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P28668

- SYEP_DROME

UniProt

P28668 - SYEP_DROME

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Protein
Bifunctional glutamate/proline--tRNA ligase
Gene
Aats-glupro, CG5394
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation
ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171ATP By similarity
Binding sitei404 – 4041ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi438 – 4425ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA binding Source: UniProtKB-KW
  3. glutamate-tRNA ligase activity Source: UniProtKB-EC
  4. proline-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: InterPro
  2. prolyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiREACT_214144. Cytosolic tRNA aminoacylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional glutamate/proline--tRNA ligase
Alternative name(s):
Bifunctional aminoacyl-tRNA synthetase
Including the following 2 domains:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Proline--tRNA ligase (EC:6.1.1.15)
Alternative name(s):
Prolyl-tRNA synthetase
Short name:
ProRS
Gene namesi
Name:Aats-glupro
ORF Names:CG5394
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0005674. Aats-glupro.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17141714Bifunctional glutamate/proline--tRNA ligaseUniRule annotation
PRO_0000119741Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1110 – 11101Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP28668.
PRIDEiP28668.

Expressioni

Gene expression databases

BgeeiP28668.

Interactioni

Subunit structurei

Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.

Protein-protein interaction databases

BioGridi67770. 45 interactions.
IntActiP28668. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP28668.
SMRiP28668. Positions 195-688, 748-797, 816-872, 894-943, 973-1022, 1048-1096, 1217-1714.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini744 – 80057WHEP-TRS 1
Add
BLAST
Domaini816 – 87257WHEP-TRS 2
Add
BLAST
Domaini890 – 94657WHEP-TRS 3
Add
BLAST
Domaini969 – 102557WHEP-TRS 4
Add
BLAST
Domaini1044 – 110057WHEP-TRS 5
Add
BLAST
Domaini1118 – 117457WHEP-TRS 6
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni170 – 754585Glutamate--tRNA ligaseUniRule annotation
Add
BLAST
Regioni1207 – 1714508Proline--tRNA ligaseUniRule annotation
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi209 – 22012"HIGH" regionUniRule annotation
Add
BLAST
Motifi438 – 4425"KMSKS" regionUniRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1174 – 11807Poly-GlyUniRule annotation

