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Protein

Contactin-2

Gene

CNTN2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-GGA-373760. L1CAM interactions.
R-GGA-419037. NCAM1 interactions.
R-GGA-447038. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonin-1
Gene namesi
Name:CNTN2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei? – 1036Removed in mature formPRO_0000014702
Signal peptidei1 – 2323Or 25Sequence analysisAdd
BLAST
Chaini24 – ?Contactin-2PRO_0000014701

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 106Combined sources1 Publication
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi150 ↔ 202Combined sources1 Publication
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence analysis
Disulfide bondi256 ↔ 301Combined sources1 Publication
Disulfide bondi343 ↔ 390Combined sources1 Publication
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence analysis
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis
Glycosylationi770 – 7701N-linked (GlcNAc...)Sequence analysis
Glycosylationi900 – 9001N-linked (GlcNAc...)Sequence analysis
Glycosylationi914 – 9141N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP28685.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034589.

Structurei

Secondary structure

1
1036
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 367Combined sources
Beta strandi41 – 444Combined sources
Beta strandi51 – 544Combined sources
Beta strandi57 – 626Combined sources
Beta strandi65 – 706Combined sources
Beta strandi81 – 866Combined sources
Beta strandi89 – 946Combined sources
Helixi97 – 1004Combined sources
Beta strandi102 – 1109Combined sources
Beta strandi113 – 1164Combined sources
Beta strandi120 – 1278Combined sources
Beta strandi138 – 1414Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi154 – 1574Combined sources
Beta strandi160 – 1678Combined sources
Beta strandi176 – 1805Combined sources
Turni182 – 1843Combined sources
Beta strandi187 – 1915Combined sources
Helixi194 – 1963Combined sources
Beta strandi198 – 20811Combined sources
Beta strandi211 – 2166Combined sources
Beta strandi220 – 2267Combined sources
Beta strandi232 – 2387Combined sources
Beta strandi242 – 2476Combined sources
Beta strandi252 – 2554Combined sources
Beta strandi257 – 2626Combined sources
Beta strandi265 – 2706Combined sources
Beta strandi280 – 2889Combined sources
Helixi293 – 2953Combined sources
Beta strandi297 – 3059Combined sources
Beta strandi308 – 32619Combined sources
Beta strandi331 – 3344Combined sources
Beta strandi339 – 3424Combined sources
Beta strandi344 – 3496Combined sources
Beta strandi352 – 3576Combined sources
Beta strandi366 – 3716Combined sources
Beta strandi374 – 3796Combined sources
Helixi382 – 3843Combined sources
Beta strandi386 – 3949Combined sources
Beta strandi397 – 40812Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CS6X-ray1.80A28-409[»]
ProteinModelPortaliP28685.
SMRiP28685. Positions 28-409.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12392Ig-like C2-type 1Add
BLAST
Domaini128 – 22396Ig-like C2-type 2Add
BLAST
Domaini234 – 31784Ig-like C2-type 3Add
BLAST
Domaini322 – 40685Ig-like C2-type 4Add
BLAST
Domaini412 – 49988Ig-like C2-type 5Add
BLAST
Domaini504 – 59895Ig-like C2-type 6Add
BLAST
Domaini605 – 70399Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini708 – 80598Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini810 – 90798Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini911 – 100393Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni599 – 60810HingeSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi601 – 6077Gly/Pro-rich

