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Protein

Retinoic acid receptor RXR-beta

Gene

Rxrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi192 – 257Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri192 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri228 – 252NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • 9-cis retinoic acid receptor activity Source: MGI
  • nuclear receptor activity Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  • sequence-specific DNA binding Source: MGI
  • steroid hormone receptor activity Source: InterPro
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
  • transcription regulatory region DNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cardiac muscle cell proliferation Source: MGI
  • cellular response to retinoic acid Source: UniProtKB
  • in utero embryonic development Source: MGI
  • maternal placenta development Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • retinoic acid receptor signaling pathway Source: MGI
  • ventricular cardiac muscle cell differentiation Source: MGI

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway
R-MMU-5362517 Signaling by Retinoic Acid

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-beta
Alternative name(s):
MHC class I regulatory element-binding protein H-2RIIBP
Nuclear receptor subfamily 2 group B member 2
Retinoid X receptor beta
Gene namesi
Name:Rxrb
Synonyms:Nr2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98215 Rxrb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4047
GuidetoPHARMACOLOGYi611

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535731 – 520Retinoic acid receptor RXR-betaAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Omega-N-methylarginineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiP28704
PaxDbiP28704
PeptideAtlasiP28704
PRIDEiP28704

PTM databases

iPTMnetiP28704
PhosphoSitePlusiP28704

Expressioni

Tissue specificityi

In all tissues tested, including brain, thymus, spleen and liver.2 Publications

Gene expression databases

BgeeiENSMUSG00000039656
CleanExiMM_RXRB
ExpressionAtlasiP28704 baseline and differential
GenevisibleiP28704 MM

Interactioni

Subunit structurei

Homodimer (in vitro). Heterodimer with other retinoic acid receptor family members. Binds DNA preferentially as a RAR/RXR heterodimer. Interacts with NR1H3 (By similarity). Interacts with AKAP13 (PubMed:20139090).By similarity1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi203039, 2 interactors
IntActiP28704, 1 interactor
STRINGi10090.ENSMUSP00000036585

Chemistry databases

BindingDBiP28704

Structurei

3D structure databases

ProteinModelPortaliP28704
SMRiP28704
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini283 – 516NR LBDPROSITE-ProRule annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 191ModulatingBy similarityAdd BLAST191
Regioni258 – 382HingeAdd BLAST125

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.1 Publication

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 212NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri228 – 252NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiP28704
KOiK08525
PhylomeDBiP28704

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform Long (identifier: P28704-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSWATRPPFL PPRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA
60 70 80 90 100
AAGEQQALEP EPGEAGRDGM GDSGRDSRSP DSSSPNPLSQ GIRPSSPPGP
110 120 130 140 150
PLTPSAPPPP MPPPPLGSPF PVISSSMGSP GLPPPAPPGF SGPVSSPQIN
160 170 180 190 200
STVSLPGGGS GPPEDVKPPV LGVRGLHCPP PPGGPGAGKR LCAICGDRSS
210 220 230 240 250
GKHYGVYSCE GCKGFFKRTI RKDLTYSCRD NKDCTVDKRQ RNRCQYCRYQ
260 270 280 290 300
KCLATGMKRE AVQEERQRGK DKDGDGDGAG GAPEEMPVDR ILEAELAVEQ
310 320 330 340 350
KSDQGVEGPG ATGGGGSSPN DPVTNICQAA DKQLFTLVEW AKRIPHFSSL
360 370 380 390 400
PLDDQVILLR AGWNELLIAS FSHRSIDVRD GILLATGLHV HRNSAHSAGV
410 420 430 440 450
GAIFDRVLTE LVSKMRDMRM DKTELGCLRA IILFNPDAKG LSNPGEVEIL
460 470 480 490 500
REKVYASLET YCKQKYPEQQ GRFAKLLLRL PALRSIGLKC LEHLFFFKLI
510 520
GDTPIDTFLM EMLEAPHQLA
Length:520
Mass (Da):55,866
Last modified:February 1, 1996 - v2
Checksum:i71FAEAEC0D2DB505
GO
Isoform Short (identifier: P28704-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:410
Mass (Da):44,396
Checksum:i76353141EEA68AB0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73 – 75SGR → MGP in AAA40081 (PubMed:1310259).Curated3
Sequence conflicti75 – 77RDS → EFP in AAA37772 (PubMed:2554307).Curated3
Sequence conflicti433L → M in AAA40081 (PubMed:1310259).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0036781 – 110Missing in isoform Short. CuratedAdd BLAST110

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21831 Genomic DNA Translation: BAA04858.1
D21831 Genomic DNA Translation: BAA04859.1
AF100956 Genomic DNA Translation: AAC69904.1
BC049773 mRNA Translation: AAH49773.1
M84818 mRNA Translation: AAA40081.2
M26804 mRNA Translation: AAA37772.1
X66224 mRNA Translation: CAA46963.1
CCDSiCCDS57068.1 [P28704-2]
PIRiA34418
D41727
I84718
S26669
RefSeqiNP_001192145.1, NM_001205216.1 [P28704-2]
NP_035436.1, NM_011306.4 [P28704-1]
UniGeneiMm.1243

Genome annotation databases

EnsembliENSMUST00000116612; ENSMUSP00000112311; ENSMUSG00000039656 [P28704-2]
GeneIDi20182
KEGGimmu:20182
UCSCiuc008cax.2 mouse [P28704-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRXRB_MOUSE
AccessioniPrimary (citable) accession number: P28704
Secondary accession number(s): P33243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 180 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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