A., Evans R.M.
      Genes Dev. 6:329-344(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM SHORT).
      Tissue: Liver.

    Entry informationi

    Entry nameiRXRB_MOUSE
    AccessioniPrimary (citable) accession number: P28704
    Secondary accession number(s): P33243
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: February 1, 1996
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3