Sequence similaritiesi

In the N-terminal section; belongs to the class-I aminoacyl-tRNA synthetase family.
In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.
Contains 6 WHEP-TRS domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0442.
GeneTreeiENSGT00750000118170.
InParanoidiP28668.
KOiK14163.
OMAiVAMLHIK.
OrthoDBiEOG754HNH.
PhylomeDBiP28668.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
1.10.287.10. 6 hits.
1.20.1050.10. 1 hit.
2.40.240.10. 2 hits.
3.30.110.30. 1 hit.
3.40.50.620. 2 hits.
3.40.50.800. 1 hit.
HAMAPiMF_01571. Pro_tRNA_synth_type3.
InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR001412. aa-tRNA-synth_I_CS.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF14497. GST_C_3. 1 hit.
PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF00458. WHEP-TRS. 6 hits.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SMARTiSM00946. ProRS-C_1. 1 hit.
SM00991. WHEP-TRS. 6 hits.
[Graphical view]
SUPFAMiSSF47060. SSF47060. 6 hits.
SSF47616. SSF47616. 1 hit.
SSF50715. SSF50715. 1 hit.
SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.
TIGR00408. proS_fam_I. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 6 hits.
PS51185. WHEP_TRS_2. 6 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform A (identifier: P28668-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSIKLKANLN NPPISGLATA HLINGTVPVE IVWSKEETSL QFPDNRLLVC     50
HSNNDVLRAL ARAAPDYKLY GETAIERTQI DHWLSFSLTC EDDISWALSF 100
LDKSIAPVTY LVANKLTIAD FALFNEMHSR YEFLAAKGIP QHVQRWYDLI 150
TAQPLIQKVL QSLPEDAKVK RSPQSSKEQT PAKTGERKQE GKFVDLPGAE 200
MGKVVVRFPP EASGYLHIGH AKAALLNQYY ALAFQGTLIM RFDDTNPAKE 250
TVEFENVILG DLEQLQIKPD VFTHTSNYFD LMLDYCVRLI KESKAYVDDT 300
PPEQMKLERE QRVESANRSN SVEKNLSLWE EMVKGSEKGQ KYCVRAKIDM 350
SSPNGCMRDP TIYRCKNEPH PRTGTKYKVY PTYDFACPIV DAIENVTHTL 400
RTTEYHDRDD QFYWFIDALK LRKPYIWSYS RLNMTNTVLS KRKLTWFVDS 450
GLVDGWDDPR FPTVRGIIRR GMTVEGLKEF IIAQGSSKSV VFMNWDKIWA 500
FNKKVIDPIA PRYTALEKEK RVIVNVAGAK VERIQVSVHP KDESLGKKTV 550
LLGPRIYIDY VDAEALKEGE NATFINWGNI LIRKVNKDAS GNITSVDAAL 600
NLENKDFKKT LKLTWLAVED DPSAYPPTFC VYFDNIISKA VLGKDEDFKQ 650
FIGHKTRDEV PMLGDPELKK CKKGDIIQLQ RRGFFKVDVA YAPPSGYTNV 700
PSPIVLFSIP DGHTKDVPTS GLKVNAPDAK ATKKASSPVS SSGQASELDS 750
QISQQGDLVR DLKSKKAAKD QIDVAVKKLL ALKADYKSAT GKDWKPGQTS 800
ASSAPVPAAS SSSANDAVSV NASIVKQGDL VRDLKGKKAS KPEIDAAVKT 850
LLELKAQYKT LTGQDWKPGT VPTTAAPSAS AAPSVGVNDS VAQILSQITA 900
QGDKVRELKS AKADKATVDA AVKTLLSLKA DYKAATGSDW KPGTTAPAPA 950
AAPVKVKQEK NPDPASVLTV NTLLNKIAQQ GDKIRQLKSA KSEKSLVEAE 1000
VKLLLALKTD YKSLTGQEWK PGTVAPAPTT VNVIDLTGGD SGSDVGSVLS 1050
KIQAQGDKIR KLKSEKAAKN VIDPEVKTLL ALKGEYKTLS GKDWTPDAKS 1100
EPAVVKKEAS PVSMASPAKD ELTQEINAQG EKVRAAKGNK AAKEVIDAEV 1150
AKLLALKAKY KEVTGTDFPV AGRGGGGGGG SAKKAPKEAQ PKPAKPVKKE 1200
PAADASGAVK KQTRLGLEAT KEDNLPDWYS QVITKGEMIE YYDVSGCYIL 1250
RQWSFAIWKA IKTWFDAEIT RMGVKECYFP IFVSKAVLEK EKTHIADFAP 1300
EVAWVTKSGD SDLAEPIAVR PTSETVMYPA YAKWVQSYRD LPIRLNQWNN 1350
VVRWEFKQPT PFLRTREFLW QEGHTAFADK EEAAKEVLDI LDLYALVYTH 1400
LLAIPVVKGR KTEKEKFAGG DYTTTVEAFI SASGRAIQGA TSHHLGQNFS 1450
KMFEIVYEDP ETQQKKYVYQ NSWGITTRTI GVMIMVHADN QGLVLPPHVA 1500
CIQAIVVPCG ITVNTKDDER AQLLDACKAL EKRLVGGGVR CEGDYRDNYS 1550
PGWKFNHWEL KGVPLRLEVG PKDLKAQQLV AVRRDTVEKI TIPLADVEKK 1600
IPALLETIHE SMLNKAQEDM TSHTKKVTNW TDFCGFLEQK NILLAPFCGE 1650
ISCEDKIKAD SARGEEAEPG APAMGAKSLC IPFDQPAPIA ASDKCINPSC 1700
TNKPKFYTLF GRSY 1714
Length:1,714
Mass (Da):189,412
Last modified:March 1, 2004 - v2
Checksum:i3F8CF3DB128765A8
GO
Isoform B (identifier: P28668-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-718: Missing.
     719-732: TSGLKVNAPDAKAT → MLNYLACGSLSSTS

Note: No experimental confirmation available.

Show »
Length:996
Mass (Da):107,835
Checksum:i0E0D298DF6D006C9
GO

Sequence cautioni

The sequence AAN71400.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 718718Missing in isoform B.
VSP_009609Add
BLAST
Alternative sequencei719 – 73214TSGLK…DAKAT → MLNYLACGSLSSTS in isoform B.
VSP_009610Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti102 – 1065DKSIA → TSPLP1 Publication
Sequence conflicti102 – 1065DKSIA → TSPLP1 Publication
Sequence conflicti233 – 2342AF → VC1 Publication
Sequence conflicti233 – 2342AF → VC1 Publication
Sequence conflicti341 – 3455KYCVR → NTACA1 Publication
Sequence conflicti341 – 3455KYCVR → NTACA1 Publication
Sequence conflicti583 – 5831R → K1 Publication
Sequence conflicti583 – 5831R → K1 Publication
Sequence conflicti692 – 6921A → L1 Publication
Sequence conflicti692 – 6921A → L1 Publication
Sequence conflicti753 – 7531S → T1 Publication
Sequence conflicti753 – 7531S → T1 Publication
Sequence conflicti802 – 8021S → T1 Publication
Sequence conflicti802 – 8021S → T1 Publication
Sequence conflicti873 – 8731T → P1 Publication
Sequence conflicti873 – 8731T → P1 Publication
Sequence conflicti887 – 8871V → G1 Publication
Sequence conflicti887 – 8871V → G1 Publication
Sequence conflicti1035 – 10351D → G in AAN71400. 1 Publication
Sequence conflicti1202 – 12021Missing1 Publication
Sequence conflicti1202 – 12021Missing1 Publication
Sequence conflicti1461 – 14611E → EK1 Publication
Sequence conflicti1461 – 14611E → EK1 Publication
Sequence conflicti1587 – 15871V → G1 Publication
Sequence conflicti1587 – 15871V → G1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74104 mRNA. Translation: AAA28594.1.
U59923 Genomic DNA. Translation: AAC47469.1.
AE014297 Genomic DNA. Translation: AAF56211.1.
AE014297 Genomic DNA. Translation: AAN13964.1.
AY058703 mRNA. Translation: AAL13932.1.
BT001645 mRNA. Translation: AAN71400.1. Different initiation.
PIRiS18644.
RefSeqiNP_524471.2. NM_079747.3. [P28668-1]
NP_732925.1. NM_170103.2. [P28668-2]
UniGeneiDm.1304.

