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P28668

- SYEP_DROME

UniProt

P28668 - SYEP_DROME

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Protein

Bifunctional glutamate/proline--tRNA ligase

Gene

Aats-glupro

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA.By similarity

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171ATPBy similarity
Binding sitei404 – 4041ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi438 – 4425ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-tRNA ligase activity Source: UniProtKB-EC
  3. proline-tRNA ligase activity Source: UniProtKB-EC
  4. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: InterPro
  2. prolyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_214144. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional glutamate/proline--tRNA ligase
Alternative name(s):
Bifunctional aminoacyl-tRNA synthetase
Including the following 2 domains:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Proline--tRNA ligase (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:Aats-glupro
ORF Names:CG5394
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0005674. Aats-glupro.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17141714Bifunctional glutamate/proline--tRNA ligasePRO_0000119741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1110 – 11101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP28668.
PRIDEiP28668.

Expressioni

Gene expression databases

BgeeiP28668.

Interactioni

Subunit structurei

Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

Protein-protein interaction databases

BioGridi67770. 45 interactions.
IntActiP28668. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP28668.
SMRiP28668. Positions 37-162, 195-688, 748-797, 816-872, 894-943, 973-1022, 1217-1714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini744 – 80057WHEP-TRS 1Add
BLAST
Domaini816 – 87257WHEP-TRS 2Add
BLAST
Domaini890 – 94657WHEP-TRS 3Add
BLAST
Domaini969 – 102557WHEP-TRS 4Add
BLAST
Domaini1044 – 110057WHEP-TRS 5Add
BLAST
Domaini1118 – 117457WHEP-TRS 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni170 – 754585Glutamate--tRNA ligaseAdd
BLAST
Regioni1207 – 1714508Proline--tRNA ligaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi209 – 22012"HIGH" regionAdd
BLAST
Motifi438 – 4425"KMSKS" region

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1174 – 11807Poly-Gly

Sequence similaritiesi

In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.Curated
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.Curated
Contains 6 WHEP-TRS domains.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0442.
GeneTreeiENSGT00550000074815.
InParanoidiP28668.
KOiK14163.
OMAiVAMLHIK.
OrthoDBiEOG754HNH.
PhylomeDBiP28668.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
1.10.287.10. 6 hits.
1.20.1050.10. 1 hit.
2.40.240.10. 2 hits.
3.30.110.30. 1 hit.
3.40.50.620. 2 hits.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR001412. aa-tRNA-synth_I_CS.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF14497. GST_C_3. 1 hit.
PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF00458. WHEP-TRS. 6 hits.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00946. ProRS-C_1. 1 hit.
SM00991. WHEP-TRS. 6 hits.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 6 hits.
SSF47616. SSF47616. 1 hit.
SSF50715. SSF50715. 1 hit.
SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
TIGR00408. proS_fam_I. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 6 hits.
PS51185. WHEP_TRS_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P28668) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIKLKANLN NPPISGLATA HLINGTVPVE IVWSKEETSL QFPDNRLLVC
60 70 80 90 100
HSNNDVLRAL ARAAPDYKLY GETAIERTQI DHWLSFSLTC EDDISWALSF
110 120 130 140 150
LDKSIAPVTY LVANKLTIAD FALFNEMHSR YEFLAAKGIP QHVQRWYDLI
160 170 180 190 200
TAQPLIQKVL QSLPEDAKVK RSPQSSKEQT PAKTGERKQE GKFVDLPGAE
210 220 230 240 250
MGKVVVRFPP EASGYLHIGH AKAALLNQYY ALAFQGTLIM RFDDTNPAKE
260 270 280 290 300
TVEFENVILG DLEQLQIKPD VFTHTSNYFD LMLDYCVRLI KESKAYVDDT
310 320 330 340 350
PPEQMKLERE QRVESANRSN SVEKNLSLWE EMVKGSEKGQ KYCVRAKIDM
360 370 380 390 400
SSPNGCMRDP TIYRCKNEPH PRTGTKYKVY PTYDFACPIV DAIENVTHTL
410 420 430 440 450
RTTEYHDRDD QFYWFIDALK LRKPYIWSYS RLNMTNTVLS KRKLTWFVDS
460 470 480 490 500
GLVDGWDDPR FPTVRGIIRR GMTVEGLKEF IIAQGSSKSV VFMNWDKIWA
510 520 530 540 550
FNKKVIDPIA PRYTALEKEK RVIVNVAGAK VERIQVSVHP KDESLGKKTV
560 570 580 590 600
LLGPRIYIDY VDAEALKEGE NATFINWGNI LIRKVNKDAS GNITSVDAAL
610 620 630 640 650
NLENKDFKKT LKLTWLAVED DPSAYPPTFC VYFDNIISKA VLGKDEDFKQ
660 670 680 690 700
FIGHKTRDEV PMLGDPELKK CKKGDIIQLQ RRGFFKVDVA YAPPSGYTNV
710 720 730 740 750
PSPIVLFSIP DGHTKDVPTS GLKVNAPDAK ATKKASSPVS SSGQASELDS
760 770 780 790 800
QISQQGDLVR DLKSKKAAKD QIDVAVKKLL ALKADYKSAT GKDWKPGQTS
810 820 830 840 850
ASSAPVPAAS SSSANDAVSV NASIVKQGDL VRDLKGKKAS KPEIDAAVKT
860 870 880 890 900
LLELKAQYKT LTGQDWKPGT VPTTAAPSAS AAPSVGVNDS VAQILSQITA
910 920 930 940 950
QGDKVRELKS AKADKATVDA AVKTLLSLKA DYKAATGSDW KPGTTAPAPA
960 970 980 990 1000
AAPVKVKQEK NPDPASVLTV NTLLNKIAQQ GDKIRQLKSA KSEKSLVEAE
1010 1020 1030 1040 1050
VKLLLALKTD YKSLTGQEWK PGTVAPAPTT VNVIDLTGGD SGSDVGSVLS
1060 1070 1080 1090 1100
KIQAQGDKIR KLKSEKAAKN VIDPEVKTLL ALKGEYKTLS GKDWTPDAKS
1110 1120 1130 1140 1150
EPAVVKKEAS PVSMASPAKD ELTQEINAQG EKVRAAKGNK AAKEVIDAEV
1160 1170 1180 1190 1200
AKLLALKAKY KEVTGTDFPV AGRGGGGGGG SAKKAPKEAQ PKPAKPVKKE
1210 1220 1230 1240 1250
PAADASGAVK KQTRLGLEAT KEDNLPDWYS QVITKGEMIE YYDVSGCYIL
1260 1270 1280 1290 1300
RQWSFAIWKA IKTWFDAEIT RMGVKECYFP IFVSKAVLEK EKTHIADFAP
1310 1320 1330 1340 1350
EVAWVTKSGD SDLAEPIAVR PTSETVMYPA YAKWVQSYRD LPIRLNQWNN
1360 1370 1380 1390 1400
VVRWEFKQPT PFLRTREFLW QEGHTAFADK EEAAKEVLDI LDLYALVYTH
1410 1420 1430 1440 1450
LLAIPVVKGR KTEKEKFAGG DYTTTVEAFI SASGRAIQGA TSHHLGQNFS
1460 1470 1480 1490 1500
KMFEIVYEDP ETQQKKYVYQ NSWGITTRTI GVMIMVHADN QGLVLPPHVA
1510 1520 1530 1540 1550
CIQAIVVPCG ITVNTKDDER AQLLDACKAL EKRLVGGGVR CEGDYRDNYS
1560 1570 1580 1590 1600
PGWKFNHWEL KGVPLRLEVG PKDLKAQQLV AVRRDTVEKI TIPLADVEKK
1610 1620 1630 1640 1650
IPALLETIHE SMLNKAQEDM TSHTKKVTNW TDFCGFLEQK NILLAPFCGE
1660 1670 1680 1690 1700
ISCEDKIKAD SARGEEAEPG APAMGAKSLC IPFDQPAPIA ASDKCINPSC
1710
TNKPKFYTLF GRSY
Length:1,714
Mass (Da):189,412
Last modified:March 1, 2004 - v2
Checksum:i3F8CF3DB128765A8
GO
Isoform B (identifier: P28668-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-718: Missing.
     719-732: TSGLKVNAPDAKAT → MLNYLACGSLSSTS

Note: No experimental confirmation available.

