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Protein

Contactin-2

Gene

CNTN2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity).By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-GGA-373760. L1CAM interactions.
R-GGA-419037. NCAM1 interactions.
R-GGA-447038. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonin-1
Gene namesi
Name:CNTN2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000014702? – 1036Removed in mature form
Signal peptidei1 – 23Or 25Sequence analysisAdd BLAST23
ChainiPRO_000001470124 – ?Contactin-2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 106Combined sources1 Publication
Glycosylationi71N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi150 ↔ 202Combined sources1 Publication
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi256 ↔ 301Combined sources1 Publication
Disulfide bondi343 ↔ 390Combined sources1 Publication
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Glycosylationi770N-linked (GlcNAc...)Sequence analysis1
Glycosylationi900N-linked (GlcNAc...)Sequence analysis1
Glycosylationi914N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP28685.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034589.

Structurei

Secondary structure

11036
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 36Combined sources7
Beta strandi41 – 44Combined sources4
Beta strandi51 – 54Combined sources4
Beta strandi57 – 62Combined sources6
Beta strandi65 – 70Combined sources6
Beta strandi81 – 86Combined sources6
Beta strandi89 – 94Combined sources6
Helixi97 – 100Combined sources4
Beta strandi102 – 110Combined sources9
Beta strandi113 – 116Combined sources4
Beta strandi120 – 127Combined sources8
Beta strandi138 – 141Combined sources4
Beta strandi146 – 148Combined sources3
Beta strandi154 – 157Combined sources4
Beta strandi160 – 167Combined sources8
Beta strandi176 – 180Combined sources5
Turni182 – 184Combined sources3
Beta strandi187 – 191Combined sources5
Helixi194 – 196Combined sources3
Beta strandi198 – 208Combined sources11
Beta strandi211 – 216Combined sources6
Beta strandi220 – 226Combined sources7
Beta strandi232 – 238Combined sources7
Beta strandi242 – 247Combined sources6
Beta strandi252 – 255Combined sources4
Beta strandi257 – 262Combined sources6
Beta strandi265 – 270Combined sources6
Beta strandi280 – 288Combined sources9
Helixi293 – 295Combined sources3
Beta strandi297 – 305Combined sources9
Beta strandi308 – 326Combined sources19
Beta strandi331 – 334Combined sources4
Beta strandi339 – 342Combined sources4
Beta strandi344 – 349Combined sources6
Beta strandi352 – 357Combined sources6
Beta strandi366 – 371Combined sources6
Beta strandi374 – 379Combined sources6
Helixi382 – 384Combined sources3
Beta strandi386 – 394Combined sources9
Beta strandi397 – 408Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CS6X-ray1.80A28-409[»]
ProteinModelPortaliP28685.
SMRiP28685.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP28685.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 123Ig-like C2-type 1Add BLAST92
Domaini128 – 223Ig-like C2-type 2Add BLAST96
Domaini234 – 317Ig-like C2-type 3Add BLAST84
Domaini322 – 406Ig-like C2-type 4Add BLAST85
Domaini412 – 499Ig-like C2-type 5Add BLAST88
Domaini504 – 598Ig-like C2-type 6Add BLAST95
Domaini605 – 703Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini708 – 805Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini810 – 907Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST98
Domaini911 – 1003Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni599 – 608HingeSequence analysis10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi601 – 607Gly/Pro-rich7

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP28685.
KOiK06760.
PhylomeDBiP28685.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28685-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGTAAFICT SLAVIICVVW CQAQSGMRSY GPVFEEQPAH TLFPEGSAEE
60 70 80 90 100
KVTLTCRARA NPPATYRWKM NGTELKMGPD SRYRLVAGDL VISNPVKAKD
110 120 130 140 150
AGSYQCVATN ARGTVVSREA SLRFGFLQEF SAEERDPVKI TEGWGVMFTC
160 170 180 190 200
SPPPHYPALS YRWLLNEFPN FIPADGRRFV SQTTGNLYIA KTEASDLGNY
210 220 230 240 250
SCFATSHIDF ITKSVFSKFS QLSLAAEDAR QYAPSIKAKF PADTYALTGQ
260 270 280 290 300
MVTLECFAFG NPVPQIKWRK LDGSQTSKWL SSEPLLHIQN VDFEDEGTYE
310 320 330 340 350
CEAENIKGRD TYQGRIIIHA QPDWLDVITD TEADIGSDLR WSCVASGKPR
360 370 380 390 400
PAVRWLRDGQ PLASQNRIEV SGGELRFSKL VLEDSGMYQC VAENKHGTVY
410 420 430 440 450
ASAELTVQAL APDFRLNPVK RLIPAARSGK VIIPCQPRAA PKATVLWTKG
460 470 480 490 500
TELLTNSSRV TITADGTLIL QNISKSDEGK YTCFAENFMG KANSTGILSV
510 520 530 540 550
RDATKITLAP SSADINVGEN LTLQCHASHD PTMDLTFTWS LDDFPIDLDK
560 570 580 590 600
SEGHYRRASV KEAVGDLAIV NAQLKHSGRY TCTAQTVVDS TSESATLTVR
610 620 630 640 650
GPPGPPGGVV VRDIGDTTVQ LSWSRGFDNH SPIARYSIEA RTLLSNKWKQ
660 670 680 690 700
MRTNPVNIEG NAETAQVVNL IPWMDYEFRV LASNILGVGE PSLPSSKIRT
710 720 730 740 750
KEAAPTVAPS GLGGGGGAPN ELIINWTPTL RDYQNGDGFG YILSFRKKGT
760 770 780 790 800
QGWLTARVPH AESLHYVYRN ESIGPYTPFE VKIKAYNRKG EGPESLTAIV
810 820 830 840 850
YSAEEEPKVA PFRVTAKAVL SSEMDVSWEP VEQGDMTGVL LGYEIRYWKD
860 870 880 890 900
GDKEEAADRV RTAGLVTSAH VTGLNPNTKY HVSVRAYNRA GAGPPSPSTN
910 920 930 940 950
ITTTKPPPRR PPGNISWTLT GSTVTIKWDP VVAQADESAV TGYKMLYRQD
960 970 980 990 1000
SHSAPTLYLA SKSRIDIPVP EDFTHAFVQI RVTGPGGDGT PAEVHIVRNS
1010 1020 1030
GTSMMVEDSV TRPVPHAAII TTNSLAMVAL IRYLEL
Length:1,036
Mass (Da):113,302
Last modified:December 1, 1992 - v1
Checksum:i08B80143BE779794
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63101 mRNA. Translation: CAA44815.1.
X79607 Genomic DNA. No translation available.
PIRiS22383.
RefSeqiNP_001004395.1. NM_001004395.1.
UniGeneiGga.2766.

Genome annotation databases

GeneIDi419825.
KEGGigga:419825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63101 mRNA. Translation: CAA44815.1.
X79607 Genomic DNA. No translation available.
PIRiS22383.
RefSeqiNP_001004395.1. NM_001004395.1.
UniGeneiGga.2766.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CS6X-ray1.80A28-409[»]
ProteinModelPortaliP28685.
SMRiP28685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000034589.

Proteomic databases

PaxDbiP28685.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi419825.
KEGGigga:419825.

Organism-specific databases

CTDi6900.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiP28685.
KOiK06760.
PhylomeDBiP28685.

Enzyme and pathway databases

ReactomeiR-GGA-373760. L1CAM interactions.
R-GGA-419037. NCAM1 interactions.
R-GGA-447038. NrCAM interactions.

Miscellaneous databases

EvolutionaryTraceiP28685.
PROiP28685.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN2_CHICK
AccessioniPrimary (citable) accession number: P28685
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.