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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828By similarityAdd
BLAST
Peptidei29 – 6436Neuropeptide YPRO_0000025333Add
BLAST
Peptidei68 – 9730C-flanking peptide of NPYPRO_0000025334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei64 – 641Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP28673.

Expressioni

Gene expression databases

ExpressionAtlasiP28673. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017870.

Structurei

3D structure databases

ProteinModelPortaliP28673.
SMRiP28673. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP28673.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG7WDN4S.
PhylomeDBiP28673.
TreeFamiTF332778.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGTMRLWVS VLTFALSLLI CLGTLAEAYP SKPDSPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLLR ESTENIPRSR FEDPSMW
Length:97
Mass (Da):11,097
Last modified:December 1, 1992 - v1
Checksum:i9C924B0E2D9B27CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87294 mRNA. Translation: AAA48991.1.
M87295, M87298 Genomic DNA. Translation: AAA48992.1.
PIRiA41979.
RefSeqiNP_990804.1. NM_205473.1.
UniGeneiGga.837.

Genome annotation databases

EnsembliENSGALT00000017891; ENSGALP00000017870; ENSGALG00000010983.
GeneIDi396464.
KEGGigga:396464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87294 mRNA. Translation: AAA48991.1.
M87295, M87298 Genomic DNA. Translation: AAA48992.1.
PIRiA41979.
RefSeqiNP_990804.1. NM_205473.1.
UniGeneiGga.837.

3D structure databases

ProteinModelPortaliP28673.
SMRiP28673. Positions 29-64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017870.

Proteomic databases

PaxDbiP28673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017891; ENSGALP00000017870; ENSGALG00000010983.
GeneIDi396464.
KEGGigga:396464.

Organism-specific databases

CTDi4852.

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP28673.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG7WDN4S.
PhylomeDBiP28673.
TreeFamiTF332778.

Enzyme and pathway databases

ReactomeiR-GGA-375276. Peptide ligand-binding receptors.
R-GGA-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi20816503.
PROiP28673.

Gene expression databases

ExpressionAtlasiP28673. baseline and differential.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Strong evolutionary conservation of neuropeptide Y: sequences of chicken, goldfish, and Torpedo marmorata DNA clones."
    Blomqvist A.G., Soederberg C., Lundell I., Milner R.J., Larhammar D.
    Proc. Natl. Acad. Sci. U.S.A. 89:2350-2354(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNPY_CHICK
AccessioniPrimary (citable) accession number: P28673
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.