Show »
Length:996
Mass (Da):107,835
Checksum:i0E0D298DF6D006C9
GO

Sequence cautioni

The sequence AAN71400.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1065DKSIA → TSPLP(PubMed:1756734)Curated
Sequence conflicti102 – 1065DKSIA → TSPLP(PubMed:9063462)Curated
Sequence conflicti233 – 2342AF → VC(PubMed:1756734)Curated
Sequence conflicti233 – 2342AF → VC(PubMed:9063462)Curated
Sequence conflicti341 – 3455KYCVR → NTACA(PubMed:1756734)Curated
Sequence conflicti341 – 3455KYCVR → NTACA(PubMed:9063462)Curated
Sequence conflicti583 – 5831R → K(PubMed:1756734)Curated
Sequence conflicti583 – 5831R → K(PubMed:9063462)Curated
Sequence conflicti692 – 6921A → L(PubMed:1756734)Curated
Sequence conflicti692 – 6921A → L(PubMed:9063462)Curated
Sequence conflicti753 – 7531S → T(PubMed:1756734)Curated
Sequence conflicti753 – 7531S → T(PubMed:9063462)Curated
Sequence conflicti802 – 8021S → T(PubMed:1756734)Curated
Sequence conflicti802 – 8021S → T(PubMed:9063462)Curated
Sequence conflicti873 – 8731T → P(PubMed:1756734)Curated
Sequence conflicti873 – 8731T → P(PubMed:9063462)Curated
Sequence conflicti887 – 8871V → G(PubMed:1756734)Curated
Sequence conflicti887 – 8871V → G(PubMed:9063462)Curated
Sequence conflicti1035 – 10351D → G in AAN71400. (PubMed:12537569)Curated
Sequence conflicti1202 – 12021Missing(PubMed:1756734)Curated
Sequence conflicti1202 – 12021Missing(PubMed:9063462)Curated
Sequence conflicti1461 – 14611E → EK(PubMed:1756734)Curated
Sequence conflicti1461 – 14611E → EK(PubMed:9063462)Curated
Sequence conflicti1587 – 15871V → G(PubMed:1756734)Curated
Sequence conflicti1587 – 15871V → G(PubMed:9063462)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 718718Missing in isoform B. 1 PublicationVSP_009609Add
BLAST
Alternative sequencei719 – 73214TSGLK…DAKAT → MLNYLACGSLSSTS in isoform B. 1 PublicationVSP_009610Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74104 mRNA. Translation: AAA28594.1.
U59923 Genomic DNA. Translation: AAC47469.1.
AE014297 Genomic DNA. Translation: AAF56211.1.
AE014297 Genomic DNA. Translation: AAN13964.1.
AY058703 mRNA. Translation: AAL13932.1.
BT001645 mRNA. Translation: AAN71400.1. Different initiation.
PIRiS18644.
RefSeqiNP_524471.2. NM_079747.3. [P28668-1]
NP_732925.1. NM_170103.2. [P28668-2]
UniGeneiDm.1304.

Genome annotation databases

EnsemblMetazoaiFBtr0084511; FBpp0083898; FBgn0005674. [P28668-1]
GeneIDi42834.
KEGGidme:Dmel_CG5394.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74104 mRNA. Translation: AAA28594.1 .
U59923 Genomic DNA. Translation: AAC47469.1 .
AE014297 Genomic DNA. Translation: AAF56211.1 .
AE014297 Genomic DNA. Translation: AAN13964.1 .
AY058703 mRNA. Translation: AAL13932.1 .
BT001645 mRNA. Translation: AAN71400.1 . Different initiation.
PIRi S18644.
RefSeqi NP_524471.2. NM_079747.3. [P28668-1 ]
NP_732925.1. NM_170103.2. [P28668-2 ]
UniGenei Dm.1304.

3D structure databases

ProteinModelPortali P28668.
SMRi P28668. Positions 37-162, 195-688, 748-797, 816-872, 894-943, 973-1022, 1217-1714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67770. 45 interactions.
IntActi P28668. 2 interactions.

Proteomic databases

PaxDbi P28668.
PRIDEi P28668.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084511 ; FBpp0083898 ; FBgn0005674 . [P28668-1 ]
GeneIDi 42834.
KEGGi dme:Dmel_CG5394.

Organism-specific databases

CTDi 42834.
FlyBasei FBgn0005674. Aats-glupro.

Phylogenomic databases

eggNOGi COG0442.
GeneTreei ENSGT00550000074815.
InParanoidi P28668.
KOi K14163.
OMAi VAMLHIK.
OrthoDBi EOG754HNH.
PhylomeDBi P28668.

Enzyme and pathway databases

Reactomei REACT_214144. Cytosolic tRNA aminoacylation.

Miscellaneous databases

GenomeRNAii 42834.
NextBioi 830817.
PROi P28668.

Gene expression databases

Bgeei P28668.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
1.10.287.10. 6 hits.
1.20.1050.10. 1 hit.
2.40.240.10. 2 hits.
3.30.110.30. 1 hit.
3.40.50.620. 2 hits.
3.40.50.800. 1 hit.
HAMAPi MF_01571. Pro_tRNA_synth_type3.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR001412. aa-tRNA-synth_I_CS.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF14497. GST_C_3. 1 hit.
PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF00458. WHEP-TRS. 6 hits.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SMARTi SM00946. ProRS-C_1. 1 hit.
SM00991. WHEP-TRS. 6 hits.
[Graphical view ]
SUPFAMi SSF47060. SSF47060. 6 hits.
SSF47616. SSF47616. 1 hit.
SSF50715. SSF50715. 1 hit.
SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
TIGR00408. proS_fam_I. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 6 hits.
PS51185. WHEP_TRS_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase."
    Cerini C., Kerjan P., Astier M., Gratecos D., Mirande M., Semeriva M.
    EMBO J. 10:4267-4277(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex."
    Cerini C., Semeriva M., Gratecos D.
    Eur. J. Biochem. 244:176-185(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
    Strain: Oregon-R.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSYEP_DROME
AccessioniPrimary (citable) accession number: P28668
Secondary accession number(s): Q8IGR4
, Q8IMX9, Q95TL3, Q9VCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: March 1, 2004
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3