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP28685.
KOiK06760.
PhylomeDBiP28685.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTAAFICT SLAVIICVVW CQAQSGMRSY GPVFEEQPAH TLFPEGSAEE
60 70 80 90 100
KVTLTCRARA NPPATYRWKM NGTELKMGPD SRYRLVAGDL VISNPVKAKD
110 120 130 140 150
AGSYQCVATN ARGTVVSREA SLRFGFLQEF SAEERDPVKI TEGWGVMFTC
160 170 180 190 200
SPPPHYPALS YRWLLNEFPN FIPADGRRFV SQTTGNLYIA KTEASDLGNY
210 220 230 240 250
SCFATSHIDF ITKSVFSKFS QLSLAAEDAR QYAPSIKAKF PADTYALTGQ
260 270 280 290 300
MVTLECFAFG NPVPQIKWRK LDGSQTSKWL SSEPLLHIQN VDFEDEGTYE
310 320 330 340 350
CEAENIKGRD TYQGRIIIHA QPDWLDVITD TEADIGSDLR WSCVASGKPR
360 370 380 390 400
PAVRWLRDGQ PLASQNRIEV SGGELRFSKL VLEDSGMYQC VAENKHGTVY
410 420 430 440 450
ASAELTVQAL APDFRLNPVK RLIPAARSGK VIIPCQPRAA PKATVLWTKG
460 470 480 490 500
TELLTNSSRV TITADGTLIL QNISKSDEGK YTCFAENFMG KANSTGILSV
510 520 530 540 550
RDATKITLAP SSADINVGEN LTLQCHASHD PTMDLTFTWS LDDFPIDLDK
560 570 580 590 600
SEGHYRRASV KEAVGDLAIV NAQLKHSGRY TCTAQTVVDS TSESATLTVR
610 620 630 640 650
GPPGPPGGVV VRDIGDTTVQ LSWSRGFDNH SPIARYSIEA RTLLSNKWKQ
660 670 680 690 700
MRTNPVNIEG NAETAQVVNL IPWMDYEFRV LASNILGVGE PSLPSSKIRT
710 720 730 740 750
KEAAPTVAPS GLGGGGGAPN ELIINWTPTL RDYQNGDGFG YILSFRKKGT
760 770 780 790 800
QGWLTARVPH AESLHYVYRN ESIGPYTPFE VKIKAYNRKG EGPESLTAIV
810 820 830 840 850
YSAEEEPKVA PFRVTAKAVL SSEMDVSWEP VEQGDMTGVL LGYEIRYWKD
860 870 880 890 900
GDKEEAADRV RTAGLVTSAH VTGLNPNTKY HVSVRAYNRA GAGPPSPSTN
910 920 930 940 950
ITTTKPPPRR PPGNISWTLT GSTVTIKWDP VVAQADESAV TGYKMLYRQD
960 970 980 990 1000
SHSAPTLYLA SKSRIDIPVP EDFTHAFVQI RVTGPGGDGT PAEVHIVRNS
1010 1020 1030
GTSMMVEDSV TRPVPHAAII TTNSLAMVAL IRYLEL
Length:1,036
Mass (Da):113,302
Last modified:December 1, 1992 - v1
Checksum:i08B80143BE779794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63101 mRNA. Translation: CAA44815.1.
X79607 Genomic DNA. No translation available.
PIRiS22383.
RefSeqiNP_001004395.1. NM_001004395.1.
UniGeneiGga.2766.

Genome annotation databases

GeneIDi419825.
KEGGigga:419825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63101 mRNA. Translation: CAA44815.1.
X79607 Genomic DNA. No translation available.
PIRiS22383.
RefSeqiNP_001004395.1. NM_001004395.1.
UniGeneiGga.2766.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CS6X-ray1.80A28-409[»]
ProteinModelPortaliP28685.
SMRiP28685. Positions 28-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034589.

Proteomic databases

PaxDbiP28685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi419825.
KEGGigga:419825.

Organism-specific databases

CTDi6900.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP28685.
KOiK06760.
PhylomeDBiP28685.

Enzyme and pathway databases

ReactomeiR-GGA-373760. L1CAM interactions.
R-GGA-419037. NCAM1 interactions.
R-GGA-447038. NrCAM interactions.

Miscellaneous databases

EvolutionaryTraceiP28685.
PROiP28685.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN2_CHICK
AccessioniPrimary (citable) accession number: P28685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: June 8, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.