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P28686

- NOV_CHICK

UniProt

P28686 - NOV_CHICK

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Protein

Protein NOV

Gene

NOV

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of NOV gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro.

GO - Biological processi

  1. regulation of cell growth Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein
Gene namesi
Name:NOV
Synonyms:CCN3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 351327Protein NOVPRO_0000014413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi258 ↔ 295By similarity
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi275 ↔ 309By similarity
Disulfide bondi286 ↔ 325By similarity
Disulfide bondi289 ↔ 327By similarity
Disulfide bondi294 ↔ 331By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP28686.

Expressioni

Tissue specificityi

Brain and heart, and at a lower level in muscle and intestine, in the embryo. Lung and less so in brain and spleen, in adult chicken.

Developmental stagei

MAV1-induced nephroblastomas express a high level of NOV gene whose transcription is normally arrested in adult kidney.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025912.

Structurei

3D structure databases

ProteinModelPortaliP28686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10175IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini104 – 17067VWFCPROSITE-ProRule annotationAdd
BLAST
Domaini201 – 24646TSP type-1PROSITE-ProRule annotationAdd
BLAST
Domaini258 – 33275CTCKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CCN family.Curated
Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72934.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiP28686.
PhylomeDBiP28686.

Family and domain databases

InterProiIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamiPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28686-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METGGGQGLP VLLLLLLLLR PCEVSGREAA CPRPCGGRCP AEPPRCAPGV
60 70 80 90 100
PAVLDGCGCC LVCARQRGES CSPLLPCDES GGLYCDRGPE DGGGAGICMV
110 120 130 140 150
LEGDNCVFDG MIYRNGETFQ PSCKYQCTCR DGQIGCLPRC NLGLLLPGPD
160 170 180 190 200
CPFPRKIEVP GECCEKWVCD PRDEVLLGGF AMAAYRQEAT LGIDVSDSSA
210 220 230 240 250
NCIEQTTEWS ACSKSCGMGF STRVTNRNQQ CEMVKQTRLC MMRPCENEEP
260 270 280 290 300
SDKKGKKCIQ TKKSMKAVRF EYKNCTSVQT YKPRYCGLCN DGRCCTPHNT
310 320 330 340 350
KTIQVEFRCP QGKFLKKPMM LINTCVCHGN CPQSNNAFFQ PLDPMSSEAK

I
Length:351
Mass (Da):38,268
Last modified:December 1, 1992 - v1
Checksum:i1ECB3FA3058C6797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59284 mRNA. Translation: CAA41975.1.
PIRiS20078.
RefSeqiNP_990599.1. NM_205268.1.
UniGeneiGga.2587.

Genome annotation databases

GeneIDi396204.
KEGGigga:396204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59284 mRNA. Translation: CAA41975.1 .
PIRi S20078.
RefSeqi NP_990599.1. NM_205268.1.
UniGenei Gga.2587.

3D structure databases

ProteinModelPortali P28686.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000025912.

Proteomic databases

PaxDbi P28686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396204.
KEGGi gga:396204.

Organism-specific databases

CTDi 4856.

Phylogenomic databases

eggNOGi NOG72934.
HOGENOMi HOG000231462.
HOVERGENi HBG000635.
InParanoidi P28686.
PhylomeDBi P28686.

Miscellaneous databases

NextBioi 20816256.
PROi P28686.

Family and domain databases

InterProi IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view ]
PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTi SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEi PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas."
    Joliot V., Martinerie C., Dambrine G., Plassiart G., Brisac M., Crochet J., Perbal B.
    Mol. Cell. Biol. 12:10-21(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown leghorn.

Entry informationi

Entry nameiNOV_CHICK
AccessioniPrimary (citable) accession number: P28686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3