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P28686

- NOV_CHICK

UniProt

P28686 - NOV_CHICK

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Protein

Protein NOV

Gene
NOV, CCN3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of NOV gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein
Gene namesi
Name:NOV
Synonyms:CCN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 351327Protein NOVPRO_0000014413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi258 ↔ 295 By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi275 ↔ 309 By similarity
Disulfide bondi286 ↔ 325 By similarity
Disulfide bondi289 ↔ 327 By similarity
Disulfide bondi294 ↔ 331 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28686.

Expressioni

Tissue specificityi

Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.

Developmental stagei

MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025912.

Structurei

3D structure databases

ProteinModelPortaliP28686.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10175IGFBP N-terminalAdd
BLAST
Domaini104 – 17067VWFCAdd
BLAST
Domaini201 – 24646TSP type-1Add
BLAST
Domaini258 – 33275CTCKAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP28686.
PhylomeDBiP28686.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28686-1 [UniParc]FASTAAdd to Basket

« Hide

METGGGQGLP VLLLLLLLLR PCEVSGREAA CPRPCGGRCP AEPPRCAPGV    50
PAVLDGCGCC LVCARQRGES CSPLLPCDES GGLYCDRGPE DGGGAGICMV 100
LEGDNCVFDG MIYRNGETFQ PSCKYQCTCR DGQIGCLPRC NLGLLLPGPD 150
CPFPRKIEVP GECCEKWVCD PRDEVLLGGF AMAAYRQEAT LGIDVSDSSA 200
NCIEQTTEWS ACSKSCGMGF STRVTNRNQQ CEMVKQTRLC MMRPCENEEP 250
SDKKGKKCIQ TKKSMKAVRF EYKNCTSVQT YKPRYCGLCN DGRCCTPHNT 300
KTIQVEFRCP QGKFLKKPMM LINTCVCHGN CPQSNNAFFQ PLDPMSSEAK 350
I 351
Length:351
Mass (Da):38,268
Last modified:December 1, 1992 - v1
Checksum:i1ECB3FA3058C6797
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59284 mRNA. Translation: CAA41975.1.
PIRiS20078.
RefSeqiNP_990599.1. NM_205268.1.
UniGeneiGga.2587.

Genome annotation databases

GeneIDi396204.
KEGGigga:396204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59284 mRNA. Translation: CAA41975.1 .
PIRi S20078.
RefSeqi NP_990599.1. NM_205268.1.
UniGenei Gga.2587.

3D structure databases

ProteinModelPortali P28686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000025912.

Proteomic databases

PaxDbi P28686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396204.
KEGGi gga:396204.

Organism-specific databases

CTDi 4856.

Phylogenomic databases

eggNOGi NOG72934.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P28686.
PhylomeDBi P28686.

Miscellaneous databases

NextBioi 20816256.
PROi P28686.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas."
    Joliot V., Martinerie C., Dambrine G., Plassiart G., Brisac M., Crochet J., Perbal B.
    Mol. Cell. Biol. 12:10-21(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown leghorn.

Entry informationi

Entry nameiNOV_CHICK
AccessioniPrimary (citable) accession number: P28686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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