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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28By similarityAdd BLAST28
PeptideiPRO_000002533329 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002533468 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP28673.

Expressioni

Gene expression databases

BgeeiENSGALG00000010983.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017870.

Structurei

3D structure databases

ProteinModelPortaliP28673.
SMRiP28673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP28673.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP28673.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P28673-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGTMRLWVS VLTFALSLLI CLGTLAEAYP SKPDSPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLLR ESTENIPRSR FEDPSMW
Length:97
Mass (Da):11,097
Last modified:December 1, 1992 - v1
Checksum:i9C924B0E2D9B27CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87294 mRNA. Translation: AAA48991.1.
M87295, M87298 Genomic DNA. Translation: AAA48992.1.
PIRiA41979.
RefSeqiNP_990804.1. NM_205473.1.
UniGeneiGga.837.

Genome annotation databases

EnsembliENSGALT00000017891; ENSGALP00000017870; ENSGALG00000010983.
GeneIDi396464.
KEGGigga:396464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87294 mRNA. Translation: AAA48991.1.
M87295, M87298 Genomic DNA. Translation: AAA48992.1.
PIRiA41979.
RefSeqiNP_990804.1. NM_205473.1.
UniGeneiGga.837.

3D structure databases

ProteinModelPortaliP28673.
SMRiP28673.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017870.

Proteomic databases

PaxDbiP28673.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017891; ENSGALP00000017870; ENSGALG00000010983.
GeneIDi396464.
KEGGigga:396464.

Organism-specific databases

CTDi4852.

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP28673.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP28673.
TreeFamiTF332778.

Miscellaneous databases

PROiP28673.

Gene expression databases

BgeeiENSGALG00000010983.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPY_CHICK
AccessioniPrimary (citable) accession number: P28673
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: December 1, 1992
Last modified: March 15, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.