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Protein

Retinoic acid receptor RXR-gamma

Gene

RXRG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi143 – 20866Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri143 – 16321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20325NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3
Retinoid X receptor gamma
Gene namesi
Name:RXRG
Synonyms:NR2B3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • cell Source: AgBase
  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 467467Retinoic acid receptor RXR-gammaPRO_0000053578Add
BLAST

Proteomic databases

PaxDbiP28701.

Expressioni

Tissue specificityi

Isoform 1 is highly expressed inliver. Isoform 2 is abundantly expressed in eye and dorsal root ganglia.1 Publication

Developmental stagei

At stage 16, in the posterior trunk region, expressed in the neural crest and in neural crest cells migrating into the sclerotome. From stages 24 to 27, expressed in the liver and in elements of the developing peripheral nervous system derived from the neural crest, including dorsal root ganglia, cranial ganglia, enteric ganglia and peripheral nerve tracts.1 Publication

Interactioni

Subunit structurei

Homodimer. Heterodimer; with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005377.

Structurei

3D structure databases

ProteinModelPortaliP28701.
SMRiP28701. Positions 136-218, 235-467.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 142142ModulatingBy similarityAdd
BLAST
Regioni209 – 23224HingeAdd
BLAST
Regioni233 – 467235Ligand-bindingAdd
BLAST

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri143 – 16321NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri179 – 20325NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28701.
KOiK08526.
PhylomeDBiP28701.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P28701-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGNYPHFIK FPAGFGNSPV HASSTSVSPS SSLSVGSTVD GHHNYLEAPT
60 70 80 90 100
NASRALPSPM NTIGSPVNAL GSPYRVIASS IGSHPVALSS SAPGMNFVTH
110 120 130 140 150
SPQPNVLNNV SSSEDIKPLP GLPGIGNMNY PSTSPGSLAK HICAICGDRS
160 170 180 190 200
SGKHYGVYSC EGCKGFFKRT IRKDLIYTCR DNKDCLIDKR QRNRCQYCRY
210 220 230 240 250
QKCLAMGMKR EAVQEERQGS RERSENEAES TSGGSEDMPV ERILEAELAV
260 270 280 290 300
EPKTEAYSDV NTESSTNDPV TNICHAADKQ LFTLVEWAKR IPHFSDLTLE
310 320 330 340 350
DQVILLRAGW NELLIASFSH RSVSVQDGIL LATGLHVHRS SAHSAGVGSI
360 370 380 390 400
FDRVLTELVS KMKDMQMDKS ELGCLRAIVL FNPDAKGLSS PSEVESLREK
410 420 430 440 450
VYATLEAYTK QKYPEQPGRF AKLLLRLPAL RSIGLKCLEH LFFFKLIGDT
460
PIDTFLMEML ETPLQVT
Length:467
Mass (Da):51,233
Last modified:December 1, 1992 - v1
Checksum:iCE340877BD66C8A2
GO
Isoform 2 (identifier: P28701-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: MYGNYPHFIKFPAGFGN → MQPGMQAPYSLEMGSFPHF

Show »
Length:469
Mass (Da):51,428
Checksum:iED89BA42DE9CF9FE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1717MYGNY…AGFGN → MQPGMQAPYSLEMGSFPHF in isoform 2. 1 PublicationVSP_011846Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58997 mRNA. Translation: CAA41743.1.
S72435 mRNA. Translation: AAB31348.2.
PIRiA43781.
S46479.
RefSeqiNP_990625.1. NM_205294.1. [P28701-1]
UniGeneiGga.11071.
Gga.717.

Genome annotation databases

GeneIDi396231.
KEGGigga:396231.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58997 mRNA. Translation: CAA41743.1.
S72435 mRNA. Translation: AAB31348.2.
PIRiA43781.
S46479.
RefSeqiNP_990625.1. NM_205294.1. [P28701-1]
UniGeneiGga.11071.
Gga.717.

3D structure databases

ProteinModelPortaliP28701.
SMRiP28701. Positions 136-218, 235-467.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005377.

Proteomic databases

PaxDbiP28701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396231.
KEGGigga:396231.

Organism-specific databases

CTDi6258.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260821.
HOVERGENiHBG005606.
InParanoidiP28701.
KOiK08526.
PhylomeDBiP28701.

Miscellaneous databases

PROiP28701.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021780. Nuc_recep-AF1.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000003. Retinoid-X_rcpt/HNF4.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF11825. Nuc_recep-AF1. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00545. RETINOIDXR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A member of the RXR nuclear receptor family is expressed in neural-crest-derived cells of the developing chick peripheral nervous system."
    Rowe A., Eager N.S.C., Brickell P.M.
    Development 111:771-778(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE.
  2. "The chicken retinoid-X-receptor-gamma gene gives rise to two distinct species of mRNA with different patterns of expression."
    Seleiro E.A., Darling D., Brickell P.M.
    Biochem. J. 301:283-288(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-17 (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Liver.

Entry informationi

Entry nameiRXRG_CHICK
AccessioniPrimary (citable) accession number: P28701
Secondary accession number(s): Q91380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.