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P28686

- NOV_CHICK

UniProt

P28686 - NOV_CHICK

Protein

Protein NOV

Gene

NOV

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of NOV gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.

    GO - Biological processi

    1. regulation of cell growth Source: InterPro

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein NOV
    Alternative name(s):
    CCN family member 3
    Nephroblastoma-overexpressed gene protein
    Gene namesi
    Name:NOV
    Synonyms:CCN3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 351327Protein NOVPRO_0000014413Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi258 ↔ 295By similarity
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 309By similarity
    Disulfide bondi286 ↔ 325By similarity
    Disulfide bondi289 ↔ 327By similarity
    Disulfide bondi294 ↔ 331By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP28686.

    Expressioni

    Tissue specificityi

    Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.

    Developmental stagei

    MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000025912.

    Structurei

    3D structure databases

    ProteinModelPortaliP28686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini27 – 10175IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini104 – 17067VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini201 – 24646TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini258 – 33275CTCKPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG72934.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiP28686.
    PhylomeDBiP28686.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P28686-1 [UniParc]FASTAAdd to Basket

    « Hide

    METGGGQGLP VLLLLLLLLR PCEVSGREAA CPRPCGGRCP AEPPRCAPGV    50
    PAVLDGCGCC LVCARQRGES CSPLLPCDES GGLYCDRGPE DGGGAGICMV 100
    LEGDNCVFDG MIYRNGETFQ PSCKYQCTCR DGQIGCLPRC NLGLLLPGPD 150
    CPFPRKIEVP GECCEKWVCD PRDEVLLGGF AMAAYRQEAT LGIDVSDSSA 200
    NCIEQTTEWS ACSKSCGMGF STRVTNRNQQ CEMVKQTRLC MMRPCENEEP 250
    SDKKGKKCIQ TKKSMKAVRF EYKNCTSVQT YKPRYCGLCN DGRCCTPHNT 300
    KTIQVEFRCP QGKFLKKPMM LINTCVCHGN CPQSNNAFFQ PLDPMSSEAK 350
    I 351
    Length:351
    Mass (Da):38,268
    Last modified:December 1, 1992 - v1
    Checksum:i1ECB3FA3058C6797
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59284 mRNA. Translation: CAA41975.1.
    PIRiS20078.
    RefSeqiNP_990599.1. NM_205268.1.
    UniGeneiGga.2587.

    Genome annotation databases

    GeneIDi396204.
    KEGGigga:396204.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59284 mRNA. Translation: CAA41975.1 .
    PIRi S20078.
    RefSeqi NP_990599.1. NM_205268.1.
    UniGenei Gga.2587.

    3D structure databases

    ProteinModelPortali P28686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000025912.

    Proteomic databases

    PaxDbi P28686.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396204.
    KEGGi gga:396204.

    Organism-specific databases

    CTDi 4856.

    Phylogenomic databases

    eggNOGi NOG72934.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi P28686.
    PhylomeDBi P28686.

    Miscellaneous databases

    NextBioi 20816256.
    PROi P28686.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas."
      Joliot V., Martinerie C., Dambrine G., Plassiart G., Brisac M., Crochet J., Perbal B.
      Mol. Cell. Biol. 12:10-21(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Brown leghorn.

    Entry informationi

    Entry nameiNOV_CHICK
    AccessioniPrimary (citable) accession number: P28686
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3