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P28686 (NOV_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NOV
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein
Gene names
Name:NOV
Synonyms:CCN3
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of NOV gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.

Subcellular location

Secreted.

Tissue specificity

Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.

Developmental stage

MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseProto-oncogene
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 351327Protein NOV
PRO_0000014413

Regions

Domain27 – 10175IGFBP N-terminal
Domain104 – 17067VWFC
Domain201 – 24646TSP type-1
Domain258 – 33275CTCK

Amino acid modifications

Glycosylation2741N-linked (GlcNAc...) Potential
Disulfide bond258 ↔ 295 By similarity
Disulfide bond275 ↔ 309 By similarity
Disulfide bond286 ↔ 325 By similarity
Disulfide bond289 ↔ 327 By similarity
Disulfide bond294 ↔ 331 By similarity

Sequences

Sequence LengthMass (Da)Tools
P28686 [UniParc].

Last modified December 1, 1992. Version 1.
Checksum: 1ECB3FA3058C6797

FASTA35138,268
        10         20         30         40         50         60 
METGGGQGLP VLLLLLLLLR PCEVSGREAA CPRPCGGRCP AEPPRCAPGV PAVLDGCGCC 

        70         80         90        100        110        120 
LVCARQRGES CSPLLPCDES GGLYCDRGPE DGGGAGICMV LEGDNCVFDG MIYRNGETFQ 

       130        140        150        160        170        180 
PSCKYQCTCR DGQIGCLPRC NLGLLLPGPD CPFPRKIEVP GECCEKWVCD PRDEVLLGGF 

       190        200        210        220        230        240 
AMAAYRQEAT LGIDVSDSSA NCIEQTTEWS ACSKSCGMGF STRVTNRNQQ CEMVKQTRLC 

       250        260        270        280        290        300 
MMRPCENEEP SDKKGKKCIQ TKKSMKAVRF EYKNCTSVQT YKPRYCGLCN DGRCCTPHNT 

       310        320        330        340        350 
KTIQVEFRCP QGKFLKKPMM LINTCVCHGN CPQSNNAFFQ PLDPMSSEAK I 

« Hide

References

[1]"Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas."
Joliot V., Martinerie C., Dambrine G., Plassiart G., Brisac M., Crochet J., Perbal B.
Mol. Cell. Biol. 12:10-21(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown leghorn.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X59284 mRNA. Translation: CAA41975.1.
PIRS20078.
RefSeqNP_990599.1. NM_205268.1.
UniGeneGga.2587.

3D structure databases

ProteinModelPortalP28686.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000025912.

Proteomic databases

PaxDbP28686.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396204.
KEGGgga:396204.

Organism-specific databases

CTD4856.

Phylogenomic databases

eggNOGNOG72934.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidP28686.
PhylomeDBP28686.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816256.
PROP28686.

Entry information

Entry nameNOV_CHICK
AccessionPrimary (citable) accession number: P28686
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families