Genome annotation databases

EnsemblMetazoaiFBtr0084511; FBpp0083898; FBgn0005674. [P28668-1]
GeneIDi42834.
KEGGidme:Dmel_CG5394.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74104 mRNA. Translation: AAA28594.1 .
U59923 Genomic DNA. Translation: AAC47469.1 .
AE014297 Genomic DNA. Translation: AAF56211.1 .
AE014297 Genomic DNA. Translation: AAN13964.1 .
AY058703 mRNA. Translation: AAL13932.1 .
BT001645 mRNA. Translation: AAN71400.1 . Different initiation.
PIRi S18644.
RefSeqi NP_524471.2. NM_079747.3. [P28668-1 ]
NP_732925.1. NM_170103.2. [P28668-2 ]
UniGenei Dm.1304.

3D structure databases

ProteinModelPortali P28668.
SMRi P28668. Positions 195-688, 748-797, 816-872, 894-943, 973-1022, 1048-1096, 1217-1714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 67770. 45 interactions.
IntActi P28668. 2 interactions.

Proteomic databases

PaxDbi P28668.
PRIDEi P28668.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0084511 ; FBpp0083898 ; FBgn0005674 . [P28668-1 ]
GeneIDi 42834.
KEGGi dme:Dmel_CG5394.

Organism-specific databases

CTDi 42834.
FlyBasei FBgn0005674. Aats-glupro.

Phylogenomic databases

eggNOGi COG0442.
GeneTreei ENSGT00750000118170.
InParanoidi P28668.
KOi K14163.
OMAi VAMLHIK.
OrthoDBi EOG754HNH.
PhylomeDBi P28668.

Enzyme and pathway databases

Reactomei REACT_214144. Cytosolic tRNA aminoacylation.

Miscellaneous databases

GenomeRNAii 42834.
NextBioi 830817.
PROi P28668.

Gene expression databases

Bgeei P28668.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
1.10.287.10. 6 hits.
1.20.1050.10. 1 hit.
2.40.240.10. 2 hits.
3.30.110.30. 1 hit.
3.40.50.620. 2 hits.
3.40.50.800. 1 hit.
HAMAPi MF_01571. Pro_tRNA_synth_type3.
InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR001412. aa-tRNA-synth_I_CS.
IPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR010987. Glutathione-S-Trfase_C-like.
IPR004046. GST_C.
IPR004499. Pro-tRNA-ligase_IIa_arc-type.
IPR016061. Pro-tRNA_ligase_II_C.
IPR017449. Pro-tRNA_synth_II.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009068. S15_NS1_RNA-bd.
IPR000738. WHEP-TRS.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF14497. GST_C_3. 1 hit.
PF03129. HGTP_anticodon. 1 hit.
PF09180. ProRS-C_1. 1 hit.
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
PF00458. WHEP-TRS. 6 hits.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SMARTi SM00946. ProRS-C_1. 1 hit.
SM00991. WHEP-TRS. 6 hits.
[Graphical view ]
SUPFAMi SSF47060. SSF47060. 6 hits.
SSF47616. SSF47616. 1 hit.
SSF50715. SSF50715. 1 hit.
SSF52954. SSF52954. 1 hit.
SSF64586. SSF64586. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
TIGR00408. proS_fam_I. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
PS50862. AA_TRNA_LIGASE_II. 1 hit.
PS00762. WHEP_TRS_1. 6 hits.
PS51185. WHEP_TRS_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A component of the multisynthetase complex is a multifunctional aminoacyl-tRNA synthetase."
    Cerini C., Kerjan P., Astier M., Gratecos D., Mirande M., Semeriva M.
    EMBO J. 10:4267-4277(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "Evolution of the aminoacyl-tRNA synthetase family and the organization of the Drosophila glutamyl-prolyl-tRNA synthetase gene. Intron/exon structure of the gene, control of expression of the two mRNAs, selective advantage of the multienzyme complex."
    Cerini C., Semeriva M., Gratecos D.
    Eur. J. Biochem. 244:176-185(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
    Strain: Oregon-R.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1110, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiSYEP_DROME
AccessioniPrimary (citable) accession number: P28668
Secondary accession number(s): Q8IGR4
, Q8IMX9, Q95TL3, Q9VCF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 1992
Last sequence update: March 1, 2004
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi